Yu-Ting Xuan, Ph.D.

Professor of Medicine - Cardiology
Ph.D., Duke University
ED.D: Exercise Physiology, West Virginia University, Morgantown, WV


Research Interests

The JAK-STAT axis plays a critical role in cell signaling initiated by various growth factors as related to cell survival and apoptosis. Over the last decade, Dr. Yu-Ting Xuan's work has identified a role of this pathway in protection of heart muscle against ischemic injury. Dr. Xuan's NIH-funded research is focused on understanding the complex signaling pathway involved in the activation of transcriptional factors leading to the upregulation of cardioprotective proteins during myocardial ischemia/reperfusion injury and ischemic preconditioning. Additionally, Dr. Xuan's team is also working on understanding the apoptotic and anti-apoptotic mechanisms of bone-marrow-derived adult stem cells and on improving the survival of these cells after transplantation into the heart. Results from these projects are likely to provide important information that may benefit patients with coronary artery disease who experience heart attacks

Selected Publications

  • Brooks AC, Singh M, Guo Y, McCracken J, Xuan YT, Srivastava S, Bolli R, Bhatnagar A. Endoplasmic reticulum stress-dependent activation of ATF3 mediates the late phase of ischemic preconditioning. J Mol Cell Cardiol. 2014 Aug 22. pii:S0022-2828(14)00258-2. doi: 10.1016/j.yjmcc.2014.08.011. [Epub ahead of print] PubMed PMID: 25151953.
  • Thangavel J, Malik AB, Elias HK, Rajasingh S, Simpson AD, Sundivakkam PK, Vogel SM, Xuan YT, Dawn B, Johnson R. Combinatorial Therapy with Acetylation and Methylation Modifiers Attenuates Lung Vascular Hyperpermeability in Endotoxemia-Induced Mouse Inflammatory Lung Injury. Am J Pathol. 2014 Jun 11. pii: S0002-9440(14)00282-X. doi: 10.1016/j.ajpath.2014.05.008. [Epub ahead of print] PubMed PMID: 24929240.
  • Stein AB, Bolli R, Dawn B, Sanganalmath SK, Zhu Y, Wang OL, Guo Y, Motterlini R, Xuan YT. Carbon monoxide induces a late preconditioning-mimetic cardioprotective and antiapoptotic milieu in the myocardium. J Mol Cell Cardiol. 2012 Jan;52(1):228-36.
  • Sanganalmath SK, Abdel-Latif A, Bolli R, Xuan YT, Dawn B. Hematopoietic cytokines for cardiac repair: mobilization of bone marrow cells and beyond.  Basic Res Cardiol.  2011 May 4. [Epub ahead of print]. 
  • Bolli R, Stein AB, Guo Y, Wang OL, Rokosh G, Dawn B, Molkentin JD, Sanganalmath SK, Zhu Y, Xuan YT.   A murine model of inducible, cardiac-specific deletion of STAT3: Its use to determine the role of stat3 in the upregulation of cardioprotective proteins by ischemic preconditioning. J Mol Cell Cardiol. 50(4):589-97, 2011.
  • Watson LJ, Facundo HT, Ngoh GA, Ameen M, Brainard RE, Prabhu SD, Xuan YT, Jones SP.  O-linked b-N-acetylglucosamine transferase is indispensable in the failing heart.  Proc. Natl. Acad. Sci. USA.  107: 17797-17802, 2010. 
  • 4 Hamid T, Gu Y, Ortines RV, Bhattacharya C, Wang G, Xuan YT, Prabhu SD.  Diver Divergent Tumor Necrosis Factor Receptor-Related Remodeling Responses in Heart Failure Role of Nuclear Factor-kB and Inflammatory Activation.  Circulation. 119:1386-1397, 2009.
  • West MB, Rokosh G, Obal D, Velayutham M, Xuan YT, Hill BG, Keith RJ, Schrader J, Guo Y, Conklin DJ, Prabhu SD, Zweier JL, Bolli R, Bhatnagar A.  Cardiac myocyte-specific expression of inducible nitric oxide synthase protects against ischemia/reperfusion injury by preventing mitochondrial permeability transition.  Circulation.  118:1970-8, 2008.
  • Xuan YT, Guo Y, Zhu Y, Wang OL, Rokosh G, Bolli R.  Endothelial nitric oxide synthase plays an obligatory role in the late phase of ischemic preconditioning by activating the protein kinase C{epsilon}-p44/42 mitogen-activated protein kinase-pSer-signal transducers and activators of transcription1/3 pathway.  Circulation. 116(5):535-44, 2007.
  • Stein AB, Stein AB, Bolli R, Guo Y, Wang OL, Tan W, Wu WJ, Zhu XP, Zhu Y, Xuan YT.  The late phase of ischemic preconditioning induces a prosurvival genetic program that results in marked attenuation of apoptosis.  J Mol Cell Cardiol.  42:1075-1085, 2007.
  • Xuan YT, Guo Y, Zhu Y, Wang OL, Rokosh G, Messing RO, Bolli R.  Role of the PKCe-Raf-1-MEK-1/2-p44/42 MAPK signaling cascade in the activation of STAT1 and STAT3 and induction of COX-2 following ischemic preconditioning. Circulation. 112:1971-8, 2005.
  • Dawn B, Xuan YT, Guo Y, Rezazadeh A, Stein AB, Hunt G, Wu WJ, Tan W, Bolli R.  IL-6 plays an obligatory role in late preconditioning via JAK-STAT signaling and upregulation of iNOS and COX-2. Cardiovascular Research  64:61-71, 2004.
  • Dawn B, Guo Y, Rezazadeh A, Wang OL, Stein AB, Hunt G, Varma J, Xuan YT, Wu WJ, Tan W, Zhu X, Bolli R.  Tumor necrosis factor-alpha does not modulate ischemia/reperfusion injury in naive myocardium but is essential for the development of late preconditioning.  J Mol Cell Cardiol. 37(1):51-61, 2004.
  • Xuan YT, Guo Y, Zhu Y, Han H, Dawn B, Bolli R.:  Mechanism of cyclooxygenase-2 upregulation in late preconditioning.  J Mol Cell Cardiol  35:525-37, 2003.
  • Bolli R, Dawn B, Xuan YT. Role of the JAK-STAT pathway in protection against myocardial ischemia/reperfusion injury.  Trends in Cardiovascular Medicine  13:72-79, 2003.
  • Kodani E, Xuan YT, Takano H, Shinmura K, Tang XL, Bolli R.:  Role of cyclic guanosine monophosphate in late preconditioning in conscious rabbits.  Circulation  105:3046-52, 2002. 
  • Shinmura K, Xuan YT, Tang XL, Kodani E, Han H, Zhu Y, Bolli R.  Inducible nitric oxide synthase modulates cyclooxygenase-2 activity in the heart of conscious rabbits during the late phase of ischemic preconditioning.  Circ Res 90(5):602-608, 2002.
  • Xuan YT, Yiru G, Hui H, Yanqing Z, and Bolli R.  An essential role of the JAK-STAT pathway in ischemic preconditioning.  Proc. Natl. Acad. Sci. USA  98:9050-9055, 2001.
  • Bolli R, Dawn B, and Xuan YT.  Emerging role of the JAK-STAT pathway as a mechanism of protection against ischemia/reperfusion injury.  J Mol Cell Cardiol  33(11):1893-6, 2001.
  • Dawn B, Xuan YT, Marian M, Flaherty MP, Murphree SS, Smith TL, Bolli R, and Jones WK. Cardiac-specific abrogation of NF-kB activation in mice by transdominant overexpression of a mutant IkB.  J. Mol. Cell. Cardiol.  33:161-173, 2001. 
  • Xuan YT, Tang XL, Qiu Y, Banerjee S, Takano H, Han H, Bolli R. Biphasic response of cardiac NO synthase isoforms to ischemic preconditioning in conscious rabbits. Am J Physiol. 279: H2360-71, 2000.
  • Xuan YT, Tang XL, Banerjee B, Takano H, Li RCX, Han H, Qiu Y, Li, JJ, Bolli R. Nuclear factor kB plays an essential role in the late phase of ischemic preconditioning in conscious rabbits. Circ Res. 84:1095-1109, 1999.
  • Dawn B, Xuan YT, Qiu Y, Takano H, Tang XL, Ping P, Banerjee S, Bolli R. Bifunctional role of protein tyrosine kinases in late preconditioning against myocardial stunning in conscious rabbits. Circ Res. 85:1154-1163, 1999.

Selected Abstracts Presented at National Meetings

  • Roberto Bolli, Yanqing Zhu, Ou-Li Wang, Yiru Guo, Gregg Rokosh, Adam B Stein, Buddhadeb Dawn, and Yu-Ting Xuan. STAT1 Transcription Factor is Required for the Delayed Protection Against Cardiomyocyte Apoptosis by Ischemic Preconditioning. Circulation. 2013;128:A12113.
  • Roberto Bolli, Yanqing Zhu, Ou-Li Wang, Yiru Guo, Gregg Rokosh, Adam B Stein, Buddhadeb Dawn, and Yu-Ting Xuan. STAT1 Signaling is Critical for the Infarct-Sparing Effects of Late Ischemic Preconditioning Circulation. 2013;128:A12143.
  • Xuan Y, Zhu Y, Wang O, Cheng G, Elias H, Davani A, Yang Y,Girgis M, Vincent RJ, Hauptman J, and Dawn B.STAT3 Activation Prevents Mesenchymal Stem Cell Apoptosis and Improves Infarct Repair. Circulation. 2012;126:A12591
  • Zuba-Surma EK, Xuan Y, Labedz-Maslowska A, Elias H, Kamycka E, Abdel-Latif A, Zhu Y, Wang O, Davani A, and Dawn B.Greater Antiapoptotic, Antiinflammatory, and Proangiogenic Attributes of a Defined Subpopulation of Bone Marrow Mesenchymal Stem Cells May Facilitate Cardiac Repair via Paracrine Effects. Circulation. 2012;126:A12650
  • Chen L, Xuan Y, Elias H, Cantilena A, Zuba-Surma E, Davani A, Cheng G, Wang O, Vincent RJ, Yang Y, and Dawn B .The Activation of STAT3 via CamKII is Critical for the Induction of Cardiac Differentiation by Wnt11 in Bone Marrow Mesenchymal Stem Cells.Circulation. 2012;126:A12638
  • Cheng G, Xuan YT, Quinn CM, Sanganalmath Sk, Girgis M, Wang OL, Zhu Y, Yang Y, Flaherty MP, Lietzau-Mourer S, Zuba-Surma EK, Vincent R, Xu D, Davani A, Dawn B. Wnt11-pretreated bone marrow stem cells induce superior cardiac repair after a reperfused myocardial infarction. Circulation 124:A9899.
  • Cheng G, Zuba-Surma EK, Xuan YT, Yang Y, Girgis M, Wang OL, Zhu Y, Sanganalmath SK, Lietzau-Mourer S, Xu D, Dawn B. Transplantation of an antigenically-selected subpopulation of bone marrow mesenchymal stem cells results in superior cardiac repair after a reperfused infarction. Circulation 124:A17476.
  • Sanganalmath SK, Xuan YT, Zhu Y, Guo Y, Vincent R, Crawford TC, Wead WB, Joshua IG, Bolli R, Dawn B. Doxorubicin-induced myocardial inflammation, apoptosis, and remodeling are attenuated by cardiac-specific transgenic inhibition of nuclear factor-kappaB. J Am Coll Cardiol 2011;57:E271.
Last modified: Sep 05, 2014

Yu-Ting Xuan, Ph.D.

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Yu-Ting Xuan, Ph.D.
Professor of Medicine - Cardiology

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