Guangming Cheng, MD., Ph.D.

Research Assistant Professor of Medicine - Cardiology
Internal Medicine

M.D.,PhD., Tongji Medical University, Wuhan, China
Research Associate III, University of California, San Francisco (UCSF)
Postdoctoral, University of Maryland, Baltimore


Research Interests

  • Biology of adult stem cells and adult cell therapy for cardiac repair
  • Left ventricular post-myocardial infarction remodeling
  • Coronary graft failure, Bioengineering tissue and graft with stem cells
  • LV unloaded remodeling
  • Mechanisms of myocardial hypertrophy and failure 

Awards

  • 2011 BCVS(the Basic Cardiovascular) Travel Award of AHA, Chicago, IL. 

Selected Publications

  • Wong VM, Wenk JF, Zhang Z, Cheng G, Acevedo-Bolton G, Burger M, Saloner DA, Wallace AW, Guccione JM, Ratcliffe MB, Ge L. The effect of mitral annuloplasty shape in ischemic mitral regurgitation: a finite element simulation. Ann Thorac Surg. 2012 Mar; 93(3):776-82.
  • Soleimani M, Khazalpour M, Cheng G, Zhang Z, Acevedo-Bolton G, Saloner DA, Mishra R, Wallace AW, Guccione JM, Ge L, Ratcliffe MB. Moderate mitral regurgitation accelerates left ventricular remodeling after posterolateral myocardial infarction. Ann Thorac Surg. 2011 Nov; 92(5):1614-20.
  • Jonathan F Wenk, Zhihong Zhang, Guangming Cheng, Deepak Malhotra, Gabriel Acevedo-Bolton, Mike Burger, Takamaro Suzuki, David A Saloner, Arthur W Wallace, Julius M Guccione, Mark B Ratcliffe. A method for Developing MRI-based Finite Element Models of the Left Ventricle with Mitral Valve and Chordae Tendineae. Ann Thorac Surg 2010; 89:1546 -54).
  • T Zhang, G Cheng, A Koert, J Zhang, B Gellman, GK Yankey, A Satpute, KA Dasse, RJ Gilbert, BP Griffith, ZJ Wu. Functional and Biocompatibility Performances of an Integrated Maglev Pump-Oxygenator. Artificial Organs, 2009 Jan; 33(1): 36-45.
  • Yankey GK, Li T, Kilic A, Cheng G, Satpute A, Savai K, Li S, Moainie SL, Prastein D, DeFillipi C, Wu ZJ, Griffith BP. Regional remodeling strain and its association with myocardial apoptosis after myocardial infarction in an ovine model. J Thorac Cardiovasc Surg. 2008 May; 135(5):991-8, 998.e1-2.
  • Ilanchezian Shanmugam, Guangming Cheng, Paul Terranova, J.Brantley Thrasher, Christie Thomas, Benyi Li. Serum/glucocorticoid-induced protein kinase-1 facilitates androgen receptor-dependent cell survival. Cell Death and Differentiation. 2007 Dec;14 (12):2085-94.
  • Ahmet Kilic, Timothy D.C. Nolan, Tieluo Li, G Kwame Yankey, Deyanira J. Prastein, Guangming Cheng, Robert K. Jarvik, Zhongjun J.Wu, and Bartley P. Griffith. Early In Vivo Experience With the Pediatric Jarvik 2000 Heart. ASAIO Journal 2007; 53:374-378.
  • Cheng G, Lan H, Sun Z, Du Xe. Myocardial protective effect of amino acids in prolonged cardioplegia. Chinese Circulation Journal. 1998, 3:311-313.
  • Cheng G, Lan H, Sun Z, Du X. Protective effect of warm induction and terminal reperfusion of blood cardioplegia enriched with amino acids on ischemic rat hearts. Chinese J of Thoracic and Cardiovasc Surg. 1997, 13: 364-366.
  • Cheng G, Lan H, Sun Z, Zhang K, Du X. Experimental study on the effects of aprotinin on myocardial ischemic and reperfusion. J Tongji Med Univ (English issue). 1997, 17(1): 36-9.
  • Zhang K, Lan H, Cheng G, Fu P, Huang Y, Xu Z. Effect of amino acid cardioplegia on myocardial metabolism and function of ischemic canine heart. J Tongji Med Univ (English issue) 1997, 17(4):239-243.
  • Lan H, Cai J, Zhang K, Xu Z Cheng G. Protective effect of cold crystalloid cardioplegia anterograde perfusion and coronary sinus obstruction on ischemic dog hearts with coronary artery branch occlusion. Chinese J of Experimental Surg. 1995; 12(6):370-371

Abstracts Presented at National Meeting (2007-2013)

  • Guangming Cheng, Yu-Ting Xuan, Harold Elias, Magdy Girgis, Lin Zhao, Yanqing Zhu, Ou-Li Wang, Arash Davani, Yanjuan Yang, Lei Chen, Jeryl Hauptman, Robert J Vincent, Buddhadeb Dawn. Genetic Deletion of IL-6 Attenuates Pressure Overload-induced Left Ventricular Hypertrophy and Failure. Circulation. 2013; 128: A18105. 2013 AHA Scientific Sessions, Dallas, TX.
  • Guangming Cheng, Magdy Girgis, Arash Davani, Lei Chen, Harold Elias, Yanjuan Yang, Santosh K Sanganalmath, Carrie M Quinn, and Buddhadeb Dawn .The Absence of C/EBP Homologous Protein Improves Left Ventricular Remodeling After a Reperfused Myocardial Infarction. Circulation. 2012; 126: A13727. 2012 AHA, Los Angeles, CA.
  • Yu-Ting Xuan, Yanqing Zhu, Ou-Li Wang, Guangming Cheng, Harold Elias, Arash Davani, Yanjuan Yang, Magdy Girgis, Robert J Vincent, Jeryl Hauptman, and Buddhadeb Dawn.STAT3 Activation Prevents Mesenchymal Stem Cell Apoptosis and Improves Infarct Repair. 2012 AHA Scientific Sessions, Los Angeles, CA.
  • Guangming Cheng, Yanjuan Yang, Magdy Girgis, Arash Davani, Carrie M. Quinn, Harold Elias, Jeryl Hauptman, Buddhadeb Dawn. Cardiac-Specific Transgenic inhibition of NF-KB Activation Protects against Myocardial Ischemia/Reperfusion Injury. Journal of the American College of Cardiology, Volume 59, Issue 13, Supplement, 27 March 2012, Page E546.American College of Cardiology(ACC) 61th Annual Scientific Session,2012,Chicago,IL.
  • Santosh Sanganalmath, Guangming Cheng, Magdy Girgis, Yu-Ting Xuan, Yanjuan Yang, Harold Elias, Robert J. Vincent, Buddhadeb Dawn. Cardiac-Specific Transgenic Silencing of NF-KB Ameliorates Left ventricular Dysfunction and Remodeling after Acute Myocardial Infarction. 61st ACC Annual Scientific Session, 2012, Chicago, IL.
  • Guangming Cheng, Yu-Ting Xuan, Carrie Quinn, Santosh Sanganalmath, Magdy Girgis, Ou-Li Wang, Yanqing Zhu, Yanjuan Yang, Michael Flaherty, Shelley Lietzau-Mourer, Ewa K. Zuba-Surma, Robert J. Vincent, Dong Xu, Arash Davani, Buddhadeb Dawn. Wnt11-Pretreated Bone Marrow Mesenchymal Stem Cells Induce Superior Cardiac Repair after a Reperfused Myocardial Infarction. Circulation. 2011;124: A9899. 2012 AHA Scientific Sessions, Orlando, FL.
  • Guangming Cheng, Ewa K. Zuba-Surma, Yu-Ting Xuan, Yanjuan Yang, Magdy Girgis, Ou-Li Wang, Yanqing Zhu, Robert J. Vincent, Santosh K. Sanganalmath, Shelley Lietzau-Mourer, Dong Xu, Buddhadeb Dawn. Transplantation of an Antigenically-Defined Subpopulation of Bone Marrow Mesenchymal Stem Cells Results in Superior cardiac Repair after a Reperfused Myocardial Infarction. Circulation. 2011;124: A17476. 2011 AHA Scientific Sessions, Orlando, FL.
  • Guangming Cheng, Robert Rarnan, Robert K Jarvic, Zhongjun J. Wu, Bartley P. Griffith. In Vivo Experience with Different Types of LVADs for Heart Unloading. ASAIO J. 2008 March-April; 54(2):28A. 54th American Society for Artificial Internal Organs (ASAIO) Annual Conference, 2008, San Francisco, CA.
  • K Savai, C Wu, R Farnan, G Cheng, D Morley, Z Wu, B Griffith. The impact of partial circulatory support on the strain distribution on the post-infarction left ventricular wall. ASAIO J.2008 March-April; 54(2):30A. 54th ASAIO Annual Conference, 2008, San Francisco, CA.
  • ZJ Wu, A Kilic, J Zhang, G Burgreen, G Cheng, GK Yangkey, T Li, R Jarvik, and BP Griffith. Progress and Initial In-Vivo Experience of the Pediatric Jarvic 2000 Heart. ISHLT 2007. 37th Annual Meeting and Scientific Sessions, San Francisco, CA.
  • T Zhang, G Cheng, A Koert, J Zhang, B Gellman, KA. Dasse, BP. Griffith, ZJ. Wu. Gas transfer performance, hemodynamics and biocompatibility of a novel integrated pump-oxygenator. The Fifth IASTED International Conference on Biomechanics. Honolulu, Hawaii, USA. August 20 - 22, 2007.
  • T Zhang, G Cheng, A Koert, J Zhang, B Gellman, G Yangkey, Aditee Satpute, KA. Dasse, BP. Griffith, ZJ. Wu. In-vitro and in-vivo performances of an integrated maglev pump-oxgenator(IMPO). 53RD ASAIO Annual Conference, Chicago, IL. Jane. 17, 2007.
Last modified: Jan 16, 2014

Contact

Guangming Cheng, MD., Ph.D.
Research Assistant Professor of Medicine - Cardiology

ID=x16070