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PCNA expression, as indicated by the dense red collections of stain in untreated, was significantly decreased in crocetin-treated tumors, indicating decreased proliferation associated with crocetin treatment.

Overexpression of the RNA-binding protein HuR occurs during colorectal tumorigenesis. Immunohistochemical detection of HuR expression in normal and tumor colonic tissue.

Cancer Biology

The Department of Cancer Biology is a newly developed basic science department at the University of Kansas Medical Center. The missions of our department are:

To build a strong team of basic researchers with a collaborative and translational mindset who will discover fundamental characteristics of cancer cells that can lead to novel therapeutic and preventive approaches which reduce cancer incidence, morbidities and mortality;
To understand the molecular genetic and epigenetic, biochemical, cellular and physiologic bases of cancer etiology and progression;
To understand the interactions between tumor cells and the microenvironments in which they find themselves;
To educate the next generation of cancer researchers, clinicians and patients.

Our department is funded by grants from the National Cancer Institute, National Institutes of Health, American Cancer Society, Susan G. Komen for the Cure, and the National Foundation for Cancer Research.

The Department of Cancer Biology utilizes a variety of in vivo and in vitro experimental systems.

Cancer Biology