Jason M. Springer, M.D., M.S.
Allergy, Clinical Immunology, and Rheumatology
Medical School: University of Louisville
Residency: Univeristy of Utah
Fellowship: Cleveland Clinic Foundation
Vasculitis Fellowship: Cleveland Clinic Foundation
Publications: Click here
Grannulomatosis with polyangiitis (Wegener's) | Microscopic polyangiitis | Eosinophilic granulomatosis with polyangiitis (Churg Strauss) | Polyarteriitis nodosa | Giant Cell Arteritis | Takayasu’s arteritis | Cutaneous vasculitis/Leukocytoclastic vasculitis | IgA Vasculitis (Henoch Schonlein purpura) | Cryoglobulinemic vasculitis
Grannulomatosis with polyangiitis (Wegener's) | Microscopic polyangiitis | Eosinophilic granulomatosis with polyangiitis (Churg Strauss) | Polyarteriitis nodosa | Giant Cell Arteritis | Takayasu's arteritis | Cutaneous vasculitis/Leukocytoclastic vasculitis | IgA Vasculitis (Henoch Schonlein purpura) | Cryoglobulinemic vasculitis
Funded Research Projects & Awards
2017 Lied Basic Science Award Springer (PI) 06/2017-05/2018
Suppression of aortitis through SOCS-1 pathways mediated through mast cells
Major Goals: Aim #1: Test the hypothesis that mast cell degranulation inhibit inhibits both histologic and cytokine signatures of vasculitis in the CAWS model. Aim #2: Determine the effects mast cell deficiency on the development of vasculitis in the CAWS model.
Role: Principle investigator
5R01HL115041-03 Merkel, Krischer (co-PI's) 9/01/2014-5/31/18
Novel Methods for the Conduct of Clinical Trials
Major Goals: Funding from the VCRC to utilize the Greater Plains Collaborative (CDRN) in the conduct of a randomized trial known as The Assessment of Prednisone in Remission trial (TAPIR).
Role: site PI
CDRN-1501-26643 Waitman (PI) 9/07/15-09/07/18
Patient Centered Outcomes Research Institute
The Greater Plains Collaborative; a PCORnet Clinical Data Research Network
Major Goals: extend the capacity of the research network that captures complete and comprehensive data from patients at twelve medical centers. Continue governance, regulatory processes, technical infrastructure, and patient engagement strategies to enable a learning healthcare system by integrating Comparative Effectiveness Research within clinical workflows. Develop sustainable model for this digital infrastructure.
2014 Basic Research Development Award Springer (PI) 07/2014-10/2015
Kansas University Internal Medicine Department
Defining the role of mast cells and SOCS-1 in aortitis
Major Goals: Preliminary data from our group has shown that mast cells inhibit LPS induced aortic IL-6 production. The goal of this project is to clarify the mechanisms through which mast cells mediate aortic inflammation.
Role: Principle investigator
Research Program Committee (RPC) Springer (PI) 12/2010-05/2013
Cleveland Clinic Foundation
Relapse rate with long term maintenance therapy in granulomatosis with polyangiitis (Wegener's)
Major Goal: Determine the if long term maintenance therapy for greater than two years is associated with fewer relapses and an acceptable safety profile compared to shorter maintenance regiments in granulomatosis with polyangiitis (Wegener's).