Siddhartha Ganguly, M.D., FACP


Rank: Professor of Medicine

Position: Associate Clinical Director, Blood and Marrow Transplantation Program

Position: Director, Lymphoma/Myeloma Program


Clinical Interest(s):

Bone Marrow Transplantation ι Stem Cell Transplantation ι Hematological Malignancies ι Lymphoma ι Multiple Myeloma

Research Interest(s):

Clinical Research in Hematologic Malignancies ι Stem cell and marrow transplantation

Publications:

  1. Ganguly S, Divine CL, Deauna-Limayo D, Bodensteiner DC, Cook JD, Lewis JN and Skikne BS. Autologous Transplantation in Patients with Relapsed or High Grade Follicular Lymphoma Provides Long Term Disease Free Survival and Best Median Duration of Response. Ann Hematol 2005; 84: 526-31.
  2. Ganguly S.,  Singh J., Divine, CL, Deauna-Limayo D, Bodensteiner DC, Lewis JN, Curran K, and Skikne BS. Is There a Plateau in The Survival Curve After Autologous Transplantation in Patients With Intermediate and High-Risk Acute Myeloid Leukemia? A 20-Year Single Institution Experience. Leukemia Res 2007; 31: 1253-1257
  3. Ganguly S, Patel V. R-CHOP versus R-CVP in the Treatment of Follicular Lymphoma: A Meta-Analysis and Critical Appraisal of Current Literature. Journal of Hematology and Oncology. 2009; 2: 14 (March 24, 2009)
  4. Ganguly S, Jain V, Divine CL, Aljitawi O, Abhyankar S, McGuirk JP. Busulphan, Melphalan, and Thiotepa as a Preparative Regimen for Auto-transplantation in Hodgkin's disease. Bone Marrow Transplant. 2012 Feb;47(2):311-2. 
  5. Stefan Faderl, Meir Wetzler, David Rizzieri, Gary Schiller, Madan Jagasia, Robert Stuart, Siddhartha Ganguly, et al. Clofarabine Plus Cytarabine Compared with Cytarabine Alone in Older Patients with Relapsed or Refractory Acute Myelogenous Leukemia: Results from the Randomized, Double-Blind, Placebo-Controlled Phase 3 CLASSIC I Trial. Journal of Clinical Oncology July 10, 2012;30:2492-9
  6. Fiskus W, Rao R, Balusu R, Ganguly S, Tao Jianguo, Sotomayor E, Mudunuru U, Smith JE, Hembruff SL, Atadja P, Marquez VE, Bhalla K. Superior efficacy of a combined epigenetic therapy against human Mantle Cell Lymphoma (MCL) cells. Clin Cancer Res. 2012 Nov 15;18(22):6227-38
  7. HDAC Inhibitors and Chaperone Function. Rao R, Fiscus W, Ganguly S, Kambhapati S, Bhalla KN. Advances in Cancer Research  2012;116:239-62.
  8. Ganguly S, Amin M, Divine CL, Aljitawi OS, Abhyankar S, and McGuirk JP. Decitabine in Patients with Relapsed AML after Allogeneic BMT. Ann Hematol. 2013 Apr 92(4):549-50 
  9. Ganguly S, McRae J, He J, Divine CL, Abhyankar S, Aljitawi O, and McGuirk JP. Routine Radiographic Screening after Completion of Initial Chemotherapy and Relapse-Free Survival after Transplantation in Patients with Relapsed Lymphoma. Leuk Lymphoma. 2014 May 14:1-6.
  10. Hamadani M, Hari PN,  Zhang Y, Carreras J,  Akpek G,  Aljurf MD,  Ayala E, Bachanova V, Chen AI, Chen YB, Costa LJ, Fenske TS,  Freytes CO, Ganguly S, Hertzberg MS, Holmberg LA,  Inwards DJ, Kamble RT, Kanfer EJ, Lazarus HM, Marks DI, Nishihori T, Olsson R, Reddy NM, Rizzieri DA, Savani BN, Solh M, Vose JM, Wirk B, Maloney DG, Smith SM,  Montoto S,  and Saber W. Early failure of frontline rituximab-containing chemo-immunotherapy in diffuse large B cell lymphoma does not predict futility of autologous hematopoietic cell transplantation. Biol Blood and Marrow Transplantation 2014; 20(11):1729-36
  11. Shah N, Callander N, Ganguly S, Gul Z, Hamadani M, Costa L, Sengsayadeth S, Abidi M, Hari P, Mohty M, Chen YB, Koreth J, Landau H, Lazarus H, Leather H, Majhail N, Nath R, Osman K, Perales MA, Schriber J, Shaughnessy P, Vesole D, Vij R, Wingard J, Giralt S, Savani B., Hematopoietic Stem Cell Transplantation for Multiple Myeloma: Guidelines from the ASBMT, Biol Blood Marrow Transplantation 2015 Jul;21(7):1155-116
  12. Anita D'Souza, Angela Dispenzieri, Baldeep Wirk, Mei-Jie Zhang, Jiaxing Huang, Morie Gertz, Robert Kyle, Shaji Kumar, Raymond Comenzo, Robert Gale, Hillard Lazarus, Bipin Savani, Robert Cornell, Brendan Weiss, Dan Vogl, Cesar Freytes, Emma Scott, Heather Landau, Jan Moreb, Luciano Costa, Muthalagu Ramanathan, Natalie Callander, Rammurti Kamble, Richard Olsson, Siddhartha Ganguly, Taiga Nishihori, Tamila Kindwall-Keller, William Wood, Tomer Mark, Parameswaran Hari. Improved outcomes after autologous hematopoietic cell transplantation for light chain amyloidosis: A Center for International Blood and Marrow Transplant Research Study- J Clin Oncol. 2015 Nov 10;33(32):3741-9
  13. Satwani P, Ahn KW, Carreras J, Abdel-Azim H, Cairo MS, Cashen A, Chen AI, Cohen JB, Costa LJ, Dandoy C, Fenske TS, Freytes CO, Ganguly S, Gale RP, Ghosh N, Hertzberg MS, Hayashi RJ, Kamble RT, Kanate AS, Keating A, Kharfan-Dabaja MA, Lazarus HM, Marks DI, Nishihori T, Olsson RF, Prestidge TD, Rolon JM, Savani BN, Vose JM, Wood WA, Inwards DJ, Bachanova V, Smith SM, Maloney DG, Sureda A, Hamadani M. A Prognostic Model Predicting Autologous Transplantation Outcomes in Children, Adolescents and Young Adults with Hodgkin Lymphoma. Bone Marrow Transplant. 2015 Nov;50(11):1416-23
  14. Uy GL, Costa LJ, Hari PN, Zhang MJ, Huang JX, Anderson KC, Bredeson CN, Callander NS, Cornell RF, Perez MA, Dispenzieri A, Freytes CO, Gale RP, Garfall A, Gertz MA, Gibson J, Hamadani M, Lazarus HM, Kalaycio ME, Kamble RT, Kharfan-Dabaja MA, Krishnan AY, Kumar SK, Kyle RA, Landau HJ, Lee CH, Maiolino A, Marks DI, Mark TM, Munker R, Nishihori T, Olsson RF, Ramanathan M, Rodriguez TE, Saad AA, Savani BN, Schiller GJ, Schouten HC, Schriber JR, Scott E, Seo S, Sharma M, Ganguly S, Stadtmauer EA, Tay J, To LB, Vesole DH, Vogl DT, Wagner JL, Wirk B, Wood WA, D'Souza A. Contribution of chemotherapy mobilization to disease control in multiple myeloma treated with autologous hematopoietic cell transplantation. Bone Marrow Transplant. 2015 Dec;50(12):1513-8
  15. Klyuchnikov E, Bacher U,  Kröger N, Hari P,  Ahn KW, Carreras J, Bachanova V, Bashey A,  Cohen JB, D'Souza A, Freytes CO, Gale RP, Ganguly S, Hertzberg MS, HolmbergLS, Kharfan-Dabaja MA,  Klein A, Ku GH, Laport G, LazarusHM, Miller AM, Mussetti A, Olsson RF, Slavin S, Usmani SZ, Vij R, Wood WA, Maloney D, Sureda AM, Smith SM, and Hamadani M. Reduced-intensity allografting as first transplantation approach in relapsed/refractory grade 1-2 follicular lymphoma provides improved outcomes in long-term survivors. Biol Blood Marrow Transplant. 2015 Dec;21(12):2091-9
  16. Iliff A, Divine C, Diaz, F, Aljitawi O, Abhyankar S, McGuirk J, and Ganguly S. Adequacy of Peripheral Blood Stem Cell Mobilization in Patients with Relapsed B Cell Non Hodgkin Lymphoma Treated with Bendamustine. Leuk Lymphoma. 2015 Oct 12:1-2
  17. Ganguly S, Home T, Yacoub A, Kambhampati S, Shi H, Dandwate P, Padhye S, Saluja AK, McGuirk J and Rao. Targeting HSF1 disrupts HSP90 Chaperone Function in Chronic Lymphocytic Leukemia. Oncotarget. 2015 Oct 13;6(31):31767-79
  18. Veronika Bachanova, Linda J. Burns,   Kwang Woo Ahn,  Ginna G. Laport,  Görgün Akpek, , Mohamed A. Kharfan-Dabaja,  Taiga Nishihori,  Edward Agura, Philippe Armand,  Samantha M. Jaglowski, Mitchell S. Cairo, Amanda F. Cashen, Jonathon B. Cohen,  Anita D'Souza,  César O. Freytes, Robert Peter Gale,  Siddhartha Ganguly,  Nilanjan Ghosh,  Leona A. Holmberg, David J. Inwards,  Abraham S. Kanate, Hillard M. Lazarus, Adriana K. Malone, Reinhold Munker,  Alberto Mussetti, Maxim Norkin,  Tim D. Prestidge,  Jacob M. Rowe, Prakash Satwani, Tanya Siddiqi,  Patrick J. Stiff, Basem M. William,  Baldeep Wirk, David G. Maloney,  Sonali M. Smith ,  Anna M. Sureda,  Jeanette Carreras and Mehdi Hamadani. For Center for International Blood and Marrow Transplant Research (CIBMTR®) Lymphoma Working Committee. Impact of "real-world" interpretation of pre-transplant FDG-PET status on outcomes after allogeneic hematopoietic cell transplantation for non-Hodgkin lymphoma. Biol Blood Marrow Transplant. 2015 Sep;21(9):1605-11
  19. Pasquini MC, Zhang MJ, Medeiros BC, Armand P, Hu ZH, Nishihori T, Aljurf MD, Akpek G, Cahn JY, Cairo MS, Cerny J, Copelan EA, Deol A, Freytes CO, Gale RP, Ganguly S, George B, Gupta V, Hale GA, Kamble RT, Klumpp TR, Lazarus HM, Luger SM, Liesveld JL, Litzow MR, Marks DI, Martino R, Norkin M, Olsson RF, Oran B, Pawarode A, Pulsipher MA, Ramanathan M, Reshef R, Saad AA, Saber W, Savani BN, Schouten HC, Ringdén O, Tallman MS, Uy GL, Wood WA Jr, Wirk B, Pérez WS, Batiwalla M, Weisdorf DJ. Hematopoietic Cell Transplantation Outcomes in Monosomal Karyotype Myeloid Malignancies. Biol Blood Marrow Transplant. 2016 Feb;22(2):248-57
  20. Abraham S. Kanate, Alberto Mussett, Mohamed A. Kharfan-Dabaja, Kwang W. Ahn, Alyssa DiGilio,Amer Beitinjaneh , Saurabh Chhabra, Timothy S. Fenske, Cesar Freytes, Robert Peter Gale, Siddhartha Ganguly, Mark Hertzberg, Evgeny Klyuchnikov, Hillard M. Lazarus , Richard Olsson, Miguel-Angel Perales, Andrew Rezvani, Marcie Riches, Ayman Saad , Shimon Slavin, Sonali M. Smith, Anna Sureda, Jean Yared, Stefan Ciurea, Philippe Armand, Rachel Salit, Javier Bolanos-Meade, Mehdi Hamadani. Reduced-intensity transplantation for lymphomas using haploidentical related donors versus HLA-matched unrelated donors. Blood. 2016 Feb 18;127(7):938-47
  21. Fenske TS, Ahn KW, Graff TM, DiGilio A, Bashir Q, Kamble RT, Ayala E, Bacher U, Brammer JE, Cairo M, Chen A, Chen YB, Chhabra S, D'Souza A, Farooq U, Freytes C, Ganguly S, Hertzberg M,  Inwards D, Jaglowski S, Kharfan-Dabaja MA, Lazarus HM, Nathan S, Pawarode A, Perales MA, Reddy N, Seo S, Sureda A, Smith SM, Hamadani M. Allogeneic Transplantation Provides Durable Remission in a Subset of DLBCL Patients Relapsing after Autologous Transplantation. Br J Haematol. 2016 Jul;174(2):235-48
  22. Ghosh N, Karmali R, Rocha V, Ahn KW, DiGilio A, Hari PN, Bachanova V, Bacher U, Dahi P, de Lima M, D'Souza A, Fenske TS, Ganguly S, Kharfan-Dabaja MA, Prestidge TD, Savani BN, Smith SM, Sureda AM, Waller EK, Jaglowski S, Herrera AF, Armand P, Salit RB, Wagner-Johnston ND, Fuchs E, Bolaños-Meade J, Hamadani M. Reduced-intensity transplantation for lymphomas using haploidentical related donors versus HLA-matched sibling donors.A CIBMTR analysis. J Clin Oncol. 2016 Jun 6. pii: JCO663476. [Epub ahead of print] PMID: 27269951
  23. Deol A, Sengsayadeth S, Ahn KW, Wang HL, Aljurf M, Antin JH, Battiwalla M, Bornhauser M, Cahn JY, Camitta B, Chen YB, Cutler CS, Gale RP, Ganguly S, Hamadani M, Inamoto Y, Jagasia M, Kamble R, Koreth J, Lazarus HM, Liesveld J, Litzow MR, Marks DI, Nishihori T, Olsson RF, Reshef R, Rowe JM, Saad AA, Sabloff M, Schouten HC, Shea TC, Soiffer RJ, Uy GL, Waller EK, Wiernik PH, Wirk B, Woolfrey AE, Bunjes D, Devine S, de Lima M, Sandmaier BM, Weisdorf D, Khoury HJ, Saber W. Does FLT3 mutation impact survival after hematopoietic stem cell transplantation for acute myeloid leukemia? A Center for International Blood and Marrow Transplant Research (CIBMTR) analysis. Cancer. 2016 Jun 17. doi: 10.1002/cncr.30140. [Epub ahead of print]
  24. Scott EC, Hari P, Sharma M, Le-Rademacher J, Huang J, Vogl D, Abidi M,  Beitinjaneh A, Fung H, Ganguly S, Hildebrandt G, Holmberg L, Kumar S, Kyle R, Lazarus HM, Lee C, Maziarz RT, Meehan K, Mikhael J, Nishihori T, Ramanathan M, Usmani S, Tay J, Vesole D, Wirk B, Yared J, Savani BN, Gasparetto C, Krishnan A, Mark T, Nieto Y, D'Souza A. Post-transplant outcomes in high-risk compared to non-high risk multiple myeloma, a CIBMTR analysis. Biol Blood Marrow Transplant. 2016 Aug 2. pii: S1083-8791(16)30223-3. doi: 10.1016/j.bbmt.2016.07.007. [Epub ahead of print] PMID:27496215
  25. Singh AK, Porrata LF, Aljitawi O, Lin T, Shune L, Ganguly S, McGuirk JP, Abhyankar S. Fatal GvHD induced by PD-1 inhibitor pembrolizumab in a patient with Hodgkin's lymphoma. Bone Marrow Transplant. 2016 Apr 25. doi: 10.1038/bmt.2016.111. [Epub ahead of print] No abstract available. PMID: 27111048

 

Education and Training:

Medical School: Post Graduate Institute of Medical Education and Research, Chandigarh, India (Doctor of Medicine)
Internship: Southern Illinois University School of Medicine, Springfield, IL
Residency: Senior Resident Institute Chandigarh, India
Residency: Baylor College of Medicine, Houston, TX (Internal Medicine)
Fellowship: GB Pant Hospital, Delhi University, New Delhi, India (Post-Doctoral Fellow (DM) Doctorate of Medicine)
Fellowship: Baylor College of Medicine, Houston, Texas (Hematology)
Fellowship: Baylor College of Medicine Center for Cell and Gene Marrow Transplantation Therapy, Houston, Texas (Bone Marrow Transplant)


 Awards:

• Best Teacher's Award, KU Internal Medicine
• Max Allen Scholar Award, Department of Medicine
• Anatomy, Medical College, University of Calcutta, India, Senior Prosector
• Goodeve Silver Medal, Medical College, University of Calcutta, India
• Gold Medal, Anatomy, Medical College, University of Calcutta, India
• Pathology, Medical College, University of Calcutta, India, Senior Class Assistant
• Medicine, Medical College, University of Calcutta, India, Senior Class Assistant
• Successive Four College Scholarships, Medical College, University of Calcutta, India

Organizations:

• American Society for Blood and Marrow Transplantation, Myeloma Guidelines Writing Committee (2014)
• Center for International Bone Marrow Transplantation Registry (CIBMTR Working Committee Member- Lymphoma and Myeloma)
• American Medical Association
• American College of Physicians
• American Society for Blood and Marrow Transplantation
• American Society of Hematology
• American College of Physicians - Elected Fellow (FACP)

Last modified: Sep 30, 2016

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Siddhartha Ganguly, M.D., FACP

Professor of Medicine

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