Richard Silverstein Professor (phased retirement) Department of Biochemistry and Molecular Biology University of Kansas Medical Center 913-588-6954 rsilvers@kumc.edu

Education and Experience:

Major Research Interests

In recent years, our research has related to host response to agents that can elicit a septic or septic-like response.  These agents have included endotoxin, killed bacteria, as well as proliferating gram-positive and gram-negative bacteria.  Most particularly, our concern has been with TNF as a mediator of that response, and with the scope and limitations of exogenous and endogenous glucocorticoids to act against it.   Parallel to these in vivo studies, mostly in mice, we have employed an in vitro mouse macrophage model to assess relevance of that cell to in vivo response.