Representative Publications of L. Yarbrough

Li, H., Tremblay, J. M, Yarbrough, L. R, and Helmkamp , G. M Jr. (2002) Both isoforms of mammalian phosphatidylinositol transfer protein are capable of binding and transporting sphingomyelin. Biochim. Biophys. Acta  1580, 67-76.

Tremblay, J.M., Li, H., Yarbrough, L.R. and Helmkamp, G.M. Jr., (2001) Modifications of cysteing residues in the solution and mebrane-associated conformations of phosphatidylinositol transfer protein have differential effects on lipid transfer activity.  Biochemistry 40(31), 9151-8. 2001

Yoder, M.D., Thomas, L. M., Tremblay, J. M., Oliver, R. L., Yarbrough, L. R., and  Helmkamp, G. M. Jr. (2001) Structure of a Multifunctional Protein: Mammalian Phosphatidylinositol Transfer Protein Complexed with Phosphatidylcholine.  J. Biol. Chemistry  276, 9246-9252.

 Yarbrough, L. R. (2000) Would prevention of gun carrying reduce US homicide rates? (letter). JAMA 284, 1789.

Oliver, R. L., Tremblay, J. M.,  Helmkamp, G. M. Jr., Yarbrough, L. R., Breakfield, N. W., and Yoder, M. L. (1999).  X-ray analysis of crystals of rat phosphatidylinositol transfer protein with bound phosphatidylcholine.  Acta Cryst. D55, 522-524.

Tremblay, J.M., Voziyan, P.A., Helmkamp, G.M.Jr., and Yarbrough, L.R. (1998). The C-terminus of phosphatidylinositol transfer protein modulates membrane interactions and transfer activity but not phospholipid binding. Biochem. Biophys. Acta 1389, 91-100.

 Voziyan, P.A., Tremblay, J.M., Yarbrough, L.R., and Helmkamp, G.M.,Jr. (1997). Importance of phospholipid in folding and conformation of phosphatidylinositol transfer protein: comparison of apo and holo species. Biochemistry 36, 10082-10088.

Tremblay, J.M., Helmkamp, G.M., Jr. and Yarbrough, L.R. (1996) Limited proteolysis of rat phosphatidylinositol transfer protein by trypsin cleaves the C-terminus, enhances binding to lipid vesicles, and reduces phospholipid transfer activity. J. Biol. Chem. 271, 21075-21080.

Voziyan, P.A., Tremblay, J.M., Yarbrough, L.R. and Helmkamp, G.M., Jr. (1996) Truncations of the C-terminus have different effects on the conformation and activity of phosphatidylinositol transfer proteins. Biochemistry 35, 12526-12531.

Goldsmith, M., Yarbrough, L.R. and van der Kooy, D. (1995) Mechanics of motility: Distinct dynein binding domains on a and b-tubulin. Biochem. Cell Biol. 73, 665-671.

Dickeson, S.K., Helmkamp, G.M., Jr. and Yarbrough, L.R. (1994) Sequence of a human cDNA encoding phosphatidylinositol transfer protein and occurrence of a related sequence in widely divergent eukaryotes. Gene 142, 301-305.

Fitzgibbon, J., Pilz, A., Gayther, S., Appukuttan, B., Dulai, K.S., Delhanty, J.D.A., Helmkamp, G.M., Jr., Yarbrough, L.R. and Hunt, D.M. (1994) Localization of the gene encoding human phosphatidylinositol transfer protein (PITPN) to 17p13.3: A gene showing homology to the Drosophila retinal degeneration B gene (rdgB). Cytogenet. Cell Genet. 67, 205-207.

Vats-Mehta, S. and Yarbrough, L.R. (1993) Expression of chick and yeast _-tubulin encoding genes in insect cells. Gene 128, 263-267.

Goldsmith, M., Connolly, J.A., Kuman, N., Wu, J., Yarbrough, L.R. and van der Kooy, D. (1991) Conserved _-tubulin binding domain for the microtubule-associated motors underlying sperm motility and fast axonal transport. Cell Motil. Cytoskeleton 20, 249-262.

Schuyler, G.T. and Yarbrough, L.R. (1990) Effects of age on myosin and creatine kinase isoforms in left ventricles of Fischer 344 rats. Mech. Ageing Dev. 56, 23-38.

Schuyler, G.T. and Yarbrough, L.R. (1990) Comparison of myosin and creatine kinase isoforms in left ventricles of young and senescent Fischer 344 rats after treatment with triiodothyronine. Mech. Ageing Dev. 56, 39-48.

Schuyler, G.T. and Yarbrough, L.R. (1990) Changes in myosin and creatine kinase mRNA levels with cardiac hypertrophy and hypothyroidism. Basic Res. Cardiol. 85, 481-494.

Dickeson, S.K., Lim, C.N., Schuyler, G.T., Dalton, T.P., Helmkamp, G.M. and Yarbrough, L.R. (1989) Isolation and sequence of cDNA clones encoding rat phosphatidylinositol transfer protein. J. Biol. Chem. 264, 16557-16564.

Wu, J. and Yarbrough, L.R. (1987) Expression of the alpha and beta tubulin genes of the African trypanosome in Escherichia coli. Gene 61, 51-63.

Kimmel, B.E., Samson, S., Wu, J., Hirschberg, R. and Yarbrough, L.R. (1985) Tubulin genes of the African trypanosome Trypanosoma brucei rhodesiense: nucleotide sequence of a 3.7-kb fragment containing genes for alpha and beta tubulins. Gene 35, 237-248.

Yarbrough, L.R. and Fishback, J.L. (1985) Kinetics of interaction of 2-amino-6-mercapto-9-beta-ribofuranosylpurine 5_-triphosphate with bovine brain tubulin. Biochemistry 24, 1708-1714.

Fishback, J.L. and Yarbrough, L.R. (1984) Interaction of 6-mercapto-GTP with bovine brain tubulin equilibrium aspects. J. Biol. Chem. 259, 1968-1973.


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