Rajat S. Barua, M.D., Ph.D.

Assistant Professor of Medicine - Cardiology
Nalanda Medical College, Patna, India
Residency, Mount Sinai School of Medicine (Internal Medicine)
Fellowship, UCSF School of Medicine (Cardiology) & Tufts University School of Medicine (Interventional)


Clinical Interests

  • Complex coronary intervention
  • Structural heart disease
  • Valvular heart disease
  • Percutaneous cardiovascular procedures

Research Interests

  • Endothelial function
  • Nitric oxide biology
  • Oxidative stress
  • Soluble bio-markers of cardiovascular dysfunction
  • Platelet fibrin interaction in coronary thrombosis
  • Angiogenesis
  • Cell therapy for cardiac repair

Recent Publications

Ambrose JA, Doss R, Geagea JP, Hawkey M, Duvuri S, Giedd K, Dominguez A, Coppola J, Nguyen TH, Palla V, Barua RS, Saha DC.  Effects of the platelet glycoprotein IIb/IIIa inhibitors, abciximab versus tirofiban, on thrombin generation during percutaneous coronary intervention. Am J Cardiol. 2001;87:1231-3.
Saha DC, Barua RS, Astiz ME, Rackow EC, Eales-Reynolds L-J.  Monophosphoryl lipid A stimulated up-regulation of reactive oxygen intermediates in human monocytes in vitro. J Leuko. Biol. 2001;70(3):381-85.
Barua RS, Ambrose JA, Eales-Reynolds L-J, De Voe MC, Zervas JG, Saha DC.  Dysfunctional endothelial nitric oxide biosynthesis in healthy smokers with impaired endothelium-dependent vasodilatation. Circulation. 2001;104:1905-1910.
Kirschenbaum LA, Adler D, Astiz ME, Barua RS, Saha DC, Rackow EC.  Mechanism of platelet-neutrophil interactions and effects on cell filtration in septic shock. Shock. 2002;6:508-12.
Barua RS, Ambrose JA, Eales-Reynolds L-J, De Voe MC, Zervas JG, Saha DC. Heavy and light cigarette smokers have similar dysfunction of endothelial vasoregulatory activity: An in vivo and in vitro correlation. J Am Coll Cardiol. 2002;39:1758-63.
Barua RS, Ambrose JA, Reynolds L-J, Saha DC. Smoking is associated with altered endothelial-derived fibrinolytic and anti-thrombotic factors: An in vitro demonstration. Circulation. 2002;106:905-908.
Ambrose JA, Gould RB, Zairis MN, DeVoe MC, Nguyen TH, Geagea JP, Arias JH, Meraj P, Barua RS. Acute coronary lesions and troponin I elevation in unstable angina or non ST elevation acute myocardial infarction. Am J Cardiol. 2002;90:770-773.
Boulos M, Astiz ME, Barua RS, Osman M. Impaired mitochondrial function induced by serum from septic shock patients is attenuated by inhibition of nitric oxide synthase and poly (ADP-ribose) synthase. Critical Care Medicine. 2003;31:353-8.
Puttappa D, Raia F, Bhat S, Braff R, Mandadi V, Barua RS, DeVoe MC, Boal BH, Ambrose JA. Peripheral left bundle block in patients with left ventricular dysfunction. Am J Cardiol. 2003;91:354-356.
Barua RS, Ambrose JA, Saha DC, Srivastava SK, DeVoe MC, L-J Eales-Reynolds. Reactive oxygen species are involved in smoking-induced dysfunction of nitric oxide biosynthesis and upregulation of endothelial nitric oxide synthase in human coronary artery endothelial cells. Circulation. 2003;107:2342-47.
Mandadi VR, DeVoe MC, Ambrose JA, Prakash AM, Varshneya N, Gould RB, Nguyen TH, Geagea JP, Radojevic, Shehat K, Barua RS. Predictors of troponin elevation after percutaneous coronary intervention. Am J Cardiol. 2004;93:747-750.
Ambrose JA, Barua RS. The pathophysiology of smoking and cardiovascular disease: An update. (State of the art paper) J Am Coll Cardiol. 2004;43:1731-37.
Srikanth S, Barua R, Ambrose J. Methamphetamine-associated acute left ventricular dysfunction: a variant of stress-induced cardiomyopathy. Cardiology. 2008;109(3):188-92.
Javed U,  Aftab W, Ambrose J, Mouanoutoua M, Wessel RJ, Huang G, Barua RS, Weilert M,  Sy F, Thatai D. Frequency of Elevated Troponin-I and Diagnosis of Acute Myocardial Infarction. Am J Cardiol. 2009;104:9-13.
Barua RS, Sy  F, Srikanth S ,  Javed U,  Buhari C , Huang G, Margosan D, Ambrose JA. Effects of Cigarette Smoke Exposure on Clot Dynamics and Fibrin Structure. An Ex-Vivo Investigation. Arterioscler Thromb Vasc Biol. 2010;30:75-79.
Barua RS, Sy  F, Srikanth S ,  Javed U,  Buhari C , Huang G, Margosan D, Aftab W, Ambrose JA. Acute cigarette smoke exposure reduces clot lysis -- association between altered fibrin architecture and the response to t-PA. Thromb Res. 2010;126 :426-430.
Barua RS, Ambrose JA. Mechanisms of coronary thrombosis in cigarette smoke exposure. Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1460-7. doi:10.1161/ATVBAHA.112.300154. Epub 2013 May 16. Review. PubMed PMID: 23685556.
Barua RS, Sharma M, Dileepan KN. Cigarette Smoke Amplifies Inflammatory Response and Atherosclerosis Progression Through Activation of the H1R-TLR2/4-COX2 Axis. Front Immunol. 2015 Nov 9;6:572. doi:10.3389/fimmu.2015.00572. eCollection 2015. Review. PubMed PMID: 26617606; PubMed Central PMCID: PMC4638143.
Sharma R, Oni OA, Gupta K, Chen G, Sharma M, Dawn B, Sharma R, Parashara D,Savin VJ, Ambrose JA, Barua RS. Normalization of testosterone level is associated with reduced incidence of myocardial infarction and mortality in men. Eur Heart J. 2015 Oct 21;36(40):2706-15. doi: 10.1093/eurheartj/ehv346. Epub 2015 Aug 6.PubMed PMID: 26248567.
Sharma R, Oni OA, Chen G, Sharma M, Dawn B, Sharma R, Parashara D, Savin VJ,Barua RS, Gupta K. Association Between Testosterone Replacement Therapy and the Incidence of DVT and Pulmonary Embolism: A Retrospective Cohort Study of the Veterans Administration Database. Chest. 2016 Sep;150(3):563-71. doi10.1016/j.chest.2016.05.007. Epub 2016 May 12. PubMed PMID: 27179907.
Sharma R, Oni OA, Gupta K, Sharma M, Sharma R, Singh V, Parashara D, Kamalakar S, Dawn B, Chen G, Ambrose JA, Barua RS. Normalization of Testosterone Levels After Testosterone Replacement Therapy Is Associated With Decreased Incidence of Atrial Fibrillation. J Am Heart Assoc. 2017 May 9;6(5). pii: e004880. doi:10.1161/JAHA.116.004880. PubMed PMID: 28487389.

 

Last modified: May 11, 2017

Rajat S.Barua, MD, Ph.D.

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Rajat S. Barua, M.D., Ph.D.
Assistant Professor of Medicine - Cardiology

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