Representative Publications: Richard Silverstein

R. Silverstein. (2004) The D-Galactosamine Lethality Model: Scope and Limitations. J. Endotox. Res. 10:147-162. 

R. Silverstein and D. C. Johnson. (2003)  Endogenous versus exogenous glucocorticoid responses to experimental bacterial sepsis: review.  J. Leukocyte Biol., 73:417-427.

C.J. Papasian, R. Silverstein, J.J. Gao, D. Bamberger, and D.C. Morrison. (2002)  The Anomalous Role of TNF-alpha in Experimental Enterococcal Infection.  Infect. Immun., 70:6628-6637.


Cui, W., Morrison, D.C., and Silverstein, R. (2000). Differential TNF-Alpha Expression and Release from Peritoneal Macrophages In Vitro in Response to Proliferating Gram-positive vs. Gram-negative Bacteria, Infect. Immun. 68:4422-4429.

Silverstein, R., Wood, J.G., Xue, Q., Norimatsu, M., Horn, D.L. and Morrison, D.C. (2000). Differential Host Inflammatory Responses to Viable vs. Antibiotic-killed Bacteria in Experimental Microbial Sepsis. Infect. Immun. 68:2301-2308.

Gao, J.J., Zuvanich, E.G., Xue, Q., Horn, D.L., Silverstein, R., and Morrison, D.C. (1999). Bacterial DNA and Lipopolysaccharides Act in Synergy in Inducing Nitric Oxide Production in RAW 264.7 Macrophages. J. Immunol. Cutting Edge: 163:4095-4099.

Silverstein, R., Johnson, D.C., and Norimatsu, M. (1999) Glucocorticoid Control of Endotoxin Responses, in: Endotoxin in Health and Disease, ed D.C. Morrison, Marcel Dekker, N.Y., pp. 769-779.

Silverstein, R. (1997).  Urdine Protection against D-Galactosamine-sensitized Mice is Complete.  J. Endotoxin. Res. 4:463-465.

Silverstein, R., Norimatsu, M., and Morrison, D.C. (1997).  Fundamental Differences during Gram-positive vs. Gram-negative Sepsis Become Apparent during Bacterial Challenge of D-Galactosamine-treated mice, J. Endotoxin Res. 4:173-4, 181.

Silverstein, R., Johnson, W.M., Bucklin, S.E., and Johnson, D.C. (1996) A Protein Kinase C Activator, PMA, Modulates LPS Lethality in Normal Mice and Protects Against LPS Lethality in D-Galactosamine-sensitized Mice, J. Endotox. Res., 3:29-37.

Johnson, D.C., Freudenberg, M. A., Jia, F., Gonzalez, J.C., Galanos, C., Morrison, D.C., and Silverstein, R. (1994) Contribution of Tumor Necrosis Factor-alpha and Glucocorticoid in Hydrazine Sulfate Protection Against Endotoxin Lethality, Circ. Shock, 43:1-8.

Silverstein, R., Turley, B.R., Christoffersen, C.A., Johnson, D.C. and Morrison, D.C. (1991) Hydrazine sulfate protects D-galactosamine-sensitized mice against endotoxin and tumor necrosis factor/cachectin lethality: evidence of a role for the pituitary. J. Exp. Med. 173:357-365.

Silverstein, R., Bhatia, P. and Svoboda, D.J. (1989) Effect of hydrazine sulfate on glucose regulating enzymes in the normal and cancerous rat. Immunopharmacol. 17:37-43.

Silverstein, R., Lin, C.-C., and Rawitch, A.B. (1980). Evidence for an essential hydrophobic domain in the maintenance of phosphoenolpyruvate carboxykinase activity. Site-specific binding and inactiviation by 1-anilinonaphthalene-8-sulphonate. J. Biol. Chem., 255:1374-1379.

Silverstein, R. and Willis, M.S. (1973) Concerted regulation in vitro of phosphoenolpyruvate carboxylase from Escherichia coli. J. Biol. Chem. 248:8402-8407.


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