Rhea C. Pimentel, MD, FACC

Associate Professor of Medicine - Cardiology
Program Director, CCEP Fellowship
Medical School, Feinberg School of Medicine, Northwestern University (Chicago, IL)
Residency, University Hospitals of Cleveland (Cleveland, OH)
CV Fellowship, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, Cleveland Ohio
CCEP Fellowship, Washington University School of Medicine (St. Louis, MO)


Clinical Interests

  • Cardiac Electrophysiology
  • Cardiac Device Implantation (Pacemaker/ICD/CRT)
  • Radiofrequency Ablation(AFIB/SVT/VT)
  • Sudden Cardiac Death Screening
  • Device/Pacemaker/ICD Lead Extraction

Research Projects

Active projects

  • REVEAL AF study sponsored by Medtronic.

Selected Publications

  • Pillarisetti J, Reddy N, Biria M, Ryschon K, Nagarajan D, Murray C, Atkins D, Bommana S, Reddy MY, Dibiase L, Pimentel R, Berenbom L, Dawn B, Natale A, Lakkireddy D. Elevated brain natriuretic peptide level in patients undergoing atrial fibrillation ablation: is it a predictor of failed ablation or a mere function of atrial rhythm and rate at a point in time? J Interv Card Electrophysiol. 2014 May 8. [Epub ahead of print] PubMed PMID: 24800931.
  • Vallakati A, Reddy YM, Emert M, Janga P, Mansour MC, Heist EK, Pimentel R, Dendi R, Atkins D, Bommana S, Mahapatra S, Heard M, Ruskin J, Berenbom L, Dawn B, Lakkireddy D. Impact of nonfluoroscopic MediGuideTM tracking system on radiation exposure in radiofrequency ablation procedures (LESS-RADS registry)-an initial experience. J Interv Card Electrophysiol. 2013 Nov;38(2):95-100. doi: 10.1007/s10840-013-9825-3. Epub 2013 Sep 12. PubMed PMID: 24026968.
  • Lakkireddy D, Reddy YM, Di Biase L, Vanga SR, Santangeli P, Swarup V, Pimentel R, Mansour MC, D'Avila A, Sanchez JE, Burkhardt JD, Chalhoub F, Mohanty P, Coffey J, Shaik N, Monir G, Reddy VY, Ruskin J, Natale A. Feasibility and safety of dabigatran versus warfarin for periprocedural anticoagulation in patients undergoing radiofrequency ablation for atrial fibrillation: results from a multicenter prospective registry. J Am Coll Cardiol. 2012 Mar 27;59(13):1168-74.
  • Simmons A, Pimentel R, Lakkireddy D. Sudden cardiac death in women. Rev Cardiovasc Med. 2012;13(1):e37-42. Review.
  • Lakkireddy D, Nagarajan D, Di Biase L, Vanga SR, Mahapatra S, Bunch TJ, Day JD, Burkhardt DJ, Umbarger L, Dendi R, Pimentel R, Berenbom L, Emert M, Gerken A, Bommana S, Ray W, Atkins D, Murray C, Dawn B, Natale A. Radio Frequency Ablation (RFA) of Atrial Fibrillation in Patients with Mitral or Aortic Mechanical Prosthetic Valves - A Feasibility, Safety and Efficacy Study. Heart Rhythm. 2011;8(7):975-80.
  • Sweeney MO, Ellenbogen KA, Tang AS, Whellan D, Mortensen PT, Giraldi F, Sandler DA, Sherfesee L, Sheldon T; Managed Ventricular Pacing Versus VVI 40 Pacing Trial Investigators(Pimentel R). Atrial pacing or ventricular backup-only pacing in implantable cardioverter-defibrillator patients. Heart Rhythm. 2010 Nov;7(11):1552-60. doi: 10.1016/j.hrthm.2010.05.038. Epub 2010 Jun 4. PubMed
    PMID: 20685401.
  • Lakkireddy D, Rangisetty U, Prasad S, Verma A, Biria M, Berenbom L, Pimentel R, Emert M, Rosamond T, Fahmy T, Patel D, Di Biase L, Schweikert R, Burkhardt D, Natale A. Intracardiac echo guided radiofrequency catheter ablation of atrial fibrillation in patients with atrial septal defect (ASD) or patent foramen ovale (PFO) repair: a feasibility, safety and efficacy study. J Cardiovasc Electrophysiol. 2008 Nov;19(11):1137-42. Epub 2008 Jul 25.
  • Pimentel RC, Yamada KA, Kléber AG, Saffitz JE. Autocrine regulation of myocyte Cx43 expression by VEGF. Circ Res. 2002 Apr 5;90(6):671-7. PubMed PMID: 11934834.

Selected Abstracts Presented at National Meetings

  • Rhea C. Pimentel, MD, Pitayadet Jumrussirikul, MD, Pierce Vatterott, MD, Brian Lee, BS, Holly Norman, PhD, Matthew Calovich, BS, Madhu Reddy, MD, Donita Atkins, RN, BSN, Arun Kanmanthareddy, MBBS and Dhanujaya R. Lakkireddy, MD, FHRS. Impact of gender and body mass index on tissue insertion forces related to body mass index - implications to injectable subcutaneous implantable devices. Heart Rhythm, 2014;11(5): S502. 
  • Madhu Reddy, MD, Kirill Lipatov, BS, Gopi Chowdari, MBBS, Pramod Janga, MBBS, Arun Kanmanthareddy, MD, Jayasree Pillarisetti, MD, Rhea C. Pimentel, MD, Martin P. Emert, MD, Raghuveer Dendi, MD, Dhanujaya R. Lakkireddy, MD, FHRS and Loren D. Berenbom, MD. Lead extraction in african americans: not different from the rest. Heart Rhythm, 2014;11(5): S503. 
  • Madhu Reddy; Kirill Lipatov; Gopi Ponnaganti; Arun Kanmanthareddy; Jayasree Pillarisetti; Rhean Linette Pimentel; Martin Emert; Raghuveer Dendi; Sudharani Bommana; Dhanunjaya Lakkireddy; Loren Berenbom. Lead extraction in african americans: not different from the rest. J Am Coll Cardiol. 2014;63(12_S):. doi:10.1016/S0735-1097(14)60382-X. 
  • Arun Kanmanthareddy; Madhu Reddy; Pramod Janga; Sudharani Bommana; Ajay Vallakati; Jayasree Pillarisetti; Raghuveer Dendi; Loren Berenbom; Rhean Linette Pimentel; Martin Emert; Dhanunjaya Lakkireddy. Tricuspid regurgitation is an independent predictor of failure of av node ablation. J Am Coll Cardiol. 2014;63(12_S):. doi:10.1016/S0735-1097(14)60437-X. 
  • Reddy M, Vallakati A, Janga P,Sharma S, Pillai A, Dendi R, Emert M, Berenbom L, Pimentel RL, Lakkireddy D. Externalization of conductor cables in quicksite and quickflex left ventricular leads.J Am Coll Cardiol. 2013;61(10_S):. doi:10.1016/S0735-1097(13)60247-8. 
  • Lakkireddy D, Reddy M, Atkins D, Pimentel R, Bommana S, Johnson R, Olyaee M, Dusing R, Dawn B. Impact of Atrial Fibrillation on the Functional Integrity of Upper Gastrointestinal System. Heart Rhythm, 2013;10(5):S83-84. 
  • Lakkireddy D, Vallakati A, Janga P, Atkins D, Reddy M, Bommana S, Pimentel R, Dawn B. Impact of Yoga on Sympoms, Head Up Tilt Table Test and Functional Status of Patients with Neurocardiogenic Syncope -- A Preliminary Experience. Heart Rhythm, 2013;10(5):S39-40. 
  • Reddy M, Vallakati A, Janga P, Sharma S, Pillai A, Dendi R, Emert M, Berenbom L, Pimentel R, Lakkireddy D. Exterilization of Conductor Cables in QuickSite and QuickFlex Left Ventricular Leads. Heart Rhythm Society Annual Meeting 2013. Heart Rhythm, 2013;10(5):S70. 
  • Madhu Y Reddy, Ajay Vallakati, Kirill Lipatov, Pramod Janga, Gopi C Ponnaganti, Vivek Yarlagadda, Ramchandur Bakhtiani, Donita Atkins, Sudharani Bommana, Namratha Reddy, Rhea Pimentel, Martin Emert, Raghuveer Dendi, Luigi DiBiase, Andrea Natale, Buddhadeb Dawn, Dhanunjaya Lakkireddy, and Loren Berenbom. A Comparison of Complexity of Extraction Between Sprint Fidelis and Other Right Ventricular Leads. Circulation.2013;128:A18460. 
  • Ajay Vallakati, Madhu Y Reddy, Gopi C Ponnaganti, Vivek Yarlagadda, Donita Atkins, Sudharani Bommana, Pramod Janga, Arun Raghav Mahankali Sridhar, Ryan Maybrook, Rhea C Pimentel, Luigi DiBiase, Andrea Natale, Buddhadeb Dawn, and Dhanunjaya Lakkireddy. Catheter Ablation as a First-Line Therapy for Atrial Fibrillation - A Meta-Analysis. Circulation. 2013;128:A18526. 
  • Reddy M, Boolani H, Duthuluru S, Reddy N, Williamson T, Spikes L, Bommana S, Atkins D, Chikkam V, Pillarisetti J, Berenbom L, Dendi R, Emert M, Pimentel R, Lakkireddy D. Complications of Implantable Cardiac-Defibrillator Implantation in Patients With Pulmonary Hypertension.J Am Coll Cardiol. 2012;59(13s1):E708-E708. doi:10.1016/S0735-1097(12)60709-8.
  • Pillarisetti J, Biria M, Reddy M, Atkins D, Pimentel R, Berenbom L, Emert M, Dendi R, Reddy N, Murray C, Bommana S, Dawn B, Lakkireddy D. Impact of Pocket Revision on the Rate of Infection and Other Complications in Patients Requiring Pocket Manipulation for Generator Replacement and/or Lead Replacement or Revision (MAKE IT CLEAN): A Prospective Randomized Study. Heart Rhythm, 2012;9(5):S25.
  • Reddy M, Chaung J, Boolani H, Atrouni W, Atkins D, Bommana S, Pimentel R, Emert M, Berenbom L, Vacek J, Lakkireddy D, and Dendi R. Long-term Mortality After Cardiovascular Implantable Electronic Device Infection. Circulation. 2012;126:A17922
  • Reddy M, Berenbom L, Reddy N, Atkins D, Bhaktiani R, Bommana S, Pimentel R, Emert M, Dendi R, and Lakkireddy D. Increasing Complexity of Sprint Fidelis Lead Extraction: A Single Center Experience.Circulation. 2012;126:A17906
  • Nagarajan DV, Vanga SR, Biria M, Chikkam V, Ittaman S, Shanberg D, Jeevanantham V, Berenbom L, Emert M, Pimentel R, Dendi R, Umberger L, Bommana S, DiBiasi L, Natale A, Dawn B, Lakkireddy D. Can CHADS2 score predict the outcomes of radiofrequency ablation in patients with atrial fibrillation? Heart Rhythm 2011;8(5):S449.
  • Biria M, Mahapatra S, Vanga S, Nagarajan D, Bommana S, Dendi R, Mohtashemipour H, Emert M, Berenbom L, Pimentel R, Lakkireddy D. Characterization and radiofrequency ablation ventricular tachycardia in patients with cocaine use unresponsive to medical therapy. Heart Rhythm 2001;8(5):S481.
  • Lakkireddy D, Pillarisetti J, Atkins D, Vanga SR, Emert M, Pimentel R, Murray C, Bommana S, Ryschon K, Berenbom L, Dawn B, Dendi R, Drisko J. Impact of yoga on arrhythmia burden and quality of life (QoL) in patients with symptomatic paroxysmal atrial fibrillation. J Am Coll Cardiol 2011;57:E129.
  • Vanga SR, Biria M, Pillarisetti J, Atikins D, Murray C, Chen W, Berenbom L, Emert M, Pimentel R, Dendi R, Bommana S, Vacek J, Dawn B, Di Biasi L, Natale A, Lakkireddy D. Radiofrequency ablation improves quality of life scores not only in patients with atrial fibrillation but their significant others too! J Am Coll Cardiol 2011;57:E132.
  • Pillarisetti J, Falbe J, Dendi R, Pimentel R, Emert M, Lakkireddy D, Berenbom L. Experience with Fidelis Lead Extractions at a Single Academic Center. Presented at the 59th Annual ACC Scientific Sessions 2010, March 14-16 2010, Atlanta Georgia.
  • Vanga S, Subramaniyam P, Berenbom L, Emert M, Pimentel R, Dendi R, Lakkireddy D. Narrowing of Pulmonary Vein Ostial Dimensions After Isolation in Patients with Atrial Fibrillation: True Stenosis or Volume Reduction? Presented at the Heart Rhythm Society Annual Sessions 2010, May 12-15 2010, Denver Colorado.
  • Vanga S, Bicknell D, Dendi R, Pimentel R, Berenbom L, Emert M, Gerken A, Newton D, Natale A, Di Biase L, Dawn B, Lakkireddy D. Radio Frequency Ablation (RFA) for Sinus Rhythm Restoration in Atrial Fibrillation Patients with Mitral or Aortic Mechanical Prosthetic Valves - Feasibility, Safety and Efficacy. Presented at the Heart Rhythm Society Annual Sessions 2010, May 12-15 2010, Denver Colorado.
  • Subramaniyam P, Vanga S, Guda R, Kumari P, Murray C, Berenbom L, Pimentel R, Emert M, Dendi R, Salmons J, Lakkireddy D. Prevalence of Posttraumatic Stress Disorder, Anxiety, Depression, Phantom Shocks and Lead Failure in Patients with Medtronic Sprint Fidelis ICD Leads. Presented at the Heart Rhythm Society Annual Sessions 2010, May 12-15 2010, Denver Colorado.
  • Pillarisetti J, Biria M, Emert M, Chotia R, Guda R, Vacek J, Dendi R, Pimentel R, Berenbom L, Lakkireddy D. Reasons for Under-Utilization of Implantable Cardioverter Defibrillators in Patients with Heart Failure. Presented at the Heart Rhythm Society Annual Sessions 2010, May 12-15 2010, Denver Colorado.
  • Biria M, Pillarisetti J, Reddy N, Murray C, Patel P, Vanga S, Dendi R, Pimentel R, Emert M, Berenbom L, Vacek J, Lakkireddy D. Elevated Beta Natriuretic Peptide Levels in Patients with Atrial Fibrillation: Is it a Predictor of Successful Ablation or a Mere Function of Point in Time Atrial Rhythm? Presented at the Heart Rhythm Society Annual Sessions 2010, May 12-15 2010, Denver Colorado.
  • Lakkireddy D, Pillarisetti J, Verma A, Pimentel R, Vanga S, Rajoli S, Berenbom L, Emert M, Dendi R, Rosamond T. Impact of Common Pulmonary Veins (CPV) on the Short Term Outcomes of Radiofrequency Catheter Ablation of Atrial Fibrillation (AF). Presented at the 2009 Heart Rhythm Society Annual Meeting, May 13-16 2009, Boston Massachusetts.
  • Lakkireddy D, Pillarisetti J, Duthuluru S, Dendi R, Pimentel R, Emert M, Verma A, Natale A. Localization of Muscle Sleeves and Focal Triggers Around Superior Vena Cava (SVC) - Right Atrial (RA) Junction in Patients with Atrial Fibrillation. Presented at the 2009 Heart Rhythm Society Annual Meeting, May 13-16 2009, Boston Massachusetts.
  • Vanga S, Pillarisetti J, Biria M, Rajoli S, Berenbom L, Pimentel R, Emert M, Dendi R, Lakkireddy D. Overcoming Fluid Overload After Atrial Fibrillation Ablation with an Open Irrigated Catheter: Role of Scheduled Diuresis and Electrolyte Replacement. Presented at the 2009 Heart Rhythm Society Annual Meeting, May 13-16 2009, Boston Massachusetts.
  • Lakkireddy D, Pillarisetti J, Verma A, Natale A, Berenbom L, Emert M, Pimentel R, Dendi R. Radiofrequency Ablation in Patients with Recurrent Symptomatic Atrial Fibrillation and Gastro Esophageal Reflux Disease (GERD)/Irritable Bowel Syndrome (IBS) - The Heart to Gut Connection. Presented at the 2009 Heart Rhythm Society Annual Meeting, May 13-16 2009, Boston Massachusetts.
  • Lakkireddy D, Biria M, Pillarisetti J, Verma A, Vanga S, Pimentel R, Emert M, Berenbom L, Dendi R. Sinus Node Dysfunction, Tachy-brady Rhythm, & Extensive Biatrial Scarring - Recognizing a New Clinical Syndrome of Atriomyopathy in Patients with Atrial Fibrillation. Presented at the American Heart Association Scientific Sessions 2009, November 14-18 2009, Orlando Florida.
  • Biria M, Annapureddy C, Newton D, Pillarisetti J, Baryun E, Berenbom L, Pimentel R, Vanga S, Vacek J, Emert M, Nath J, Verma A, Khaykin Y, Natale A, Murray C, Staley J, Lakkireddy D. Leukocytosis Post Atrial Fibrillation Ablation - Is There A Reason To Worry? Presented at the 14th World Congress on Heart Disease - International Academy of Cardiology Annual Scientific Sessions 2008, July 26-29 2008, Toronto Ontario, Canada.
  • Biria M, Pillarisetti J, Annapureddy C, Baryun E, Newton D, Kreighbaum K, Murray C, Staley J, Berenbom L, Pimentel R, Vanga S, Vacek J, Emert M, Nath J, Rosamond T, Raxwal V, Mulhern K, Gupta K, Verma A, Lakkireddy D. Cardiac Resynchronization Therapy Alters Progression of Diastolic Dysfunction. Presented at the 2008 Heart Rhythm Society Annual Meeting, May 14-17 2008, San Francisco California.
  • Baryun E, Biria M, Berenbom L, Mulhern K, Rosamond T, Pimentel R, Emert M, Ray W, Lakkireddy D. Remote Magnetic Navigation and Ablation of Intra-atrial Reentrant Tachycardia Via a Retrograde Approach in a Patients with Post Mustard D-TGA. Presented at the 2008 Heart Rhythm Society Annual Meeting, May 14-17 2008, San Francisco California.
  • Biria M, Pillarisetti J, Annapureddy C, Baryun E, Newton D, Kreighbaum K, Murray C, Staley J, Berenbom L, Pimentel R, Vanga S, Vacek J, Emert M, Porter C, Genton R, Nath J, Gupta K, Lakkireddy D. The Impact of Cardiac Resynchronization Therapy on Kansas City Cardiomyopathy Questionnaire (KCCQ) Score in Patients with Congestive Heart Failure. Presented at the 2008 Heart Rhythm Society Annual Meeting, May 14-17 2008, San Francisco California.
  • Simmons A, Rosamond T, Nath J, Lakkireddy D, Wetzel L, Vacek J, Pimentel R, Emert E, Berenbom L, Biria M. 64 slice Cardiac CTA in the Diagnosis of Left Atrial Appendage Thrombus: Comparison to Transesophageal Echocardiography. Presented at the 14th World Congress on Heart Disease - International Academy of Cardiology Annual Scientific Sessions 2008, July 26-29 2008, Toronto Ontario, Canada.
  • Biria M, Baryun E, Vacek J, Dalton K, Earnest M, Emert M, Pimentel R, Lakkireddy D, Berenbom L. Outcomes and Cost Analysis of Transvenous vs. Prophylactic Intraoperative Implantation of CRT Leads (PROPEL study). Presented at the 14th World Congress on Heart Disease - International Academy of Cardiology Annual Scientific Sessions 2008, July 26-29 2008, Toronto Ontario, Canada
Last modified: Aug 22, 2014

Rhea Pimentel, MD

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Rhea C. Pimentel, MD, FACC
Associate Professor of Medicine - Cardiology
Program Director, CCEP Fellowship

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