I have had 25 years experience with yeast cell envelopes. Subject matter has included both industrial and pathogenic yeasts, as well as the yeast-like organisms which cause secondary infections in patients with compromised immune systems. The latter group of microorganisms includes many dimorphic species which are of extreme importance in terms of morbidity and mortality for HIV-infected patients. The long-term goal of my research is to understand critical aspects of biochemistry, biophysics, and ultrastructure within these pathogens (grown in pure culture) and to find chemical ways of selective interference - in short, to propose better avenues of potential therapy for these infections.
I also have a secondary interest in History of Medicine, which has yielded popular publications in Scientific American, British Medical Journal, Journal of the American Medical Association, and a widely praised book on the underlying illness of Vincent van Gogh.
Another presentation on Chopin's Illness was prepared under the auspices of the American Chemical Society - Kansas City Section.
Dr. Arnold's research has been adapted into two interactive medical teaching units which may be found here. An article on his research, and these teaching units, was featured in a recent KUMC Highlight .
Arnold, W.N. (1992) Vincent van Gogh: Chemicals, Crises, and Creativity. pp 332, Birkhäuser; Boston, Basel, Berlin. Also as German edition: Arnold, W.N. Vincent van Gogh: Ein Leben zwischen Kreativität and Krankheit. pp 371, Birkhäuser Verlag; Basel, Boston, Berlin.
Loftus, L.S. and Arnold, W.N. (1991) Vincent van Gogh's illness: acute intermittent porphyria? Brit. Med. J. 303, 1589-1591.
Arnold, W.N. (1990) The periplasmic space. In: The Yeasts, 2nd edition, Rose, A.H. and Harrison, J.S. (eds.), Academic Press, New York and London, Vol. 4, Chap. 6, pp 279-295.
Arnold, W.N. (1988) Vincent van Gogh and the thujone connection. J. Amer. Med. Assoc. 260, 3042-3044.
Arnold, W.N. (editor) (1981) Yeast Cell Envelopes: Biochemistry, Biophysics, and Ultrastructure. Vol. I and II, CRC Press, Boca Raton, Flordia.
Arnold, W.N., Pringle, A.T. and Garrison, R.G. (1980) Amphotericin B induced changes in K+ content, viability, and ultrastructure of yeast phase Histoplasma capsulatum. J. Bacteriol. 141, 350-358.
Arnold, W.N. and Garrison, R.G. (1979) An Fe3+-activated acid phosphatase in Saccharomyces rouxii. J. Biol. Chem. 254, 4919-4924.
Arnold, W.N. and Lacy, J.S. (1977) Permeability of the cell envelope and osmotic behavior in Saccharomyces cerevisiae. J. Bacteriol. 131, 564-571.
Arnold, W.N. (1972) The structure of the yeast cell wall: solubilization of a marker enzyme fructofuranosidase by the autolytic enzyme system. J. Biol. Chem. 247, 1161-1169.
Arnold, W.N. (1968) The selection of sucrose as the translocate of higher plants. J. Theoret. Biol. 21, 13-20.