Photomicrograph of dorsal root ganglion neurons stained with toluidine Blue. The DRG was embedded in plastic and sectioned at 1 micron. The lab studies the biology of both large and small DRG neurons.
Schematic representation of a dorsal root ganglion (DRG) neuron expressing receptors for the neurotrophin nerve growth factor (NGF). Certain DRG neurons bind NGF that is synthesized in the skin, internalize the receptor-ligand complex, and retrogradely transport both to the cell body where it exerts biological actions on the neuron. The lab is interested in how various neural injury or disease affect this process.
Transgenic NT-3 mice
Photos of two different lines of 6-month old transgenic mice that overexpress neurotrophin-3 (NT-3) in skeletal muscle. Top: Images of wildtype (left) and mlc/NT-3 transgenic mice. Bottom: Images of wildtype (left), low-OE myo/NT-3 (middle) and high-OE myo/NT-3 (right) adult mice. When lifted by the tail, wildtype extend their hindlimbs and digits. In contrast, all transgenic NT-3 mice retract their hindlimbs to the body and clench their paws in a "clasping phenotype". The lab is interested in how NT-3 regulates the function of neurons that are involved in reflexes from muscle.
Fluorescent labeling of cutaneous axons in glabrous skin from the adult mouse footpad. The axons are labeled using a fluorescent protein that is expressed by about 70% of axons that innervate the skin. The lab is interested how various diseases like diabetes and other neuropathy affect the innervation of the skin, and thus affect somatosensation.