One key finding in Ncb5or knockout mice is that they lose fat early in development. This phenomenon is interesting since children diagnosed with type 1 diabetes often lose fat and stop growing as an early indication of the onset of disease. By studying the role of Ncb5or in fat loss and beta cell destruction, we hope to more fully understand the early phases of type 1 diabetes.
Obesity is linked to type 2 diabetes, and both are major human health issues that are expected to worsen in coming decades. Recent research has shown that adipose tissue is the body’s largest endocrine unit, not merely inert energy storage as previously thought. Triglyceride-rich lipid droplets in adipocytes are depleted in Ncb5or knockout mice. With increased knowledge about Ncb5or’s biological function in triglyceride synthesis and energy homeostasis, we may be able to develop therapeutic drugs to combat obesity.
This work is supported by the National Institutes of Health and the School of Health Professions at KU Medical Center. Learn more about the project.
For more information, please contact:
Hao Zhu, PhD, Diabetes Research Group
2146 W. 39th Avenue
Kansas City, KS 66160