Buddhadeb Dawn, MD, FACC, FAHA, FACP

Professor of Medicine and Molecular and Integrative Physiology
Maureen & Marvin Dunn Professor of Cardiovascular Diseases
Director, Division of Cardiovascular Diseases
Director, Cardiovascular Research Institute
Director, Midwest Stem Cell Therapy Center
Vice Chairman for Research, Department of Medicine
Medical School, Calcutta Medical College, Calcutta, West Bengal, India
Residency, University of Missouri-Columbia, Columbia, Missouri(Internal Medicine)
Fellowship, University of Louisville, Louisville, Kentucky(Cardiology)

Clinical Interests

  • Stress Echocardiography
  • Atrial fibrillation
  • Biomarkers in acute coronary syndromes
  • Diagnosis of chest pain in the ER

Research Interests

  • Adult cell therapy for cardiac repair
  • Organ protection during cardiopulmonary arrest
  • Biology of adult stem cells
  • Role of cytokines in cardiac remodeling
  • Diabetes and cardiovascular injury

Research Projects

Active Clinical Trials

  • A study of the safety and efficacy of intracoronary delivery of allogenic Cardiosphere-Derived cells in patients with an anterior myocardial infarction and ischemic left ventricular dysfunction sponsored by Capricor, Inc.
  • Study of autologous CD34+ coronary infusion in STEMI sponsored by amorcyte.

Active Preclinical Projects

  • CD105- MSC transplantation after ischemia/reperfusion in mice
  • IL-6 signaling in myocardial ischemia/reperfusion injury
  • Nuclear factor kappaB signaling in apoptosis and necrosis after acute I/R
  • IL-6  signaling and ventricular hypertrophy
  • NF-kB signaling and ventricular remodeling and myocyte hypertrophy
  • CHOP signaling in cardiac pressure overload and rempdeling
  • NF-kB signaling in doxorubicin-induced cardiomyopathy
  • Cardiac repair with hUCBCSC transplantation

Selected Publications 

  • Afzal MR, Samanta A, Shah ZI, Jeevanantham V, Abdel-Latif A, Zuba-Surma EK,Dawn B. Adult Bone Marrow Cell Therapy for Ischemic Heart Disease: Evidence and Insights from Randomized Controlled Trials. Circ Res. 2015 Jul 9. pii:CIRCRESAHA.114.304792. [Epub ahead of print] PubMed PMID: 26160853.
  • Thangavel J, Samanta S, Rajasingh S, Barani B, Xuan YT, Dawn B, Rajasingh J.Epigenetic modifiers reduce inflammation and modulate macrophage phenotype during endotoxemia-induced acute lung injury. J Cell Sci. 2015 Jun 26. pii: jcs.170258.[Epub ahead of print] PubMed PMID: 26116574.
  • Bobis-Wozowicz S, Kmiotek K, Sekula M, Kedracka-Krok S, Kamycka E, Adamiak M, Jankowska U, Madetko-Talowska A, Sarna M, Bik-Multanowski M, Kolcz J,Boruczkowski D, Madeja Z, Dawn B, Zuba-Surma EK. Human Induced Pluripotent Stem Cell-derived Microvesicles Transmit RNAs and Proteins to Recipient Mature Heart Cells Modulating Cell Fate and Behavior. Stem Cells. 2015 Jun 1. doi:10.1002/stem.2078. [Epub ahead of print] PubMed PMID: 26031404.
  • Tang XL, Rokosh G, Sanganalmath SK, Tokita Y, Keith MC, Shirk G, Stowers H,Hunt GN, Wu W, Dawn B, Bolli R. Effects of Intracoronary Infusion of Escalating Doses of Cardiac Stem Cells in Rats With Acute Myocardial Infarction. Circ Heart Fail. 2015 May 20. pii: CIRCHEARTFAILURE.115.002210. [Epub ahead of print] PubMed PMID: 25995227.
  • Lakkireddy D, Reddy YM, Atkins D, Johnson R, Kanmanthareddy A, Olyaee M, Dusing R, Pimentel R, Bommana S, Dawn B. The Effect of Atrial Fibrillation Ablation on Gastric Motility "The AF Gut Study". Circ Arrhythm Electrophysiol. 2015 Mar 14. pii: CIRCEP.114.002508. [Epub ahead of print] PubMed PMID: 25772541.
  • Jeevanantham V, Chehab B, Austria E, Shrivastava R, Wiley M, Tadros P, Dawn B, Vacek JL, Gupta K. Comparison of Accuracy of Two Different Methods to Determine Ankle-Brachial Index to Predict Peripheral Arterial Disease Severity Confirmed by Angiography. Am J Cardiol. 2014 Jul 17. pii: S0002-9149(14)01451-9. doi:10.1016/j.amjcard.2014.07.023. [Epub ahead of print] PubMed PMID: 25129876.
  • Choksi K, Dawn B. Priming mononuclear cells to improve outcomes of regenerative therapy. J Am Heart Assoc. 2014 Jun 25;3(3):e001168. doi:10.1161/JAHA.114.001168. PubMed PMID: 24965029.
  • Thangavel J, Malik AB, Elias HK, Rajasingh S, Simpson AD, Sundivakkam PK, Vogel SM, Xuan YT, Dawn B, Johnson R. Combinatorial Therapy with Acetylation and Methylation Modifiers Attenuates Lung Vascular Hyperpermeability in Endotoxemia-Induced Mouse Inflammatory Lung Injury. Am J Pathol. 2014 Jun 11. pii: S0002-9440(14)00282-X. doi: 10.1016/j.ajpath.2014.05.008.[Epub ahead ofprint] PubMed PMID: 24929240.
  • Jeevanantham V, Afzal MR, Zuba-Surma EK, Dawn B. Clinical trials of cardiac repair with adult bone marrow- derived cells. Methods Mol Biol. 2013;1036:179-205. doi: 10.1007/978-1-62703-511-8_15. PubMed PMID: 23807796. 
  • Lakkireddy D, Atkins D, Pillarisetti J, Ryschon K, Bommana S, Drisko J, Vanga S, Dawn B. Effect of yoga on arrhythmia burden, anxiety, depression, and quality of life in paroxysmal atrial fibrillation: the YOGA My Heart Study. J Am Coll Cardiol. 2013 Mar 19;61(11):1177-82. doi: 10.1016/j.jacc.2012.11.060. Epub 2013 Jan 30. PubMed PMID: 23375926. 
  • Jeevanantham V, Butler M, Saad A, Abdel-Latif A, Zuba-Surma EK, Dawn B. Adult bone marrow cell therapy improves survival and induces long-term improvement in cardiac parameters: a systematic review and meta-analysis. Circulation. 2012 Jul 31;126(5):551-68. 
  • Lakkireddy D, Di Biase L, Ryschon K, Biria M, Swarup V, Reddy YM, Verma A, Bommana S, Burkhardt D, Dendi R, Dello Russo A, Casella M, Carbucicchio C, Tondo C, Dawn B, Natale A. Radiofrequency ablation of premature ventricular ectopy improves the efficacy of cardiac resynchronization therapy in nonresponders. J Am Coll Cardiol. 2012 Oct 6; 60(16):1531-9. 
  • Flaherty MP, Kamerzell TJ, Dawn B. Wnt signaling and cardiac differentiation. Prog Mol Biol Transl Sci. 2012;111:153-74. 
  • Sanganalmath SK, Abdel-Latif A, Bolli R, Xuan YT, Dawn B. Hematopoietic cytokines for cardiac repair: mobilization of bone marrow cells and beyond. Basic Res Cardiol. 2011;106(5):709-33. 
  • Zuba-Surma EK, Wojakowski W, Ratajczak MZ, Dawn B. Very small embryonic-like stem cells: biology and therapeutic potential for heart repair. Antioxis Redox Signal. 2011;15(7):1821-34. 
  • Zuba-Surma EK, Guo Y, Taher H, Sanganalmath SK, Hunt G, Vincent RJ, Kucia M, Abdel-Latif A, Tang XL, Ratajczak MZ, Dawn B, Bolli R. Transplantation of expanded bone marrow-derived very small embryonic-like stem cells (VSEL-SCs) improves left ventricular function and remodeling after myocardial infarction. J Cell Mol Med. 2011;15(6):1319-28. 
  • Tang XL, Rokosh G, Sanganalmath SK, Yuan F, Sato H, Mu J, Dai S, Li C, Chen N, Peng Y, Dawn B, Hunt G, Leri A, Kajstura J, Tiwari S, Shirk G, Anversa P, Bolli R. Intracoronary administration of cardiac progenitor cells alleviates left ventricular dysfunction in rats with a 30-day-old infarction. Circulation. 2010 Jan 19;121(2):293-305. Epub 2010 Jan 4.
  • Dawn B, Abdel-Latif A, Sanganalmath SK, Flaherty MP, Zuba-Surma EK. Cardiac repair with adult bone marrow-derived cells: the clinical evidence. Antioxid Redox Signal. 2009 Aug;11(8):1865-82.
  • Li Q, Guo Y, Ou Q, Cui C, Wu WJ, Tan W, Zhu X, Lanceta LB, Sanganalmath SK, Dawn B, Shinmura K, Rokosh GD, Wang S, Bolli R. Gene transfer of inducible nitric oxide synthase affords cardioprotection by upregulating heme oxygenase-1 via a nuclear factor-{kappa}B-dependent pathway. Circulation. 2009 Sep 29;120(13):1222-30. Epub 2009 Sep 14.
  • Dawn B, Tiwari S, Kucia MJ, Zuba-Surma EK, Guo Y, Sanganalmath SK, Abdel-Latif A, Hunt G, Vincent RJ, Taher H, Reed NJ, Ratajczak MZ, Bolli R. Transplantation of bone marrow-derived very small embryonic-like stem cells attenuates left ventricular dysfunction and remodeling after myocardial infarction. Stem Cells. 2008 Jun;26(6):1646-55. Epub 2008 Apr 17.
  • Flaherty MP, Abdel-Latif A, Li Q, Hunt G, Ranjan S, Ou Q, Tang XL, Johnson RK, Bolli R, Dawn B. Noncanonical Wnt11 signaling is sufficient to induce cardiomyogenic differentiation in unfractionated bone marrow mononuclear cells. Circulation. 2008 Apr 29;117(17):2241-52. Epub 2008 Apr 21.
  • Abdel-Latif A, Zuba-Surma EK, Case J, Tiwari S, Hunt G, Ranjan S, Vincent RJ, Srour EF, Bolli R, Dawn B. TGF-beta1 enhances cardiomyogenic differentiation of skeletal muscle-derived adult primitive cells. Basic Res Cardiol. 2008 Nov;103(6):514-24. Epub 2008 May 23.
  • Abdel-Latif A, Bolli R, Zuba-Surma EK, Tleyjeh IM, Hornung CA, Dawn B. Granulocyte colony-stimulating factor therapy for cardiac repair after acute myocardial infarction: a systematic review and meta-analysis of randomized controlled trials. Am Heart J. 2008 Aug;156(2):216-226.e9. Epub 2008 Jun 20.
  • Flaherty MP, Guo Y, Tiwari S, Rezazadeh A, Hunt G, Sanganalmath SK, Tang XL, Bolli R, Dawn B. The role of TNF-alpha receptors p55 and p75 in acute myocardial ischemia/reperfusion injury and late preconditioning. J Mol Cell Cardiol. 2008 Dec;45(6):735-41. Epub 2008 Sep 12.
  • Stein AB, Tiwari S, Thomas P, Hunt G, Levent C, Stoddard MF, Tang XL, Bolli R, Dawn B. Effects of anesthesia on echocardiographic assessment of left ventricular structure and function in rats. Basic Res Cardiol. 2007 Jan;102(1):28-41. Epub 2006 Oct 2. PubMed PMID: 17006633.
  • Zuba-Surma EK, Abdel-Latif A, Case J, Tiwari S, Hunt G, Kucia M, Vincent RJ,Ranjan S, Ratajczak MZ, Srour EF, Bolli R, Dawn B. Sca-1 expression is associated with decreased cardiomyogenic differentiation potential of skeletal muscle-derived adult primitive cells. J Mol Cell Cardiol. 2006 Oct;41(4):650-60.Epub 2006 Aug 30. PubMed PMID: 16938308.
  • Dawn B, Guo Y, Rezazadeh A, Huang Y, Stein AB, Hunt G, Tiwari S, Varma J, Gu Y, Prabhu SD, Kajstura J, Anversa P, Ildstad ST, Bolli R. Postinfarct cytokine therapy regenerates cardiac tissue and improves left ventricular function. Circ Res. 2006 Apr 28;98(8):1098-105. Epub 2006 Mar 23. PubMed PMID: 16556872; PubMed  Central PMCID: PMC3652380.
  • Dawn B, Hasnie AM, Calzada N, Longaker RA, Stoddard MF. Transesophageal echocardiography impacts management and evaluation of patients with stroke, transient ischemic attack, or peripheral embolism. Echocardiography. 2006 Mar;23(3):202-7. PubMed PMID: 16524390.
  • Bolli R, Li QH, Tang XL, Guo Y, Xuan YT, Rokosh G, Dawn B. The late phase of preconditioning and its natural clinical application--gene therapy. Heart Fail Rev. 2007 Dec;12(3-4):189-99. Review. PubMed PMID: 17541820; PubMed Central PMCID: PMC3652384.
  • Abdel-Latif A, Bolli R, Tleyjeh IM, Montori VM, Perin EC, Hornung CA, Zuba-Surma EK, Al-Mallah M, Dawn B. Adult bone marrow-derived cells for cardiac repair: a systematic review and meta-analysis. Arch Intern Med. 2007 May 28;167(10):989-97. Review. PubMed PMID: 17533201.
  • Dawn B, Bolli R. Adult bone marrow-derived cells: regenerative potential, plasticity, and tissue commitment. Basic Res Cardiol. 2005 Nov;100(6):494-503. Review. PubMed PMID: 16237509; PubMed Central PMCID: PMC3685421.
  • Dawn B, Paliwal VS, Raza ST, Mastali K, Longaker RA, Stoddard MF. Left ventricular outflow tract obstruction provoked during dobutamine stress echocardiography predicts future chest pain, syncope, and near syncope. Am Heart J. 2005 May;149(5):908-16. PubMed PMID: 15894976.
  • Dawn B, Stein AB, Urbanek K, Rota M, Whang B, Rastaldo R, Torella D, Tang XL, Rezazadeh A, Kajstura J, Leri A, Hunt G, Varma J, Prabhu SD, Anversa P, Bolli R. Cardiac stem cells delivered intravascularly traverse the vessel barrier,regenerate infarcted myocardium, and improve cardiac function. Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3766-71. Epub 2005 Feb 25. PubMed PMID: 15734798;PubMed Central PMCID: PMC553298.
  • Kucia M, Dawn B, Hunt G, Guo Y, Wysoczynski M, Majka M, Ratajczak J, Rezzoug  F, Ildstad ST, Bolli R, Ratajczak MZ. Cells expressing early cardiac markers reside in the bone marrow and are mobilized into the peripheral blood after myocardial infarction. Circ Res. 2004 Dec 10;95(12):1191-9. Epub 2004 Nov 18. PubMed PMID: 15550692; PubMed Central PMCID: PMC3679649.
  • Dawn B, Xuan YT, Guo Y, Rezazadeh A, Stein AB, Hunt G, Wu WJ, Tan W, Bolli R. IL-6 plays an obligatory role in late preconditioning via JAK-STAT signaling and  upregulation of iNOS and COX-2. Cardiovasc Res. 2004 Oct 1;64(1):61-71. PubMed PMID: 15364614; PubMed Central PMCID: PMC3691700.
  • Bolli R, Shinmura K, Tang XL, Kodani E, Xuan YT, Guo Y, Dawn B. Discovery of  a new function of cyclooxygenase (COX)-2: COX-2 is a cardioprotective protein that alleviates ischemia/reperfusion injury and mediates the late phase of preconditioning. Cardiovasc Res. 2002 Aug 15;55(3):506-19. Review. PubMed PMID: 12160947; PubMed Central PMCID: PMC3242376.
  • Dawn B, Bolli R. Role of nitric oxide in myocardial preconditioning. Ann N Y Acad Sci. 2002 May;962:18-41. Review. PubMed PMID: 12076960.
  • Leesar MA, Stoddard MF, Dawn B, Jasti VG, Masden R, Bolli R. Delayed preconditioning-mimetic action of nitroglycerin in patients undergoing coronary angioplasty. Circulation. 2001 Jun 19;103(24):2935-41. PubMed PMID: 11413083.
  • Dawn B, Xuan YT, Marian M, Flaherty MP, Murphree SS, Smith TL, Bolli R, Jones WK. Cardiac-specific abrogation of NF- kappa B activation in mice by transdominant expression of a mutant I kappa B alpha. J Mol Cell Cardiol. 2001 Jan;33(1):161-73. PubMed PMID: 11133232.
  • Dawn B, Xuan YT, Qiu Y, Takano H, Tang XL, Ping P, Banerjee S, Hill M, Bolli  R. Bifunctional role of protein tyrosine kinases in late preconditioning against myocardial stunning in conscious rabbits. Circ Res. 1999 Dec 3-17;85(12):1154-63. PubMed PMID: 10590242.





Last modified: Oct 28, 2015

Buddhadeb Dawn, MD


Buddhadeb Dawn, MD, FACC, FAHA, FACP
Professor of Medicine and Molecular and Integrative Physiology
Maureen & Marvin Dunn Professor of Cardiovascular Diseases
Director, Division of Cardiovascular Diseases
Director, Cardiovascular Research Institute
Director, Midwest Stem Cell Therapy Center
Vice Chairman for Research, Department of Medicine