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Cancer Biology

School of Medicine > Cancer Biology > Faculty > Tomoo Iwakuma, MD, Ph.D.

Tomoo Iwakuma, M.D., Ph.D.

Professor
Frank B. Tyler Professor of Cancer Research
Adjunct faculty, Department of Molecular & Integrative Physiology, KUMC
Director, Translational Laboratory Oncology Research Program at the Children's Mercy Research Institute
M.D.: 1991, Kyushu University
Ph.D.: 1997, Kyushu University
Postdoctoral: 1997-2005, University of Florida, MD Anderson Cancer Center
Assistant Professor: 2005-2011, Louisiana State University Health Sciences Center
Associate Professor: 2011-2018, KU Medical Center
Assistant Professor: 2005-2011, Louisiana State University Health Sciences Center


See Publications

Dr. Iwakuma's primary research focuses on the field of Cancer Research, specifically on cancer progression including liver cancer, head and neck squamous cell carcinoma, and bone and soft tissue sarcoma. Over 50 percent of human cancers have mutations in the tumor suppressor p53 which regulates cell cycle progression, cell death, senescence, chromosome integrity, DNA repair, metabolism and metastasis. Therefore, understanding of the pathway involved in the regulation of p53 is essential for discovering novel cancer therapies. With special focus on the tumor suppressor p53 pathway, Dr. Iwakuma dissects the mechanism of cancer progression using several mouse models, attempts to discover novel compounds to target the p53 pathway and applies disease models to translational research, to ultimately cure cancer.

Lab Members

Photo of Iwakuma Lab members

Front row left to right: Satomi Yamamoto, M.D., research assistant; Elizabeth Thoenen, graduate student.
Back row left to right: Tomoo Iwakuma, M.D., Ph.D., professor; Atul Ranjan, Ph.D., postdoctoral fellow; Alejandro Perrales, Ph.D.,
postdoctoral fellow; Alalem Mohamed, Ph.D., postdoctoral fellow; Hongyi Ren, graduate student.

Last modified: Jul 08, 2019

Tomoo Iwakuma, M.D., Ph.D.

Contact

Tomoo Iwakuma, M.D., Ph.D.
Professor
Frank B. Tyler Professor of Cancer Research
Adjunct faculty, Department of Molecular & Integrative Physiology, KUMC
Director, Translational Laboratory Oncology Research Program at the Children's Mercy Research Institute

2005 Wahl East, Mailstop 1027
3901 Rainbow Boulevard
Kansas City, KS 66160

P: (913) 588-7412
tiwakuma@kumc.edu

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