Mark A. Wiley, MD, FACC, FSCAI

Assistant Professor of Medicine - Cardiology
Medical School, University of Kansas School of Medicine, Kansas City KS
Internship, University of Kansas Medical Center, Kansas City KS
Residency, University of Kansas Medical Center, Kansas City KS
Fellowship, University of Kansas Medical Center, Kansas City KS (Cardiology, Interventional Cardiology)


Clinical Interests

  • Diagnostic Catheterization
  • Cardiovascular Research
  • Peripheral Artery Disease
  • Peripheral Vascular Intervention
  • Interventional Cardiology

Research Projects

Active projects

  • A study of clinical evaluation of Absorb BVS, the Everolimus Eluting Bioresorbable Vascular Scaffold in the Treatment of Subjects with de novo Native Coronary Artery Leisons sponsored by Abbott Vascular.
  • A study to learn if the Parachute device is safe and effective for the treatment of heart failure.

Selected Publications

  • Shah Z, Wiley M, Sridhar AM, Masoomi R, Biria M, Lakkireddy D, Dawn B, Gupta K. Inverse Correlation of Venous Brain Natriuretic Peptide Levels with Body Mass Index Is due to Decreased Production. Cardiology. 2017 Apr 8;137(3):159-166. doi:10.1159/000464111. [Epub ahead of print] PubMed PMID: 28391273.
  • Stanojevic D, Gunasekaran P, Tadros P, Wiley M, Earnest M, Mehta A, Lippmann M, Levine M, Dawn B, Gupta K. Intravenous Adenosine Infusion is Safe and Well Tolerated During Coronary Fractional Flow Reserve Assessment in Elderly Patients With Severe Aortic Stenosis. J Invasive Cardiol. 2016 Sep;28(9):357-61. Epub 2016 Jun 15. PubMed PMID: 27315577.
  • Ellis SG, Kereiakes DJ, Metzger DC, Caputo RP, Rizik DG, Teirstein PS, Litt MR, Kini A, Kabour A, Marx SO, Popma JJ, McGreevy R, Zhang Z, Simonton C, Stone GW; ABSORB III Investigators.. Everolimus-Eluting Bioresorbable Scaffolds for Coronary Artery Disease. N Engl J Med. 2015 Nov 12;373(20):1905-15. doi:10.1056/NEJMoa1509038. Epub 2015 Oct 12. PubMed PMID: 26457558.
  • Maybrook RJ, Sharma S, Gupta K, Wiley M, Parashara D. Percutaneous closure of a coronary artery-to-vein graft anastomotic pseudoaneurysm presenting as acute coronary syndrome after recent coronary artery bypass grafting. Tex Heart Inst J.2015 Jun 1;42(3):265-9. doi: 10.14503/THIJ-14-4102. eCollection 2015 Jun. PubMed PMID: 26175645; PubMed Central PMCID: PMC4473626.
  • Jeevanantham V, Chehab B, Austria E, Shrivastava R, Wiley M, Tadros P, Dawn B, Vacek JL, Gupta K. Comparison of accuracy of two different methods to determine ankle-brachial index to predict peripheral arterial disease severity confirmed by angiography. Am J Cardiol. 2014 Oct 1;114(7):1105-10. doi:10.1016/j.amjcard.2014.07.023. Epub 2014 Jul 17. PubMed PMID: 25129876.
  • Adams DH, Popma JJ, Reardon MJ, Yakubov SJ, Coselli JS, Deeb GM, Gleason TG, Buchbinder M, Hermiller J Jr, Kleiman NS, Chetcuti S, Heiser J, Merhi W, Zorn G, Tadros P, Robinson N, Petrossian G, Hughes GC, Harrison JK, Conte J, Maini B, Mumtaz M, Chenoweth S, Oh JK; U.S. CoreValve Clinical Investigators.Transcatheter aortic-valve replacement with a self-expanding prosthesis. N Engl J Med. 2014 May 8;370(19):1790-8. doi: 10.1056/NEJMoa1400590. Epub 2014 Mar 29.PubMed PMID: 24678937.
  • Popma JJ, Adams DH, Reardon MJ, Yakubov SJ, Kleiman NS, Heimansohn D,Hermiller J Jr, Hughes GC, Harrison JK, Coselli J, Diez J, Kafi A, Schreiber T, Gleason TG, Conte J, Buchbinder M, Deeb GM, Carabello B, Serruys PW, Chenoweth S, Oh JK; CoreValve United States Clinical Investigators.. Transcatheter aortic valve replacement using a self-expanding bioprosthesis in patients with severe aortic stenosis at extreme risk for surgery. J Am Coll Cardiol. 2014 May 20;63(19):1972-81. doi: 10.1016/j.jacc.2014.02.556. Epub 2014 Mar 19. PubMed PMID: 24657695.
  • Nicholls SJ, Kastelein JJ, Schwartz GG, Bash D, Rosenson RS, Cavender MA, Brennan DM, Koenig W, Jukema JW, Nambi V, Wright RS, Menon V, Lincoff AM, Nissen SE; VISTA-16 Investigators.. Varespladib and cardiovascular events in patients with an acute coronary syndrome: the VISTA-16 randomized clinical trial. JAMA.2014 Jan 15;311(3):252-62. doi: 10.1001/jama.2013.282836. PubMed PMID: 24247616.
  • Jayasree Pillarisetti MD, Sowjanya Duthuluru MD, Hari Sayana MD, Haley Goucher Goucher BA, Akshar Patel BA, Mazda Biria MD, James Vacek MD, Loren Berenbom MD, Sudharani Bommana M.Phil, Jayan Nath MD, Mark Wiley MD, Ajay Nangia MD, Luigi Di Biase MD, Andrea Natale MD, Madhuri Reddy MD, Buddhadeb Dawn, MD, Dhanunjaya Lakkireddy MD. Age-Dependent Impact of Fluoroscopic Radiation on the Gender of Off-Spring: An International Survey of Cardiologists. Journal of Atrial Fibrillation. Online publication 2013(5).
  • Wiley M, Kumar A, Vacek J. Review - Peripheral Arterial Disease. Consultant 2012; 52:601-610.
  • Pillarisetti J, Patel P, Duthuluru S, Roberts J, Chen W, Genton R, Wiley M, Candipan R, Tadros P, Gupta K. Cardiac catheterization in patients with end-stage liver disease: safety and outcomes. Catheter Cardiovasc Interv. 2011;77(1):45-8.

Selected Abstracts Presented at National Meetings

  • Fanari Z, Gunasekaran P, Shaukat A, Thapa J, Persad K, Hammami S, West J, Wiley M, Dawn B, Weintraub W, Tadros P, Doorey AJ. Hemodynamic assessment of low flow, low gradient severe aortic stenosis with preserved EF using a pressure wire. J Am Coll Cardiol .2017;69(11_S):1242.
  • Fanari Z, Gunasekaran P, Shaukat A, Hammami S, Doorey AJ, Weintraub W, Wiley M, Dawn B, Tadros P. Safety and efficacy of using pressure wire with dobutamin infusion in themoynamic Assessment of low flow low gradient aortic stenosis. J Am Coll Cardiol. 2017;69(11_S):1037.
  • Fanari Z, Gunasekaran P, Thapa J, Shaukat A, Persad K, Hammami S, Wiley M, Dawn B, West J, Weintraub W, Doorey A, Tadros P. The impact of transaortic gradient and transaortic flow on the discrepancy Between echocardiographic and cardiac catheterization evaluation of severe Aortic stenosis with preserved ejection fraction. J Am Coll Cardiol. 2017;69(11_S):1264.
  • Matthew Lippmann, Jigar Patel, Jared Kvapil, Michael Pierpoline, Peter Tadros, Mark Wiley, Matthew Earnest, Ashwani Mehta, Eric Hockstad, Kamal Gupta. Safety and feasibility of rotational atherectomy in elderly patients with severe aortic stenosis and calcific coronary artery disease undergoing evaluation for transcatheter aortic valve replacement. J Am Coll Cardiol. 2017;69(11_S):1261
  • Prasad C. Gunasekaran, Reza Masoomi, Dusan Stanojevic, Taylor Drees, John Fritzlen, Megan Haghnegahdar, Matthew McCullough, Ashwani Mehta, Matthew Earnest, Mark Wiley, Eric Hockstad, Peter Tadros, Kamal Gupta. Clinical presentation, natural history and management of coronary artery ectasia. J Am Coll Cardiol. 2017;69(11_S):1388
  •  Patrick Tobbia, Cassandra Kimber, Ben Jang, Micah Levine, Alisher Abdoullayev, Robert Funk, David Jacobs, Mark Wiley, Ashwani Mehta, Matthew Earnest, Peter Tadros, Buddhadeb Dawn, Kamal Gupta. The role of remote ischemic preconditioning in the prevention of contrast induced nephropathy. J Am Coll Cardiol. 2016;67(13_S):2348 http://dx.doi.org/10.1016/S0735-1097(16)32349-X. (//www.sciencedirect.com/science/article/pii/S073510971632349X).
  • Dusan A. Stanojevic; Prasad Gunasekaran; Micah Levine; Mark Reichuber; Randall Genton; Ashwani Mehta; Matthew Earnest; Mark Wiley; Peter Tadros; Buddhadeb Dawn; Kamal Gupta. Intravenous adenosine infusion is safe and well tolerated during coronary fractional flow reserve assessment in severe aortic stenosis. J Am Coll Cardiol. 2015;65(10_S):.  doi:10.1016/S0735-1097(15)61931-3.
  • Dusan Stanojevic, Suresh Sharma, Vinodh Jeevanantham, Bassem Chehab, Matthew McCullough, Matthew McCullough,Buddhadeb Dawn, Kamal Gupta, Peter Tadros, Mark Wiley. Clinical significance of Micro Coronary Edge Dissection and Plaque Prolapse visualized with Optical Coherence Tomography post Percutaneous Coronary Intervention. Catheterization and Cardiovascular Interventions. 2013; 81(S1):S88-S89. DOI: 10.1002/ccd.24919. 
  • Stanojevic D; Sharma S; Jeevanantham V; Chehab B; McCullough M; Tadros P; Dawn B; Wiley M. Evaluation of micro coronary edge dissection and coronary artery plaque prolapse post coronary artery percutaneous intervention using optical coherence tomography. J Am Coll Cardiol. 2013;61(10_S):. doi:10.1016/S0735-1097(13)61875-6. 
  • Jeevanantham V; Chehab B; Shrivastava R; Wiley M; Tadros P; Nath J; Dawn B; Gupta K. Utility of two methods of calculating ankle brachial index in detecting below knee peripheral arterial disease confirmed by angiography. J Am Coll Cardiol. 2013;61(10_S):. doi:10.1016/S0735-1097(13)62075-6. 
  • Jeevanantham V, Chehab B, Nagavalli S, Austria E, Shrivastava R, Wiley M, Tadros P, Nath J, Dawn B, Gupta K. Differences Between Two Methods of Calculating Ankle Brachial Index in Prediction of Below Knee Peripheral Arterial Disease Burden Confirmed by Angiography. Catherization and Cardiovascular Interventions, 2013; 81(S1): S74-S75.
  • Chehab B, Jeevanantham V, Nagavalli S, Austria E, Shrivastava R, Wiley M, Tadros P, Nath J, Dawn B, Gupta K. Two Methods of Calculating Ankle Brachial Index: Differences in Prediction of Peripheral Arterial Disease Burden. J Am Coll Cardiol. 2012;59(13s1):E2127-E2127. doi:10.1016/S0735-1097(12)62128-7.
  • Chehab B, Jeevanantham V, Saad A, Vacek J, Gupta K, Dawn B, Tadros P, Wiley M. Feasibility, Safety, and Outcomes with a Coronary Pressure Wire System used for the Assessment of Severe Aortic Stenosis.J Am Coll Cardiol. 2012;59(13s1):E134-E134. doi:10.1016/S0735-1097(12)60135-1. 
  • Bassem Chehab, Vinodh Jeevanantham, Andre Saad,Matthew Bulter, James Vacek, Thomas Rosamond,Kamal Gupta, M.D., Buddhadeb Dawn, Peter Tadros, Mark Wiley, Normal Coronary Anatomic Variants Influence False Positive Results of Myocardial Perfusion Imaging. Catheterization and Cardiovascular Interventions, 2012;79(S1):S40-S41.
  • Chehab B, Nagavalli S, Austria E, Jeevanantham V, Shrivastava R, Wiley M, Tadros P, Nath J, Dawn B, Gupta K. A study of diagnostic accuracy of two methods of calculating ankle brachial index to detect occlusive peripheral arterial disease. Catheter Cardiovasc Interv 2011;78:S50-51.
  • Saad A, Chehab BM, Jeevanantham V, Gupta R, Nath J, Lakkireddy DJ, Wiley M, Tadros P, Dawn B, Gupta K. Role of side-to-side difference in renal resistive index as an index for clinical improvement in renal artery stenosis revascularization. Catheter Cardiovasc Interv 2011;78:S50.
  • Pillarisetti J, Patel P, Duthuluru S, Patel A, Chen W, Genton R, Wiley M, Candipan R, Tadros P, Gupta K. Cardiac catheterization in patients with end-stage liver disease: safety and outcomes. Circ Cardiovasc Qual and Outcomes Abstracts 2009:e61.
  • Maugans C, Grier B, Humera D, Jones C, Sheldon S, Vacek J, Wiley M. Correlation of fluctuating ozone levels with hospital and emergency department admissions for chest pain or acute coronary syndromes. Presented at the 2009 Combined Annual Meeting, Central Society for Clinical Research, Midwestern Section American Federation for Medical Research.
  • Pillarisetti J, Lakkireddy D, Tadros P, Sayana H, Goucher H, Duthuluru S, Patel A, Biria M, Vacek J, Berenbom L, Gupta K, Nath J, Wiley M. Interventional cardiologists and electrophysiologists beware - your job can impact the gender of your offspring too. Heart Rhythm 2009;6(5):S262. 
  • Sheldon S, Tadros P, Jones C, Rosamond T, Wiley M. Coronary Artery Dominance:  Correlation With False Positive Regional Myocardial Perfusion Abnormalities. Presented at the 2008 Midwestern Section of the American Federation for Medical Research Annual Meeting, April 24-25 2008, Chicago Illinois.
  • Franano FN, Bland KS, Ding BC, Wiley M, Vacek J, Smirnov I, Henry C. PRT-101 Can Effect Positive Remodeling of the Porcine Iliac Artery. Presented at the 20th Annual Transcatheter Cardiovascular Therapeutics Symposium 2008, October 12-17 2008, Washington DC.
  • Franano FN, Bland KS, Ding BC, Wiley M, Vacek J, Smirnov I, Henry C. Prt-201 is a locally-acting recombinant human type I elastase that safely and persistently dilates segments of blood vessels in animal models and can be used as a "biological stent". Invited Oral Presentation, 20th Annual Transcatheter Cardiovascular Therapeutics Symposium 2008, October 12-17 2008, Washington DC.
Last modified: Apr 13, 2017

Mark A. Wiley, MD, FACC, FSCAI

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Mark A. Wiley, MD, FACC, FSCAI
Assistant Professor of Medicine - Cardiology

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