Anatomy and Cell Biology
Ph.D.: 2000, Eotvos University, Budapest, Hungary
Postdoctoral: 2000-2003, University of Kansas Medical Center
Publications:List of Publications in PubMed
Vasculogenesis, the de novo assembly of vessels from endothelial precursors, is a fundamental process common to both embryonic development and certain pathophysiologies. Recent advances in imaging technology allowed the in vivo visualization of endothelial cell dynamics during vasculogenesis in avian embryos. We showed that the formation of vascular cords from isolated clusters of angioblasts involves extensive invasive activity. During this process, vasculogenic sprouting, a group of endothelial cells invades hundreds of micrometers into avascular areas, and thereby lays down the structure of the primordial vascular plexus. We aim to determine the specific role of growth factor signaling and extracellular matrix components, primarily fibronectin, in the patterning mechanism.
We utilize an in vivo computational bioassay, i.e., the quantitative characterization of in situ endothelial cell behavior, when subjected to experimental agents perturbing normal cell surface receptor function. Such studies give a substantial insight into the control of vascular cell behavior and vascular bed patterning. Understanding these mechanisms is required for therapeutic vascularization approaches to ischemic disease, repairing endothelial injury, as well as establishing a blood supply in engineered tissues.
The University of Kansas Medical Center
Department of Anatomy and Cell Biology
3901 Rainbow Blvd.
Kansas City, KS 66160
(913) 945-6683 (office tele)
(913) 945-6703 (lab tele)
András Czirók, PhD