Research

We have been engaged in bench-to-bedside research on infectious diseases for more than 50 years, since Dr. Chien Liu, professor emeritus of medicine - widely recognized as one of the physician scientists who helped discover the etiology of primary atypical pneumonia - founded our division in 1958.

Our Infectious Diseases Clinical Research Program is currently directed by Dr. Lisa Clough and focuses on the safety and effectiveness of anti-microbial treatments; therapeutic and prophylactic vaccines; the study of influenza, HIV and other viruses; the mechanisms of disease production in pneumococcal infections; stem cell transplant and complicated lung infections. We are carrying out a variety of NIH and independently funded trials, as well as investigator-initiated endeavors.

Current Research

NIH Funded
	Title	PI/Sub	Status
2009-2012	An Observational Study of the Clinical and Virologic Manifestations of Novel and Seasonal Influenza	Clough	Completed
1999-2012	A Phase III Double-Blind, Placebo-Controlled Trial of Long Term Therapy of Herpes Simplex Encephalitis (HSE): An Evaluation of Valacyclovir	Hinthorn	Completed
2006-2011	ART Adherence: Enhanced Counseling And Observed Therapy	Clough	Completed

Industry Sponsored
	Title	PI/Sub	Status
2012-present	DEFLECT-1: A Phase 3b Multi-Center, Double-Blind Randomized, Placebo Controlled Study to Demonstrate the Safety and Efficacy of Fidaxomicin for Prophylaxis Against Clostridium difficile Associated Diarrhea in Adults Undergoing Hematopoietic Stem Cell Transplantation	Clough	Start Up
2012-present	A Phase III, Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy, Safety and Tolerability of a Single Infusion of MK-6072 (Human Monoclonal Antibody to C. difficile toxin B), and MK-3415A (Human Monoclonal Antibodies to C. difficile toxin A and B) in Patients Receiving Antibiotic Therapy for C. difficile Infection (MODIFY II)	Clough	Enrollment Underway
2012-present	Pharmacokinetics, Safety, and Tolerability of Intravenous Posaconazole Solution Followed by Oral Posaconazole Suspension (SCH 56592) in Subjects at High Risk for Invasive Fungal Infections	Clough	Enrollment Completed
2010-2011	Clostridium Difficile Toxoid Vaccine: A Phase II Randomized, Placebo-Controlled, Double-blind, Dose Ranging Study to Assess the Immunogenicity and Safety of a Clostridium Difficile Toxoid Vaccine in Subjects with Clostridium Difficile Infection (CDI).	Clough	Completed
2010-2011	A Randomized, Double-Blinded, Active-Controlled, Dose Ranging Study of Study Antibiotic in Patients with Clostridium Difficile Infection.	Clough: Sub-I	Completed

Investigator Initiated
	Title	PI/Sub	Status
2011-present	Vancomycin Nephrotoxicity in the Outpatient Setting: High Trough Dosing Versus Standard Trough Dosing Regimens	Hammoud	Data Collection Underway
2011-present	Trends in Invasive Pneumococcal Disease in Adults in a Major Teaching Hospital in the Midwest	Merino Clough	Data Collection Underway
2011-present	A Retrospective Review of Respiratory Viral Pathogen Infections in a Hospitalized Hematopoetic Stem Cell Transplant (HSCT) Population at the University of Kansas Medical Center	Hawkinson Pandeya Clough	Data Analysis Underway
2011-present	Yield of Sonicated Cultures in Diagnosing Orthopaedic Hardware Infection.	El Atrouni Khumri	Data Analysis Underway
2011-present	A Validation of Prediction Model for Cardiovascular Implantable Electronic Device-Related Infections and Infective Endocarditis	El Atrouni Chaung Clough	Data Analysis Underway
2011-present	A Retrospective Review of a Comprehensive Cohort of Candidal Septic Shock: Impact of Antifungal Therapy on Outcome	Clough Newman	Data Analysis Underway
2009-present	A Retrospective Review of the Incidence of Ocular Candidiasis in Candida Bloodstream Infection	Eid Khalid Clough	Data Analysis Underway
2009-present	Immune Response after Monovalent Influenza A (H1N1) 2009 Vaccine in Hemodialysis Patients	Clough	Data Analysis Underway
2008-present	Evaluation of Antigen Detection for Diagnosis of Histoplasmosis and Blastomycosis	Hammoud	Data Analysis Underway
2010-2011	Pre-emptive Treatment with Rituximab for Epstein-Barr Virus Reactivation after Allogenic Hematopoietic Stem Cell Transplantation: A Safety and Efficacy Study	Ganguly, N. Maalouf Clough	Completed
2009-2011	Use of Cidofovir in the Treatment of BK Virus Infection in Patients Undergoing Allogenic Stem Cell Transplantation	Ganguly, N. Clough	Completed
2008-2011	Exploring the Use of a Novel Device for Reducing Catheter-related Bloodstream Infections	Waller Clough	Completed
2009-2010	Clinical and Laboratory Features Predicting Abdominal Abscess in Patients with Post-Liver (OLT) Transplant Fluid Collections	Waller Eid Clough	Completed
2008-2010	A Comparative Study of Incidence and Spectrum of Infections in Patients with Chronic Graft Versus Host Disease (GVHD) before, during, and after Extracorporeal Photopheresis (ECP).	BMT Ganguly, N. Clough	Completed
2007-2009	Routine Use of a Whole Blood Interferon-γ Assay for the Diagnosis of Mycobacterium Tuberculosis at a Tertiary-Care University-Affiliated Hospital.	Clough Hammoud	Completed
2007-2009	A Retrospective Review of Candida Bloodstream Infection in a Tertiary Medical Center. Time to Initiation of Appropriate Antifungal Therapy and its Association with Outcome.	Clough	Completed

Basic Science Device Development
	Title	PI/Sub	Status
2011-present	Development of Novel Medical Device Removal System	Waller	Data Collection Underway
2010-present	Development of Medication Delivery Device	Waller	Data Collection Underway

Basic Science Infection Prevention
	Title	PI/Sub	Status
2011-present	Prevention of Early Wound Infection	Waller Clough Newman	Data Analysis Underway

Last modified: Oct 02, 2012

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