Guoqin Yu, Ph.D.
Assistant Professor, Department of Biostatistics & Data Science
B.S., Biology & Computer Science, Zhejiang University, Hangzhou China
M.S., Genetics, Zhejiang University, Hangzhou China
Ph.D., Evolution, Ecology and Population Genetics, Washington University, St. Louis, MO
2016 - NIH Fellows Award for Research Excellence (FARE), NIH, Bethesda, MD
2016 - NIH Summer Research Mentor Award, NIH, Bethesda, MD
2015 - DCEG Fellows Award for Research Excellence (DFARE), NIH, Bethesda, MD
2009 - Travel Award for National Graduate Student Research Festival, NIH, Bethesda, MD
2009 - Graduate Studies Travel Award, Washington University, St. Louis, MO
Microbiome, Molecular Cancer Epidemiology, Genomics, Bioinformatics, high-dimensional data, statistical genomics, clustering and classification, and DNA repair
My research focus on how the human microbiome influences on cancer development and progression, towards manipulating the human microbiome for cancer prevention and treatment (Figure 1). I perform cutting-edge research that integrates microbiome, genomics, and cancer epidemiology by using both experimental (mainly sequencing-based) and bioinformatic techniques. I have been studying on how microbiome affect cancer risk factors (e. g. smoking) and how microbiome affect cancer development, progression and treatment by integrative analysis of omics, epidemiological and clinical data. I collaborate closely with clinicians for human fecal, oral or tissue samples. I built a lab for microbiome and other sequencing-based assay.
Web-coverage of the research
Twitter ID: @guoqinyu
2018 (current) - American Cancer Society Institutional Research Grant, KUMC ($35,000)
2015 (completed) - NCI Director's Intramural Innovation Award, Career Development Grant ($10,000)
2013 (completed) - NCI Director's Intramural Innovation Award, Career Development Grant ($10,000)
2012 (completed) - DCEG Director's Reserve Funds ($20,364)
2012 (completed) - DCEG Director's Reserve Funds ($36,970)
1. Yu G, Hu N, Humphry M, Wang L, Wang C, Ding T, Ravel J, Taylor PR, Abnet CC, Goldstein AM. 2017. Gastric microbiota associates with gastric risk factors and tumor grade: a pilot study in gastric cancer patients from Shanxi, China. International Journal of Cancer; 141(1):45-51.
2. Yu G*, Philips S, Gail MH, Goedert JJ, Humphry M, Ravel J, Ren Y, Caporaso N. Evaluation of buccal cell samples for investigation of the oral microbiota. Cancer Epidemiology, Biomarkers & Prevention, 2017; 26(2):249-253.
3. Yu G, Philips S, Gail MH, Goedert JJ, Humphry M, Ravel J, Ren Y, Caporaso N. 2017. The effect of cigarette smoking on the oral and nasal microbiota. Microbiome; 5:3.
4. Yu G, Gail MH, Consonni D, Carugno M, Humphrys M, Pesatori AC, Caporaso NE, Goedert JJ, Ravel J, Landi MT. 2016. Characterizing human lung tissue microbiota and its relationship to epidemiological and clinical features. Genome Biology; 17(1):163.
5. Yu G, Philips S, Gail MH, Goedert JJ, Humphry M, Ravel J, Ren Y, Caporaso N. 2016. Evaluation of buccal cell samples for investigation of the oral microbiota. Cancer Epidemiology, Biomarkers & Prevention; cebp.0538.
6. Flores R, Shi J, Yu G, Ravel J, Goedert JJ, Sinha R. 2015. Effect of media and delayed freezing on microbial composition and diversity in human feces: lessons for epidemiological studies. Microbiome; 12;3:33
7. Goedert JJ, Gong YM, Hua X, Zhong H, He Y, Peng P, Yu G, Wang W, Ravel J, Shi J, Zheng Y. 2015. Fecal microbiota characteristics of patients with colorectal adenoma detected by screening, a population-based study, EBioMedicine; 2(6): 597-603.
8. Goedert, JJ, Jones G, Hua X, Xu, X, Yu G, Flores R, Falk RT, Gail MH, Shi J, Ravel J, Feigelson HS. 2015. Investigation of the association between the fecal microbiota and breast cancer in postmenopausal women: A population-based case-control pilot study. Journal of National Cancer Institute; 107(8).
9. Yu G*, Dye BA, Gail MH, Shi J, Klepac-Ceraj V, Paster BJ, Wang G, Wei W, Fan J, Qiao Y, Dawsey SM, Freedman ND, Abnet, CC. 2014. Association between upper digestive tract microbiota and oral health. MBC, public health; 14:1110.
10. Yu G, Fadrosh D, Ma B, Ravel J, Goedert JJ. 2014. Anal microbiota profiles in HIV-positive and HIV-negative MSM. AIDS; 28(5):753-60.
11. Yu G*, Gail MH, Shi J, Klepac-Ceraj V, Dye BA, Paster BJ, Wang G, Wei W, Fan J, Qiao Y, Dawsey SM, Freedman ND, Abnet, CC. 2014. Association between upper digestive tract microbiota and two precancerous conditions in upper digestive tract. Cancer Epidemiology, Biomarkers & Prevention; 23(5):735-41.
12. Cozen W, Yu G*, Gail MH, Ridaura VK, Nathwani BN, Hwang AE, Hamilton AS, Mack TM, Gordon JI, Goedert JJ. 2013. Fecal microbiota diversity in survivors of adolescent/young adult Hodgkin lymphoma: a study of twins. British Journal of Cancer; 108:1163-1167.
13. Yu G*, Murphy G, Michel A, Weinstein SJ, Mannisto S, Albanes D, Pawlita M, Stolzenberg-Solomon RZ. 2013. Seropositivity to helicobacter pylori and risk of pancreatic cancer. Cancer Epidemiology, Biomarkers & Prevention; 22:2416-2419.
14. Yu G*, Stoltzfus A, 2012. Population diversity of ORFan genes in Escherichia coli. Genome Biology and Evolution; 4(11):1176-1187.
15. Yu G*, Olsen KM, Schaal BA. 2011. Association between nonsynonymous mutations of starch synthase lla and starch quality in rice (Oryza sativa). New Phytologist; 189:593-601.
16. Yu G*, Olsen KM, Schaal BA. 2011. Molecular evolution of the endosperm starch synthesis pathway genes in rice (Oryza sativa L.) and its wild ancestor, O. rufipogon L. Molecular Biology & Evolution; 28:659-671.