KUMC Jared Grantham

	Jared Grantham Professor E-mail address: jgrantha@kumc.edu Office phone: (913) 588-6074 Office location:4015 Sudler

Jared Grantham

Professor

E-mail address: jgrantha@kumc.edu
Office phone: (913) 588-6074
Office location:4015 Sudler

My research interests are: polycystic kidney disease, mechanisms of cyst formation and growth; role of a novel neutral lipid in the progression of autosomal dominant polycystic kidney disease; mechanisms of fluid secretion in epithelium of renal cysts; role adenylyl cyclase signal transduction in cyst growth.

Recent Publications

Grantham, J.J., The Jeremiah Metzger Lecture. Polycystic kidney disease: old disease in a new context. Trans Am Clin Climatol Assoc. 2002;113:211-24; discussion 224-6.

Wallace, D.P., G. Reif, M. Christensen, F. Belibi, B. Thrasher, D. Herrell, and J.J. Grantham. cAMP agonists induces anion and fluid secretion by human inner medullary collecting duct cells. Am. J. Physiol.

Yamaguchi, T. S. Nagao, D.P. Wallace, F. Belibi, B.D. Cowley, Jr., J.C. Pelling and J.J. Grantham. cAMP activates B-Raf kinase and extracellular signal-regulated kinase (ERK) in epithelial cells from autosomal dominant polycystic kidneys. Kidney Int.

Sullivan, L.P., D.P. Wallace, T. Grover, P.A. Welling, T. Yamaguchi, R. Maser, J.W. Eppler and J.J. Grantham. Sulfonylurea sensitive K⁺ transport is involved in Cl secretion and cyst growth by cultured ADPKD cells. J. Am. Soc. Nephrol.

Belibi, F.A., D.P. Wallace, T. Yamaguchi, M. Christensen, G. Reif and J.J. Grantham. The effect of caffeine on renal epithelial cells from patients with Autosomal Dominant Polycystic Kidney Disease. J. Am. Soc. Nephrol.

Grantham J.J., Wallace, D.P., Return of the secretory kidney. Am J Physiol Renal Physiol. 2002 Jan;282(1):F1-9. Review.

Grantham, J.J., Polycystic kidney disease: from the bedside to the gene and back. Curr Opin Nephrol Hypertens. 2001 Jul;10(4):533-42.

Wallace D.P., Rome L.A., Sullivan L.P., Grantham, J.J., cAMP-dependent fluid secretion in rat inner medullary collecting ducts. Am J Physiol Renal Physiol. 2001 Jun;280(6):F1019-29.

Calvet, J.P. and Grantham, J.J.. The genetics and physiology of polycystic kidney disease. Semin Nephrol. 2001 Mar;21(2):107-23. Review.

Grantham, J.J. and Calvet, J.P., Polycystic kidney disease: In danger of being X-rated? Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):790-2. Review. No abstract available

Wallace, D.P., J.M. Tomich, J.W. Eppler, T. Iwamoto, J.J. Grantham, and L.P. Sullivan. A synthetic channel-forming peptide induces Cl- secretion: Modulation by Ca2+-dependent K+ channels. Biochim et Biophys Acta 1464: 69-82, 2000.

Yamaguchi, T., Pelling, J.C., Ramaswamy, N.T., Eppler, J.W., Wallace, D.P., Nagao, S., Rome, L.A., Sullivan, L.P., Grantham, J.J., cAMP stimulates the in vitro proliferation of renal cyst epithelial cells by activating the extracellular signal-regulated kinase pathway. Kidney Int. 2000 Apr;57(4):1460-71.

Nagao, S., Yamaguchi, T., Kasahara, M., Kusaka, M., Matsuda, J., Ogiso, N., Takahashi, H. and Grantham, J.J., Effect of probucol in a murine model of slowly progressive polycystic kidney disease. Am J Kidney Dis. 2000 Feb;35(2):221-6.

Grantham, J.J., Time to treat polycystic kidney diseases like the neoplastic disorders that they are. Kidney Int. 2000 Jan;57(1):339-40. No abstract available.