Detlef Wencker, MD

Associate Professor of Medicine - Cardiology
Medical School, Medical Faculty, Westphalen Wilhelms University of Munster (Westfälische Wilhelms-University, Münster, Germany)
Residency, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, New York
Fellowship, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York (Clinical Cardiovascular)
Fellowship, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York [Mentor: Dr. Sonnenblick, Dr. Thierry LeJemtel) (Heart Failure & Transplant)

Clinical Interests

  • Heart Failure
  • Cardiac Transplant

Research Interests

  • Drug and Device Therapy for CHF

Research Projects

Active Projects

  • A study to evaluate the efficacy, safety and tolerability of Serelaxin when added to standard therapy in acute heart failure patients.

Selected Publications

  •  Moazami N, Steffen RJ, Naka Y, Jorde U, Bailey S, Murali S, Camacho MT, Zucker M, Marascalco PJ, Rao V, Feldman D; SUSTAIN Investigators. Lessons learned from the first fully magnetically levitated centrifugal LVAD trial in the United States: the DuraHeart trial. Ann Thorac Surg. 2014 Aug;98(2):541-7. doi:10.1016/j.athoracsur.2014.04.048. Epub 2014 Jun 10. PubMed PMID: 24928670.
  • Singh R, De Aguiar RB, Naik S, Mani S, Ostadsharif K, Wencker D, Sotoudeh M,Malekzadeh R, Sherwin RS, Mani A. LRP6 enhances glucose metabolism by promoting TCF7L2-dependent insulin receptor expression and IGF receptor stabilization in humans, Cell Metab. 2013 Feb 5;17(2):197-209.
  • Gluck JA, Thompson S, Wencker D. "VLAD": a novel approach to community left ventricular assist device education using an interactive medical simulator. J Heart Lung Transplant. 2012 Dec;31(12):1321-2. doi: 10.1016/j.healun.2012.09.020. Epub 2012 Oct 11. PubMed PMID: 23063322.
  • M. Rai, C. M. Statz,  A. Ras, J. Rahn, L. O'Bara, F. Zaeem, R. Mulamalla, J. Hammond, D. Wencker (pending). The Effects of Outpatient Infusion Therapy on Morbidity and Hospital Readmission for Acute Heart Failure Syndrome. New England Journal of Medicine (submitted for publication)
  • C. M. Statz, A. Ras, R. Mulamalla, F. Zaeem, D. Wencker (pending).  Caspase 1: A novel biomarker and indicator for predicting heart failure severity and optimization of advanced heart failure therapy.  JCI (Submitted)
  • Rai, M., Statz, C., Ras, A., Rahn, J., O'Bara, L., Zaeem, F., Mulamalla, R., Hammond, J., Wencker, D. (2011) NGAL Lacks Specificity for Acute Kidney Injury in Acute Heart Failure Syndrome. Journal of Heart and Lung Transplantation. 30:4; S180-S181
  • Jacob JC, Kiernan FJ, Patel N, Rock J, Hammond J Jr, Wencker D, Lasala AF (2011).  SCAD: a rare case of cardiac arrest in a young female. Conn Med. 2011 Mar;75(3):147-52.
  • Statz, C., Rai, M., Ras, A., Imse, J., Zaeem, F., Mulamalla, R., Hammond, J., Wencker, D. (2011) Novel Findings of Upregulated Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Myocytes of Advanced Heart Failure Patients. Journal of Cardiac Failure. 17:8; S36
  • Zannad F, McMurray JJ, Krum H, van Veldhuisen DJ, Swedberg K, Shi H, Vincent J, Pocock SJ, Pitt B; D.Wencker, EMPHASIS-HF Study Group (2011). Eplerenone in patients with systolic heart failure and mild symptoms, N Engl J Med. 2011 Jan 6;364(1):11-21
  • Rai, M., Statz, C., Ras, A., Rahn, J., O'Bara, L., Zaeem, F., Mulamalla, R., Hammond, J., Wencker, D. (2011) NGAL Lacks Specificity for Acute Kidney Injury in Acute Heart Failure Syndrome. Journal of Cardiac Failure. 17:8, S33
  • Massie BM, O'Connor CM, Metra M, Ponikowski P, Teerlink JR, Cotter G, Weatherley BD, Cleland JG, Givertz MM,Voors A, DeLucca P, Mansoor GA, Salerno CM,Bloomfield DM, Dittrich HC;Wencker D, PROTECT Investigators and Committees (2011). Rolofylline, an adenosine A1-receptor antagonist, in acute heart failure,  N Engl J Med. 2010 Oct 7;363(15):1419-28
  • Weatherley BD, Cotter G, Dittrich HC, DeLucca P, Mansoor GA, Bloomfield DM, Ponikowski P, O'Connor CM, Metra M, Massie BM; PROTECT Steering Committee, Investigators, and CoordinatorsDesign and rationale of the PROTECT study: a placebo-controlled randomized study of the selective A1 adenosine receptor antagonist rolofylline for patients hospitalized with acute decompensated heart failure and volume overload to assess treatment effect on congestion and renal function,  J Card Fail. 2010 Jan;16(1):25-35.
  • Yi-Da Tang, M.D., Ph.D., Thomas A. Dewland, Detlef Wencker, Stuart D. Katz  (2009) Post-Exercise Heart Rate Recovery Independently Predicts Mortality Risk in Patients with Chronic Heart Failure. J Card Failure, 2009 (10):850-5.
  • Gualberto Ruaño, James Bernene, Andreas Windemuth, Bruce Bower, Detlef Wencker, Richard L. Seip, Mohan Kocherla, Theodore R. Holford, William Petit, Stephen Hanks.  (2009) Physiogenomic Comparison of Edema and BMI in Patients Receiving Rosiglitazone or Pioglitazone (Clin Chim Acta. 2009 Feb;400(1-2):48-55)
  • Detlef Wencker, Acute Cardio-Renal Syndrome:  (2007) Progression from Congestive Heart Failure to Congestive Kidney Failure, Current Heart Failure Reports. 4(3), 134-138
  • Luisa F Durango, Stuart D Katz, Hung-Kei Li, Detlef Wencker.  (2006) Outpatient Treatment of Refractory Heart Failure with Intravenous Furosemide Infusion. J Cardiac Failure 6: S115.
  • Carlos Mena, MD, Detlef Wencker, MD, Harlan M. Krumholz, MD, SM, Robert L. McNamara, MD.  (2006). Detection Of Heart Transplant Rejection In Adults By Echocardiographic Diastolic Indices: A Quality Review Of The Literature,  J Am Soc Echocardiogr. 2006 Oct; 19(10):1295-300.
  • Wencker D, Chandra M, Nguyen K, Miao W, Garantziotis S, Factor SM, Shirani J, Armstrong RC, Kitsis RN. (2003)  A Mechanistic Role for Cardiac Myocyte Apoptosis in Heart Failure J Clin Invest 111; 1497-1504.
  • Wencker D, Borer JS, Hochreiter C, Devereux RB, Roman MJ, Kligfield P, Supino P, Krieger K, Isom OW.  (2000) Preoperative predictors' of late postoperative outcome among patients with non-ischemic mitral regurgitation with 'high risk' descriptors and comparison with unoperated patients.  Cardiology 93(1-2):37-42.
  • Fujio Y, Nguyen T, Wencker D, Kitsis RN, Walsh K.  (2000) Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart. Circulation 101:660-7.
  • De Windt LJ, Lim HW, Taigen T, Wencker D, Condorelli G, Dorn GW 2nd, Kitsis RN,  Molkentin JD.  (2000) Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo: An apoptosis-independent model of dilated heart failure.  Circ Res. 86:255-63.
  • Borer JS, Hochreiter C, Herrold EM, Supino P, Aschermann M, Wencker D, Devereux RB, Roman MJ, Szulc M, Kligfield P, Isom OW. (1998) Prediction of indications for valve replacement among asymptomatic or minimally symptomatic patients with chronic aortic regurgitation and normal left ventricular performance.  Circulation 97:525-34.
  • Borer JS, Wencker D, Hochreiter C.  (1996) Management Decisions in Valvular Heart Disease: The Role of Radionuclide-based Assessment of Ventricular Function and Performance".  Journal of Nuclear Cardiology 3: 72-81.
  • Borer JS, Wencker D, Hochreiter C.  (1996) Management decisions in valvular heart disease: the role of radionuclide-based assessment of ventricular function and performance.  J. Nucl. Cardiol. 3:72-81.
  • Muto P, Lastoria S, Varrella P, Vergara E, Salvatore M, Morgano G, Lister-James J,  Bernardy JD, Dean RT, Wencker D. (1995)  Detecting deep venous thrombosis with  technetium-99m-labeled synthetic peptide P280.  J. Nucl. Med. 36:1384-91.
  • Borer JS, Supino P, Wencker D, Aschermann M, Bacharach SL, Green MV. (1994) Assessment of coronary artery disease by radionuclide cineangiography. History, current applications, and new directions.  Cardiol. Clin. 12:333-57.


  •  Cara M Statz, Aleksandra M Ras, Kevin D Ballard, Jason A Gluck, and Detlef Wencker. A Paradoxical Rise in Serum Copeptin After Non-Pulsatile LVAD: a New SIADH? Circulation. 2014;130:A15253.





Last modified: Jul 17, 2015


Detlef Wencker, MD
Associate Professor of Medicine - Cardiology