Department of Biochemistry and Molecular Biology
University of California, Los Angeles, Ph.D., 1967
University of Illinois (Postdoctoral Fellow), 1967-69
Kent State University, Kent, OH (Assistant and Associate Professor), 1969-75
My laboratory is interested in the structure and function of thyroid proteins as they relate to the biosynthesis of thyroid hormone. In addition, we have studied structure and function in other polypeptide hormones including relaxin (an ovarian hormone important in the late stages of pregnancy), pancreatic polypeptide and related members of the NPY neuroendocrine family. My laboratory uses a variety of physical techniques, including fluorescence spectroscopy, along with he methods of modern protein chemistry in these studies. Future plans include the expression of specific domains derived from thyroid proteins in recombinant systems to allow extended studies of these proteins with and without post-translational modifications (e.g., glycosylation) and the characterization of thyroid metalloproteases.
Sen Xiao, H. Gail Pollock, Alvin Taurog and Allen B. Rawitch (1995) Characterization of Hormonogenic Sites in an N-Terminal, Cyanogen Bromide Fragment of Human Thyroglobulin. Arch. Biochem. Biophys. 320, 111-121.
Cindy Duval-Jobe, Michael Leeson, Allen B. Rawitch and Michael J. Parmely. (1995) Mechanism by Which U937 Promoncytic Cells Inactivate Human Interferon Gamma. J. Interferon and Cytokine Research 15, 557-65.
Satya Yadav and Allen B. Rawitch (1994) Effect of Peptide Acetylation on Its Interaction with Antipeptide Antibody. Biochem. Biophys. Res. Comm. 205, 1688-1695.
Chong-Sheng Yuan, Jerry Yeh, T. Squier, A. B. Rawitch and Ronald T. Borchardt (1993) Ligand-Dependent Intrinsic Fluorescence Changes of S-Adenosylhomocysteine Hydrolase: Implications about The Mechanism of Inhibitor-Induced Inhibition. Biochemistry 39, 10414-10422
Rawitch, A.B., Yang, S.X. and Pollock, H.G. (1993) Glycosylation in bovine thyroglobulin: localization and nature of the N-linked oligosaccharides. Arch. Biochem. Biophys. 300, 271-279.
Ramachandra, M., Nakano, R., Mohan, A., Rawitch, A. and Padmanabhan R. (1993) Adenovirus DNA polymerase is a phosphoprotein. J. Biol. Chem. 268, 442-448.
Rawitch, A.B., Pollock, G., Yang, S.X. and Taurog, A. (1992) Thyroid peroxidase glycosylation: the location and nature of the N-linked oligosaccharide units in porcine thyroid peroxidase. Arch. Biochem. Biophys. 297, 321-327.
Rawitch, A.B., Pollock, G. and Brodin, L. (1992) A neuropeptide Y (NPY) - related peptide is present in the river lamprey CNS. Neurosci. Lett. 140, 165-168.
Rawitch, A.B., Pollock, G., Yang, Shi-Xin and Taurog, A. (1990) The location and nature of the N-linked oligosaccharide units in porcine thyroid peroxidase: studies on the tryptic glycopeptides. Colloque Inserm 207, 69-76.
Deb, S., Boone, K., Hashizume, K., Southard, J., Talamantes, F., Rawitch A.B. and Soares, M. (1989) Antipeptide antibodies reveal structural and functional characteristics of rat placental lactogen-II. Mol. Cell. Embryol. 63, 45-56.
Deb, S., Youngblood, T., Rawitch, A.B. and Soares, M. (1989) Placental prolactin-like protein-A: identification and characterization of two major glycoprotein species with antipeptide antibodies. J. Biol. Chem. 264, 14348-14353.
Brodin, L., Rawitch, A.B., Taylor, T., Ohta, Y., Ring, H., Hokfelt, T., Grillner, S. and Terenius, L. (1989) Multiple forms of pancreatic polypeptide-related compounds in the lamprey CNS: partial characterization and immunohistochemical localization in the brainstem and spinal cord. J. Neurosci. 9, 3428-3442.
Gregg, J.D., Dziadik-Turner, C., Rouse, J., Hamilton, J. and Rawitch. A.B. (1988) A comparison of 30 KDa and 10 KDa hormone-containing fragments of bovine thyroglobulin. J. Biol. Chem. 263, 5190-5196.
Frieden, E.H., Rawitch, A.B., Steinitz, B.G. and Pollock, H.G. (1988) Structure of a porcine relaxin inactive on the mouse pubic ligament. Arch. Biochem. Biophys. 266, 334-342.
Dziadik-Turner, C., Hamilton, W., Taurog, A. and Rawitch, A.B. (1988) Hormone-containing peptides from normal and goiter human thyroglobulins. Arch. Biochem. Biophys. 266, 377-385.
Allen B. Rawitch, Ph.D.