The course aims to inform of
new developments in radiobiology, explain how these integrate within classic
radiobiological concepts, and provide a framework within which to consider new
biology-based strategies for improving the radiotherapeutic benefit. Faculty:
J. Martin Brown, Ph.D. - Stanford University Medical Center
Amato Giaccia, Ph.D. - Stanford University Medical Center
Bill McBride, D.Sc., Ph.D. - UCLA Center Health Sciences
Bill Morgan (Ph.D.) - University of Maryland
Simon Powell, M.D., Ph.D. - Massachusetts General Hospital
Dietmar Siemann, Ph.D. - University of Florida
Moderator/monitor: Mark Dewhirst, D.V.M., Ph.D. - Duke University Medical Center
Preliminary Program:
DNA damage and repair pathways following irradiation.
Radiation-induced chromosome aberrations and their relevance to radiation responses.
Cyclins and cell cycle checkpoints; the effect of cell cycle variation in radiation
responses.
Radiation- and stress-induced signal transduction pathways; sensors and transducers.
Effector pathways to cell death and survival - apoptosis and mitotic catastrophe.
Determiners of intrinsic radioresponsiveness - predictive assays, new molecular
approaches, such as gene arrays.
Genetic influences of tumor suppressor and oncogenic mutations on radiation responses.
Radiation-induced genetic instability: mutations and carcinogenesis.
The oxygen effect.
Angiogenesis and the tumor microenvironment.
Normal tissue and tumor regeneration.
Biology-based strategies for improving radiotherapeutic benefit.
Registration:
Member $250
Resident $150
Non-member $350
Log onto www.astro.org for further
information on hotel and airline reservations as well as to register for the meeting.