Buddhadeb Dawn, MD

Professor of Medicine
Maureen & Marvin Dunn Professor of Cardiovascular Diseases
Director, Division of Cardiovascular Diseases
Director, Cardiovascular Research Institute
Vice Chairman for Research, Department of Medicine
Medical School, Calcutta Medical College, Calcutta, West Bengal, India
Residency, University of Missouri-Columbia, Columbia, Missouri
Fellowship, University of Louisville, Louisville Kentucky

Clinical Interests

  • Stress Echocardiography
  • Atrial fibrillation
  • Biomarkers in acute coronary syndromes
  • Diagnosis of chest pain in the ER

Research Interests

  • Adult cell therapy for cardiac repair
  • Organ protection during cardiopulmonary arrest
  • Biology of adult stem cells
  • Role of cytokines in cardiac remodeling
  • Diabetes and cardiovascular injury

Selected Publications

  • Dawn B, Abdel-Latif A, Sanganalmath SK, Flaherty MP, Zuba-Surma EK. Cardiac repair with adult bone marrow-derived cells: the clinical evidence. Antioxid Redox Signal. 2009 Aug;11(8):1865-82.
  • Flaherty MP, Dawn B, Solankhi NK. Iatrogenic submedial coronary artery intramural hematoma presenting subacutely. J Invasive Cardiol. 2009 Jul;21(7):E128-31.
  • Sanganalmath SK, Stein AB, Guo Y, Tiwari S, Hunt G, Vincent RJ, Huang Y, Rezazadeh A, Ildstad ST, Dawn B, Bolli R. The beneficial effects of postinfarct cytokine combination therapy are sustained during long-term follow-up. J Mol Cell Cardiol. 2009 Oct;47(4):528-35. Epub 2009 Jul 16.
  • Srivastava S, Vladykovskaya E, Barski OA, Spite M, Kaiserova K, Petrash JM, Chung SS, Hunt G, Dawn B, Bhatnagar A. Aldose reductase protects against early atherosclerotic lesion formation in apolipoprotein E-null mice. Circ Res. 2009 Oct 9;105(8):793-802. Epub 2009 Sep 3.
  • Li Q, Guo Y, Ou Q, Cui C, Wu WJ, Tan W, Zhu X, Lanceta LB, Sanganalmath SK, Dawn B, Shinmura K, Rokosh GD, Wang S, Bolli R. Gene transfer of inducible nitric oxide synthase affords cardioprotection by upregulating heme oxygenase-1 via a nuclear factor-{kappa}B-dependent pathway. Circulation. 2009 Sep 29;120(13):1222-30. Epub 2009 Sep 14.
  • Abdel-Latif A, Zuba-Surma EK, Case J, Tiwari S, Hunt G, Ranjan S, Vincent RJ, Srour EF, Bolli R, Dawn B. TGF-beta1 enhances cardiomyogenic differentiation of skeletal muscle-derived adult primitive cells. Basic Res Cardiol. 2008 Nov;103(6):514-24. Epub 2008 May 23.
  • Abdel-Latif A, Bolli R, Zuba-Surma EK, Tleyjeh IM, Hornung CA, Dawn B. Granulocyte colony-stimulating factor therapy for cardiac repair after acute myocardial infarction: a systematic review and meta-analysis of randomized controlled trials. Am Heart J. 2008 Aug;156(2):216-226.e9. Epub 2008 Jun 20.
  • Flaherty MP, Leesar MA, Dawn B. Acute myocardial infarction in a 19 year-old female owing to hypercoagulable state of pregnancy and the puerperium. J Invasive Cardiol. 2008 Sep;20(9):E262-4.
  • Flaherty MP, Guo Y, Tiwari S, Rezazadeh A, Hunt G, Sanganalmath SK, Tang XL, Bolli R, Dawn B. The role of TNF-alpha receptors p55 and p75 in acute myocardial ischemia/reperfusion injury and late preconditioning. J Mol Cell Cardiol. 2008 Dec;45(6):735-41. Epub 2008 Sep 12.
  • Flaherty MP, Dawn B. Noncanonical Wnt11 signaling and cardiomyogenic differentiation. Trends Cardiovasc Med. 2008 Oct;18(7):260-8.
  • Bolli R, Dawn B. The cornucopia of "pleiotropic" actions of statins: myogenesis as a new mechanism for statin-induced benefits? Circ Res. 2009 Jan 30;104(2):144-6.
  • Chugh AR, Zuba-Surma EK, Dawn B. Bone marrow-derived mesenchymal stems cells and cardiac repair. Minerva Cardioangiol. 2009 Apr;57(2):185-202.
  • Dawn B, Tiwari S, Kucia MJ, Zuba-Surma EK, Guo Y, Sanganalmath SK, Abdel-Latif A, Hunt G, Vincent RJ, Taher H, Reed NJ, Ratajczak MZ, Bolli R. Transplantation of bone marrow-derived very small embryonic-like stem cells attenuates left ventricular dysfunction and remodeling after myocardial infarction. Stem Cells. 2008 Jun;26(6):1646-55. Epub 2008 Apr 17.
  • Zuba-Surma EK, Kucia M, Dawn B, Guo Y, Ratajczak MZ, Bolli R. Bone marrow-derived pluripotent very small embryonic-like stem cells (VSELs) are mobilized after acute myocardial infarction. J Mol Cell Cardiol. 2008 May;44(5):865-73. Epub 2008 Mar 4.
  • Flaherty MP, Abdel-Latif A, Li Q, Hunt G, Ranjan S, Ou Q, Tang XL, Johnson RK, Bolli R, Dawn B. Noncanonical Wnt11 signaling is sufficient to induce cardiomyogenic differentiation in unfractionated bone marrow mononuclear cells. Circulation. 2008 Apr 29;117(17):2241-52. Epub 2008 Apr 21.
  • Dawn B, Bolli R. Mutation in the prostacyclin receptor, cardiovascular disease, and coxibs. American Heart Association Learning Library; published online May 12, 2008. http://www.ahalibrary.com/pt/re/aha/commentarytoc.htm
  • Gonzalez A, Rota M, Nurzynska D, Misao Y, Tillmanns J, Ojaimi C, Padin-Iruegas ME, Müller P, Esposito G, Bearzi C, Vitale S, Dawn B, Sanganalmath SK, Baker M, Hintze TH, Bolli R, Urbanek K, Hosoda T, Anversa P, Kajstura J, Leri A. Activation of cardiac progenitor cells reverses the failing heart senescent phenotype and prolongs lifespan. Circ Res. 2008 Mar 14;102(5):597-606. Epub 2008 Jan 17.
  • Zuba-Surma EK, Kucia M, Abdel-Latif A, Dawn B, Hall B, Singh R, Lillard JW Jr, Ratajczak MZ. Morphological characterization of very small embryonic-like stem cells (VSELs) by ImageStream system analysis. J Cell Mol Med. 2008 Jan-Feb;12(1):292-303. Epub 2007 Nov 20.

Abstracts Presented at National Meetings (2008-2010)

  • Vanga S, Pillarisetti J, Guda R, Feldkamp M, Rosamond T, Vacek JL, Dawn B, Lakkireddy D. Left Atrial Appendage Far Field Potentials Mimicking Left Superior Pulmonary Vein Potentials After Pulmonary Vein Isolation: Does Proximity Matter? ACC Annual Scientific Sessions 2010.
  • Vanga S, Bicknell D, Dendi R, Pimentel R, Berenbom L, Emert M, Gerken A, Newton D, Natale A, Di Biase L, Dawn B, Lakkireddy D. Radio Frequency Ablation (RFA) for Sinus Rhythm Restoration in Atrial Fibrillation Patients with Mitral or Aortic Mechanical Prosthetic Valves - Feasibility, Safety and Efficacy. Heart Rhythm Society Annual Meeting 2010.
Last modified: Nov 20, 2012

Buddhadeb Dawn, MD


Buddhadeb Dawn, MD
Professor of Medicine
Maureen & Marvin Dunn Professor of Cardiovascular Diseases
Director, Division of Cardiovascular Diseases
Director, Cardiovascular Research Institute
Vice Chairman for Research, Department of Medicine