Guangming Cheng, MD., Ph.D.

Research Assistant Professor of Medicine - Cardiology
Internal Medicine

M.D.,PhD., Tongji Medical University, Wuhan, China
Research Associate III, University of California, San Francisco (UCSF)
Postdoctoral, University of Maryland, Baltimore


Research Interests

  • Biology of adult stem cells and adult cell therapy for cardiac repair
  • Left ventricular post-myocardial infarction remodeling
  • Coronary graft failure, Bioengineering tissue and graft with stem cells
  • LV unloaded remodeling
  • Mechanisms of myocardial hypertrophy and failure 

Rewards

  • 2015 America Heart Association Travel Award for Early Career in the Basic Cardiovascular Science Council, Orlando,FL.
  • 2015  America Heart Association Travel Award for Trainee (Lin Zhao) in the Basic Cardiovascular Science Council, Orlando,FL. (equal contribution)
  • 2011 America Heart Association Travel Award for Trainee in the Basic Cardiovascular Science Council,   Chicago,IL.
  • 2000 Scientific and Technological Progress Award, Certificate No. 2000J-197-3-127-111-R04 (Hubei Province Government).

Selected Publications

  • Zhao L*,Cheng G*, Jin R, Afzal MR, Samanta A, Xuan YT, Girgis M, Elias HK, Zhu Y, Davani A, Yang Y, Chen X, Ye S, Wang OL, Chen L, Hauptman J, Vincent RJ, Dawn B. Deletion of Interleukin-6 Attenuates Pressure Overload-Induced Left Ventricular Hypertrophy and Dysfunction. Circulation research. 2016; 118(12):1918-29. NIHMSID: NIHMS783123 PubMed [journal] PMID: 27126808, PMCID: PMC4902783. * Equal contribution
  • Wong VM, Wenk JF, Zhang Z, Cheng G, Acevedo-Bolton G, Burger M, Saloner DA, Wallace AW, Guccione JM, Ratcliffe MB, Ge L. The effect of mitral annuloplasty shape in ischemic mitral regurgitation: a finite element simulation. The Annals of thoracic surgery. 2012; 93(3):776-82. NIHMSID: NIHMS397233 PubMed [journal].PMID: 22245588, PMCID: PMC3432639
  • Soleimani M, Khazalpour M, Cheng G, Zhang Z, Acevedo-Bolton G, Saloner DA, Mishra R, Wallace AW, Guccione JM, Ge L, Ratcliffe MB. Moderate mitral regurgitation accelerates left ventricular remodeling after posterolateral myocardial infarction. The Annals of thoracic surgery. 2011; 92(5):1614-20. NIHMSID: NIHMS346680 PubMed [journal] PMID: 21945222, PMCID: PMC3253877.
  • Wenk JF, Zhang Z, Cheng G, Malhotra D, Acevedo-Bolton G, Burger M, Suzuki T, Saloner DA, Wallace AW, Guccione JM, Ratcliffe MB. First finite element model of the left ventricle with mitral valve: insights into ischemic mitral regurgitation. The Annals of thoracic surgery. 2010; 89(5):1546-53. NIHMSID: NIHMS207713 PubMed [journal] PMID: 20417775, PMCID: PMC2887313.
  • Zhang T, Cheng G, Koert A, Zhang J, Gellman B, Yankey GK, Satpute A, Dasse KA, Gilbert RJ, Griffith BP, Wu ZJ. Functional and biocompatibility performances of an integrated Maglev pump-oxygenator. Artificial organs. 2009; 33(1):36-45. PubMed [journal] PMID: 19178439.
  • Yankey GK, Li T, Kilic A, Cheng G, Satpute A, Savai K, Li S, Moainie SL, Prastein D, DeFillipi C, Wu ZJ, Griffith BP. Regional remodeling strain and its association with myocardial apoptosis after myocardial infarction in an ovine model. The Journal of thoracic and cardiovascular surgery. 2008; 135(5):991-8, 998.e1-2. PubMed [journal] PMID: 18455574.
  • Shanmugam I, Cheng G, Terranova PF, Thrasher JB, Thomas CP, Li B. Serum/glucocorticoid-induced protein kinase-1 facilitates androgen receptor-dependent cell survival. Cell death and differentiation. 2007; 14(12):2085-94. PubMed [journal] PMID: 17932503.
  • Kilic A, Nolan TD, Li T, Yankey GK, Prastein DJ, Cheng G, Jarvik RK, Wu ZJ, Griffith BP. Early in vivo experience with the pediatric Jarvik 2000 heart. ASAIO journal 2007; 53(3):374-8. PubMed [journal] PMID: 17515732.
  • Cheng G, Liu J, Lan H, Liang J, Lu J. Protective effect of warm induction and terminal reperfusion of blood cardioplegia enriched with amino acids on ischemic myocardium--a results of 60 rheumatic cardiac valve replacements. Chinese J of cardiovascular Review 2005, 1:37-38.
  • Cheng G, Gao Z, Sun J. Surgical treatment of bronchoesophageal fistula combined with achalasia. 2005. Chinese J of Clinical thoracic and Cardiovascular Surgery. 12 (3):214
  • Cheng G, Lan H, Sun Z, Du Xe. Myocardial protective effect of amino acids in prolonged cardioplegia. Chinese Circulation Journal 1998, 3:311-313.
  • Zhang K, Lan H, Cheng G, Fu P, Huang Y, Xu Z, Feng H. Effect of amino acid cardioplegia on myocardial metabolism and function of ischemic canine heart. Journal of Tongji Medical University = Tong ji yi ke da xue xue bao. 1997; 17(4):239-43. PubMed [journal] PMID: 9812789.
  • Cheng G, Lan H, Sun Z, Zhang K, Du X. Experimental study on the effects of aprotinin on myocardial ischemia and reperfusion. Journal of Tongji Medical University = Tong ji yi ke da xue xue bao. 1997; 17(1):36-9. PubMed [journal] PMID: 9639783
  • Cheng G, Lan H, Sun Z, Du X. Protective effect of warm induction and terminal reperfusion of blood cardioplegia enriched with amino acids on ischemic rat hearts. Chinese J of Thoracic and Cardiovasc Surg 1997, 13: 364-366.
  • Zhang K, Lan H, Cheng G, Fu P, Huang Y Xu Z. 1997. Myocardial protection of warm induction and terminal reperfusion of blood cardioplegia enriched with amino acids on ischemic dog hearts. Chinese J of Experimental Surg.14: 175-176.
  • Cheng G, Lan H, Sun Z, Du X. 1996. Effects of aprotinin on myocardial ischemia and reperfusion---an experimental study. Chinese J of Experimental Surg. 13(supplement): 127-128.
  • Lan H, Cai J, Zhang K, Xu Z Cheng G. Protective effect of cold crystalloid cardioplegia anterograde perfusion with coronary sinus obstruction on acute ischemic/reperfusion hearts with LAD occlusion in dog. Chinese J of Experimental Surg 1995; 12(6):370-371.   

Selected Abstracts Presented at National Meetings

  • Guangming Cheng, Xing Chen, Lin Zhao, Anweshan Samanta, Magdy Girgis, Sheng Ye, Arash Davani, Anja Browning, Yanjuan Yang,  Jianye Yang, Amy Cantilena, Jeryl Hauptman, Robert Vincent, Buddhadeb Dawn. CHOP Serves a Positive Feedback toward Activation of CaMKII in ER Stress Mediated-apoptosis and Cardiac Dysfunction----Novel Signaling pathway in Cardiac Pressure Overload. Circulation. 2016: A17333.
  • Sheng Ye*, Guangming Cheng*, Jiafeng Lin, Xing Chen, Lin Zhao, Anweshan Samanta, Magdy Girgis, Arash Davani, Anja Browning,Yanjuan Yang, Jeryl Hauptman, Robert Vincent, Buddhadeb Dawn. Cardiac-specific NF-κB Inhibition Protects against Cardiomyocyte Cellular Senescence and age-related Cardiac Dysfunction. Circulation. 2016: A18099. . * Equal contribution
  • Sheng Ye*, Guangming Cheng*, Jiafeng Lin, Xing Chen, Lin Zhao, Anweshan Samanta, Magdy Girgis, Arash Davani, Yanjuan Yang, Jeryl Hauptman, Robert Vincent, Buddhadeb Dawn. NF-κB Signaling Plays an Important and Detrimental Role in Cardiomyocyte Senescence. Circulation. 2016: A17891. * Equal contribution
  • Xing Chen*, Guangming Cheng*, Shiming Liu, Sheng Ye, Lin Zhao, Anweshan Samanta, Anja Browning, Robert Vincent, Yanjuan Yang, Jeryl Hauptman, Buddhadeb Dawn. Pressure-overload induced LV Hypertrophy and Dysfunction: Critical Roles of CaMKII and P38 MAP kinase in ER Stress Signaling Pathway. J Am Coll Cardiol. 2016;67(13_S):1403-1403. . * Equal contribution.
  • Sheng Ye*, Guangming Cheng*, Jiafeng Lin, Xing Chen, Lin Zhao, Samanta A, Girgis M, Vincent R, Yang Y, Hauptman J, Dawn B. Cardiac-specific transgenic inhibition of NF-kB attenuates apoptosis and remodeling in the aging heart. Circulation 2015;132:A14642. . * Equal contribution.
  • Guangming Cheng, Marta Adamiak, Yu-Ting Xuan1, Anweshan Samanta1,Sylwia Bobis-Wozowicz, Magdy Girgis,Ou-Li Wang, Elzbieta Karnas, Arash Davani1,Sylwia Kedracka-Krok, Michal Sarna, Robert J Vincent1,Yanjuan Yang, Zbigniew Madeja, Ewa Zuba-Surma, Buddhadeb Dawn. Intramyocardial Delivery of Extracellular Vesicles Released From Induced Pluripotent Stem Cells Induces Cardiac Repair After Myocardial Infarction. Circulation. 2015;132:Suppl 3 A16280
  • Guangming Cheng, Anna Labedz-Maslowska, Dominika Berdecka, Yu-Ting Xuan, Anweshan Samanta, Magdy Girgis, Ou-Li Wang, Sylwia Kedracka-Krok, Arash Davani, Robert J Vincent, Yanjuan Yang, Elzbieta Karnas, Michal Sarna, Jeryl Hauptman, Zbigniew Madeja, Buddhadeb Dawn, Ewa Zuba-Surma. Intramyocardial Injection of MSC-derived Extracellular Vesicles Confers Superior Cardiac Repair After a Reperfused Myocardial Infarction. Circulation. 2015;132:Suppl 3 A16673
  • Guangming Cheng, Sheng Ye, Magdy Girgis, Lin Zhao, Xing Chen, Anweshan Samanta, Yanjuan Yang, Jeryl Hauptman, Robert Vincent, Buddhadeb Dawn. Inhibition of NF-kB Signaling Attenuates Age-related Aggravation of Myocardial Ischemia/Reperfusion Injury. Circulation. 2015;132:Suppl 3 A15948.
  • Marta Adamiak, Sylwia Bobis-Wozowicz, Elzbieta Karnas, Sylwia Kedracka-Krok, Michal Sarna, Guangming Cheng, Anweshan Samanta, Magdy Girgis, Zbigniew Madeja, Buddhadeb Dawn, Ewa Zuba-Surma. Bioactive contents and cardiovascular regenerative potential of extracellular vesicles derived from induced pluripotent stem cells. Circulation. 2015;132:Suppl 3 A15466.
  • Kashyap Choksi, Guangming Cheng, Arash Davani, Anweshan Samanta, Magdy Girgis, Amy Cantilena, Robert Vincent, Yanjuan Yang, Harold K Elias, Carl Weiner, Buddhadeb Dawn. Transplantation of Human Umbilical Cord Blood Mononuclear Cells Improves LV function and Remodeling After a reperfused Myocardial Infarction. Circulation. 2014;130:Suppl 2 A14804.
  • Guangming Cheng, Zhao L, Chen L, Chen X, Davani A, Samanta A, Girgis M, Elias H, Yang Y, Vincent RJ, Hauptman, J, Dawn B. CamKII links ER stress signaling in pressure overload-induced left ventricular hypertrophy and failure. Circulation 2014;130:15923.
  • Guangming Cheng, Yanjuan Yang, Magdy Girgis, Arash Davani, Carrie M. Quinn, Harold Elias, Jeryl Hauptman, Buddhadeb Dawn. Cardiac-Specific Transgenic inhibition of NF-KB Activation Protects against Myocardial Ischemia/Reperfusion Injury. J Am Coll Cardiol. 2012;59(13s1):E546.
  • Sanganalmath SK, Guangming Cheng, Girgis M, Xuan Y, Yang Y, Elias H, Vincent R, Dawn B. Cardiac-specific transgenic silencing of NF-κB ameliorates left ventricular dysfunction and remodeling after acute myocardial infarction. J Am Coll Cardiol 2012;59:E909.  
  • Guangming Cheng, Girgis M, Davani A, Chen L, Elias H, Yang Y, Sanganalmath SK, Quinn CM, Dawn B. The absence of C/EBP homologous protein improves left ventricular remodeling after a reperfused myocardial infarction. Circulation 2012;126:A13727.
  • Guangming Cheng, Ewa K. Zuba-Surma, Yu-Ting Xuan, Yanjuan Yang, Magdy Girgis, Ou-Li Wang, Yanqing Zhu, Robert J. Vincent, Santosh K. Sanganalmath, Shelley Lietzau-Mourer, Dong Xu, Buddhadeb Dawn. Transplantation of an Antigenically-Defined Subpopulation of Bone Marrow Mesenchymal Stem Cells Results in Superior cardiac Repair after a Reperfused Myocardial Infarction. Circulation. 2011;124: A17476.
  • Guangming Cheng, Yu-Ting Xuan, SK Sanganalmath, Xuan YT, Quinn CM, Sanganalmath Sk, Girgis M, Wang OL, Zhu Y, Yang Y, Flaherty MP, Lietzau-Mourer S, Zuba-Surma EK, Vincent R, Xu D, Davani A, Dawn B. Wnt11-pretreated bone marrow stem cells induce superior cardiac repair after a reperfused myocardial infarction. Circulation. 2011;124:Suppl 21 A9899.
  • Guangming Cheng, Robert Rarnan, Robert K Jarvic, Zhongjun J. Wu, Bartley P. Griffith. In Vivo Experience with Different Types of LVADs for Heart Unloading. ASAIO J. 2008 March-April; 54(2):28A.
  • K Savai, C Wu, R Farnan, G Cheng, D Morley, Z Wu, B Griffith. The impact of partial circulatory support on the strain distribution on the post-infarction left ventricular wall. ASAIO J.2008 March-April; 54(2):30A.   
Last modified: Aug 11, 2016

Contact

Guangming Cheng, MD., Ph.D.
Research Assistant Professor of Medicine - Cardiology

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