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Robert Simari, MD

Professor of Medicine
Executive Vice Chancellor
Medical School, University of Kansas School of Medicine, Kansas city, Kansas
Residency, Beth Israel Hospital, Harvard Medical School, Boston, MA
Fellowship, Mayo Graduate School of Medicine, Mayo Clinic College of Medicine(Cardiology and Interventional Cardiology),Rochester, Minnesota
Postdoctoral Fellowship,University of Michigan(Laboratory of Elizabeth G. Nabel, M.D.), MI


 Professional highlights

  • Member, American Society of Clinical Investigation
  • Chair, Cardiovascular Cell Therapy Research Network
  • Editorial Board, Arteriosclerosis, Thrombosis and Vascular Biology
  • Editorial Board, Texas Heart Institute Journal
  • Charter Member, Vascular Cell Molecular Biology Study Section, National Institutes of Health (NIH), 2005-2009

 Interests

  • Atherosclerosis
  • Cardiovascular cell therapy
  • Vascular biology
  • Molecular medicine/cardiovascular research
  • Angiogenesis
  • Thrombosis

Research Activities

Long-term research aim:

  • Develop novel biological therapies for cardiovascular disease through enhanced understanding of the molecular basis of vascular disease

Mid-term research aims:

  • Better define the coordinated regulation of thrombosis and angiogenesis
  • Define the phenotype and function of progenitor cells in the adult vasculature
  • Develop novel biologic approaches to generation of prosthetic heart valves
  • Perform early (first-in-man or phase I) clinical trials of novel therapies for cardiovascular disease

Focus areas

  • Vascular hematopoietic progenitor cells. The lab's recent discovery of a population of hematopoietic progenitor cells in adult aortas suggests that vascular leukocytes may come from local sources, not bone marrow sources (Psaltis et al, Circulation, 2012). These findings may lead to a new understanding of vascular disease.
  • Biologic heart valves. The lab has recently extended its work in the area of biologic therapies to include the development of biologic heart valves. Dr. Simari's group is pursuing development of decellularized valves as scaffolds for autologous progenitor cells.
  • Cardiovascular Cell Therapy Research Network. Dr. Simari has the honor of chairing the Cardiovascular Cell Therapy Research Network, which is sponsored by the National Heart, Lung, and Blood Institute. The network performs early phase I and II trials of cell-based therapies for heart disease. It has completed three trials for acute and chronic left ventricular dysfunction and is currently pursuing studies in novel cardiovascular populations.
  • B-type natriuretic peptide (BNP). Dr. Simari's lab has identified a novel alternative splice variant of BNP (Pan et al, Proceedings of the National Academy of Sciences, 2009) and generated a biodesigned peptide that is currently being tested in phase I clinical trials. 

Publications 

  • Perin EC, Murphy MP, March KL, Bolli R, Loughran J, Yang PC, Leeper NJ, Dalman RL, Alexander J, Henry TD, Traverse JH, Pepine CJ, Anderson RD, Berceli S,Willerson JT, Muthupillai R, Gahremanpour A, Raveendran G, Velasquez O, Hare JM, Hernandez Schulman I, Kasi VS, Hiatt WR, Ambale-Venkatesh B, Lima JA, Taylor DA, Resende M, Gee AP, Durett AG, Bloom J, Richman S, G'Sell P, Williams S, Khan F,Gyang Ross E, Santoso MR, Goldman J, Leach D, Handberg E, Cheong B, Piece N,DiFede D, Bruhn-Ding B, Caldwell E, Bettencourt J, Lai D, Piller L, Simpson L,Cohen M, Sayre SL, Vojvodic RW, Moyé L, Ebert RF, Simari RD, Hirsch AT;Cardiovascular Cell Therapy Research Network (CCTRN).. Evaluation of Cell Therapy on Exercise Performance and Limb Perfusion in Peripheral Artery Disease: The CCTRN PACE Trial (Patients With Intermittent Claudication Injected With ALDH Bright Cells). Circulation. 2017 Apr 11;135(15):1417-1428. doi:10.1161/CIRCULATIONAHA.116.025707. Epub 2017 Feb 16. PubMed PMID: 28209728;PubMed Central PMCID: PMC5388585.
  • Bhatnagar A, Bolli R, Johnstone BH, Traverse JH, Henry TD, Pepine CJ,Willerson JT, Perin EC, Ellis SG, Zhao DX, Yang PC, Cooke JP, Schutt RC,Trachtenberg BH, Orozco A, Resende M, Ebert RF, Sayre SL, Simari RD, Moyé L,Cogle CR, Taylor DA; Cardiovascular Cell Therapy Research Network (CCTRN).. Bone marrow cell characteristics associated with patient profile and cardiac performance outcomes in the LateTIME-Cardiovascular Cell Therapy Research Network (CCTRN) trial. Am Heart J. 2016 Sep;179:142-50. doi: 10.1016/j.ahj.2016.06.018.Epub 2016 Jul 6. PubMed PMID: 27595689; PubMed Central PMCID: PMC5014395.
  • Gyöngyösi M, Wojakowski W, Navarese EP, Moye LÀ; ACCRUE Investigators(Simari RD).Meta-Analyses of Human Cell-Based Cardiac Regeneration Therapies: Controversies in Meta-Analyses Results on Cardiac Cell-Based Regenerative Studies. Circ Res.2016 Apr 15;118(8):1254-63. doi: 10.1161/CIRCRESAHA.115.307347. PubMed PMID:27081108; PubMed Central PMCID: PMC4834852.
  • Golpanian S, Schulman IH, Ebert RF, Heldman AW, DiFede DL, Yang PC, Wu JC,Bolli R, Perin EC, Moyé L, Simari RD, Wolf A, Hare JM; Cardiovascular Cell Therapy Research Network.. Concise Review: Review and Perspective of Cell Dosage and Routes of Administration From Preclinical and Clinical Studies of Stem Cell Therapy for Heart Disease. Stem Cells Transl Med. 2016 Feb;5(2):186-91. doi:10.5966/sctm.2015-0101. Epub 2015 Dec 18. Review. PubMed PMID: 26683870; PubMed Central PMCID: PMC4729551.
  • Taylor DA, Perin EC, Willerson JT, Zierold C, Resende M, Carlson M, Nestor B, Wise E, Orozco A, Pepine CJ, Henry TD, Ellis SG, Zhao DX, Traverse JH, Cooke JP, Schutt RC, Bhatnagar A, Grant MB, Lai D, Johnstone BH, Sayre SL, Moyé L, Ebert RF, Bolli R, Simari RD, Cogle CR; Cardiovascular Cell Therapy Research Network (CCTRN).. Identification of Bone Marrow Cell Subpopulations Associated With Improved Functional Outcomes in Patients With Chronic Left Ventricular Dysfunction: An Embedded Cohort Evaluation of the FOCUS-CCTRN Trial. Cell Transplant. 2016;25(9):1675-1687. Epub 2015 Nov 19. PubMed PMID: 26590374; PubMed Central PMCID: PMC5088500.
  • Helder MR, Hennessy RS, Spoon DB, Tefft BJ, Witt TA, Marler RJ, Pislaru SV,Simari RD, Stulak JM, Lerman A. Low-Dose Gamma Irradiation of Decellularized Heart Valves Results in Tissue Injury In Vitro and In Vivo. Ann Thorac Surg. 2016 Feb;101(2):667-74. doi: 10.1016/j.athoracsur.2015.07.080. Epub 2015 Oct 9. PubMed PMID: 26453425; PubMed Central PMCID: PMC5341747.
  • Jana S, Lerman A, Simari RD. An In Vitro Model of a Fibrosa Layer of a Heart Valve. ACS Appl Mater Interfaces. 2015 Aug 21. [Epub ahead of print] PubMed PMID:26295833.
  • Psaltis PJ, Simari RD. Vascular Wall Progenitor Cells in Health and Disease. Circ Res. 2015 Apr 10;116(8):1392-1412. Review. PubMed PMID: 25858065.
  • Collin J, Gössl M, Matsuo Y, Cilluffo RR, Flammer AJ, Loeffler D, Lennon RJ,Simari RD, Spoon DB, Erbel R, Lerman LO, Khosla S, Lerman A. Osteogenic monocytes within the coronary circulation and their association with plaque vulnerability in patients with early atherosclerosis. Int J Cardiol. 2014 Nov 26;181C:57-64.doi: 10.1016/j.ijcard.2014.11.156. [Epub ahead of print] PubMed PMID: 25482280.
  • Jana S, Simari RD, Spoon DB, Lerman A. Drug delivery in aortic valve tissue engineering. J Control Release. 2014 Oct 22;196C:307-323. doi:10.1016/j.jconrel.2014.10.009. [Epub ahead of print] Review. PubMed PMID:25459428.
  • Pan S, Chen HH, Correia C, Dai H, Witt TA, Kleppe LS, Burnett JC Jr, Simari RD. Cell surface protein disulfide isomerase regulates natriuretic Peptide generation of cyclic guanosine monophosphate. PLoS One. 2014 Nov 24;9(11):e112986. doi: 10.1371/journal.pone.0112986. eCollection 2014. PubMed PMID: 25419565; PubMed Central PMCID: PMC4242536.
  • Schutt RC, Trachtenberg B, Cooke JP, Traverse JH, Henry TD, Pepine CJ, Willerson JT, Perin EC, Ellis SG, Zhao D, Bhatnagar A, Johnstone BH, Lai D,Resende M, Ebert RF, Wu JC, Sayre SL, Orozco A, Zierold C, Simari RD, Moyé L,Cogle CR, Taylor D. Bone Marrow Characteristics Associated with Changes in Infarct Size after STEMI: A Biorepository Evaluation from the CCTRN TIME Trial.
    Circ Res. 2014 Nov 18. pii: CIRCRESAHA.114.304710. [Epub ahead of print] PubMed PMID: 25406300.
  • Simonetto DA, Yang HY, Yin M, deAssuncao TM, Kwon JH, Hilsher M, Pan S, Yang L, Bi Y, Beyder A, Cao S, Simari RD, Ehman R, Kamath PS, Shah VH. Chronic passive venous congestion drives hepatic fibrogenesis via sinusoidal thrombosis and mechanical forces. Hepatology. 2014 Aug 20. doi: 10.1002/hep.27387. [Epub ahead of print] PubMed PMID: 25142214.
  • Cogle CR, Wise E, Meacham AM, Zierold C, Traverse JH, Henry TD, Perin EC, Willerson JT, Ellis SG, Carlson MA, Zhao D, Bolli R, Cooke JP, Anwaruddin S, Bhatnagar A, Cabreira-Graca M, Grant MB, Lai D, Moyé L, Ebert RF, Olson RE, Sayre SL, Schulman IH, Scott EW, Simari RD, Pepine CJ, Taylor D. A Detailed Analysis of Bone Marrow from Patients with Ischemic Heart Disease and Left Ventricular Dysfunction: BM CD34, CD11b and Clonogenic Capacity as Biomarkers for Clinical Outcomes. Circ Res. 2014 Aug 18. pii: CIRCRESAHA.114.304353. [Epub ahead of print] PubMed PMID: 25136078.
  • Psaltis PJ, Puranik AS, Spoon DB, Chue CD, Hoffman SJ, Witt TA, Delacroix S, Kleppe LS, Mueske CS, Pan S, Gulati R, Simari RD. Characterization of a resident population of adventitial macrophage progenitor cells in postnatal vasculature.Circ Res. 2014 Jul 18;115(3):364-75. doi: 0.1161/CIRCRESAHA.115.303299. Epub 2014 Jun 6. PubMed PMID: 24906644.
  • Simari RD, Pepine CJ, Traverse JH, Henry TD, Bolli R, Spoon DB, Yeh E, Hare JM, Schulman IH, Anderson RD, Lambert C, Sayre SL, Taylor DA, Ebert RF, Moyé LA. Bone marrow mononuclear cell therapy for acute myocardial infarction: a perspective from the cardiovascular cell therapy research network. Circ Res. 2014 May 9;114(10):1564-8. doi: 10.1161/CIRCRESAHA.114.303720. Review. PubMed PMID:24812350.
  • Jana S, Tefft BJ, Spoon DB, Simari RD. Scaffolds for tissue engineering of cardiac valves. Acta Biomater. 2014 Jul;10(7):2877-93. doi:10.1016/j.actbio.2014.03.014. Epub 2014 Mar 24. PubMed PMID: 24675108.
  • Spoon DB, Psaltis PJ, Singh M, Holmes DR Jr, Gersh BJ, Rihal CS, Lennon RJ,Moussa ID, Simari RD, Gulati R. Trends in cause of death after percutaneous coronary intervention. Circulation. 2014 Mar 25;129(12):1286-94. doi:10.1161/CIRCULATIONAHA.113.006518. Epub 2014 Feb 10. PubMed PMID: 24515993.
  • Delewi R, Hirsch A, Tijssen JG, Schächinger V, Wojakowski W, Roncalli J,Aakhus S, Erbs S, Assmus B, Tendera M, Goekmen Turan R, Corti R, Henry T,Lemarchand P, Lunde K, Cao F, Huikuri HV, Sürder D, Simari RD, Janssens S,Wollert KC, Plewka M, Grajek S, Traverse JH, Zijlstra F, Piek JJ. Impact of intracoronary bone marrow cell therapy on left ventricular function in the setting of ST-segment elevation myocardial infarction: a collaborative meta-analysis. Eur Heart J. 2014 Apr;35(15):989-98. doi:10.1093/eurheartj/eht372. Epub 2013 Sep 11. PubMed PMID: 24026778.
  • Psaltis PJ, Peterson KM, Xu R, Franchi F, Witt T, Chen IY, Lerman A, Simari RD, Gambhir SS, Rodriguez-Porcel M. Noninvasive monitoring of oxidative stress in transplanted mesenchymal stromal cells. JACC Cardiovasc Imaging. 2013 Jul;6(7):795-802. doi: 10.1016/j.jcmg.2012.11.018. Epub 2013 May 1. PubMed PMID: 23643284; PubMed Central PMCID: PMC3710523.
  • Hare JM, Bolli R, Cooke JP, Gordon DJ, Henry TD, Perin EC, March KL, Murphy MP, Pepine CJ, Simari RD, Skarlatos SI, Traverse JH, Willerson JT, Szady AD, Taylor DA, Vojvodic RW, Yang PC, Moyé LA; Cardiovascular Cell Therapy Research Network. Phase II clinical research design in cardiology: learning the right lessons too well: observations and recommendations from the Cardiovascular Cell Therapy Research Network (CCTRN). Circulation. 2013 Apr 16;127(15):1630-5. doi:10.1161/CIRCULATIONAHA.112.000779. PubMed PMID: 23588961; PubMed Central PMCID:PMC3967793.
  • Moyé LA, Simari RD, Skarlatos SI; Cardiovascular Cell Therapy Research Network (CCTRN). Bone marrow-derived cell therapy after myocardial infarction. JAMA. 2013 Apr 10;309(14):1459. doi: 10.1001/jama.2013.2601. PubMed PMID:23571574.
  • Eirin A, Zhu XY, Li Z, Ebrahimi B, Zhang X, Tang H, Korsmo MJ, Chade AR,Grande JP, Ward CJ, Simari RD, Lerman A, Textor SC, Lerman LO. Endothelial outgrowth cells shift macrophage phenotype and improve kidney viability in swine renal artery stenosis. Arterioscler Thromb Vasc Biol. 2013 May;33(5):1006-13. doi: 10.1161/ATVBAHA.113.301164. Epub 2013 Feb 21. PubMed PMID: 23430615; PubMed Central PMCID: PMC3644980.
  • Wang D, Warner GM, Yin P, Knudsen BE, Cheng J, Butters KA, Lien KR, Gray CE, Garovic VD, Lerman LO, Textor SC, Nath KA, Simari RD, Grande JP. Inhibition of p38 MAPK attenuates renal atrophy and fibrosis in a murine renal artery stenosis model. Am J Physiol Renal Physiol. 2013 Apr 1;304(7):F938-47. doi:10.1152/ajprenal.00706.2012. Epub 2013 Jan 30. PubMed PMID: 23364805; PubMed Central PMCID: PMC3625852.
  • Traverse JH, Henry TD, Pepine CJ, Willerson JT, Zhao DX, Ellis SG, Forder JR,Anderson RD, Hatzopoulos AK, Penn MS, Perin EC, Chambers J, Baran KW, Raveendran G, Lambert C, Lerman A, Simon DI, Vaughan DE, Lai D, Gee AP, Taylor DA, Cogle CR, Thomas JD, Olson RE, Bowman S, Francescon J, Geither C, Handberg E, Kappenman C, Westbrook L, Piller LB, Simpson LM, Baraniuk S, Loghin C, Aguilar D, Richman S, Zierold C, Spoon DB, Bettencourt J, Sayre SL, Vojvodic RW, Skarlatos SI, Gordon DJ, Ebert RF, Kwak M, Moyé LA, Simari RD; Cardiovascular Cell Therapy Research Network (CCTRN). Effect of the use and timing of bone marrow mononuclear cell delivery on left ventricular function after acute myocardial infarction: the TIME randomized trial. JAMA. 2012 Dec 12;308(22):2380-9. Erratum in: JAMA. 2013 Jan 23;309(4):343. PubMed PMID: 23129008; PubMed Central PMCID: PMC3652242.
  • Hoffman SJ, Psaltis PJ, Clark KJ, Spoon DB, Chue CD, Ekker SC, Simari RD. An in vivo method to quantify lymphangiogenesis in zebrafish. PLoS One.2012;7(9):e45240. doi: 10.1371/journal.pone.0045240. Epub 2012 Sep 13. PubMed PMID: 23028871; PubMed Central PMCID: PMC3441694.
  • Flammer AJ, Gössl M, Li J, Matsuo Y, Reriani M, Loeffler D, Simari RD, Lerman LO, Khosla S, Lerman A. Patients with an HbA1c in the prediabetic and diabetic range have higher numbers of circulating cells with osteogenic and endothelial progenitor cell markers. J Clin Endocrinol Metab. 2012 Dec;97(12):4761-8. doi: 10.1210/jc.2012-2642. Epub 2012 Sep 26. PubMed PMID: 23015657; PubMed Central PMCID: PMC3513527.
  • Cullen EL, Breen JF, Rihal CS, Simari RD, Ammash NM. Levoatriocardinal vein with partial anomalous venous return and a bidirectional shunt. Circulation. 2012 Sep 18;126(12):e174-7. doi: 10.1161/CIRCULATIONAHA.111.085555. PubMed PMID:22988048.
  • Flammer AJ, Gössl M, Widmer RJ, Reriani M, Lennon R, Loeffler D, Shonyo S,Simari RD, Lerman LO, Khosla S, Lerman A. Osteocalcin positive CD133+/CD34-/KDR+ progenitor cells as an independent marker for unstable atherosclerosis. Eur Heart J. 2012 Dec;33(23):2963-9. doi: 0.1093/eurheartj/ehs234. Epub 2012 Jul 31.PubMed PMID: 22855739; PubMed Central PMCID: PMC3511794.
  • Tweet MS, Hayes SN, Pitta SR, Simari RD, Lerman A, Lennon RJ, Gersh BJ,Khambatta S, Best PJ, Rihal CS, Gulati R. Clinical features, management, and prognosis of spontaneous coronary artery dissection. Circulation. 2012 Jul 31;126(5):579-88. doi: 10.1161/CIRCULATIONAHA.112.105718. Epub 2012 Jul 16. PubMed PMID: 22800851.
  • Rodriguez-Porcel M, Kronenberg MW, Henry TD, Traverse JH, Pepine CJ, Ellis SG, Willerson JT, Moyé LA, Simari RD. Cell tracking and the development of cell-based therapies: a view from the Cardiovascular Cell Therapy Research Network. JACC Cardiovasc Imaging. 2012 May;5(5):559-65. doi:10.1016/j.jcmg.2011.12.018. Review. PubMed PMID: 22595165; PubMed Central PMCID: PMC3632261.
  • Perin EC, Willerson JT, Pepine CJ, Henry TD, Ellis SG, Zhao DX, Silva GV, Lai D, Thomas JD, Kronenberg MW, Martin AD, Anderson RD, Traverse JH, Penn MS,Anwaruddin S, Hatzopoulos AK, Gee AP, Taylor DA, Cogle CR, Smith D, Westbrook L, Chen J, Handberg E, Olson RE, Geither C, Bowman S, Francescon J, Baraniuk S,Piller LB, Simpson LM, Loghin C, Aguilar D, Richman S, Zierold C, Bettencourt J,Sayre SL, Vojvodic RW, Skarlatos SI, Gordon DJ, Ebert RF, Kwak M, Moyé LA, Simari RD; Cardiovascular Cell Therapy Research Network (CCTRN). Effect of transendocardial delivery of autologous bone marrow mononuclear cells on functional capacity, left ventricular function, and perfusion in chronic heart failure: the FOCUS-CCTRN trial. JAMA. 2012 Apr 25;307(16):1717-26. doi:10.1001/jama.2012.418. Epub 2012 Mar 24. PubMed PMID: 22447880; PubMed Central PMCID: PMC3600947.
  • Richman S, Gee AP, McKenna DH, Traverse JH, Henry TD, Fisk D, Pepine CJ,Bloom J, Willerson JT, Prater K, Zhao D, Koç JR, Anwaruddin S, Taylor DA, Cogle CR, Moyé LA, Simari RD, Skarlatos SI. Factors affecting the turnaround time for manufacturing, testing, and release of cellular therapy products prepared at multiple sites in support of multicenter cardiovascular regenerative medicine protocols: a Cardiovascular Cell Therapy Research Network (CCTRN) study. Transfusion. 2012 Oct;52(10):2225-33. doi: 10.1111/j.1537-2995.2011.03543.x. Epub 2012 Feb 10. PubMed PMID: 22320233; PubMed Central PMCID: PMC3355200.
  • Holroyd EW, Delacroix S, Larsen K, Harbuzariu A, Psaltis PJ, Wang L, Pan S,White TA, Witt TA, Kleppe LS, Mueske CS, Mukhopadhyay D, Simari RD. Tissue factor pathway inhibitor blocks angiogenesis via its carboxyl terminus. Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):704-11. doi:10.1161/ATVBAHA.111.243733. Epub 2012 Jan 5. PubMed PMID: 22223730; PubMed Central PMCID: PMC3288894.
  • Psaltis PJ, Harbuzariu A, Delacroix S, Witt TA, Holroyd EW, Spoon DB, Hoffman SJ, Pan S, Kleppe LS, Mueske CS, Gulati R, Sandhu GS, Simari RD. Identification of a monocyte-predisposed hierarchy of hematopoietic progenitor cells in the adventitia of postnatal murine aorta. Circulation. 2012 Jan 31;125(4):592-603.doi: 10.1161/CIRCULATIONAHA.111.059360. Epub 2011 Dec 27. PubMed PMID: 22203692;PubMed Central PMCID: PMC3270202.
  • Holroyd EW, White TA, Pan S, Simari RD. Tissue factor pathway inhibitor as a multifunctional mediator of vascular structure. Front Biosci (Elite Ed). 2012 Jan 1;4:392-400. Review. PubMed PMID: 22201881; PubMed Central PMCID: PMC3904648.
  • Delacroix S, Simari RD. Tissue factor-thrombin-PAR-1 pathway: a novel link between bone marrow and blood vessel. Arterioscler Thromb Vasc Biol. 2012 Jan;32(1):3-4. doi: 10.1161/ATVBAHA.111.240507. PubMed PMID: 22173975.
  • Traverse JH, Henry TD, Ellis SG, Pepine CJ, Willerson JT, Zhao DX, Forder JR,Byrne BJ, Hatzopoulos AK, Penn MS, Perin EC, Baran KW, Chambers J, Lambert C,Raveendran G, Simon DI, Vaughan DE, Simpson LM, Gee AP, Taylor DA, Cogle CR,Thomas JD, Silva GV, Jorgenson BC, Olson RE, Bowman S, Francescon J, Geither C,Handberg E, Smith DX, Baraniuk S, Piller LB, Loghin C, Aguilar D, Richman S,Zierold C, Bettencourt J, Sayre SL, Vojvodic RW, Skarlatos SI, Gordon DJ, Ebert RF, Kwak M, Moyé LA, Simari RD; Cardiovascular Cell Therapy ResearchNetwork.Effect of intracoronary delivery of autologous bone marrow mononuclear cells 2 to 3 weeks following acute myocardial infarction on left ventricular function: the LateTIME randomized trial. JAMA. 2011 Nov 16;306(19):2110-9. doi:10.1001/jama.2011.1670. Epub 2011 Nov 14. PubMed PMID: 22084195; PubMed Central PMCID: PMC3600981.
  • Psaltis PJ, Simari RD. Cell therapy for refractory angina: time for more ACTion. Stem Cell Res Ther. 2011 Nov 9;2(6):43. doi: 10.1186/scrt84. PubMed PMID:22070933; PubMed Central PMCID: PMC3340552.
  • McKie PM, Schirger JA, Costello-Boerrigter LC, Benike SL, Harstad LK, Bailey KR, Hodge DO, Redfield MM, Simari RD, Burnett JC Jr, Chen HH. Impaired natriuretic and renal endocrine response to acute volume expansion in pre-clinical systolic and diastolic dysfunction. J Am Coll Cardiol. 2011 Nov 8;58(20):2095-103. doi: 10.1016/j.jacc.2011.07.042. PubMed PMID: 22051332; PubMed Central PMCID: PMC3835631.
  • Psaltis PJ, Simari RD, Rodriguez-Porcel M. Emerging roles for integrated imaging modalities in cardiovascular cell-based therapeutics: a clinical perspective. Eur J Nucl Med Mol Imaging. 2012 Jan;39(1):165-81. doi:10.1007/s00259-011-1925-7. Epub 2011 Sep 8. Review. PubMed PMID: 21901381; PubMed Central PMCID: PMC3347473.
  • Moyé LA, Henry TD, Baran KW, Bettencourt J, Bruhn-Ding B, Caldwell E,Chambers J, Flood K, Francescon J, Bowman S, Kappenman C, Kar B, Lambert C,LaRock J, Lerman A, Mazzurco S, Prashad R, Raveendran G, Simon D, Westbrook L,Simari RD. Cell therapy and satellite centers: the Cardiovascular Cell Therapy Research Network experience. Contemp Clin Trials. 2011 Nov;32(6):841-7. doi:10.1016/j.cct.2011.07.001. Epub 2011 Jul 8. Review. PubMed PMID: 21767663; PubMed Central PMCID: PMC3202446.
  • Mohammed SF, Storlie JR, Oehler EA, Bowen LA, Korinek J, Lam CS, Simari RD,Burnett JC Jr, Redfield MM. Variable phenotype in murine transverse aortic constriction. Cardiovasc Pathol. 2012 May-Jun;21(3):188-98. doi:10.1016/j.carpath.2011.05.002. Epub 2011 Jul 18. PubMed PMID: 21764606; PubMed Central PMCID: PMC3412352. 
  • Ganesh SK, Joo J, Skelding K, Mehta L, Zheng G, O'Neill K, Billings EM,Helgadottir A, Andersen K, Thorgeirsson G, Gudnason T, Geller NL, Simari RD,Holmes DR, O'Neill WW, Nabel EG. Time course analysis of gene expression identifies multiple genes with differential expression in patients with in-stent  restenosis. BMC Med Genomics. 2011 Feb 28;4:20. doi: 10.1186/1755-8794-4-20.PubMed PMID: 21356094; PubMed Central PMCID: PMC3053213.
  • Psaltis PJ, Harbuzariu A, Delacroix S, Holroyd EW, Simari RD. Resident vascular progenitor cells--diverse origins, phenotype, and function. J Cardiovasc Transl Res. 2011 Apr;4(2):161-76. doi: 10.1007/s12265-010-9248-9. Epub 2010 Nov 30. Review. PubMed PMID: 21116882; PubMed Central PMCID: PMC3048921.
  • Traverse JH, Henry TD, Vaughan DE, Ellis SG, Pepine CJ, Willerson JT, Zhao DX, Simpson LM, Penn MS, Byrne BJ, Perin EC, Gee AP, Hatzopoulos AK, McKenna DH, Forder JR, Taylor DA, Cogle CR, Baraniuk S, Olson RE, Jorgenson BC, Sayre SL,Vojvodic RW, Gordon DJ, Skarlatos SI, Moyè LA, Simari RD; Cardiovascular Cell Therapy Research Network. LateTIME: a phase-II, randomized, double-blinded, placebo-controlled, pilot trial evaluating the safety and effect of administration of bone marrow mononuclear cells 2 to 3 weeks after acute myocardial infarction. Tex Heart Inst J. 2010;37(4):412-20. PubMed PMID:20844613; PubMed Central PMCID: PMC2929864.
  • Kiernan TJ, Boilson BA, Tesmer L, Harbuzariu A, Simari RD, Barsness GW.Effect of enhanced external counterpulsation on circulating CD34+ progenitor cell subsets. Int J Cardiol. 2011 Dec 1;153(2):202-6. doi:10.1016/j.ijcard.2010.08.020. Epub 2010 Sep 16. PubMed PMID: 20843569; PubMed Central PMCID: PMC3021100.
  • Willerson JT, Perin EC, Ellis SG, Pepine CJ, Henry TD, Zhao DX, Lai D, Penn MS, Byrne BJ, Silva G, Gee A, Traverse JH, Hatzopoulos AK, Forder JR, Martin D,Kronenberg M, Taylor DA, Cogle CR, Baraniuk S, Westbrook L, Sayre SL, Vojvodic RW, Gordon DJ, Skarlatos SI, Moyé LA, Simari RD; Cardiovascular Cell Therapy Research Network (CCTRN). Intramyocardial injection of autologous bone marrow mononuclear cells for patients with chronic ischemic heart disease and left ventricular dysfunction (First Mononuclear Cells injected in the US [FOCUS]):Rationale and design. Am Heart J. 2010 Aug;160(2):215-23. doi:10.1016/j.ahj.2010.03.029. PubMed PMID: 20691824; PubMed Central PMCID:PMC2921924.
  • Simari RD, Gulati R. Peripheral blood CD31+ cells for the treatment of ischemic vascular disease. J Am Coll Cardiol. 2010 Aug 10;56(7):608-9. doi:10.1016/j.jacc.2010.01.069. PubMed PMID: 20688216.
  • Mohammed SF, Ohtani T, Korinek J, Lam CS, Larsen K, Simari RD, Valencik ML,Burnett JC Jr, Redfield MM. Mineralocorticoid accelerates transition to heart failure with preserved ejection fraction via "nongenomic effects". Circulation.2010 Jul 27;122(4):370-8. doi: 10.1161/CIRCULATIONAHA.109.915215. Epub 2010 Jul 12. PubMed PMID: 20625113; PubMed Central PMCID: PMC2938025.
  • Boilson BA, Larsen K, Harbuzariu A, Delacroix S, Korinek J, Froehlich H,Bailey KR, Scott CG, Shapiro BP, Boerrigter G, Chen HH, Redfield MM, Burnett JC Jr, Simari RD. Regulation of circulating progenitor cells in left ventricular dysfunction. Circ Heart Fail. 2010 Sep;3(5):635-42. doi:10.1161/CIRCHEARTFAILURE.109.879437. Epub 2010 Jun 23. PubMed PMID: 20573992; PubMed Central PMCID: PMC3096994.
  • White TA, Johnson T, Zarzhevsky N, Tom C, Delacroix S, Holroyd EW, Maroney SA, Singh R, Pan S, Fay WP, van Deursen J, Mast AE, Sandhu GS, Simari RD.Endothelial-derived tissue factor pathway inhibitor regulates arterial thrombosis but is not required for development or hemostasis. Blood. 2010 Sep 9;116(10):1787-94. doi: 10.1182/blood-2009-10-250910. Epub 2010 Jun 1. PubMed PMID: 20516367; PubMed Central PMCID: PMC2947398.
  • Simari RD, Moyé LA, Skarlatos SI, Ellis SG, Zhao DX, Willerson JT, Henry TD, Pepine CJ. Development of a network to test strategies in cardiovascular cell delivery: the NHLBI-sponsored Cardiovascular Cell Therapy Research Network (CCTRN). J Cardiovasc Transl Res. 2010 Feb;3(1):30-6. doi:10.1007/s12265-009-9160-3. PubMed PMID: 20445812; PubMed Central PMCID:PMC2863075.
  • Correa de Sa DD, Hodge DO, Slusser JP, Redfield MM, Simari RD, Burnett JC,Chen HH. Progression of preclinical diastolic dysfunction to the development of symptoms. Heart. 2010 Apr;96(7):528-32. doi: 10.1136/hrt.2009.177980. PubMed PMID: 20350989; PubMed Central PMCID: PMC2977526.
  • Holroyd EW, Simari RD. Interdependent biological systems, multi-functional molecules: the evolving role of tissue factor pathway inhibitor beyond anti-coagulation. Thromb Res. 2010 Apr;125 Suppl 1:S57-9. doi:10.1016/j.thromres.2010.01.039. Epub 2010 Feb 24. Review. PubMed PMID: 20185167;PubMed Central PMCID: PMC2840704.
  • Holmes DR Jr, Hodgson PK, Simari RD, Nishimura RA. Mentoring: making the transition from mentee to mentor. Circulation. 2010 Jan 19;121(2):336-40. doi:10.1161/CIRCULATIONAHA.108.798321. PubMed PMID: 20083720.
  • Frye RL, Simari RD, Gersh BJ, Burnett JC, Brumm S, Myerle K, Jaffe AS, Holmes DR, Lerman A, Terzic A. Ethical issues in cardiovascular research involving humans. Circulation. 2009 Nov 24;120(21):2113-21. doi:10.1161/CIRCULATIONAHA.107.752766. Review. PubMed PMID: 19933950.
  • Gersh BJ, Simari RD, Behfar A, Terzic CM, Terzic A. Cardiac cell repair therapy: a clinical perspective. Mayo Clin Proc. 2009 Oct;84(10):876-92. doi:10.1016/S0025-6196(11)60505-3. Review. PubMed PMID: 19797777; PubMed Central PMCID: PMC2755807.
  • Holmes DR Jr, Hodgson PK, Nishimura RA, Simari RD. Manuscript preparation and publication. Circulation. 2009 Sep 8;120(10):906-13. doi:10.1161/CIRCULATIONAHA.107.752782. PubMed PMID: 19738151.
  • Pan S, White TA, Witt TA, Chiriac A, Mueske CS, Simari RD. Vascular-directed tissue factor pathway inhibitor overexpression regulates plasma cholesterol and reduces atherosclerotic plaque development. Circ Res. 2009 Sep 25;105(7):713-20,8 p following 720. doi: 10.1161/CIRCRESAHA.109.195016. Epub 2009 Aug 27. PubMed PMID: 19713537; PubMed Central PMCID: PMC2852138.
  • Traverse JH, Henry TD, Vaughan DE, Ellis SG, Pepine CJ, Willerson JT, Zhao DX, Piller LB, Penn MS, Byrne BJ, Perin EC, Gee AP, Hatzopoulos AK, McKenna DH,Forder JR, Taylor DA, Cogle CR, Olson RE, Jorgenson BC, Sayre SL, Vojvodic RW,Gordon DJ, Skarlatos SI, Moye' LA, Simari RD; Cardiovascular Cell Therapy Research Network (CCTRN). Rationale and design for TIME: A phase II, randomized, double-blind, placebo-controlled pilot trial evaluating the safety and effect of timing of administration of bone marrow mononuclear cells after acute myocardial infarction. Am Heart J. 2009 Sep;158(3):356-63. doi: 10.1016/j.ahj.2009.06.009.Epub 2009 Jul 23. Erratum in: Am Heart J. 2009 Dec;158(6):1045. Vaughn, Douglas E [corrected to Vaughan, Douglas E]. PubMed PMID: 19699857; PubMed Central PMCID:PMC2784639.
  • White TA, Witt TA, Pan S, Mueske CS, Kleppe LS, Holroyd EW, Champion HC,Simari RD. Tissue factor pathway inhibitor overexpression inhibits hypoxia-induced pulmonary hypertension. Am J Respir Cell Mol Biol. 2010 Jul;43(1):35-45. doi: 10.1165/rcmb.2009-0144OC. Epub 2009 Jul 31. PubMed PMID:19648471; PubMed Central PMCID: PMC2911569.
  • Kiernan TJ, Boilson BA, Witt TA, Dietz AB, Lerman A, Simari RD.Vasoprotective effects of human CD34+ cells: towards clinical applications. J Transl Med. 2009 Jul 29;7:66. doi: 10.1186/1479-5876-7-66. PubMed PMID: 19640275; PubMed Central PMCID: PMC2724497.
  • Pan S, Chen HH, Dickey DM, Boerrigter G, Lee C, Kleppe LS, Hall JL, Lerman A,Redfield MM, Potter LR, Burnett JC Jr, Simari RD. Biodesign of a renal-protective peptide based on alternative splicing of B-type natriuretic peptide. Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11282-7. doi: 10.1073/pnas.0811851106. Epub 2009 Jun 18. PubMed PMID: 19541613; PubMed Central PMCID: PMC2708694.
  • Chen HH, Martin FL, Gibbons RJ, Schirger JA, Wright RS, Schears RM, Redfield MM, Simari RD, Lerman A, Cataliotti A, Burnett JC Jr. Low-dose nesiritide in human anterior myocardial infarction suppresses aldosterone and preserves ventricular function and structure: a proof of concept study. Heart. 2009 Aug;95(16):1315-9. doi: 10.1136/hrt.2008.153916. Epub 2009 May 15. PubMed PMID:19447837; PubMed Central PMCID: PMC3835541.
  • Maroney SA, Ferrel JP, Pan S, White TA, Simari RD, McVey JH, Mast AE.Temporal expression of alternatively spliced forms of tissue factor pathway inhibitor in mice. J Thromb Haemost. 2009 Jul;7(7):1106-13. doi:10.1111/j.1538-7836.2009.03454.x. Epub 2009 Apr 24. PubMed PMID: 19422457; PubMed Central PMCID: PMC2776060.
  • White TA, Pan S, Witt TA, Simari RD. Murine strain differences in hemostasis and thrombosis and tissue factor pathway inhibitor. Thromb Res. 2010 Jan;125(1):84-9. doi: 10.1016/j.thromres.2009.03.006. Epub 2009 Apr 26. PubMed PMID: 19398123; PubMed Central PMCID: PMC2826594.
  • Froehlich H, Gulati R, Boilson B, Witt T, Harbuzariu A, Kleppe L, Dietz AB,Lerman A, Simari RD. Carotid repair using autologous adipose-derived endothelial cells. Stroke. 2009 May;40(5):1886-91. doi: 10.1161/STROKEAHA.108.539932. Epub 2009 Mar 12. PubMed PMID: 19286583; PubMed Central PMCID: PMC2674532.
  • Gulati R, Simari RD. Defining the potential for cell therapy for vascular disease using animal models. Dis Model Mech. 2009 Mar-Apr;2(3-4):130-7. doi:10.1242/dmm.000562. Review. PubMed PMID: 19259386; PubMed Central PMCID: PMC2650189.
  • Kiernan TJ, Boilson BA, Sandhu GS, Lennon RJ, Roger VL, Barsness GW, Lerman A, Rihal CS, Simari RD. Nonrevascularizable coronary artery disease following coronary artery bypass graft surgery: a population-based study in Olmsted County, Minnesota. Coron Artery Dis. 2009 Mar;20(2):106-11. doi:10.1097/MCA.0b013e3283239819. PubMed PMID: 19225399; PubMed Central PMCID:PMC2729703.
  • Chade AR, Zhu X, Lavi R, Krier JD, Pislaru S, Simari RD, Napoli C, Lerman A, Lerman LO. Endothelial progenitor cells restore renal function in chronic experimental renovascular disease. Circulation. 2009 Feb 3;119(4):547-57. doi:10.1161/CIRCULATIONAHA.108.788653. Epub 2009 Jan 19. PubMed PMID: 19153272;PubMed Central PMCID: PMC2758066.
  • Simari RD, Chen H, Burnett JC Jr. The FDA and the new biology. J Cardiovasc Transl Res. 2008 Dec;1(4):246-7. doi: 10.1007/s12265-008-9060-y. Epub 2008 Sep 23. PubMed PMID: 20559929.
  • Gersh BJ, Simari RD. Cardiac stem cell repair therapy: a clinical perspective. Indian Heart J. 2006 Jul-Aug;58(4):308-14. Review. PubMed PMID:19039146.
  • Boilson BA, Kiernan TJ, Harbuzariu A, Nelson RE, Lerman A, Simari RD. Circulating CD34+ cell subsets in patients with coronary endothelial dysfunction. Nat Clin Pract Cardiovasc Med. 2008 Aug;5(8):489-96. doi: 10.1038/ncpcardio1277. Epub 2008 Jun 24. PubMed PMID: 18578002; PubMed Central PMCID: PMC2518072.
  • Akyürek LM, San H, Nabel EG, Singh R, Simari RD. Gene transfer to arteries.Curr Protoc Hum Genet. 2002 Feb;Chapter 13:Unit13.1. doi:10.1002/0471142905.hg1301s31. PubMed PMID: 18428325.
  • Satran D, Traverse JH, Barsness GW, Lerman A, Simari RD, Poulose AK, Johnson RK, Henry TD. Emerging therapies for refractory angina. Minn Med. 2008 Jan;91(1):36-9. PubMed PMID: 18269067.
  • Gulati R, Simari RD. Cell therapy for acute myocardial infarction. Med Clin North Am. 2007 Jul;91(4):769-85; xiii. Review. PubMed PMID: 17640547.
  • Harrington SC, Simari RD, Conover CA. Genetic deletion of pregnancy-associated plasma protein-A is associated with resistance to atherosclerotic lesion development in apolipoprotein E-deficient mice challenged  with a high-fat diet. Circ Res. 2007 Jun 22;100(12):1696-702. Epub 2007 May 17. PubMed PMID: 17510462.
  • Lavi S, Prasad A, Yang EH, Mathew V, Simari RD, Rihal CS, Lerman LO, Lerman A. Smoking is associated with epicardial coronary endothelial dysfunction and elevated white blood cell count in patients with chest pain and early coronary artery disease. Circulation. 2007 May 22;115(20):2621-7. Epub 2007 May 7. PubMed PMID: 17485580.
  • Yang EH, Lerman S, Lennon RJ, Simari RD, Lerman LO, Lerman A. Relation of depression to coronary endothelial function. Am J Cardiol. 2007 Apr 15;99(8):1134-6. Epub 2007 Mar 7. PubMed PMID: 17437742.
  • Smits PA, Kleppe LS, Witt TA, Mueske CS, Vile RG, Simari RD. Distribution of circulation-derived endothelial progenitors following systemic delivery.Endothelium. 2007 Jan-Feb;14(1):1-5. PubMed PMID: 17364891.
  • Skelding KA, Gerhard GS, Simari RD, Holmes DR Jr. The effect of HapMap on cardiovascular research and clinical practice. Nat Clin Pract Cardiovasc Med. 2007 Mar;4(3):136-42. Review. PubMed PMID: 17330125.
  • Pislaru SV, Harbuzariu A, Gulati R, Witt T, Sandhu NP, Simari RD, Sandhu GS. Magnetically targeted endothelial cell localization in stented vessels. J Am Coll Cardiol. 2006 Nov 7;48(9):1839-45. Epub 2006 Oct 17. PubMed PMID: 17084259.
  • Resch ZT, Simari RD, Conover CA. Targeted disruption of the pregnancy-associated plasma protein-A gene is associated with diminished smooth muscle cell response to insulin-like growth factor-I and resistance to neointimal hyperplasia after vascular injury. Endocrinology. 2006 Dec;147(12):5634-40. Epub  2006 Sep 7. PubMed PMID: 16959843.
  • Pislaru SV, Harbuzariu A, Agarwal G, Witt T, Gulati R, Sandhu NP, Mueske C, Kalra M, Simari RD, Sandhu GS. Magnetic forces enable rapid endothelialization of synthetic vascular grafts. Circulation. 2006 Jul 4;114(1 Suppl):I314-8. PubMed PMID: 16820592.
  • Kiernan TJ, Simari RD. Vasculoprotective effects of erythropoietin: new developments and new alternatives. Circ Res. 2006 Jun 9;98(11):1341-3. Review. PubMed PMID: 16763168.
  • Gersh BJ, Simari RD. Cardiac cell-repair therapy: clinical issues. Nat Clin Pract Cardiovasc Med. 2006 Mar;3 Suppl 1:S105-9. Review. PubMed PMID: 16501615.
  • Pislaru S, Simari RD. The translation of transcription. Circ Res. 2005 Nov 25;97(11):1083-4. PubMed PMID: 16306450.
  • Pislaru SV, Simari RD. Gene transfer for ischemic cardiovascular disease: is this the end of the beginning or the beginning of the end? Nat Clin Pract Cardiovasc Med. 2005 Mar;2(3):138-44. Review. PubMed PMID: 16265457.
  • Gulati R, Simari RD. Cell therapy for angiogenesis: embracing diversity. Circulation. 2005 Sep 13;112(11):1522-4. Review. PubMed PMID: 16157781.
  • Gulati R, Lerman A, Simari RD. Therapeutic uses of autologous endothelial  cells for vascular disease. Clin Sci (Lond). 2005 Jul;109(1):27-37. Review. PubMed PMID: 15966869.
  • Katsube K, Bishop AT, Simari RD, Ylä-Herttuala S, Friedrich PF. Vascular  endothelial growth factor (VEGF) gene transfer enhances surgical revascularization of necrotic bone. J Orthop Res. 2005 Mar;23(2):469-74. Epub 2004 Nov 30. PubMed PMID: 15734264.
  • Gulati R, Simari RD. Autologous cell-based therapies for vascular disease.Trends Cardiovasc Med. 2004 Oct;14(7):262-7. Review. PubMed PMID: 15542377.
  • Pan S, Kleppe LS, Witt TA, Mueske CS, Simari RD. The effect of vascular smooth muscle cell-targeted expression of tissue factor pathway inhibitor in a murine model of arterial thrombosis. Thromb Haemost. 2004 Sep;92(3):495-502. PubMed PMID: 15351845.
  • Jevremovic D, Gulati R, Hennig I, Diaz RM, Cole C, Kleppe L, Cosset FL, Simari RD, Vile RG. Use of blood outgrowth endothelial cells as virus-producing vectors for gene delivery to tumors. Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H494-500. PubMed PMID: 15277193.
  • Loewen N, Leske DA, Cameron JD, Chen Y, Whitwam T, Simari RD, Teo WL, Fautsch MP, Poeschla EM, Holmes JM. Long-term retinal transgene expression with FIV versus adenoviral vectors. Mol Vis. 2004 Apr 13;10:272-80. PubMed PMID: 15094709.
  • Gulati R, Jevremovic D, Witt TA, Kleppe LS, Vile RG, Lerman A, Simari RD.Modulation of the vascular response to injury by autologous blood-derived outgrowth endothelial cells. Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H512-7. Epub 2004 Apr 8. PubMed PMID: 15072951.
  • Pan S, Gulati R, Mueske CS, Witt TA, Lerman A, Burnett JC Jr, Simari RD. Gene transfer of a novel vasoactive natriuretic peptide stimulates cGMP and lowers blood pressure in mice. Am J Physiol Heart Circ Physiol. 2004 Jun;286(6):H2213-8. Epub 2004 Feb 12. PubMed PMID: 14962842.
  • Hall JL, Grindle S, Han X, Fermin D, Park S, Chen Y, Bache RJ, Mariash A,Guan Z, Ormaza S, Thompson J, Graziano J, de Sam Lazaro SE, Pan S, Simari RD,Miller LW. Genomic profiling of the human heart before and after mechanical support with a ventricular assist device reveals alterations in vascular signaling networks. Physiol Genomics. 2004 May 19;17(3):283-91. PubMed PMID: 14872006.
  • Gulati R, Jevremovic D, Peterson TE, Chatterjee S, Shah V, Vile RG, Simari RD. Diverse origin and function of cells with endothelial phenotype obtained from adult human blood. Circ Res. 2003 Nov 28;93(11):1023-5. Epub 2003 Nov 6. PubMed PMID: 14605020.
  • Pislaru SV, Pislaru C, Kinnick RR, Singh R, Gulati R, Greenleaf JF, Simari  RD. Optimization of ultrasound-mediated gene transfer: comparison of contrast agents and ultrasound modalities. Eur Heart J. 2003 Sep;24(18):1690-8. PubMed PMID: 14499233.
  • Hermann J, Gulati R, Napoli C, Woodrum JE, Lerman LO, Rodriguez-Porcel M,Sica V, Simari RD, Ciechanover A, Lerman A. Oxidative stress-related increase in ubiquitination in early coronary atherogenesis. FASEB J. 2003 Sep;17(12):1730-2. Epub 2003 Jul 18. PubMed PMID: 12958191.
  • Gulati R, Jevremovic D, Peterson TE, Witt TA, Kleppe LS, Mueske CS, Lerman A,Vile RG, Simari RD. Autologous culture-modified mononuclear cells confer vascular protection after arterial injury. Circulation. 2003 Sep 23;108(12):1520-6. Epub 2003 Sep 2. PubMed PMID: 12952850.
  • Chatterjee S, Cao S, Peterson TE, Simari RD, Shah V. Inhibition of GTP-dependent vesicle trafficking impairs internalization of plasmalemmal eNOS and cellular nitric oxide production. J Cell Sci. 2003 Sep 1;116(Pt 17):3645-55. Epub 2003 Jul 22. PubMed PMID: 12876216.
  • •93.   Peterson TE, Guicciardi ME, Gulati R, Kleppe LS, Mueske CS, Mookadam M, Sowa G, Gores GJ, Sessa WC, Simari RD. Caveolin-1 can regulate vascular smooth muscle cell fate by switching platelet-derived growth factor signaling from a proliferative to an apoptotic pathway. Arterioscler Thromb Vasc Biol. 2003 Sep 1;23(9):1521-7. Epub 2003 Jun 19. PubMed PMID: 12816877.
  • Singh R, Pan S, Mueske CS, Witt TA, Kleppe LS, Peterson TE, Caplice NM, Simari RD. Tissue factor pathway inhibitor deficiency enhances neointimal proliferation and formation in a murine model of vascular remodelling. Thromb Haemost. 2003 Apr;89(4):747-51. PubMed PMID: 12669131.
  • Caplice NM, Simari RD, Holmes DR. Molecular biology and gene transfer in atherosclerosis in the stenting era. Int J Cardiovasc Intervent. 1999;2(3):141-152. PubMed PMID: 12623583.
  • Khurana VG, Weiler DA, Witt TA, Smith LA, Kleppe LS, Parisi JE, Simari RD,O'Brien T, Russell SJ, Katusic ZS. A direct mechanical method for accurate and efficient adenoviral vector delivery to tissues. Gene Ther. 2003 Mar;10(5):443-52. PubMed PMID: 12601399.
  • Kim TH, Skelding KA, Nabel EG, Simari RD. What can cardiovascular gene transfer learn from genomics: and vice versa? Physiol Genomics. 2002 Dec 3;11(3):179-82. Epub 2002 Dec 3. PubMed PMID: 12464691.
  • Llano M, Kelly T, Vanegas M, Peretz M, Peterson TE, Simari RD, Poeschla EM. Blockade of human immunodeficiency virus type 1 expression by caveolin-1. J Virol. 2002 Sep;76(18):9152-64. PubMed PMID: 12186899; PubMed Central PMCID:PMC136432.
  • Pislaru S, Janssens SP, Gersh BJ, Simari RD. Defining gene transfer before expecting gene therapy: putting the horse before the cart. Circulation. 2002 Jul  30;106(5):631-6. Review. PubMed PMID: 12147548. 
  • Panetta CJ, Miyauchi K, Berry D, Simari RD, Holmes DR, Schwartz RS, Caplice NM. A tissue-engineered stent for cell-based vascular gene transfer. Hum Gene Ther. 2002 Feb 10;13(3):433-41. PubMed PMID: 11860710.
  • Simari RD, O'Brien T. Clinical trials in vascular gene therapy: the missing piece of the puzzle. Arch Pathol Lab Med. 2002 Mar;126(3):317-9. Review. PubMed PMID: 11860306.
  • Singh R, Pislaru SV, Simari RD. ABCs of molecular cardiology and the impact of the Human Genome Project on clinical cardiology. Cardiol Rev. 2002 Jan-Feb;10(1):24-33. Review. PubMed PMID: 11790266.
  • Caplice NM, Panetta C, Peterson TE, Kleppe LS, Mueske CS, Kostner GM, Broze GJ Jr, Simari RD. Lipoprotein (a) binds and inactivates tissue factor pathway inhibitor: a novel link between lipoproteins and thrombosis. Blood. 2001 Nov 15;98(10):2980-7. PubMed PMID: 11698280.
  • Stalboerger PG, Panetta CJ, Simari RD, Caplice NM. Plasmin proteolysis of endothelial cell and vessel wall associated tissue factor pathway inhibitor. Thromb Haemost. 2001 Sep;86(3):923-8. PubMed PMID: 11583328.
  • Wilson SH, Simari RD, Lerman A. The effect of endothelin-1 on nuclear factor kappa B in macrophages. Biochem Biophys Res Commun. 2001 Sep 7;286(5):968-72. PubMed PMID: 11527395.
  • Singh R, Pan S, Mueske CS, Witt T, Kleppe LS, Peterson TE, Slobodova A, Chang JY, Caplice NM, Simari RD. Role for tissue factor pathway in murine model of vascular remodeling. Circ Res. 2001 Jul 6;89(1):71-6. PubMed PMID: 11440980.
  • Wilson SH, Simari RD, Best PJ, Peterson TE, Lerman LO, Aviram M, Nath KA, Holmes DR Jr, Lerman A. Simvastatin preserves coronary endothelial function in hypercholesterolemia in the absence of lipid lowering. Arterioscler Thromb Vasc Biol. 2001 Jan;21(1):122-8. PubMed PMID: 11145943.
  • O'Brien T, Simari RD. Gene therapy for atherosclerotic cardiovascular disease: a time for optimism and caution. Mayo Clin Proc. 2000 Aug;75(8):831-4.Review. PubMed PMID: 10943238.
  • Rust C, Karnitz LM, Paya CV, Moscat J, Simari RD, Gores GJ. The bile acid  taurochenodeoxycholate activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade. J Biol Chem. 2000 Jun 30;275(26):20210-6. PubMed PMID: 10770953.
  • Schirger JA, Grantham JA, Kullo IJ, Jougasaki M, Wennberg PW, Chen HH, Lisy  O, Miller V, Simari RD, Burnett JC Jr. Vascular actions of brain natriuretic peptide: modulation by atherosclerosis and neutral endopeptidase inhibition. J Am Coll Cardiol. 2000 Mar 1;35(3):796-801. PubMed PMID: 10716485.
  • Peterson TE, Kleppe LS, Caplice NM, Pan S, Mueske CS, Simari RD. The regulation of caveolin expression and localization by serum and heparin in vascular smooth muscle cells. Biochem Biophys Res Commun. 1999 Nov 30;265(3):722-7. PubMed PMID: 10600487.
  • Wilson SH, Caplice NM, Simari RD, Holmes DR Jr, Carlson PJ, Lerman A. Activated nuclear factor-kappaB is present in the coronary vasculature in experimental hypercholesterolemia. Atherosclerosis. 2000 Jan;148(1):23-30. PubMed PMID: 10580167.
  • Cable DG, Caccitolo JA, Caplice N, O'Brien T, Simari RD, Daly RC, Dearani JA, Mullany CJ, Orszulak TA, Schaff HV. The role of gene therapy for intimal hyperplasia of bypass grafts. Circulation. 1999 Nov 9;100(19 Suppl):II392-6. PubMed PMID: 10567335.
  • Hasdai D, Sangiorgi G, Spagnoli LG, Simari RD, Holmes DR Jr, Kwon HM, Carlson PJ, Schwartz RS, Lerman A. Coronary artery apoptosis in experimental hypercholesterolemia. Atherosclerosis. 1999 Feb;142(2):317-25. PubMed PMID: 10030383.
  • Kullo IJ, Simari RD, Schwartz RS. Vascular gene transfer : from bench to bedside. Arterioscler Thromb Vasc Biol. 1999 Feb;19(2):196-207. Review. PubMed PMID: 9974398.
  • Simari RD, Yang ZY, Ling X, Stephan D, Perkins ND, Nabel GJ, Nabel EG. Requirements for enhanced transgene expression by untranslated sequences from the human cytomegalovirus immediate-early gene. Mol Med. 1998 Nov;4(11):700-6. PubMed PMID: 9932107; PubMed Central PMCID: PMC2230344.
  • Best PJ, Hasdai D, Sangiorgi G, Schwartz RS, Holmes DR Jr, Simari RD, Lerman A. Apoptosis. Basic concepts and implications in coronary artery disease. Arterioscler Thromb Vasc Biol. 1999 Jan;19(1):14-22. Review. PubMed PMID: 9888861.
  • Caplice NM, Mueske CS, Kleppe LS, Peterson TE, Broze GJ Jr, Simari RD. Expression of tissue factor pathway inhibitor in vascular smooth muscle cells and its regulation by growth factors. Circ Res. 1998 Dec 14-28;83(12):1264-70. PubMed PMID: 9851943.
  • Jougasaki M, Schirger JA, Simari RD, Burnett JC Jr. Autocrine role for the endothelin-B receptor in the secretion of adrenomedullin. Hypertension. 1998 Nov;32(5):917-22. PubMed PMID: 9822453.
  • Rekhter MD, Shah N, Simari RD, Work C, Kim JS, Nabel GJ, Nabel EG, Gordon D. Graft permeabilization facilitates gene therapy of transplant arteriosclerosis in a rabbit model. Circulation. 1998 Sep 29;98(13):1335-41. PubMed PMID: 9751684.
  • Caplice NM, Mueske CS, Kleppe LS, Simari RD. Presence of tissue factor pathway inhibitor in human atherosclerotic plaques is associated with reduced tissue factor activity. Circulation. 1998 Sep 15;98(11):1051-7. PubMed PMID: 9736590.
  • Rabbani RR, Bell MR, Grill DE, Simari RD, Holmes DR. Clinical outcomes after successful percutaneous coronary angioplasty of saphenous vein graft disease and  the importance of long-term assessment. Int J Cardiol. 1998 Jun 1;65(1):11-7. PubMed PMID: 9699925.
  • Rekhter MD, Simari RD, Work CW, Nabel GJ, Nabel EG, Gordon D. Gene transfer into normal and atherosclerotic human blood vessels. Circ Res. 1998 Jun 29;82(12):1243-52. PubMed PMID: 9648720.
  • Niu H, Simari RD, Zimmermann EM, Christman GM. Nonviral vector-mediated thymidine kinase gene transfer and ganciclovir treatment in leiomyoma cells. Obstet Gynecol. 1998 May;91(5 Pt 1):735-40. PubMed PMID: 9572221.
  • Staab ME, Simari RD, Srivatsa SS, Hasdai D, Pompili VJ, Holmes DR Jr,Schwartz RS. Enhanced angiogenesis and unfavorable remodeling in injured porcine  coronary artery lesions: effects of local basic fibroblast growth factor delivery. Angiology. 1997 Sep;48(9):753-60. PubMed PMID: 9313624.
  • Simari RD. Gene Therapy for Restenosis. J Invasive Cardiol. 1996 Nov;8(9):478-480. PubMed PMID: 10785755.
  • Stephan DJ, Yang ZY, San H, Simari RD, Wheeler CJ, Felgner PL, Gordon D, Nabel GJ, Nabel EG. A new cationic liposome DNA complex enhances the efficiency of arterial gene transfer in vivo. Hum Gene Ther. 1996 Oct 1;7(15):1803-12. PubMed PMID: 8894672.
  • Yang Z, Simari RD, Tanner F, Stephan D, Nabel GJ, Nabel EG. Gene transfer approaches to the regulation of vascular cell proliferation. Semin Interv Cardiol. 1996 Sep;1(3):181-4. Review. PubMed PMID: 9552509.
  • Yang ZY, Simari RD, Perkins ND, San H, Gordon D, Nabel GJ, Nabel EG. Role of the p21 cyclin-dependent kinase inhibitor in limiting intimal cell proliferation  in response to arterial injury. Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7905-10. PubMed PMID: 8755575; PubMed Central PMCID: PMC38847.
  • Simari RD, San H, Rekhter M, Ohno T, Gordon D, Nabel GJ, Nabel EG. Regulation of cellular proliferation and intimal formation following balloon injury in atherosclerotic rabbit arteries. J Clin Invest. 1996 Jul 1;98(1):225-35. PubMed PMID: 8690797; PubMed Central PMCID: PMC507420.
  • Simari RD, Nabel EG. Genetic therapy. Semin Interv Cardiol. 1996 Mar;1(1):77-83. Review. PubMed PMID: 9552497.
  • Schwartz RS, Chu A, Edwards WD, Srivatsa SS, Simari RD, Isner JM, Holmes DR  Jr. A proliferation analysis of arterial neointimal hyperplasia: lessons for antiproliferative restenosis therapies. Int J Cardiol. 1996 Jan;53(1):71-80. PubMed PMID: 8776280.
  • Núñez BD, Simari RD, Keelan ET, Menke KK, Garratt KN, Holmes DR Jr. A novel approach to the placement of Palmaz-Schatz biliary stents in saphenous vein grafts. Cathet Cardiovasc Diagn. 1995 Aug;35(4):350-3 discussion 354. PubMed PMID: 7497509.
  • Simari RD, Berger PB, Bell MR, Gibbons RJ, Holmes DR Jr. Coronary angioplasty in acute myocardial infarction: primary, immediate adjunctive, rescue, or deferred adjunctive approach? Mayo Clin Proc. 1994 Apr;69(4):346-58. Review. PubMed PMID: 8170179.
  • Simari RD, Gibbons RJ. Is primary angioplasty a suitable alternative to thrombolytic therapy? Coron Artery Dis. 1994 Apr;5(4):292-6. Review. PubMed PMID: 8044340.
  • Wright RS, Simari RD, Orszulak TA, Edwards WD, Gleich GJ, Reeder GS. Eosinophilic endomyocardial disease presenting as cyanosis, platypnea, and orthodeoxia. Ann Intern Med. 1992 Sep 15;117(6):482-3. PubMed PMID: 1503351.
  • Simari RD, Bell MR, Schwartz RS, Nishimura RA, Holmes DR Jr. Ventricular relaxation and myocardial ischemia: a comparison of different models of tau during coronary angioplasty. Cathet Cardiovasc Diagn. 1992 Apr;25(4):278-84. PubMed PMID: 1571988.
  • Simari RD, Bell MR, Schaff HV, Holmes DR Jr. Percutaneous transluminal coronary angioplasty and the changing indications for coronary artery bypass grafting for single-vessel coronary artery disease. Mayo Clin Proc. 1992 Apr;67(4):317-22. PubMed PMID: 1548945.
  • Simari RD, Miller TD, Zinsmeister AR, Gibbons RJ. Capabilities of supine exercise  electrocardiography versus exercise radionuclide angiography in predicting coronary events. Am J Cardiol. 1991 Mar 15;67(7):573-7. PubMed PMID: 2000789.

Abstracts 

  • Barry H Trachtenberg, John P Cooke, Jay H Traverse, Timothy D Henry, Carl J Pepine, James T Willerson, Emerson C Perin, Stephen G Ellis, David X Zhao, Aruni Bhatnagar, Brian H Johnstone, Dejian Lai, Micheline Resende, Ray F Ebert, Joseph C Wu, Shelly L Sayre, Robert D Simari, Lem Moye', Christopher R Cogle, and Doris A Taylor. Bone Marrow Characteristics are Associated With Changes in Infarct Size Following STEMI: A Biorepository Evaluation From the CCTRN TIME Trial Robert C Schutt, Barry H Trachtenberg, John P Cooke, Jay H Traverse, Timothy D Henry, Carl J Pepine, James T Willerson, Emerson C Perin, Stephen G Ellis, David X Zhao, Aruni Bhatnagar, Brian H Johnstone, Dejian Lai, Micheline Resende, Ray F Ebert, Joseph C Wu, Shelly L Sayre, Robert D Simari, Lem Moye', Christopher R Cogle, and Doris A Taylor . Circulation. 2014;130:A16161.
  • Aruni Bhatnagar, Brian H Johnston, Jay H Traverse, Timothy D Henry, Carl J Pepine, James T Willerson, Emerson C Perin, Stephen G Eillis, David X Zhao, Dejian Lai, John P Cooke, Robert C Schutt, Barry H rachtenberg, Micheline Resende, Ray F Ebert, Shelly L Sayre, Michelle Cohen, Michelle Cohen, Robert D Simari, Lem Moye', Christopher R Cogle, and Doris A Taylor. Patient and Cell Characteristics Associated With Clinical Outcomes in the CCTRN LateTIME Trial.  Circulation. 2014;130:A16663.
  • Jay H Traverse, Timothy D Henry, Carl J Pepine, James T Willerson, David X Zhao, Stephen G Ellis, Dejian Lai, Emerson C Perin, Marc S Penn, Antonis K Hatzopoulos, Jeffrey Chambers, Kenneth W Baran, Ganesh Raveendran, Charles Lambert, Amir Lerman, Daniel I Simon, Adrian P Gee, John R Forder, Doris A Taylor, Christopher R Cogle, Ray F Ebert, Lem Moye', and Robert D Simari. The NHLBI and Cardiovascular Cell Therapy Research Network (CCTRN) TIME Trial: Two-Year Results. Circulation. 2014;130:A15644.

 

 

Last modified: Aug 26, 2019

Robert Simari, MD

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Robert Simari, MD
Professor of Medicine
Executive Vice Chancellor

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