rrsNews

Vol. XXXVII, No. 1 February, 2004


Biographical Sketches for Candidates
for Election for Offices
in the Radiation Research Society


For Interviews with the Vice-President-Elect Candidates, click here.

VICE-PRESIDENT-ELECT

CANDIDATE:   Mary Helen Barcellos-Hoff, Ph.D. Mary Helen Barcellos-Hoff
Current Position: Staff Scientist
Dept/Institution: Department of Cancer Biology, Life Sciences Division, Lawrence Berkeley Laboratory
Education/Training: The University of Chicago, IL A.B. Biopsychology 1973-1978; University of California, San Francisco Ph.D. Experimental Pathology 1981-1986; Lawrence Berkeley Laboratory Postdoctoral Cell Biology 1986-1988
Appointments: Department Head, Department of Cancer Biology, Life Sciences Division, LBNL 2003-Present; Acting Department Head, Department of Cell and Molecular Biology, Life Sciences Division, LBNL 2001-2003; Group Leader, Cancer and Tissue Biology, Life Sciences Division, Lawrence Berkeley; National Laboratory (LBNL), University of California 2000-2003; Staff Biologist; Life Sciences Division, Lawrence Berkeley Laboratory, University of California 1988-Present; Adjunct Assistant Professor; Department of Anatomy, University of California, San Francisco 1993-Present; Affiliate Faculty; Dept. of Radiological Health Sciences, Colorado State University, Ft. Collins 1992-Present; Postgraduate Researcher; Department of Anatomy, School of Medicine, University of California, Davis 1988; Postdoctoral Fellow; Biophysics Training Program, Univ. Calif., Berkeley 1986-1988; Research Assistant; Department of Neurological Surgery, University of California, San Francisco 1982- 1986
Honors and Professional Service: University Scholarship, University of Chicago, 1973-78. Basic Science Research Award, University of California, San Francisco, 1982 &1984. Student Travel Award, Radiation Research Society, 1984 & 1986. Student Travel Award, Cell Kinetics Society, 1985. NIH Fellowship Biophysics Training Grant, University of California, Berkeley, 1986-88. Gordon Conference Invited Speaker, Mammary Gland Biology, 1993. 10th International Congress of Radiation Research Symposia Speaker, 1995. Keystone Symposia Invited Speaker, Breast and Prostate Cancer, 1998. Gordon Conference Invited Speaker, Mammary Gland Biology, 1999. Co-chair (2001) and Chair (2003) Mammary Gland Gordon Conference DOD Breast Cancer Program, Review: Pathobiology 1 Study Section, 1994, 1995; Cell Biology 1 Study Section, 1996, 1997; Pathobiology 2 2000, 2001; NIH Study Section, Metabolic Pathology, ad hoc, 2000, 2001, 2003. Editorial Board, Women and Cancer, 1997-present; Breast Cancer Research, 1990-present; Susan Love MD Breast Cancer Found. 2003-present.
Patent: Number 5,616,561: “TGF-b Antagonists as Mitigators of Radiation-Induced Tissue Damage” M.H. Barcellos-Hoff (Inventor) and Regents of the University of California (Assignee), April 1, 1997.

For Interviews with the Vice-President-Elect Candidates, click here.

 


VICE-PRESIDENT-ELECT

Candidate: William McBride, Ph.D., D.Sc.Bill McBride

Current Position: Professor and Vice Chair, Roy E. Coats Research Laboratories
Dept/Institution: Department of Radiation Oncology, David Geffen School of Medicine at UCLA City/County: Los Angeles, CA
Date of Birth: 04/14/44
Place of Birth: Worcester, England
Educational Background: University of Edinburgh B.Sc. Zoology 1966; University of Edinburgh Ph.D. Medical Sciences 1971; University of Edinburgh D.Sc. Medical Sciences 1987; Royal College of Pathologists, London MRCPath. Pathology 1980; Royal College of Pathologists, London FRCPath. Pathology 1990
Pre-Doctoral Positions: University of Edinburgh, Scotland
Post-Doctoral Positions: University of Edinburgh, Scotland
Special Fellowships, Honors, etc.: Failla Award Lectureship, Radiation Research Society, 2003; Honorary Membership, Austrian Society for Radiation Oncology, Radiation Biology and Medical Radiation Physics, 2003
Work Experience: Lecturer, Dept of Bacteriology, University of Edinburgh Medical School Edinburgh, Scotland 1971-1982; Sr. Lecturer, Dept of Bacteriology, University of Edinburgh Medical School Edinburgh, Scotland 1982-1984; Project Investigator, Dept of Experimental Radiotherapy, M.D. Anderson Cancer Center, Houston 1975, 1979, 1982; Adjunct Professor, Dept. of Radiation Oncology, David Geffen School of Medicine at UCLA 1984-1987; Professor, Dept. of Radiation Oncology, David Geffen School of Medicine at UCLA 1987-Present; Division Chief, Dept. of Radiation Oncology, David Geffen School of Medicine at UCLA 1989-1991; Division Chief, Dept. of Radiation Oncology, David Geffen School of Medicine at UCLA 1994-Present; Vice Chair Research, Dept. of Radiation Oncology, David Geffen School of Medicine at UCLA 1995-Present; Adjunct Professor, Health Sciences Department, California State University, Long Beach 1991-2000
Society Memberships: American Association for Cancer Research, American Association of Immunologists, American Society Therapeutic Radiology and Oncology, British Association for Cancer Research (until 1994), British Society of Immunology (until 1994), Jonsson Comprehensive Cancer Center, Radiation Research Society, Royal College of Pathologists, U.K., European Society for Therapeutic Radiology and Oncology
Current Interests: Squash

For Interviews with the Vice-President-Elect Candidates, click here.

 


COUNCILOR (BIOLOGY)

CANDIDATE: Michael Cornforth, Ph.D. Michael Cornforth

Current Position: Associate Professor and Director of Biology
Dept/Institution: Departments of Radiation Oncology, and Human Biological Chemistry and Genetics, University of Texas, Medical Branch, Galveston
Date of Birth: November 29, 1952
Place of Birth: Fargo, North Dakota
Education: 1976 B.S. (Biology) University of Nevada-Reno, Reno, Nevada; 1980 M.S. (Biology) University of Nevada-Reno, Reno, Nevada; 1985 Ph.D. (Radiation Biology) Colorado State University, Fort Collins, CO; 1987 (Postdoc) Los Alamos National Laboratory, Los Alamos, NM
Professional Experience: 1976-77 Graduate Teaching Fellow, University of Nevada-Reno; 1977-79 Clinical cytogenetics technician, Nevada Mental Health Institute; 1979-80 Research Technician, University of Nevada-Reno; 1980-85 Grad. Student, Department of Radiology & Radiation Biology, Colorado State University (CSU); 1982-85 Research Associate, Department of Radiology and Radiation Biology, CSU; 1985-87 Postdoctoral Fellow, Genetics Group, Life Sciences Division, Los Alamos National Laboratory (LANL); 1987-91 Staff Scientist, Cell Biology Group, Life Sciences Division, LANL; 1991-present Associate Professor, Biology Division, Department of Radiation Therapy, The University of Texas Medical Branch, Galveston (UTMB); 1991-present  Associate Professor, Department of Human Biology Chemistry & Genetics UTMB; 2001-present Tenured appointment, Department of Radiation Oncology, UTMB; 2001-present Director of Biology, Department of Radiation Oncology, UTMB
Editorial: 1992-95 Editorial Board, International Journal of Radiation Biology; 1998-2002 Associate Editor, Radiation Research
Fellowships/Honors: 2001-present Vincent P. Collins Distinguished Professorship in Radiation Oncology
Society Memberships: 1980-present Radiation Research Society; full member since 1985
Research Interests: Radiation cytogenetics; mechanisms of chromosomal aberration formation, genetic and cytogenetic instability caused by ionizing radiation; recombinational processes underlying the formation of complex chromosomal aberrations; combinatorial whole chromosome painting; fundamental mechanisms of telomere maintenance.

 


COUNCILOR (BIOLOGY)

CANDIDATE: Carmel Mothersill, Ph.D.Carmel Mothersill

Current Position: Professor
Dept/Institution: Medical Physics and Applied Radiation Sciences Unit, McMaster University, Hamilton Ontario
Date of Birth: 29 September 1950
Place of Birth: Badoeynhausen Germany
Educational Background: B.Sc. (2.1) from National University of Ireland, in Zoology with Biochemistry as minor subject 1972; PhD from National University of Ireland in muscle biochemistry
Pre-Doctoral Positions: PhD student working in the Agricultural Institute in Dublin on stress susceptibility in pigs and the effect of pre-slaughter stress on post mortem muscle biochemistry and meat quality 1972-76
Post-Doctoral Positions: 1976-77: Research Assistant, Biological Records Centre, Conservation and Amenity Section, An Foras Forbartha, (The Planning Authority). Work experience in surveying sites of special scientific interest, identification of flowering plants, lichens, and several invertebrate animal groups. Special interest in Opilionidae. 1977-80: Post Doctoral Fellow, Dept. Physics, Dublin Institute of Technology, (DIT), Kevin Street, Dublin. Work experience in assay of biological effects of radiation, including survival assays and models, cell culture, dosimetry. 1980-83: Post Doctoral Research at St. Luke’s Hospital, Radiotherapy Centre, Dublin. Work experience similar to above but concentrating on tumour culture and radiobiology. 1983-95: Lecturer in Medical Physics and Radiation Biology, Dept Physics, Dublin Institute of Technology, (DIT), Kevin Street, Dublin. Seconded Half-time to run the Radiation Research Group at St. Luke’s Hospital and later at the Nuclear Energy Board, Dublin. 1995-2003: Scientific Director of the Radiation and Environmental Science Centre at DIT Current appointment (since September 1st 2003): Professor and CRC chair nominee, Department of Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario, Canada, L8S 4K1
Special Fellowships, Honors: Awarded the St. Luke’s Medal for cancer research 1987. Canadian Research Foundation Chair nominee
Society Memberships: Member of the Radiation Research Society since 1986. Recently appointed President of the Low Level Radiation Study Group LOWRAD, established to collect and review data in this area. President of the editorial committee of the associated journal. Member of the editorial board for the International Journal of Radiation Biology. Membership of the UK Institute of Physics (with chartered physicist status) since 1982. Member of the Irish Area Section committee 1988-89. Member of the Institute of Biology of Ireland since 1976. Secretary from 1986-91. Membership of the UK Institute of Biology (with chartered biologist status) since 1976. Member of the Higher Education committee since 1989. Member of the Irish Radiation Research Society (founder member and secretary since 1992). Member of ESTRO since 1998. Member of the European Society for Radiation Biology since 1980. Member of the American Association for Cancer Research since 1993. Member of the European Federation of Biotechnology since 1991
Current Interests: Overall interest in the mechanisms involved in low dose radiation response especially bystander effects and delayed effects such as death, mutation and genomic instability. Comparative radiobiological effects of ionising radiation in aquatic and terrestrial species. Identification of early events in low dose radiation carcinogenesis and in the development of methods and ultimately, tests for their detection in humans. Study of the mechanisms involved in genomic instability and bystander effects, and their relevance to repair of radiation damage and radiation carcinogenesis. Identification of early radiation induced genetic/molecular damage in humans. Public perceptions issues in environmental carcinogenesis by very low dose exposure to radiation and other pollutants.

 

 



COUNCILOR (CHEMISTRY)

CANDIDATE:  David Murray, Ph.D.David Murray

Current Position: Professor of Oncology and Director
Dept/Institution:Division of Experimental Oncology, Department of Oncology, University of Alberta; Department of Experimental Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada
Educational Background: 1973 B.Sc. University of Nottingham, England, Pure Chemistry; 1978 Ph.D. University of Salford, England, Physical Chemistry
Post-Doctoral Positions: 1978-79 Robert A. Welch Fellow University of Houston Chemistry; 1979-80 Visiting Assistant Professor University of Houston Chemistry; 1980-81 Research Associate University of California, San Francisco Pharmaceutical Chemistry; 1981-84 Research Associate MD Anderson Hospital and Tumor Institute Physics
Work Experience: 1984-85 Asst Professor of Biophysics MD Anderson Hospital and Tumor Institute Biophysics; 1985-89 Assistant Physicist and Asst Professor The University of Texas/MD Anderson Cancer Centre Experimental Radiotherapy; 1989-93 Associate Physicist and Assoc Professor The University of Texas/MD Anderson Cancer Centre Experimental Radiotherapy; 1993-96 Director Cross Cancer Institute Radiobiology; 1996-98 Associate Professor University of Alberta Oncology; 1996-98 Acting Director Cross Cancer Institute Experimental Oncology; 1998-present Professor University of Alberta Oncology; 1998-present Director Cross Cancer Institute Experimental Oncology
Society Memberships: Radiation Research Society
Current Interests: My research focuses on understanding the basic mechanisms by which mammalian cells respond to ionizing radiation, with an emphasis on DNA-repair pathways. A major area of interest is in identifying the relationships between the DNA-repair capability of cells and their ability to respond to radiation under various environmental conditions (such as altered oxygenation levels typical of many tumor cells). We are particularly interested in how alterations in cellular pathways such as the p53/p21WAF1 pathway that is involved in the cellular response to DNA damage, and that is somehow altered/mutated in most human cancers, might be exploited to make radiation therapy more specific for cancer cells. Our ultimate goal is to understand the factors that govern tumor versus normal tissue radiosensitivity and to exploit these differences for therapeutic benefit. We are also trying to understand the genetic factors (especially single nucleotide polymorphisms or "SNPs") that underlie the extreme normal-tissue responses of some cancer patients to radiation therapy. We are also exploring how genetic pre-screening of cancer patients (particularly with respect to the identification of SNPs in key genes such as DNA repair genes) might avoid administering treatments that could cause severe side effects in normal tissues.

 


COUNCILOR (CHEMISTRY)

CANDIDATE: Melanie Spotheim-Maurizot, Ph.D. Melanie Spotheim-Maurizot

Current Position: Project coordinator, Senior Scientist
Dept/Institution: INSERM; Centre de Biophysique Moleculaire (CBM), CNRS, Orleans, France.
Educational Background: Ph.D. 1975, Department of Polymers, Faculty of Chemistry, Feinberg Graduate School, Weizmann Institute of Science, Israel.
Pre-Doctoral Position: 1970-1975, Ph.D. student, Nucleic Acids Laboratory, Department of Polymers, Feinberg Graduate School, Weizmann Institute of Science, Israel.
Post-Doctoral Position: 1975-1976, EMBO Post-Doctoral Fellow, Nucleic Acids Laboratory, CBM, CNRS, Orleans, France; 1976-1977, FRM Post-Doctoral Fellow, Chemical Carcinogenesis Laboratory, CBM, CNRS, Orleans, France.
Special Fellowships: Ph. D. Bursary of Weizmann Institute of Science (1970-1975); EMBO Post-Doctoral Fellowship (1975-1976); Fondation pour la Recherche Medicale (FRM) Post-Doctoral fellowship (1976-1977)
Work Experience: 1978-1982, INSERM Junior Scientist, Chemical Carcinogenesis Team, CBM, CNRS, Orleans, France; 1982-2004, INSERM Senior Scientist, Radiobiology of Nucleic Acids and Proteins Team, CBM, CNRS, Orleans, France; 1998-2004, Coordinator of the project “Nucleic Acids: alterations, interactions, structure”, CBM, CNRS, Orleans, France
Society Memberships: Radiation Research Society, Miller Trust of Radiation Chemistry, European Society of Radiation Biology, Societe Francaise de Biophysique. Elected Councilor for Chemistry on IARR board (2003-2007)
Current interests: My previous experience in the structure of nucleic acids and chemical carcinogenesis allowed me to focus my research on the radiation damage to DNA. Recently, the radiation damage studies have been extended to DNA-protein complexes and, finally, to proteins. The main goal is to understand the influence of the high-order structure of these targets on the location and type of damage. Therefore a mixed experimental - modeling approach is used. Moreover, the structural changes induced by the radiation-induced damages in these systems are searched both experimentally (by molecular biology and spectroscopic methods) and by molecular modeling. The effects of low and high LET radiations are compared. Repair and radioprotection issues are approached in collaboration with other teams of CBM and other institutes in France and abroad.


SECRETARY-TREASURER ELECT

CANDIDATE:  Richard (Dick) Peter Hill, Ph.D.Richard Hill
Current Position
: Senior Scientist; Professor
Dept/Institution: Ontario Cancer Institute/Princess Margaret Hospital, Toronto, Canada; Department of Medical Biophysics, University of Toronto
Place of Birth: Belfast, N Ireland
Education: B.A., Physics, 1964 (St Johns College, Oxford, UK)
Pre-Doctoral: PhD, Radiation Biology, 1967 (University of London, UK)
Post –Doctoral: Ontario Cancer Institute, 1967-1971; James Picker Foundation Fellow
Honors: John Yuhas Award, 2002, Dept of Radiation Oncology, University of Pennsylvania
Work Experience: 1971-1973; Scientific Staff, Institute for Cancer Research, Sutton, UK; 1973-present; Scientific Staff, Ontario Cancer Institute, Toronto, Canada
Society Memberships: RRS, AACR, ASTRO, ESTRO, MRS. Currently: Chair, Finance Committee, RRS.
Current Interests: Tumour and Normal Tissue Radiobiology, Hypoxia, Metastasis. Translational studies in radiobiology applied to radiotherapy.


SECRETARY-TREASURER ELECT

CANDIDATE: Susan J. Knox, Ph.D., M.D.Susan Knox

Current Position: Associate Professor Dept/Institution: Radiation Oncology, Stanford University Medical Center
Educational Background: A.B. Genetics University of California, Berkeley 1974; Ph.D. Microbiology University of California, Davis 1980; M.D. Stanford Univ. School of Medicine, Stanford, CA 1985;
Pre-Doctoral Positions: Residency, Dept of Radiation Oncology, Stanford University School of Medicine 7/86-6/90; Post-doctoral Fellowship, Departments of Medicine (Oncology) and Radiation Oncology, Stanford University School of Medicine 7/87-6/89; Internship, Internal Medicine, University of California Davis Medical Center 6/85-6/86
Post-Doctoral Positions: Post-doctoral Fellow/Research Assistant, Department of Medicine/Immunology, Stanford University School of Medicine, Stanford, CA 7/82-12/85; Post-doctoral Research Immunologist, Laboratory for Energy-Related Health Research, University of California, Davis 6/80-6/82
Special Fellowships, Honors Councilor Medicine, Radiation Research Society 2003; Lazard Faculty Scholar 1992-93; American Cancer Society Clinical Oncology Career Development Award 1991-94; American Cancer Society Clinical Oncology Fellowship 1989; American Society for Therapeutic Radiology and Oncology (ASTRO) Fellowship 1988; Research Honor Award at Graduation - Stanford University School of Medicine 1985
Work Experience: Assistant Dean for Medical Student Advising 9/02-present; Associate Professor, Department of Radiation Oncology, Stanford University School of Medicine 9/1/97-present; Assistant Professor, Department of Radiation Oncology, Stanford University School of Medicine 9/1/90-8/31/97
Society Memberships: American Association for the Advancement of Science, American Association for Cancer Research, American Medical Association, American Society of Clinical Oncology, American Society for Therapeutic Radiology and Oncology, California Medical Association, Northern California Radiation Oncology Society, Radiation Research Society, Santa Clara County Medical Association, Stanford Medical Alumni Association, Class Representative 1990-present
Current Interests: Current research interests include 1) study of novel therapeutic strategies to sensitize tumors to radiation and chemotherapy, with elucidation of relevant signal transduction pathways, 2) study of approaches to overcome the radioresistance associated with Bcl-2 overexpression, 3) development of a targeted nanoparticle platform technology for killing both tumor cells and tumor vasculature, 4) study of the role of integrins in angiogenesis, 5) evaluation of potential new radiosensitizers and radioprotectors, 6) study of the function of the CD20 receptor in immunotherapy, 7) elucidation of the function of erythropoietin receptors on tumor cells, and 8) study of redox regulation of apoptotic potential, with emphasis on projects with near term translational potential. Clinical research interests include radioimmunotherapy and the use of biological response modifiers in combination with radiation therapy. I am also interested in the training of physician scientists, the interface of science and medicine, and provision of service to the Radiation Research Society in order to support the Society’s efforts to represent their membership, preserve and enhance research opportunities, develop programs and contribute to policy that may have long term ramifications for research in the radiation-related sciences and the practice of radiation oncology.


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