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Bone metabolism

Elderly woman and daughter


Osteoporosis is a condition in which decreased bone tissue quantities cause a person's bones to become weak and more likely to fracture or break. The amount of bone tissue increases during childhood and early adult life, peaking by the age of 30. Normally, the body forms enough new bone tissue to balance the amount that is broken down and absorbed by the body, a process called bone turnover. After menopause in women, and in some older men, there may be a breakdown of bone tissue that leads to osteoporosis. The balanced process is lost - more bone is broken down than is formed, and bones become extremely weak.

According to the National Institutes of Health, osteoporosis is a major public health threat for more than 28 million Americans. People with osteopenia (reduced bone mass) are also at risk for developing osteoporosis.

Learn more at the American Academy of Orthopaedic Surgeons (AAOS) website:

                      Prevention  •   Risks & Symptoms   •   Falls

Paget's Disease

Paget's Disease was initially diagnosed by Sir James Paget in 1877. This condition, also known as osteitis deformans, is a disease of the osteoclast and is the most exaggerated example of disordered bone remodeling. It is characterized by excessive and accelerated bone formation, resulting in bones that are architecturally unsound. This can lead to bone pain, bone deformity and skeletal fragility.

Last modified: Sep 28, 2018