Fourth Annual Symposium
John B. Little Center for Radiation
Sciences
and Environmental Health
“Radiation Damage to DNA:
Repair and Cellular Responses”
October 12-13, 2001
Harvard School of Public Health
677 Huntington Avenue
Boston, MA 02115
Preliminary Agenda
Friday, October 12
1:00 p.m. Opening Lecture: Dr. James L. German (Weill Medical College of
Cornell University)
"Four Decades of Bloom’s Syndrome"
Presentation of John B. Little Award in Radiation Sciences to Dr. German
Dr. Warren W. Nichols, (Merck Research Laboratories)
2:00-5:30 p.m.
SESSION I.
Clustered Damage and Complex Interactions
S. James Adelstein, (HMS) Discussion Leader
- John Ward
(University of California , San Diego)
"The variety of radiation-induced DNA strand breaks"
- Sankar Mitra
(University of Texas Medical Branch, Galveston)
"Effects of oxidative stress on the dynamics of early repair enzymes for
oxidative DNA damage in human cells"
- Carol Prives
(Columbia University)
"The expanding roles of p53 and its relatives"
- Steven A. Leadon
(University of North Carolina)
"Transcription coupled repair of oxidative DNA damage"
5:30-7:30 Reception (HSPH)
Saturday, October 13:
8:30 a.m. Continental Breakfast
9:00-12:30 - SESSION II.
Mechanisms of Double Strand Break Repair
Kathryn D. Held (MGH) Discussion Leader
- Maria Jasin
(Memorial Sloan Kettering Cancer Center)
"Genomic integrity and double-strand break repair in mammalian cells"
- Alan D. D’Andrea
(Dana Farber Cancer Institute)
"Interactions of the Fanconi anemia proteins and Brca1 in a common
pathway"
- Fred Alt (Harvard Medical School)
"Interplay between non-homologous end joining and cell cycle checkpoint
pathways in normal development and tumor suppression"
- Tom K. Hei
(Columbia University)
"Radiation-induced genotoxic damage in mammalian cells: From cytoplasm to
nucleus and the bystander phenomenon"
12:30-1:30 L U N C H
1:30-5:00 - SESSION III.
Cell Responses to Radiation Damage
Bruce Demple, (HSPH) Discussion Leader
- George Iliakis
(Thomas Jefferson University)
"Double-strand break repair and cellular responses"
- John Petrini
(University of Wisconsin)
"The Mre11 complex: linking DNA recombination and cell cycle regulation to the
suppression of malignancy"
- Carrolee Barlow
(Salk Institute)
"Using ATM deficient mice to study the role of ATM in damage response
pathways"
- William F. Morgan
(University of Maryland)
"Radiation-induced genomic instability and bystander effects: A little goes a long
way"
General Discussion (Joseph D. Brain, Moderator)
"RADIATION DAMAGE TO DNA:
REPAIR AND CELLULAR RESPONSE"
October 12-13, 2001, Boston, MA
R egistration form:
Please complete and return this form no later than September 7, 2001 to:
Ms. Virginia M. Braga
Radiobiology Program
Harvard School of Public Health
665 Huntington Avenue, Boston, MA 02115
Phone: (617) 432-1184; Fax: (617) 432-0107
Email: gbraga@hsph.harvard.edu
I plan to attend this Symposium:
Friday, October 12 ________
Saturday, October 13_______
I am unable to attend this Symposium _____
Name_____________________________________________
Organization:________________________________________
Address:___________________________________________
City/State/Zip Code__________________________________
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No registration fee
Reception on Friday evening and lunch on Saturday included for all registered
participants.
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