Buddhadeb Dawn, MD

Professor of Medicine
Maureen & Marvin Dunn Professor of Cardiovascular Diseases
Director, Division of Cardiovascular Diseases
Director, Cardiovascular Research Institute
Vice Chairman for Research, Department of Medicine
Medical School, Calcutta Medical College, Calcutta, West Bengal, India
Residency, University of Missouri-Columbia, Columbia, Missouri
Fellowship, University of Louisville, Louisville Kentucky


Clinical Interests

  • Stress Echocardiography
  • Atrial fibrillation
  • Biomarkers in acute coronary syndromes
  • Diagnosis of chest pain in the ER

Research Interests

  • Adult cell therapy for cardiac repair
  • Organ protection during cardiopulmonary arrest
  • Biology of adult stem cells
  • Role of cytokines in cardiac remodeling
  • Diabetes and cardiovascular injury

Research Projects

Active Projects

  • A study of the safety and efficacy of intracoronary delivery of allogenic Cardiosphere-Derived cells in patients with an anterior myocardial infarction and ischemic left ventricular dysfunction sponsored by Capricor, Inc.
  • A study of ASCT01 vs placebo in patients with critical limb ischemia sponsored by LifeCells LLC.
  • Study of autologous CD34+ coronary infusion in STEMI sponsored by amorcyte.

Active Animal Projects

  • CD105- MSC transplantation leads to reduced remodeling into mice hearts post I/R
  • Wnt-11 Treated MSC transplantation leads to reduced remodeling into mice hearts post I/R
  • IL-6 KO mice hearts have reduced remodeling compared to control post I/R
  • IkB Tg mice hearts have reduced apoptosis and reduced stress after acute I/R
  • IL-6  KO mice hearts have decreased hypertrophic cardiomyopathy post TAC compared to controls
  • IkB Tg mice hearts have decreased hypertrophic cardiomyopathy post TAC compared to IkB NTg mice
  • IL-6 KO/IkB Tg mice hearts are better protected against hypertrophic cardiomyopathy post TAC compared to IL-6 KO or IkB Tg alone
  • CHOP KO mice have decreased hypertrophic cardiomyopathy post TAC compared to controls
  • CHOP KO/IkB Tg mice hearts are better protected against hypertrophic cardiomyopathy post TAC compared to CHOP KO or IkB Tg alone
  • IkB Tg mice have lower levels of brain damage and have improved behavior compared to NTg mice after cardiac arrest and aging
  • IL-6 KO mice hearts are better protected against Doxorubicin- induced cardiomyopathy compared to controls
  • Increased temp leads to higher level of heart damage as demonstrated by increased infarct size after I/R
  • hUCBCSC transplantation into rat hearts reduces remodeling and improves heart function post I/R
  • CHOP KO mice hearts have reduced remodeling post I/R compared to controls

In Vitro Projects

  • CaMKII mediates Foxp1 expression in cardiac hypertrophy induced by IL-6.
  • CaMKII upregulates STAT3 signaling in development of cardiomyocytes hypertrophy induced by Angiotensin II.
  • HDAC inhibitor reprogramming mesenchymal stem cells into cardiomyocyte phenotype
  • Vitamin D3 improve angiogenesis and induce mesenchymal to endothelial transition in mesenchymal stem cells
  • Wnt11 improve angiogenesis in mesenchymal stem cells
  • Wnt11 pretreatment protects against H2O2 induced oxidative stress in H9C2 cells by stat3 activation.

Selected Publications

  • Sharma S, Thapa R, Dawn B, Parashara D. Solitary coronary artery: a rare coronary anomaly. JACC Cardiovasc Interv. 2014 Oct;7(10):e125-6. doi:10.1016/j.jcin.2014.02.019. PubMed PMID: 25341713.
  • Afzal MR, Kanmanthareddy A, Earnest M, Reddy M, Atkins D, Bommana S, Bartus K,Rasekh A, Han F, Badhwar N, Cheng J, Dibiase L, Ellis CR, Dawn B, Natale A, Lee RJ, Lakkireddy D. Impact of Left Atrial Appendage Exclusion Using an Epicardial Ligation System (LARIAT) on Atrial Fibrillation Burden in Patients with Cardiac Implantable Electronic Devices. Heart Rhythm. 2014 Sep 30. pii:S1547-5271(14)01078-9. doi: 10.1016/j.hrthm.2014.09.053. [Epub ahead of print]PubMed PMID: 25281005.
  • Jeevanantham V, Chehab B, Austria E, Shrivastava R, Wiley M, Tadros P, Dawn B, Vacek JL, Gupta K. Comparison of Accuracy of Two Different Methods to Determine Ankle-Brachial Index to Predict Peripheral Arterial Disease Severity Confirmed by Angiography. Am J Cardiol. 2014 Jul 17. pii: S0002-9149(14)01451-9. doi:10.1016/j.amjcard.2014.07.023. [Epub ahead of print] PubMed PMID: 25129876.
  • Choksi K, Dawn B. Priming mononuclear cells to improve outcomes of regenerative therapy. J Am Heart Assoc. 2014 Jun 25;3(3):e001168. doi:10.1161/JAHA.114.001168. PubMed PMID: 24965029.
  • Thangavel J, Malik AB, Elias HK, Rajasingh S, Simpson AD, Sundivakkam PK, Vogel SM, Xuan YT, Dawn B, Johnson R. Combinatorial Therapy with Acetylation and Methylation Modifiers Attenuates Lung Vascular Hyperpermeability in Endotoxemia-Induced Mouse Inflammatory Lung Injury. Am J Pathol. 2014 Jun 11. pii: S0002-9440(14)00282-X. doi: 10.1016/j.ajpath.2014.05.008.[Epub ahead ofprint] PubMed PMID: 24929240.
  • Gupta K, Pillarisetti J, Biria M, Pescetto M, Abu-Salah TM, Annapureddy C, Ryschon K, Dawn B, Lakkireddy D. Clinical Utility and Prognostic Significance of Measuring Troponin I Levels in Patients Presenting to the Emergency Room With Atrial Fibrillation. Clin Cardiol. 2014 Apr 2. doi: 10.1002/clc.22251. [Epub ahead of print] PubMed PMID: 24700276.
  • Pillarisetti J, Reddy N, Biria M, Ryschon K, Nagarajan D, Murray C, Atkins D, Bommana S, Reddy MY, Dibiase L, Pimentel R, Berenbom L, Dawn B, Natale A, Lakkireddy D. Elevated brain natriuretic peptide level in patients undergoing atrial fibrillation ablation: is it a predictor of failed ablation or a mere function of atrial rhythm and rate at a point in time? J Interv Card Electrophysiol. 2014 May 8. [Epub ahead of print] PubMed PMID: 24800931.
  • Sharma S, Thapa R, Jeevanantham V, Myers T, Hu C, Brimacombe M, Vacek JL, Dawn B, Gupta K. Comparison of lipid management in patients with coronary versus peripheral arterial disease. Am J Cardiol. 2014 Apr 15;113(8):1320-5. doi: 10.1016/j.amjcard.2014.01.405. Epub 2014 Jan 31. PubMed PMID: 24560066.
  • Jeevanantham V, Afzal MR, Zuba-Surma EK, Dawn B. Clinical trials of cardiac repair with adult bone marrow- derived cells. Methods Mol Biol. 2013;1036:179-205. doi: 10.1007/978-1-62703-511-8_15. PubMed PMID: 23807796. 
  • Jeevanantham V, Butler M, Saad A, Dawn B, Abdel-Latif A, Zuba-Surma EK. Response to letter regarding article, "Adult bone marrow cell therapy improves survival and induces long-term improvement in cardiac parameters: a systematic review and meta-analysis". Circulation. 2013 Apr 16;127(15):e548. PubMed PMID: 23720830. 
  • Touchberry CD, Green TM, Tchikrizov V, Mannix JE, Mao TF, Carney BW, Girgis M, Vincent RJ, Wetmore LA, Dawn B, Bonewald LF, Stubbs JR, Wacker MJ. FGF23 is a novel regulator of intracellular calcium and cardiac contractility in addition to cardiac hypertrophy. Am J Physiol Endocrinol Metab. 2013 Apr 15;304(8):E863-73. doi: 10.1152/ajpendo.00596.2012. Epub 2013 Feb 26. PubMed PMID: 23443925; PubMed Central PMCID: PMC3625783. 
  • Sharma S, Dharshan A, Dawn B, Radparvar F. Pulmonary emboli in transit. J Gen Intern Med. 2013 Jan;28(1):154. doi: 10.1007/s11606-012-2065-x. Epub 2012 Jul 3. PubMed PMID: 22752588; PubMed Central PMCID: PMC3539033. 
  • Kwok CS, Jeevanantham V, Dawn B, Loke YK. No consistent evidence of differential cardiovascular risk amongst proton-pump inhibitors when used with clopidogrel: meta-analysis. Int J Cardiol. 2013 Aug 10;167(3):965-74. doi: 10.1016/j.ijcard.2012.03.085. Epub 2012 Mar 30. PubMed PMID: 22464478. 
  • Vallakati A, Reddy YM, Emert M, Janga P, Mansour MC, Heist EK, Pimentel R, Dendi R, Atkins D, Bommana S, Mahapatra S, Heard M, Ruskin J, Berenbom L, Dawn B, Lakkireddy D. Impact of nonfluoroscopic MediGuideTM tracking system on radiation exposure in radiofrequency ablation procedures (LESS-RADS registry)-an initial experience. J Interv Card Electrophysiol. 2013 Nov;38(2):95-100. doi: 10.1007/s10840-013-9825-3. Epub 2013 Sep 12. PubMed PMID: 24026968. 
  • Reddy YM, Singh D, Nagarajan D, Pillarisetti J, Biria M, Boolani H, Emert M, Chikkam V, Ryschon K, Vacek J, Bommana S, Atkins D, Verma A, Olyaee M, Dawn B, Lakkireddy D. Atrial fibrillation ablation in patients with gastroesophageal reflux disease or irritable bowel syndrome-the heart to gut connection! J Interv Card Electrophysiol. 2013 Sep;37(3):259-65. doi: 10.1007/s10840-013-9807-5. Epub 2013 Jun 6. PubMed PMID: 23736874. 
  • Lakkireddy D, Atkins D, Pillarisetti J, Ryschon K, Bommana S, Drisko J, Vanga S, Dawn B. Effect of yoga on arrhythmia burden, anxiety, depression, and quality of life in paroxysmal atrial fibrillation: the YOGA My Heart Study. J Am Coll Cardiol. 2013 Mar 19;61(11):1177-82. doi: 10.1016/j.jacc.2012.11.060. Epub 2013 Jan 30. PubMed PMID: 23375926. 
  • Jayasree Pillarisetti MD, Sowjanya Duthuluru MD, Hari Sayana MD, Haley Goucher Goucher BA, Akshar Patel BA, Mazda Biria MD, James Vacek MD, Loren Berenbom MD, Sudharani Bommana M.Phil, Jayan Nath MD, Mark Wiley MD, Ajay Nangia MD, Luigi Di Biase MD, Andrea Natale MD, Madhuri Reddy MD, Buddhadeb Dawn, MD, Dhanunjaya Lakkireddy MD. Age-Dependent Impact of Fluoroscopic Radiation on the Gender of Off-Spring: An International Survey of Cardiologists. Journal of Atrial Fibrillation. Online publication 2013(5). 
  • Stein AB, Bolli R, Dawn B, Sanganalmath SK, Zhu Y, Wang OL, Guo Y, Motterlini R, Xuan YT. Carbon monoxide induces a late preconditioning-mimetic cardioprotective and antiapoptotic milieu in the myocardium. J Mol Cell Cardiol. 2012 Jan;52(1):228-36. 
  • Thapa R, Dawn B, Nath J. Tricuspid regurgitation: pathophysiology and management. Curr Cardiol Rep. 2012 Apr;14(2):190-9. 
  • Jeevanantham V, Butler M, Saad A, Abdel-Latif A, Zuba-Surma EK, Dawn B. Adult bone marrow cell therapy improves survival and induces long-term improvement in cardiac parameters: a systematic review and meta-analysis. Circulation. 2012 Jul 31;126(5):551-68. 
  • Lakkireddy D, Di Biase L, Ryschon K, Biria M, Swarup V, Reddy YM, Verma A, Bommana S, Burkhardt D, Dendi R, Dello Russo A, Casella M, Carbucicchio C, Tondo C, Dawn B, Natale A. Radiofrequency ablation of premature ventricular ectopy improves the efficacy of cardiac resynchronization therapy in nonresponders. J Am Coll Cardiol. 2012 Oct 6; 60(16):1531-9. 
  • Flaherty MP, Kamerzell TJ, Dawn B. Wnt signaling and cardiac differentiation. Prog Mol Biol Transl Sci. 2012;111:153-74. 
  • Tang XL, Sanganalmath SK, Sato H, Bi Q, Hunt G, Vincent RJ, Peng Y, Shork G, Dawn B, Bolli R. Atorvastatin therapy during the peri-infarct period attenuates left ventricular dysfunction and remodeling after myocardial infarction. PLoS One. 2011;6(9):e25320. 
  • Sanganalmath SK, Abdel-Latif A, Bolli R, Xuan YT, Dawn B. Hematopoietic cytokines for cardiac repair: mobilization of bone marrow cells and beyond. Basic Res Cardiol. 2011;106(5):709-33. 
  • Li Q, Guo Y, Ou Q, Wu WJ, Chen N, Zhu X, Tan W, Yuan F, Dawn B, Luo L, Hunt GN, Bolli R. Gene transfer as a strategy to achieve permanent cardioprotection II: rAAV-mediated gene therapy with heme oxygenase-1 limits infarct size 1 year later without adverse functional consequences. Basic Res Cardiol. 2011 Nov;106(6):1367-77.
  • Li Q, Guo Y, Wu WJ, Ou Q, Zhu X, Tan W, Yuan F, Chen N, Dawn B, Luo L, O'Brien E, Bolli R. Gene transfer as a strategy to achieve permanent cardioprotection I: rAAV-mediated gene therapy with inducible nitric oxide synthase limits infarct size 1 year later without adverse functional consequences. Basic Res Cardiol. 2011 Nov;106(6):1355-66. 
  • Lakkireddy D, Nagarajan D, Di Biase L, Vanga SR, Mahapatra S, Bunch TJ, Day JD, Burkhardt DJ, Umbarger L, Dendi R, Pimentel R, Berenbom L, Emert M, Gerken A, Bommana S, Ray W, Atkins D, Murray C, Dawn B, Natale A. Radio Frequency Ablation (RFA) of Atrial Fibrillation in Patients with Mitral or Aortic Mechanical Prosthetic Valves - A Feasibility, Safety and Efficacy Study. Heart Rhythm. 2011;8(7):975-80. 
  • Hamzeh I, Rashid A, Shaib F, Dawn B. Pulmonary vein stenosis due to a compressive malignant tumor detected by transesophageal echocardiography. Circulation. 2011 Jan 25;123(3):349-50. 
  • Bolli R, Stein AB, Guo Y, Wang OL, Rokosh G, Dawn B, Molkentin JD, Sanganalmath SK, Zhu Y, Xuan YT. A murine model of inducible, cardiac-specific deletion of STAT3: Its use to determine the role of STAT3 in the upregulation of cardioprotective proteins by ischemic preconditioning. J Mol Cell Cardiol. 2011;50(4):589-97. 
  • Zuba-Surma EK, Wojakowski W, Ratajczak MZ, Dawn B. Very small embryonic-like stem cells: biology and therapeutic potential for heart repair. Antioxis Redox Signal. 2011;15(7):1821-34. 
  • Hamid T, Guo SZ, Kingery JR, Xiang X, Dawn B, Prabhu SD. Cardiomyocyte NF-{kappa}B p65 promotes adverse remodelling, apoptosis, and endoplasmic reticulum stress in heart failure. Cardiovasc Res. 2011;89(1):129-38. 
  • Zuba-Surma EK, Guo Y, Taher H, Sanganalmath SK, Hunt G, Vincent RJ, Kucia M, Abdel-Latif A, Tang XL, Ratajczak MZ, Dawn B, Bolli R. Transplantation of expanded bone marrow-derived very small embryonic-like stem cells (VSEL-SCs) improves left ventricular function and remodeling after myocardial infarction. J Cell Mol Med. 2011;15(6):1319-28. 
  • Quinn CM, Dawn B. G-CSF and Erythropoietin Combination Therapy for Infarct Repair: Two Plus Two Equals Two? : Editorial to: "Cytokine Combination Theray with Erythropoietin and Granulocyte Colony Stimulating Factor in a Porcine Model of Acute Myocardial Infarction" by F.S. Angeli et al. Cardiovasc Drugs Ther. 2010;24(5-6):369-71. 
  • Tang XL, Rokosh G, Sanganalmath SK, Yuan F, Sato H, Mu J, Dai S, Li C, Chen N, Peng Y, Dawn B, Hunt G, Leri A, Kajstura J, Tiwari S, Shirk G, Anversa P, Bolli R. Intracoronary administration of cardiac progenitor cells alleviates left ventricular dysfunction in rats with a 30-day-old infarction. Circulation. 2010 Jan 19;121(2):293-305. Epub 2010 Jan 4.
  • Dawn B, Abdel-Latif A, Sanganalmath SK, Flaherty MP, Zuba-Surma EK. Cardiac repair with adult bone marrow-derived cells: the clinical evidence. Antioxid Redox Signal. 2009 Aug;11(8):1865-82.
  • Flaherty MP, Dawn B, Solankhi NK. Iatrogenic submedial coronary artery intramural hematoma presenting subacutely. J Invasive Cardiol. 2009 Jul;21(7):E128-31.
  • Sanganalmath SK, Stein AB, Guo Y, Tiwari S, Hunt G, Vincent RJ, Huang Y, Rezazadeh A, Ildstad ST, Dawn B, Bolli R. The beneficial effects of postinfarct cytokine combination therapy are sustained during long-term follow-up. J Mol Cell Cardiol. 2009 Oct;47(4):528-35. Epub 2009 Jul 16.
  • Srivastava S, Vladykovskaya E, Barski OA, Spite M, Kaiserova K, Petrash JM, Chung SS, Hunt G, Dawn B, Bhatnagar A. Aldose reductase protects against early atherosclerotic lesion formation in apolipoprotein E-null mice. Circ Res. 2009 Oct 9;105(8):793-802. Epub 2009 Sep 3.
  • Li Q, Guo Y, Ou Q, Cui C, Wu WJ, Tan W, Zhu X, Lanceta LB, Sanganalmath SK, Dawn B, Shinmura K, Rokosh GD, Wang S, Bolli R. Gene transfer of inducible nitric oxide synthase affords cardioprotection by upregulating heme oxygenase-1 via a nuclear factor-{kappa}B-dependent pathway. Circulation. 2009 Sep 29;120(13):1222-30. Epub 2009 Sep 14.
  • Bolli R, Dawn B. The cornucopia of "pleiotropic" actions of statins: myogenesis as a new mechanism for statin-induced benefits? Circ Res. 2009 Jan 30;104(2):144-6.
  • Chugh AR, Zuba-Surma EK, Dawn B. Bone marrow-derived mesenchymal stems cells and cardiac repair. Minerva Cardioangiol. 2009 Apr;57(2):185-202.
  • Dawn B, Tiwari S, Kucia MJ, Zuba-Surma EK, Guo Y, Sanganalmath SK, Abdel-Latif A, Hunt G, Vincent RJ, Taher H, Reed NJ, Ratajczak MZ, Bolli R. Transplantation of bone marrow-derived very small embryonic-like stem cells attenuates left ventricular dysfunction and remodeling after myocardial infarction. Stem Cells. 2008 Jun;26(6):1646-55. Epub 2008 Apr 17.
  • Zuba-Surma EK, Kucia M, Dawn B, Guo Y, Ratajczak MZ, Bolli R. Bone marrow-derived pluripotent very small embryonic-like stem cells (VSELs) are mobilized after acute myocardial infarction. J Mol Cell Cardiol. 2008 May;44(5):865-73. Epub 2008 Mar 4.
  • Flaherty MP, Abdel-Latif A, Li Q, Hunt G, Ranjan S, Ou Q, Tang XL, Johnson RK, Bolli R, Dawn B. Noncanonical Wnt11 signaling is sufficient to induce cardiomyogenic differentiation in unfractionated bone marrow mononuclear cells. Circulation. 2008 Apr 29;117(17):2241-52. Epub 2008 Apr 21.
  • Dawn B, Bolli R. Mutation in the prostacyclin receptor, cardiovascular disease, and coxibs. American Heart Association Learning Library; published online May 12, 2008. http://www.ahalibrary.com/pt/re/aha/commentarytoc.htm
  • Gonzalez A, Rota M, Nurzynska D, Misao Y, Tillmanns J, Ojaimi C, Padin-Iruegas ME, Müller P, Esposito G, Bearzi C, Vitale S, Dawn B, Sanganalmath SK, Baker M, Hintze TH, Bolli R, Urbanek K, Hosoda T, Anversa P, Kajstura J, Leri A. Activation of cardiac progenitor cells reverses the failing heart senescent phenotype and prolongs lifespan. Circ Res. 2008 Mar 14;102(5):597-606. Epub 2008 Jan 17.
  • Zuba-Surma EK, Kucia M, Abdel-Latif A, Dawn B, Hall B, Singh R, Lillard JW Jr, Ratajczak MZ. Morphological characterization of very small embryonic-like stem cells (VSELs) by ImageStream system analysis. J Cell Mol Med. 2008 Jan-Feb;12(1):292-303. Epub 2007 Nov 20.
  • Abdel-Latif A, Zuba-Surma EK, Case J, Tiwari S, Hunt G, Ranjan S, Vincent RJ, Srour EF, Bolli R, Dawn B. TGF-beta1 enhances cardiomyogenic differentiation of skeletal muscle-derived adult primitive cells. Basic Res Cardiol. 2008 Nov;103(6):514-24. Epub 2008 May 23.
  • Abdel-Latif A, Bolli R, Zuba-Surma EK, Tleyjeh IM, Hornung CA, Dawn B. Granulocyte colony-stimulating factor therapy for cardiac repair after acute myocardial infarction: a systematic review and meta-analysis of randomized controlled trials. Am Heart J. 2008 Aug;156(2):216-226.e9. Epub 2008 Jun 20.
  • Flaherty MP, Leesar MA, Dawn B. Acute myocardial infarction in a 19 year-old female owing to hypercoagulable state of pregnancy and the puerperium. J Invasive Cardiol. 2008 Sep;20(9):E262-4.
  • Flaherty MP, Guo Y, Tiwari S, Rezazadeh A, Hunt G, Sanganalmath SK, Tang XL, Bolli R, Dawn B. The role of TNF-alpha receptors p55 and p75 in acute myocardial ischemia/reperfusion injury and late preconditioning. J Mol Cell Cardiol. 2008 Dec;45(6):735-41. Epub 2008 Sep 12.
  • Flaherty MP, Dawn B. Noncanonical Wnt11 signaling and cardiomyogenic differentiation. Trends Cardiovasc Med. 2008 Oct;18(7):260-8.
  • Dawn B, Bolli R. Increasing evidence that estrogen is an important modulator of bone marrow-mediated cardiac repair after acute infarction. Circulation. 2006 Nov 21;114(21):2203-5. Review. PubMed PMID: 17116779.
  • Banchs JE, Dawn B, Abdel-Latif A, Qureshi A, Agrawal N, Bouvette M, Stoddard MF. Acquired aortic cusp fusion after chronic left ventricular assist device support. J Am Soc Echocardiogr. 2006 Nov;19(11):1401.e1-3. PubMed PMID: 17098144.
  • Stein AB, Tiwari S, Thomas P, Hunt G, Levent C, Stoddard MF, Tang XL, Bolli R, Dawn B. Effects of anesthesia on echocardiographic assessment of left ventricular structure and function in rats. Basic Res Cardiol. 2007 Jan;102(1):28-41. Epub 2006 Oct 2. PubMed PMID: 17006633.
  • Siddiqui TS, Dawn B, Stoddard MF. Hypotension during dobutamine stress transesophageal echocardiography: relationship with provoked left ventricular obstruction. J Am Soc Echocardiogr. 2006 Sep;19(9):1144-9. PubMed PMID: 16950469.
  • Zuba-Surma EK, Abdel-Latif A, Case J, Tiwari S, Hunt G, Kucia M, Vincent RJ,Ranjan S, Ratajczak MZ, Srour EF, Bolli R, Dawn B. Sca-1 expression is associated with decreased cardiomyogenic differentiation potential of skeletal muscle-derived adult primitive cells. J Mol Cell Cardiol. 2006 Oct;41(4):650-60.Epub 2006 Aug 30. PubMed PMID: 16938308.
  • Tang XL, Sato H, Tiwari S, Dawn B, Bi Q, Li Q, Shirk G, Bolli R.Cardioprotection by postconditioning in conscious rats is limited to coronary occlusions <45 min. Am J Physiol Heart Circ Physiol. 2006 Nov;291(5):H2308-17. Epub 2006 Jun 30. PubMed PMID: 16815986; PubMed Central PMCID: PMC3741072.
  • Dawn B. Preconditioning by angiotensin II: a tale of more than two kinases. J Mol Cell Cardiol. 2006 Aug;41(2):223-5. Epub 2006 Jun 21. PubMed PMID: 16793059.
  • Dawn B, Guo Y, Rezazadeh A, Huang Y, Stein AB, Hunt G, Tiwari S, Varma J, Gu Y, Prabhu SD, Kajstura J, Anversa P, Ildstad ST, Bolli R. Postinfarct cytokine therapy regenerates cardiac tissue and improves left ventricular function. Circ Res. 2006 Apr 28;98(8):1098-105. Epub 2006 Mar 23. PubMed PMID: 16556872; PubMed  Central PMCID: PMC3652380.
  • Dawn B, Hasnie AM, Calzada N, Longaker RA, Stoddard MF. Transesophageal echocardiography impacts management and evaluation of patients with stroke, transient ischemic attack, or peripheral embolism. Echocardiography. 2006 Mar;23(3):202-7. PubMed PMID: 16524390.
  • Guha S, Ghosh A, Chatterjee N, Pal S, Guha S, Chatterjee S, Deb PK, Dawn B. Risk factors for coronary heart disease in Indians: a case-control study from Eastern India. Indian Heart J. 2005 Nov-Dec;57(6):738-40. PubMed PMID: 16521652.
  • Satran A, Dawn B, Leesar MA. Congenital ostial left main coronary artery stenosis associated with a bicuspid aortic valve in a young woman. J Invasive Cardiol. 2006 Mar;18(3):E114-6. PubMed PMID: 16495606.
  • Makkar A, Siddiqui TS, Stoddard MF, Lewis RK, Dawn B. Impact of valvular calcification on the diagnostic accuracy of transesophageal echocardiography for the detection of congenital aortic valve malformation. Echocardiography. 2007 Aug;24(7):745-9. PubMed PMID: 17651104.
  • Bolli R, Li QH, Tang XL, Guo Y, Xuan YT, Rokosh G, Dawn B. The late phase of preconditioning and its natural clinical application--gene therapy. Heart Fail Rev. 2007 Dec;12(3-4):189-99. Review. PubMed PMID: 17541820; PubMed Central PMCID: PMC3652384.
  • Abdel-Latif A, Bolli R, Tleyjeh IM, Montori VM, Perin EC, Hornung CA, Zuba-Surma EK, Al-Mallah M, Dawn B. Adult bone marrow-derived cells for cardiac repair: a systematic review and meta-analysis. Arch Intern Med. 2007 May 28;167(10):989-97. Review. PubMed PMID: 17533201.
  • Shah A, Alshaher M, Dawn B, Siddiqui T, Longaker RA, Stoddard MF, El-Mallakh R. Exercise tolerance is reduced in bipolar illness. J Affect Disord. 2007 Dec;104(1-3):191-5. Epub 2007 Apr 17. PubMed PMID: 17442401.
  • Dawn B, Bolli R. Bone marrow for cardiac repair: the importance of characterizing the phenotype and function of injected cells. Eur Heart J. 2007 Mar;28(6):651-2. Epub 2007 Mar 5. PubMed PMID: 17339263.
  • Alshaher M, El-Mallakh R, Dawn B, Siddiqui T, Longaker RA, Stoddard MF.Cardiac manifestations of exhaustive exercise in nonathletic adults: does cardiac fatigue occur? Echocardiography. 2007 Mar;24(3):237-42. PubMed PMID: 17313634.
  • Dawn B. Resveratrol: ready for prime time? J Mol Cell Cardiol. 2007 Mar;42(3):484-6. Epub 2007 Jan 12. PubMed PMID: 17222864.
  • Shapira AR, Stoddard MF, Dawn B. Images in cardiovascular medicine. Dehiscence of mitral annuloplasty ring. Circulation. 2005 Nov 1;112(18):e305. PubMed PMID: 16267244.
  • Bolli R, Jneid H, Dawn B. Bone marrow cell-mediated cardiac regeneration a veritable revolution. J Am Coll Cardiol. 2005 Nov 1;46(9):1659-61. Review. PubMed PMID: 16256865.
  • Dawn B, Bolli R. Adult bone marrow-derived cells: regenerative potential, plasticity, and tissue commitment. Basic Res Cardiol. 2005 Nov;100(6):494-503. Review. PubMed PMID: 16237509; PubMed Central PMCID: PMC3685421.
  • Tang XL, Takano H, Xuan YT, Sato H, Kodani E, Dawn B, Zhu Y, Shirk G, Wu WJ, Bolli R. Hypercholesterolemia abrogates late preconditioning via a tetrahydrobiopterin-dependent mechanism in conscious rabbits. Circulation. 2005 Oct 4;112(14):2149-56. Epub 2005 Sep 26. PubMed PMID: 16186416; PubMed Central PMCID: PMC3671759.
  • Li Q, Guo Y, Tan W, Stein AB, Dawn B, Wu WJ, Zhu X, Lu X, Xu X, Siddiqui T,Tiwari S, Bolli R. Gene therapy with iNOS provides long-term protection against myocardial infarction without adverse functional consequences. Am J Physiol Heart Circ Physiol. 2006 Feb;290(2):H584-9. Epub 2005 Sep 19. PubMed PMID: 16172153; PubMed Central PMCID: PMC3648984.
  • Dawn B, Zuba-Surma EK, Abdel-Latif A, Tiwari S, Bolli R. Cardiac stem cell therapy for myocardial regeneration. A clinical perspective. Minerva Cardioangiol. 2005 Dec;53(6):549-64. Review. PubMed PMID: 16333238.
  • Dawn B, Bolli R. Cardiac progenitor cells: the revolution continues. Circ Res. 2005 Nov 25;97(11):1080-2. PubMed PMID: 16306449; PubMed Central PMCID: PMC3668551.
  • Dawn B, Bolli R. HO-1 induction by HIF-1: a new mechanism for delayed cardioprotection? Am J Physiol Heart Circ Physiol. 2005 Aug;289(2):H522-4.Review. PubMed PMID: 16014614.
  • Kucia M, Reca R, Jala VR, Dawn B, Ratajczak J, Ratajczak MZ. Bone marrow as a home of heterogenous populations of nonhematopoietic stem cells. Leukemia. 2005 Jul;19(7):1118-27. Review. PubMed PMID: 15902288.
  • Dawn B, Paliwal VS, Raza ST, Mastali K, Longaker RA, Stoddard MF. Left ventricular outflow tract obstruction provoked during dobutamine stress echocardiography predicts future chest pain, syncope, and near syncope. Am Heart J. 2005 May;149(5):908-16. PubMed PMID: 15894976.
  • Dawn B, Varma J, Singh P, Longaker RA, Stoddard MF. Cardiovascular death in patients with atrial fibrillation is better predicted by left atrial thrombus and spontaneous echocardiographic contrast as compared with clinical parameters. J Am Soc Echocardiogr. 2005 Mar;18(3):199-205. PubMed PMID: 15746706.
  • Dawn B, Stein AB, Urbanek K, Rota M, Whang B, Rastaldo R, Torella D, Tang XL, Rezazadeh A, Kajstura J, Leri A, Hunt G, Varma J, Prabhu SD, Anversa P, Bolli R. Cardiac stem cells delivered intravascularly traverse the vessel barrier,regenerate infarcted myocardium, and improve cardiac function. Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3766-71. Epub 2005 Feb 25. PubMed PMID: 15734798;PubMed Central PMCID: PMC553298.
  • Dawn B, Bolli R. Bone marrow cells for cardiac regeneration: the quest for the protagonist continues. Cardiovasc Res. 2005 Feb 1;65(2):293-5. PubMed PMID: 15639465. 
  • Stein AB, Guo Y, Tan W, Wu WJ, Zhu X, Li Q, Luo C, Dawn B, Johnson TR, Motterlini R, Bolli R. Administration of a CO-releasing molecule induces late preconditioning against myocardial infarction. J Mol Cell Cardiol. 2005 Jan;38(1):127-34. Epub 2004 Dec 8. PubMed PMID: 15623429; PubMed Central PMCID: PMC3199606.
  • Kucia M, Dawn B, Hunt G, Guo Y, Wysoczynski M, Majka M, Ratajczak J, Rezzoug  F, Ildstad ST, Bolli R, Ratajczak MZ. Cells expressing early cardiac markers reside in the bone marrow and are mobilized into the peripheral blood after myocardial infarction. Circ Res. 2004 Dec 10;95(12):1191-9. Epub 2004 Nov 18. PubMed PMID: 15550692; PubMed Central PMCID: PMC3679649.
  • Stein AB, Tang XL, Guo Y, Xuan YT, Dawn B, Bolli R. Delayed adaptation of the heart to stress: late preconditioning. Stroke. 2004 Nov;35(11 Suppl 1):2676-9. Epub 2004 Sep 30. Review. PubMed PMID: 15459441; PubMed Central PMCID: PMC3242368.
  • Dawn B, Xuan YT, Guo Y, Rezazadeh A, Stein AB, Hunt G, Wu WJ, Tan W, Bolli R. IL-6 plays an obligatory role in late preconditioning via JAK-STAT signaling and  upregulation of iNOS and COX-2. Cardiovasc Res. 2004 Oct 1;64(1):61-71. PubMed PMID: 15364614; PubMed Central PMCID: PMC3691700.
  • Dawn B, Guo Y, Rezazadeh A, Wang OL, Stein AB, Hunt G, Varma J, Xuan YT, Wu WJ, Tan W, Zhu X, Bolli R. Tumor necrosis factor-alpha does not modulate  ischemia/reperfusion injury in naïve myocardium but is essential for the development of late preconditioning. J Mol Cell Cardiol. 2004 Jul;37(1):51-61. PubMed PMID: 15242735.
  • Guo Y, Stein AB, Wu WJ, Tan W, Zhu X, Li QH, Dawn B, Motterlini R, Bolli R.Administration of a CO-releasing molecule at the time of reperfusion reduces infarct size in vivo. Am J Physiol Heart Circ Physiol. 2004 May;286(5):H1649-53. Epub 2004 Jan 2. PubMed PMID: 14704226; PubMed Central PMCID: PMC3208268.
  • Dawn B, Talley JD, Prince CR, Hoque A, Morris GT, Xenopoulos NP, Stoddard MF. Two-dimensional and Doppler transesophageal echocardiographic delineation and flow characterization of anomalous coronary arteries in adults. J Am Soc Echocardiogr. 2003 Dec;16(12):1274-86. PubMed PMID: 14652607.
  • Kantelhardt SR, Pasnoori V, Varma J, Rezazadeh A, Dawn B. Recurrent aortic dissection in Marfan's syndrome: possible effects of anticoagulation. Cardiol Rev. 2003 Jul-Aug;11(4):240-3. PubMed PMID: 12852802.
  • Xuan YT, Guo Y, Zhu Y, Han H, Langenbach R, Dawn B, Bolli R. Mechanism of cyclooxygenase-2 upregulation in late preconditioning. J Mol Cell Cardiol. 2003 May;35(5):525-37. PubMed PMID: 12738234; PubMed Central PMCID: PMC3210730.
  • Stoddard MF, Singh P, Dawn B, Longaker RA. Left atrial thrombus predicts transient ischemic attack in patients with atrial fibrillation. Am Heart J. 2003 Apr;145(4):676-82. PubMed PMID: 12679765.
  • Shinmura K, Kodani E, Xuan YT, Dawn B, Tang XL, Bolli R. Effect of aspirin on late preconditioning against myocardial stunning in conscious rabbits. J Am Coll Cardiol. 2003 Apr 2;41(7):1183-94. PubMed PMID: 12679220.
  • Bolli R, Dawn B, Xuan YT. Role of the JAK-STAT pathway in protection against  myocardial ischemia/reperfusion injury. Trends Cardiovasc Med. 2003 Feb;13(2):72-9. Review. PubMed PMID: 12586443.  
  • Bolli R, Shinmura K, Tang XL, Kodani E, Xuan YT, Guo Y, Dawn B. Discovery of  a new function of cyclooxygenase (COX)-2: COX-2 is a cardioprotective protein that alleviates ischemia/reperfusion injury and mediates the late phase of preconditioning. Cardiovasc Res. 2002 Aug 15;55(3):506-19. Review. PubMed PMID: 12160947; PubMed Central PMCID: PMC3242376.
  • Dawn B, Takano H, Tang XL, Kodani E, Banerjee S, Rezazadeh A, Qiu Y, Bolli R. Role of Src protein tyrosine kinases in late preconditioning against myocardial infarction. Am J Physiol Heart Circ Physiol. 2002 Aug;283(2):H549-56. PubMed PMID: 12124200.
  • Dawn B, Bolli R. Role of nitric oxide in myocardial preconditioning. Ann N Y Acad Sci. 2002 May;962:18-41. Review. PubMed PMID: 12076960.
  • Bolli R, Dawn B, Xuan YT. Emerging role of the JAK-STAT pathway as a mechanism of protection against ischemia/reperfusion injury. J Mol Cell Cardiol. 2001 Nov;33(11):1893-6. PubMed PMID: 11708835.
  • Dawn B, Bolli R. Toward a better understanding of the metabolic effects of ischemic preconditioning in humans. J Cardiothorac Vasc Anesth. 2001 Aug;15(4):409-11. PubMed PMID: 11505340.
  • Leesar MA, Stoddard MF, Dawn B, Jasti VG, Masden R, Bolli R. Delayed preconditioning-mimetic action of nitroglycerin in patients undergoing coronary angioplasty. Circulation. 2001 Jun 19;103(24):2935-41. PubMed PMID: 11413083.
  • Dawn B, Xuan YT, Marian M, Flaherty MP, Murphree SS, Smith TL, Bolli R, Jones WK. Cardiac-specific abrogation of NF- kappa B activation in mice by transdominant expression of a mutant I kappa B alpha. J Mol Cell Cardiol. 2001 Jan;33(1):161-73. PubMed PMID: 11133232.
  • Banerjee S, Tang XL, Qiu Y, Takano H, Manchikalapudi S, Dawn B, Shirk G, Bolli R. Nitroglycerin induces late preconditioning against myocardial stunning via a PKC-dependent pathway. Am J Physiol. 1999 Dec;277(6 Pt 2):H2488-94. PubMed PMID: 10600873.
  • Dawn B, Xuan YT, Qiu Y, Takano H, Tang XL, Ping P, Banerjee S, Hill M, Bolli  R. Bifunctional role of protein tyrosine kinases in late preconditioning against myocardial stunning in conscious rabbits. Circ Res. 1999 Dec 3-17;85(12):1154-63. PubMed PMID: 10590242.
  • Guha S, Dawn B, Dutta G, Chakraborty T, Pain S. Bradycardia, reversible panconduction defect and syncope following self-medication with a homeopathic medicine. Cardiology. 1999;91(4):268-71. PubMed PMID: 10545684.
  • Ping P, Zhang J, Zheng YT, Li RC, Dawn B, Tang XL, Takano H, Balafanova Z, Bolli R. Demonstration of selective protein kinase C-dependent activation of Src  and Lck tyrosine kinases during ischemic preconditioning in conscious rabbits.Circ Res. 1999 Sep 17;85(6):542-50. PubMed PMID: 10488057.
  • Ping P, Takano H, Zhang J, Tang XL, Qiu Y, Li RC, Banerjee S, Dawn B, Balafonova Z, Bolli R. Isoform-selective activation of protein kinase C by nitric oxide in the heart of conscious rabbits: a signaling mechanism for both nitric oxide-induced and ischemia-induced preconditioning. Circ Res. 1999 Mar 19;84(5):587-604. PubMed PMID: 10082480.
  • Singer I, Dawn B, Edmonds H Jr, Stickland TJ. Syncope is predicted by neuromonitoring in patients with ICDs. Pacing Clin Electrophysiol. 1999 Jan;22(1 Pt 2):216-22. PubMed PMID: 9990634.
  • Vadlamani P, Dawn B, Perry MC. Catheter fracture and embolization from totally implanted venous access ports--case reports. Angiology. 1998 Dec;49(12):1013-6. PubMed PMID: 9855376.
  • Bolli R, Dawn B, Tang XL, Qiu Y, Ping P, Xuan YT, Jones WK, Takano H, Guo Y, Zhang J. The nitric oxide hypothesis of late preconditioning. Basic Res Cardiol. 1998 Oct;93(5):325-38. Review. PubMed PMID: 9833145; PubMed Central PMCID: PMC3701309.
  • Singer I, Dawn B, Calzada N, Spence PA. Atrial fibrillation: a delayed presentation of traumatic tricuspid valve incompetence. Cardiology. 1998 May;89(4):303-5. PubMed PMID: 9643279.
  • Dawn B, Williams JK, Walker SE. Prepatellar bursitis: a unique presentation of tophaceous gout in an normouricemic patient. J Rheumatol. 1997 May;24(5):976-8. PubMed PMID: 9150094.
  • Dawn B, Perry MC. Bilateral non-Hodgkin's lymphoma of the breast mimicking mastitis. South Med J. 1997 Mar;90(3):328-9. PubMed PMID: 9076307.

Abstracts Presented at National Meetings

  • Lin Zhao, Guangming Cheng, Runming Jin, Lei Chen, Anweshan Samanta, Magdy Girgis, Harold K Elias, Arash Davani, Kashyap Choksi, Robert Vincent, Yanjuan Yang, Jeryl Hauptman, and Buddhadeb Dawn.CaMKII Plays a Critical Role in Pressure Overload-Induced Left Ventricular Hypertrophy by Modulating Foxp1 Expression. Circulation. 2014;130:A15453.
  • Johnson Rajasingh,  Jayakumar  Thangavel, Sheeja Rajasingh, Bahar Barani, and Buddhadeb Dawn. Combinatorial Treatment with HDAC6 and DNA Methylation Modifiers  in  Attenuating Lung Vascular Hyperpermeability in LPS-induced Inflammatory Lung Injury. Circulation. 2014;130:A15604.
  • Anweshan Samanta, Guangming Cheng, Arash Davani, Magdy Girgis, Lei Chen, Kashyap Choksi, Lin Zhao, Robert J Vincent, Jeryl Hauptman, and Buddhadeb Dawn . Genetic Deletion of Interleukin-6 Attenuates Left Ventricular Dysfunction and Remodeling After a Reperfused Myocardial Infarction.Circulation. 2014;130:A15693.
  • Johnson Rajasingh, Jayakumar Thangavel, Sheeja Rajasingh, Yu-Ting Xuan, and Buddhadeb Dawn. Synergistic Effect of Acetylation and Methylation Modifiers in Attenuating Lung Vascular Hyperpermeability in Endotoxemia-Induced Inflammatory Lung Injury.Circulation. 2014;130:A15720.
  • Yu-Ting Xuan, Yanqing Zhu, Ou-Li Wang, Johnson Rajasingh, and Buddhadeb Dawn. STAT3 Inhibits Hypoxia-Induced Apoptosis via Post-Translational Modification of GSK-3β and Bad in Mesenchymal Stem Cells. Circulation. 2014;130:A15894.
  • Kashyap Choksi, Guangming Cheng, Arash Davani, Anweshan Samanta, Magdy Girgis, Amy Cantilena, Robert Vincent, Yanjuan Yang, Harold K Elias, Carl Weiner, and Buddhadeb Dawn . Transplantation of Human Umbilical Cord Blood Mononuclear Cells Improves LV function and Remodeling After a reperfused Myocardial Infarction.Circulation. 2014;130:A14804.
  • Guangming Cheng, Lin Zhao, Lei Chen, Xing Chen, Arash Davani, Anweshan Samanta, Magdy Girgis, Harold Elias, Yanjuan Yang, Robert J Vincent, Jeryl Hauptman, and Buddhadeb Dawn. CaMKII Links ER Stress Signaling in Pressure Overload-Induced Left Ventricular Hypertrophy and Failure. Circulation. 2014;130:A15923.
  • Lei Chen, Lin Zhao, Anweshan Samanta, Kashyap Choksi, Guangming Cheng, Arash Davani, Magdy Girgis, and Buddhadeb Dawn. STAT3 Inhibition Protects Against Cardiomyocyte Hypertrophy Through a Novel NF-kB p65/Nrf2/HO-1 Pathway. Circulation. 2014;130:A17436.
  • Bahar Barani, Jayakumar Thangavel, Sheeja Rajasingh, Yu-Ting Xuan, Buddhadeb Dawn, and Johnson Rajasingh. Epigenetic Modifiers Reduce Inflammation and Modulate Macrophage Phenotype to Attenuate Endotoxemia-Induced Acute Lung Injury. Circulation. 2014;130:A15634.
  • Johnson Rajasingh, Sheeja Rajasingh, Jayakumar Thangavel, Bahar Barani, and Buddhadeb Dawn .A Novel and Efficient Combinatorial Method of Using DNAs and mRNAs to Generate Integration-free Induced Pluripotent Stem Cells and Functional Cardiomyocytes. Circulation. 2014;130:A15441.
  • Jayakumar Thangavel, Sheeja Rajasingh, Bahar Barani, Buddhadeb Dawn, and Johnson Rajasingh.  Acetylation and Methylation Modifiers Attenuate Thrombin-induced eNOS/RhoA Signaling and Restore Adherens Junction Integrity in Acute Lung Injury. Circulation. 2014;130:A15825.
  • Rashmi Thapa, Suresh Sharma, Vinodh Jeevanantham, Dusan Stanojevic, Lauren Penn, Chris Johnson, Taylor Myers, John Fritzlen, Clare Prohaska, Buddhadeb Dawn, Kamal Gupta.Progression of Carotid Artery Stenosis in Asymptomatic Patients on Optimal Medical Therapy. Catherization and Cardiovascular Interventions. 2014;83(S1):S118.
  • Arun Raghav Mahankali Sridhar, MD, MPH, Madhu Reddy, MD, Ryan J. Maybrook, MD, Arun Kanmanthareddy, MD, Jayasree Pillarisetti, MD, Buddhadeb Dawn, MD, Sudharani Bommana, MSc and Dhanujaya R. Lakkireddy, MD, FHRS.Trends in acute ischemic cerebrovascular events associated with atrial fibrillation in the last decade in the united states - time for an appraisal of the progress?. Heart Rhythm, 2014;11(5): S122.
  • Dhanujaya R. Lakkireddy, MD, FHRS, Madhu Reddy, MD, Arun Raghav Mahankali Sridhar, MD, MPH, Matthew Earnest, MD, Arun Kanmanthareddy, MD, Ryan J. Maybrook, MD, Jayasree Pillarisetti, MD, Donita Atkins, RN, BSN, Sudharani Bommana, MSc, Melissa Jaeger, RN, BSN, Caroline Murray, Jayant Nath, MD, Ryan Ferrell, MD, Vijay Swarup, MD, Randall J. Lee, MD, PhD, Nitish Badhwar, MD, Krzysztof Bartus, MD, PhD, Luigi DiBiase, MD, Andrea Natale, MD and Buddhadeb Dawn, MD. Left atrial appendage ligation and ablation for persistent atrial fibrillation results of the laala-af registry. Heart Rhythm, 2014;11(5): S125.
  • Arun Raghav Mahankali Sridhar, MD, MPH, Madhu Reddy, MD, Ryan J. Maybrook, MD, Arun Kanmanthareddy, MD, Buddhadeb Dawn, MD and Dhanujaya R. Lakkireddy, MD, FHRS. Impact of hematoma after icd implantation on hospitalization costs, length of stay and mortality: an analysis of a nationwide database of 85,276 patients. Heart Rhythm, 2014;11(5): S507.
  • Rashmi Thapa; Suresh Sharma; Vinodh Jeevanantham; Casper Hu; Taylor Myers; James Vacek; Buddhadeb Dawn; Kamal Gupta. Comparison of lipid control among diabetics with noncoronary atherosclerotic vascular disease versus coronary artery disease. J Am Coll Cardiol. 2014;63(12_S):. doi:10.1016/S0735-1097(14)62132-X. 
  • Ryan Maybrook; Jayasree Pillarisetti; Vivek Yarlagadda; Arun Raghav Mahankali Sridhar; Madhu Reddy; Buddhadeb Dawn; Matthew Earnest; Ryan Ferrell; Jayant Nath; Arun Kanmanthareddy; Donita Atkins; Sudharani Bommana; Rajasingh Johnson; Dhanunjaya Lakkireddy. Hyponatremia and hemodynamic changes following percutaneous left atrial appendage ligation with the lariat device. J Am Coll Cardiol. 2014;63(12_S):. doi:10.1016/S0735-1097(14)60410-1. 
  • Dhanunjaya R. Lakkireddy; Madhu Reddy; Arun Raghav Mahankali Sridhar; Jayasree Pillarisetti; Ryan Maybrook; Arun Kanmanthareddy; Matthew Earnest; Vijay Swarup; Donita Atkins; Sudharani Bommana; Jayant Nath; Ryan Ferrell; Buddhadeb Dawn. Left atrial appendage ligation and ablation for persistent atrial fibrillation (laala-af registry). J Am Coll Cardiol. 2014;63(12_S):. doi:10.1016/S0735-1097(14)60390-9. 
  • Arun Raghav Mahankali Sridhar; Madhu Reddy; Arun Kanmanthareddy; Ryan Maybrook; Vivek Yarlagadda; Anand Pillai; Buddhadeb Dawn; Donita Atkins; Sudharani Bommana; Dhanunjaya Lakkireddy. United states experience with atrial flutter ablation a study of trends in utilization, demographic disparities and outcomes using the nationwide inpatient sample database for years 2003-2010. J Am Coll Cardiol. 2014;63(12_S):. doi:10.1016/S0735-1097(14)60433-2. 
  • Matthew Butler; Christopher Buckley; Calvin Madrigal; Arun Raghav Mahankali Sridhar; Buddhadeb Dawn. Long-term safety of concomitant use of proton pump inhibitors and h2 receptor blockers with thienopyridines in the setting of coronary stenting. J am coll cardiol. 2014;63(12_s):. Doi:10.1016/s0735-1097(14)60226-6.
  • Sharma S, Thapa R, Myers T, Hu C, Brimacombe M, Vacek JL, Dawn B, Gupta K. Comparison of Lipid Control in Patients with Coronary Versus Peripheral Arterial Diseases.Circ Cardiovasc Qual Outcomes. 2013;6:A290. 
  • Dusan Stanojevic, Suresh Sharma, Vinodh Jeevanantham, Bassem Chehab, Matthew McCullough, Matthew McCullough,Buddhadeb Dawn, Kamal Gupta, Peter Tadros, Mark Wiley. Clinical significance of Micro Coronary Edge Dissection and Plaque Prolapse visualized with Optical Coherence Tomography post Percutaneous Coronary Intervention. Catheterization and Cardiovascular Interventions. 2013; 81(S1):S88-S89. DOI: 10.1002/ccd.24919. 
  • Stanojevic D; Sharma S; Jeevanantham V; Chehab B; McCullough M; Tadros P; Dawn B; Wiley M. Evaluation of micro coronary edge dissection and coronary artery plaque prolapse post coronary artery percutaneous intervention using optical coherence tomography. J Am Coll Cardiol. 2013;61(10_S):. doi:10.1016/S0735-1097(13)61875-6 
  • Reddy M; Sridhar AR; Vallakati A; Lakkireddy D; Dawn B.Gender differences in the utilization of the type of cardiac resynchronization therapy: data from the nationwide inpatient sample 2003-2009. J Am Coll Cardiol. 2013;61(10_S):. doi:10.1016/S0735-1097(13)60669-5. 
  • Jeevanantham V; Chehab B; Shrivastava R; Wiley M; Tadros P; Nath J; Dawn B; Gupta K. Utility of two methods of calculating ankle brachial index in detecting below knee peripheral arterial disease confirmed by angiography. J Am Coll Cardiol. 2013;61(10_S):. doi:10.1016/S0735-1097(13)62075-6 
  • Jeevanantham V; Boolani H; Saad A; Dawn B; Gupta K.Alternative method of calculating resting ankle brachial index predicts abnormal post exercise ankle brachial index. J Am Coll Cardiol. 2013;61(10_S):. doi:10.1016/S0735-1097(13)62097-5. 
  • Afzal MR; Maybrook RJ; Rankin A; Russell C; Dawn B; Vacek JL. Development of a comprehensive heart failure management team and its impact in improving compliance with standard of care: insight from the get with the guidelines database. J Am Coll Cardiol. 2013;61(10_S):. doi:10.1016/S0735-1097(13)60761-5. 
  • Sridhar A, Reddy M, Parasa S, Janga P, Vallakati A, Berenbom L, Dawn B, Lakkireddy D. Trends of Lead Extractions for Cardiac Implanted Device Related Infections: Results from Nationwide Inpatient Sample for years 2003 to 2009.Heart Rhythm, 2013;10(5):S67-68. 
  • Lakkireddy D, Reddy M, Atkins D, Pimentel R, Bommana S, Johnson R, Olyaee M, Dusing R, Dawn B. Impact of Atrial Fibrillation on the Functional Integrity of Upper Gastrointestinal System. Heart Rhythm, 2013;10(5):S83-84. 
  • Lakkireddy D, Vallakati A, Janga P, Atkins D, Reddy M, Bommana S, Pimentel R, Dawn B. Impact of Yoga on Sympoms, Head Up Tilt Table Test and Functional Status of Patients with Neurocardiogenic Syncope -- A Preliminary Experience. Heart Rhythm, 2013;10(5):S39-40. 
  • Jeevanantham V, Chehab B, Nagavalli S, Austria E, Shrivastava R, Wiley M, Tadros P, Nath J, Dawn B, Gupta K. Differences Between Two Methods of Calculating Ankle Brachial Index in Prediction of Below Knee Peripheral Arterial Disease Burden Confirmed by Angiography. Catherization and Cardiovascular Interventions, 2013; 81(S1): S74-S75. 
  • Tim J Kamerzell, C. Russell Middaugh, Buddhadeb Dawn, and Calum A MacRae. Connecting Histone-Modifying Enzymes and Metabolism Through Chemical Probes and Network Pharmacology. Circulation. 2013;128:A16602. 
  • Roberto Bolli, Yanqing Zhu, Ou-Li Wang, Yiru Guo, Gregg Rokosh, Adam B Stein, Buddhadeb Dawn, and Yu-Ting Xuan. STAT1 Transcription Factor is Required for the Delayed Protection Against Cardiomyocyte Apoptosis by Ischemic Preconditioning. Circulation. 2013;128:A12113. 
  • Roberto Bolli, Yanqing Zhu, Ou-Li Wang, Yiru Guo, Gregg Rokosh, Adam B Stein, Buddhadeb Dawn, and Yu-Ting Xuan. STAT1 Signaling is Critical for the Infarct-Sparing Effects of Late Ischemic Preconditioning Circulation. 2013;128:A12143. 
  • Guangming Cheng, Magdy Girgis, Arash Davani, Yanjuan Yang, Harold Elias, Lei Chen, Jeryl Hauptman, Robert J Vincent, and Buddhadeb Dawn. Genetic Deletion of IL-6 Attenuates Pressure Overload-Induced Left Ventricular Hypertrophy and Failure. Circulation. 2013;128:A18105. 
  • Madhu Y Reddy, Anand Pillai, Ajay Vallakati, Vivek Yarlagadda, Gopi C Ponnaganti, Donita Atkins, Sudharani Bommana, Pramod Janga, Ryan Maybrook, Arun Sridhar, Buddhadeb Dawn, Luigi DiBiase, Andrea Natale, and Dhanunjaya Lakkireddy. Incidence and Recurrence of Atrial Fibrillation in Patients Undergoing Cavotricuspid Isthmus Ablation for Typical Atrial Flutter.Circulation.2013;128:A18292. 
  • Arun Raghav Mahankali Sridhar, Madhu Reddy, Ajay Vallakati, Ryan Maybrook, Loren Berenbom, Buddhadeb Dawn, and Dhanunjaya Lakkireddy. Impact of Hematoma After Pacemaker Implantation: An Analysis of a Nationwide Database of 77,074 Patients. Circulation.2013;128:A18772. 
  • Madhu Y Reddy, Ajay Vallakati, Kirill Lipatov, Pramod Janga, Gopi C Ponnaganti, Vivek Yarlagadda, Ramchandur Bakhtiani, Donita Atkins, Sudharani Bommana, Namratha Reddy, Rhea Pimentel, Martin Emert, Raghuveer Dendi, Luigi DiBiase, Andrea Natale, Buddhadeb Dawn, Dhanunjaya Lakkireddy, and Loren Berenbom. A Comparison of Complexity of Extraction Between Sprint Fidelis and Other Right Ventricular Leads. Circulation.2013;128:A18460. 
  • Ajay Vallakati, Madhu Y Reddy, Gopi C Ponnaganti, Vivek Yarlagadda, Donita Atkins, Sudharani Bommana, Pramod Janga, Arun Raghav Mahankali Sridhar, Ryan Maybrook, Rhea C Pimentel, Luigi DiBiase, Andrea Natale, Buddhadeb Dawn, and Dhanunjaya Lakkireddy. Catheter Ablation as a First-Line Therapy for Atrial Fibrillation - A Meta-Analysis. Circulation. 2013;128:A18526.
  • Chehab B, Jeevanantham V, Nagavalli S, Austria E, Shrivastava R, Wiley M, Tadros P, Nath J, Dawn B, Gupta K. Two Methods of Calculating Ankle Brachial Index: Differences in Prediction of Peripheral Arterial Disease Burden. J Am Coll Cardiol. 2012;59(13s1):E2127-E2127. doi:10.1016/S0735-1097(12)62128-7.
  • Chehab B, Jeevanantham V, Saad A, Vacek J, Gupta K, Dawn B, Tadros P, Wiley M. Feasibility, Safety, and Outcomes with a Coronary Pressure Wire System used for the Assessment of Severe Aortic Stenosis.J Am Coll Cardiol. 2012;59(13s1):E134-E134. doi:10.1016/S0735-1097(12)60135-1. 
  • Boolani H, Reddy M, Duthuluru S, Williamson T, Spikes L, Reddy N, Bommana S, Atkins D, Pillarisetti J, Dawn B, Nath J, Lakkireddy D. Pericardial Effusions in Pulmonary Hypertension: Presentation, Predictors & Outcomes. J Am Coll Cardiol. 2012;59(13s1):E1599-E1599. doi:10.1016/S0735-1097(12)61600-3
  • Cheng G, Yang Y, Girgis M, Davani A, Quinn CM, Elias H, Hauptman J, Dawn B.Cardiac-specific transgenic inhibition of NF-KB activation protects against myocardial ischemia/reperfusion injury.J Am Coll Cardiol. 2012;59(13s1):E546-E546. doi:10.1016/S0735-1097(12)60547-6.
  • Pillarisetti J, Biria M, Reddy M, Atkins D, Pimentel R, Berenbom L, Emert M, Dendi R, Reddy N, Murray C, Bommana S, Dawn B, Lakkireddy D. Impact of Pocket Revision on the Rate of Infection and Other Complications in Patients Requiring Pocket Manipulation for Generator Replacement and/or Lead Replacement or Revision (MAKE IT CLEAN): A Prospective Randomized Study. Heart Rhythm, 2012;9(5):S25.
  • Thangavel J, Dawn B, and Rajasingh J.Reprogramming of Human Somatic Cells Into Cardiomyocytes. Circulation.2012;126:A11107.
  • Cheng G, Girgis M, Davani A, Chen L, Elias H, Yang Y, Sanganalmath SK, Quinn CM, and Dawn B .The Absence of C/EBP Homologous Protein Improves Left Ventricular Remodeling After a Reperfused Myocardial Infarction. Circulation. 2012;126:A13727
  • \Sridhar AR, Patel DB, Oommen CJ, Jeevanantham V, and Dawn B.Trends in Utilization of Cardiac Resynchronization Therapy and Gender Differences in the US - Results from the Nationwide Inpatient Sample 2002-2009.Circulation.2012;126:A14672
  • Sridhar AR, Patel DB, Jeevanantham V, and Dawn B.Temporal Trends in Intra-Aortic Balloon Pump Utilization and Persistent Gender Disparities - Data from the Nationwide Inpatient Sample 1997-2009.Circulation. 2012;126:A17746
  • Xuan Y, Zhu Y, Wang O, Cheng G, Elias H, Davani A, Yang Y,Girgis M, Vincent RJ, Hauptman J, and Dawn B.STAT3 Activation Prevents Mesenchymal Stem Cell Apoptosis and Improves Infarct Repair. Circulation. 2012;126:A12591
  • Zuba-Surma EK, Xuan Y, Labedz-Maslowska A, Elias H, Kamycka E, Abdel-Latif A, Zhu Y, Wang O, Davani A, and Dawn B.Greater Antiapoptotic, Antiinflammatory, and Proangiogenic Attributes of a Defined Subpopulation of Bone Marrow Mesenchymal Stem Cells May Facilitate Cardiac Repair via Paracrine Effects. Circulation. 2012;126:A12650
  • Thangavel J, Dawn B, and Rajasingh J .Effects of Epigenetic Modifiers on Lps-induced Enos/rho Signaling And Restoration of Adherens Junction Integrity and Endothelial Barrier Protection. Circulation. 2012;126:A11114
  • Chen L, Xuan Y, Elias H, Cantilena A, Zuba-Surma E, Davani A, Cheng G, Wang O, Vincent RJ, Yang Y, and Dawn B .The Activation of STAT3 via CamKII is Critical for the Induction of Cardiac Differentiation by Wnt11 in Bone Marrow Mesenchymal Stem Cells.Circulation. 2012;126:A12638
  • Reddy M, Boolani H, Sharma S, Bakhtiani R, Duthuluri S, Reddy N, Atkins D, Bommana S, Vacek J, Nath J, Gupta K, Dawn B, and Lakkireddy D.Incidence, Predictors and Clinical Course of Atrial Tachyarrhythmias in Patients with Pulmonary Hypertension. Circulation. 2012;126:A17933
  • Bassem Chehab, Vinodh Jeevanantham, Andre Saad,Matthew Bulter, James Vacek, Thomas Rosamond,Kamal Gupta, M.D., Buddhadeb Dawn, Peter Tadros, Mark Wiley, Normal Coronary Anatomic Variants Influence False Positive Results of Myocardial Perfusion Imaging. Catheterization and Cardiovascular Interventions, 2012;79(S1):S40-S41.
  • Jeevanantham V, Shanberg D, Saad A, Abu-El-Haija B, Dawn B, Lakkireddy D. Cardiac resynchronization therapy prevents progression of renal failure in heart failure patients. Circulation 124:A13947.
  • Lakkireddy D, Vanga SR, Bunch J, Dendi R, Day J, Mahapatra S, DiBiasi L, Burkhardt D, Dawn B, Natale A. Use of percutaneous external circulatory support in patients undergoing ventricular tachycardia ablation - a multicenter experience. Circulation 124:A18282.
  • Cheng G, Xuan YT, Quinn CM, Sanganalmath Sk, Girgis M, Wang OL, Zhu Y, Yang Y, Flaherty MP, Lietzau-Mourer S, Zuba-Surma EK, Vincent R, Xu D, Davani A, Dawn B. Wnt11-pretreated bone marrow stem cells induce superior cardiac repair after a reperfused myocardial infarction. Circulation 124:A9899.
  • Vanga SR, Vacek JL, Good M, Nath J, Bommana S, Nagarajan DV, Dawn B, Lakkireddy D. Deficiency of 25-hydroxy cholecalciferol worsens the risk factor profile but confers protection against atrial fibrillation - the vitamin D paradox? Circulation 124:A16357.
  • Cheng G, Zuba-Surma EK, Xuan YT, Yang Y, Girgis M, Wang OL, Zhu Y, Sanganalmath SK, Lietzau-Mourer S, Xu D, Dawn B. Transplantation of an antigenically-selected subpopulation of bone marrow mesenchymal stem cells results in superior cardiac repair after a reperfused infarction. Circulation 124:A17476.
  • Thangavel J, Reddi AL, Dawn B, Malik AB, Johnson R. Epigenetic modifiers attenuate inflammation and improve survival in sepsis. Circulation 124:A15722.
  • Jeevanantham V, Butler M, Saad A, Abdel-Latif A, Dawn B. Impact of bone marrow cell therapy on left ventricular function, structure, and clinical outcomes in patients with ischemic heart disease: A meta-analysis. Circulation 124:A9834.
  • Frye L, Dawn B. Bridging the gap: Gender disparities in chest pain evaluation. Presented at the ACP National Meeting 2011.
  • Butler M, Jeevanantham V, Saad A, Abdel-Latif A, Dawn B. Effects of adult bone marrow cell therapy on left ventricular volumes and function in patients with ischemic heart disease: A meta-analysis. Presented at the ACP National Meeting 2011.
  • Nagarajan DV, Vanga SR, Biria M, Chikkam V, Ittaman S, Shanberg D, Jeevanantham V, Berenbom L, Emert M, Pimentel R, Dendi R, Umberger L, Bommana S, DiBiasi L, Natale A, Dawn B, Lakkireddy D. Can CHADS2 score predict the outcomes of radiofrequency ablation in patients with atrial fibrillation? Heart Rhythm 2011;8(5):S449.
  • Pillarisetti J, Reddy V, Kondur A, Alani A, Vanga S, Biria M, Bommana S, Nagarajan D, Dawn B, Reddy M, Lakkireddy D. Postpartum cardiomyopathy: Predictors of recovery and current state of implantable cardioverter defibrillator use. Heart Rhythm 2011;8(5):S438.
  • Nath J, Lakkireddy D, Gupta K, Dawn B. Why do we need mean aortic gradient in evaluation of aortic stenosis? J Am Coll Cardiol 2011;57:E1290.
  • Sanganalmath SK, Xuan YT, Zhu Y, Guo Y, Vincent R, Crawford TC, Wead WB, Joshua IG, Bolli R, Dawn B. Doxorubicin-induced myocardial inflammation, apoptosis, and remodeling are attenuated by cardiac-specific transgenic inhibition of nuclear factor-kappaB. J Am Coll Cardiol 2011;57:E271.
  • Lakkireddy D, Pillarisetti J, Atkins D, Vanga SR, Emert M, Pimentel R, Murray C, Bommana S, Ryschon K, Berenbom L, Dawn B, Dendi R, Drisko J. Impact of yoga on arrhythmia burden and quality of life (QoL) in patients with symptomatic paroxysmal atrial fibrillation. J Am Coll Cardiol 2011;57:E129.
  • Vanga SR, Biria M, Pillarisetti J, Atikins D, Murray C, Chen W, Berenbom L, Emert M, Pimentel R, Dendi R, Bommana S, Vacek J, Dawn B, Di Biasi L, Natale A, Lakkireddy D. Radiofrequency ablation improves quality of life scores not only in patients with atrial fibrillation but their significant others too! J Am Coll Cardiol 2011;57:E132.
  • Chehab B, Nagavalli S, Austria E, Jeevanantham V, Shrivastava R, Wiley M, Tadros P, Nath J, Dawn B, Gupta K. A study of diagnostic accuracy of two methods of calculating ankle brachial index to detect occlusive peripheral arterial disease. Catheter Cardiovasc Interv 2011;78:S50-51.
  • Saad A, Chehab BM, Jeevanantham V, Gupta R, Nath J, Lakkireddy DJ, Wiley M, Tadros P, Dawn B, Gupta K. Role of side-to-side difference in renal resistive index as an index for clinical improvement in renal artery stenosis revascularization. Catheter Cardiovasc Interv 2011;78:S50.
  • Jeevanantham V, Tan W, Craven S, Roberts N, Dawn B. Predictors of readmissions with 30 days of discharge in a Medicaid population. Kansas ACP Meeting 2011.
  • Sanganalmath SK, Chugh AR, Benakanakere MR, Vincent RJ, Hunt G, Bolli R, Dawn B. Therapy with adult bone marrow-derived mesenchymal stem cells ameliorates doxorubicin-induced cardiomyopathy. J Am Coll Cardiol 2010;55:A31.E297.
  • Vanga SR, Biria M, Pillarisetti J, Guda R, Feldkamp M, Rosamond T, Vacek JL, Dawn B, Lakkireddy D. Left atrial appendage far field potentials mimicking left superior pulmonary vein potentials: does proximity matter? J Am Coll Cardiol 2010:55:A6.E55.
  • Chugh AR, Chatterjee A, Elmore JB, Kuznetsov S, Loughran JH, Miller JJ, Dawn B. Serial changes in low-positive extra-sensitive troponin I levels in patients with acute severe hypertension and hypertensive emergencies are associated with increased cardiovascular events. J Clin Hypertension 2010;12(Suppl 1):A103.
  • Vanga S, Bicknell D, Dendi R, Pimentel R, Berenbom L, Emert M, Gerken A, Natale A, DiBiase L, Dawn B, Lakkireddy D. Radiofrequency ablation (RFA) for sinus rhythm restoration in atrial fibrillation patients with mitral or aortic mechanical prosthetic valves - feasibility, safety and efficacy. Heart Rhythm 2010;7(5):S143-144.
  • Vanga S, Koerber S, DiBiasi L, Verma A, Bommana S, Swarup V, Natale A, Dawn B, Lakkireddy D. Prevalence of fragmented QRS complexes in nonischemic dilated cardiomyopathy patients and long term prognosis. Circulation 2010;122:A20836.
  • Lakkireddy D, DiBiasi L, Vanga S, Nagarajan D, Swarup V, Verma A, Burkhardt D, Bommana S, Dawn B, Natale A. Radiofrequency ablation of premature ventricular ectopy can improve left ventricular function and heart failure class in nonresponders of cardiac resynchronization therapy. Circulation 2010;122:A20821.
  • Xu D, Perez RE, Truog WE, Dawn B. C/EBP homologous protein (CHOP) inhibition protects against hyperoxia-induced endothelial cell apoptosis. Circulation 2010;122:A13187.
  • Sanganalmath SK, James CR, Taher H, Hunt G, Vincent RJ, Wu R, Li Q, Bolli R, Dawn B. Genetic deletion of IL-6 attenuates pressure overload-induced left ventricular hypertrophy and dysfunction. J Am Coll Cardiol 2009;53:A149.
  • Li Q, Ou Q, Wang S, Tan W, Wu W-J, Zhu X, Sanganalmath SK, Dawn B, Guo Y, Bolli R. rAAV-mediated extracellular superoxide dismutase (ecSOD) gene therapy produces permanent cardioprotection. Circulation 2009;120:S736-S737.
  • Chugh AR, Elmore JB, Kuznetsov S, Loughran JH, Flaherty MP, Platt MA, Coleman RD, Miller JJ, Dawn B. Diagnostic value of serial changes in low-positive extra-sensitive troponin I levels for acute myocardial infarction. Circulation 2009;120:S1036.
Last modified: Dec 08, 2014

Buddhadeb Dawn, MD

Contact

Buddhadeb Dawn, MD
Professor of Medicine
Maureen & Marvin Dunn Professor of Cardiovascular Diseases
Director, Division of Cardiovascular Diseases
Director, Cardiovascular Research Institute
Vice Chairman for Research, Department of Medicine

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