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We have been engaged in bench-to-bedside research on infectious diseases for more than 50 years, since Dr. Chien Liu, professor emeritus of medicine - widely recognized as one of the physician scientists who helped discover the etiology of primary atypical pneumonia - founded our division in 1958.

Our Infectious Diseases Clinical Research Program is currently directed by Dr. Lisa Clough and focuses on the safety and effectiveness of anti-microbial treatments; therapeutic and prophylactic vaccines; the study of influenza, HIV and other viruses; the mechanisms of disease production in pneumococcal infections; stem cell transplant and complicated lung infections. We are carrying out a variety of NIH and independently funded trials, as well as investigator-initiated endeavors.

Current Research

NIH Funded
2016-Present A Phase II Multi-Center, Prospective, Randomized, Double-Blind Study to Assess the Clinical and Antiviral Efficacy and Safety of Nitazoxanide for the Treatment of Norovirus in Hematopoietic Stem Cell and Solid Organ Transplant Recipients  Clough Upcoming


Industry Sponsored
2018- Present A Phase 3, Randomized, Double-blind, Active Comparator-controlled, Multicenter Clinical Study to Evaluate the Safety, Tolerability, and Immunogenicity of V114 in Recipients of Allogeneic Hematopoietic Stem Cell Transplant (PNEU-STEM) NCT03565900 Clough Upcoming
2017-Present A Randomized, Double-Blind, Placebo-Controlled Dose Ranging Study Evaluating the Safety, Pharmacokinetics and Clinical Benefit of FLUIGIV in Hospitalized Patients with Serious Influenza A Infection NCT03315104 Clough Enrolling
2017- Present Dalvance Utilization Registry: A Multicenter, Retrospective Cohort Study to Characterize the Use of Dalvance  Clough Enrolling
2017-Present A Non-Interventional Registry Study of Systemic Antifungal Therapy in Adult Subjects with Invasive Mucormycosis or Invasive Aspergillosis Caused by a Non-fumigatus Species Clough Enrolling
2017-Present Observational Disease Registry of Patients Treated with Systemic Mold-Active Triazoles NCT03066011 Clough Enrolling
2017-Present A Phase 3, Multi-Center, Randomized, Double-Blind Study toEvaluate the Efficacy and Safety of Mino-Lok Therapy (MLT) inCombination with Systemic Antibiotics in the Treatment ofCatheter-Related or Central Line-Associated Bloodstream Infection NCT02901717 Clough Enrolling
TBD Clinical Evaluation of the QuantiFERON CMV Assay (C16-CMV-001) Waller Upcoming


Investigator Initiated
2017-present Hemophagocytic Lymphohistiocytosis case series at University of Kansas Medical Center El Atrouni Ryan Data Analysis Underway
2017-present Evaluation of the Diagnostic Approach to Native Vertebral Osteomyelitis: A 10 year retrospective cohort study  El Atrouni Weihe Abstract complete
2017-present Sexually Transmitted Disease Screening in KUMC Clinic HIV Patients: A four-year retrospective cohort study El Atrouni, Kimball, Abebe Abstract complete
2017-present Clostridium Difficile Infection as a Predictor of Acute Graft versus Host Disease among Allogenic Stem Cell Transplant Recipients  Clough   Jabr Data Analysis Underway
2016-present The feasibility and outcome study of an algorithm for using anal pap smear for early detection of precancerous and cancerous anal lesions in HIV seropositive patients attending KU Infectious Diseases clinic Clough In Progress
2016-present Infection Outcomes in 2 Stage Revision Total Knee Arthroplasty at The University of Kansas Medical Center. Association with Post-Operative Antibiotic Use Clough Abstract complete
2015-Present Incidence and Spectrum of Infection and Its Outcome after Umbilical Cord Blood Transplantation in Patients with Hematological Malignancies: A single center experience Ganguly Data Analysis Underway


Past Research

NIH Funded
2009-2012 An Observational Study of the Clinical and Virologic Manifestations of Novel and Seasonal Influenza Clough
1999-2012 A Phase III Double-Blind, Placebo-Controlled Trial of Long Term Therapy of Herpes Simplex Encephalitis (HSE): An Evaluation of Valacyclovir Hinthorn
2006-2011 ART Adherence: Enhanced Counseling And Observed


Industry Sponsored
2016-2018 A Phase 3, Randomized, Open-Label Study to Evaluate the Safety and Efficacy of Switching from Regimens Consisting of Boosted Atazanavir or Darunavir plus either Emtricitabine/Tenofovir or Abacavir/Lamivudine to GS-9883/Emtricitabine/Tenofovir Alafenamide in Virologically Suppressed HIV-1 Infected Adults NCT02603107 Clough
2015-2017 A Phase 2b, Randomized, Double-Blind, Placebo-Controlled Multi-Center Study Evaluating Antiviral Effects, Pharmacokinetics, Safety, and Tolerability of GS-5806 in Hospitalized Adults with Respiratory Syncytial Virus (RSV) Infection Clough
2014-2016 A Phase III Randomized, Placebo-controlled Clinical Trial to Evaluate the Safety and Efficacy of MK-8228 (Letermovir) for the Prevention of Clinically Significant Human Cytomegalovirus (CMV) Infection in Adult, CMV-Seropositive Allogeneic Hematopoietic Stem Cell Transplant Recipients Clough
2014-2016 A Phase II, Randomized, Double-blind, Placebo-controlled study to examine the effects of DAS181 in immunocompromised subjects with Lower Respiratory Tract Parainfluenza Infection on Supplemental Oxygen Clough
2012-2014 DEFLECT-1: A Phase 3b Multi-Center, Double-Blind Randomized, Placebo Controlled Study to Demonstrate the Safety and Efficacy of Fidaxomicin for Prophylaxis Against Clostridium difficile Associated Diarrhea in Adults Undergoing Hematopoietic Stem Cell Transplantation Clough
2012-2015 A Phase III, Randomized, Double-Blind,
Placebo-Controlled Study of the Efficacy, Safety and Tolerability of a Single Infusion of MK-6072 (Human Monoclonal Antibody to C. difficile toxin B), and MK-3415A (Human Monoclonal Antibodies to C. difficile toxin A and B) in Patients Receiving Antibiotic Therapy for C. difficile Infection (MODIFY II)
2012-2014 Pharmacokinetics, Safety, and Tolerability of Intravenous Posaconazole Solution Followed by Oral Posaconazole Suspension (SCH 56592) in Subjects at High Risk for Invasive Fungal Infections Clough
2010-2011 Clostridium Difficile Toxoid Vaccine: A Phase II Randomized, Placebo-Controlled, Double-blind, Dose Ranging Study to Assess the Immunogenicity and Safety of a Clostridium Difficile Toxoid Vaccine in Subjects with Clostridium Difficile Infection (CDI). Clough
2010-2011 A Randomized, Double-Blinded, Active-Controlled, Dose Ranging Study of Study Antibiotic in Patients with Clostridium Difficile Infection. Clough: Sub-I


Investigator Initiated
2016-2017 Cumulative and current exposure to antiretrovirals and development of CKD el Atrouni
2015 - 2016 Survey of healthcare workers (HCWs) in a Midwestern tertiary care center regarding HIV transmission risk and their opinions about HIV positive healthcare workers el Atrouni
2011-2013 Vancomycin Nephrotoxicity in the Outpatient Setting: High Trough Dosing Versus Standard Trough Dosing Regimens     PubMed Hammoud
2011-2013 Trends in Invasive Pneumococcal Disease in Adults
in a Major Teaching Hospital in the Midwest
2011-2013 A Retrospective Review of Respiratory Viral Pathogen
Infections in a Hospitalized Hematopoetic Stem Cell Transplant (HSCT) Population at the University of Kansas Medical Center
2011-2013 Yield of Sonicated Cultures in Diagnosing Orthopaedic
Hardware Infection.
El Atrouni
2011-2013 A Validation of Prediction Model for Cardiovascular Implantable Electronic Device-Related Infections and Infective Endocarditis El Atrouni
2011-2013 A Retrospective Review of a Comprehensive Cohort of Candidal Septic Shock: Impact of Antifungal Therapy on Outcome Clough
2009-2011 A Retrospective Review of the Incidence of Ocular Candidiasis in Candida Bloodstream Infection Eid
2009-2011 Immune Response after Monovalent Influenza A (H1N1) 2009 Vaccine in Hemodialysis Patients Clough
2008-2010 Evaluation of Antigen Detection for Diagnosis of Histoplasmosis and Blastomycosis Hammoud
2010-2011 Pre-emptive Treatment with Rituximab for Epstein-Barr Virus Reactivation after Allogenic Hematopoietic Stem Cell Transplantation: A Safety and Efficacy Study Ganguly, N.
2009-2011 Use of Cidofovir in the Treatment of BK Virus Infection in Patients Undergoing Allogenic Stem Cell Transplantation Ganguly, N.
2008-2011 Exploring the Use of a Novel Device for Reducing Catheter-related Bloodstream Infections Waller       Clough
2009-2010 Clinical and Laboratory Features Predicting Abdominal Abscess in Patients with Post-Liver (OLT) Transplant Fluid Collections Waller
2008-2010 A Comparative Study of Incidence and Spectrum of Infections in Patients with Chronic Graft Versus Host Disease (GVHD) before, during, and after Extracorporeal Photopheresis (ECP). BMT
Ganguly, N.
2007-2009 Routine Use of a Whole Blood Interferon-γ Assay for the Diagnosis of Mycobacterium Tuberculosis at a Tertiary-Care University-Affiliated Hospital. Clough
2007-2009 A Retrospective Review of Candida Bloodstream Infection in a Tertiary Medical Center. Time to Initiation of Appropriate Antifungal Therapy and its Association with Outcome. Clough


Basic Science Device Development
2011-2013 Development of Novel Medical Device Removal System Waller
2010-2013 Development of Medication Delivery Device Waller                


Basic Science Infection Prevention
2011-2012 Prevention of Early Wound Infection Waller

Last modified: Sep 28, 2018