The Biospecimen Repository Core Facility (BRCF) is lead by Andrew K Godwin, PhD (Director) and by Rashna Madan, MBBS, FCAP, FASCP (Clinical Pathologist and Assistant Director) and plays a vital role to support translational research by its ethical collection, storage, annotation, and distribution of high quality biospecimens, such as frozen solid tumors of varying histology and bodily fluids (blood, urine, ascites fluids). The BRCF also provides expert histopathology support and combines the expertise of pathologists, translational researchers, and technical personnel to produce a comprehensive and focused approach to support the research activities at KUCC.
Translational research requires well-characterized and highly annotated human biospecimens obtained from participants under appropriate informed consent. Therefore, the BRCF has three primary functions:
First, it identifies participants, obtains informed consent, collects tissue, blood, and/or urine samples from selected populations, and obtains information on personal and family histories of cancer, clinical intervention, and lifestyle factors for use in research. As part of the banking efforts the BRCF staff provides i) outstanding diagnostic pathology support, ii) a comprehensive informed consent process for the use of tissue, blood, and/or urine, from patients and participants for research; iii) a specialized biospecimen bank devoted to the collection and distribution of specimens to support research; and iv) extensive supporting data from the clinical record of each participant. The BRCF database is linked with the Kansas State tumor registry, which contains detailed clinical outcomes and phenotypes from the University of Kansas Hospital (KUH) electronic medical records, clinic and hospital billing records and the KUH Cancer Registry. In order to preserve privacy, a series of security procedures are undertaken once the participant has been consented, e.g., a unique patient number is automatically assigned via the database management system at the time of sample collection. This identifier is used for all subsequent reference to the sample or accompanying information and cannot be linked to other identifiers (i.e., protected health information - name, address, patient's hospital identifiers, etc.) without specific written approval by the IRB.
Second, the BRCF processes and houses human biospecimens obtained through investigator-initiated clinical studies. This second function is critical to facilitate the objective of bidirectional flow from lab bench to clinic, and to stimulate translational research associated with clinical trials. For example, the BRCF has been actively involved in the collection and storage of correlative blood and tissue samples for the Clinical Trials Management Shared Resource (CTMSR) for future translational research. The BRCF is also involved in similar clinical study projects that enroll participants outside the University of Kansas Medical Center (KUMC), including those in the Midwest Cancer Alliance (MCA) and will continue to expand its efforts to capture rural and ethnically diverse populations followed by the investigators within the CCPH Program.
Third, the BRCF provides expert histology technical procedures and pathological evaluation of tissue samples, including tissue processing, sectioning, tissue microarray (TMA) construction and immunohistochemical staining and analyses
For more information
Call toll free 855-211-1475
The University of Kansas Cancer Center
3901 Rainbow Blvd.
G001 Wahl Hall West
Kansas City, KS 66160