Sensory Nerve Disorder Lab

Sensory Nerve Disorder Lab

collage of lab images

  1. A low magnification photomicrograph of a section through a mouse dorsal root ganglion. The section has been processed to visualize neurons (white circles) that contain the enzyme thiamine monophosphatase (TMP). The coloring of the image has been inverted. The majority of these neurons are small and are involved in pain signaling. The lab is interested in these neurons because of their role in pain and their reliance on the neurotrophic factor GDNF.
  2. A high magnification photomicrograph of a single intrafusal muscle fiber that is part of a muscle spindle, a specialized sensory receptor found in nearly all muscles. The spindle fiber (red) responds to muscle lengthening and conveys information to the sensory fibers (green) that innervate it. In this case, the sensory fibers have been injured (one day prior) and the peripheral axons are in the process of degenerating. The lab is interested in muscle spindles because they are innervated by sensory axons that rely on the neurotrophic factor NT-3. A goal of the lab is to understand the role that NT-3 plays in the reinnervation of muscle spindles after injury.
  3. A low magnification photomicrograph of a section through the dorsal horn from a mouse lumbar spinal cord. The section has been processed to visualize sensory axon terminals (black) that contain the enzyme thiamine monophosphatase (TMP). The lab is interested in how various neurodegenerative diseases affect the innervation of the dorsal horn and thus alter somatosensation.
  4. A high magnification photomicrograph of a cross section through a muscle spindle, a specialized sensory receptor found in muscles. The section has been stained with hematoxylin and eosin in order to see the components within the spindle. A tough capsule surrounds 4-5 intrafusal muscle fibers. The intrafusal fibers respond to change in muscle length and signal to central nervous system. The lab is interested in what role the neurotrophic factor NT-3 plays in the development and function of muscle spindles.
  5. A high magnification confocal photomicrograph of a sensory neuron from a mouse dorsal root ganglion. The neuron has been stained for neurofilaments (green) only contained by myelinated neurons. A second stain has been used to determine if the neuron expresses a particular transcription factor, ATF3 (red). ATF3 is only expressed by DRG neurons after the peripheral axon has been damaged. The lab is interested in the molecular and cellular responses of DRG neurons to a variety of neuropathic diseases.
Last modified: Apr 11, 2011
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