Representative Publications: Glen Andrews

Andrews, G.K., Wang, H., Dey, S.K. and Palmiter, R.D., The mouse zinc transporter 1 gene provides an essential function during early embryonic development. Genesis, In Press, 2004.

Jiang, H. and Andrews, G.K., Gene-Specific and Cell Type-Specific Effects of Signal Transduction Cascades on Metal-Regulated Gene Transcription Appear to Be Independent of Changes in the Phosphorylation of Metal Response Element-Binding Transcription Factor-1. Biochem J. 382: 33-41, 2004.

Kim, B.E., Wang, F., Dufner-Beattie, J., Andrews, G.K., Eide, D.J.,  and  Petris, M.J.,
            Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the
            plasma membrane. J. Biol. Chem. 279: 4523-4530, 2004.

Wang, F., Kim, B.E., Dufner-Beattie, J., Petris, M.J., Andrews, G.K., and Eide, D.J.,
            Acrodermatitis Enteropathica mutations affect transport activity, localization, and
            zinc-responsive trafficking of the mouse ZIP4 zinc transporter. Human Mol. Gen., 13:
            563-571, 2004.

Wang, F., Dufner-Beattie, J., Kim, B.E., Petris, M.J., Andrews, G.K., and Eide, D.J., Zinc
            regulates mouse zinc-transporter mZIP1 and mZIP3 protein trafficking. J. Biol. Chem.
           279: 24631 -24639, 2004.

Lee, D-K, Geiser, J., Dufner-Beattie, J. and Andrews, G.K., Pancreatic metallothionein plays a role in zinc homeostasis during maternal dietary zinc deficiency.  J. Nutr., 133: 45-50, 2003.

Jiang, H., Daniels, P.J. and Andrews, G.K., Putative zinc-sensing zinc-fingers of metal response
            element-binding transcription factor-1 stabilize a metal-dependent chromatin complex
            on the endogenous metallothionein-I promoter. J. Biol. Chem. 278: 30394 - 30402,
            2003.

Dufner-Beattie, J., Wang, F., Kuo, Y-M., Gitschier, J.,  Eide, D. and Andrews, G.K., The
            acrodermatitis enteropathica gene ZIP4 encodes a tissue-specific, zinc regulated zinc
            transporter in mice.  J. Biol. Chem. 278: 33474 - 33481, 2003.

Dufner-Beattie, J., Langmade, S.J., Wang, F., Eide, D., and Andrews, G.K., Structure,
            function, and regulation of a subfamily of mouse zinc transporter genes. J. Biol. Chem.
            278: 50142 - 50150, 2003.

Daniels, P.J. and Andrews, G.K., Dynamics of the metal-dependent transcription factor
            complex in vivo at the mouse metallothionein-I promoter. Nucl. Acids Res. 31: 6710 -
            6721, 2003.

Daniels, P.J., Bittel, D., Smirnova, I.V., Winge, D.R. and Andrews, G.K., Mammalian metal response element-binding transcription factor-1 functions as a zinc-sensor in yeast, but not as a sensor of cadmium or oxidative stress, Nucl. Acids Res., 30: 3130 - 3140, 2002.

Johnson, D.A., Andrews, G.K. Xu, W. and Johnson, J.A., Activation of the antioxidant
             responsive element in primary cortical neuronal cultures derived from transgenic   
             reporter mice. J. Neurochem., 81: 1233 - 1241, 2002.

Andrews, G.K., Lee, D-K., Ravindra, R., Lichtlen, P., Sirito, M., Sawadogo, M. and Schaffner. W.,  The transcription factors MTF-1 and USF1 cooperate to regulate mouse metallothionein-I gene expression in visceral endoderm cells during early development. EMBO. J., 20: 1114-1122, 2001.

Andrews, G.K., Cellular zinc sensors: MTF-1 regulation of gene expression. Biometals, 14: 223-237, 2001.

Smirnova, I.V., Bittel, D.C., Ravindra, R., Jiang, H., and Andrews, G.K., Zinc and cadmium can promote rapid nuclear translocation of MTF-1. J. Biol. Chem., 275: 9377-9384, 2000.

Langmade, J. Ravindra, R., Daniels, P.J. and Andrews, G.K., The transcription factor MTF-1 mediates metal regulation of the mouse ZnT1 gene.  J. Biol. Chem., 275: 34803-34809, 2000.

Bittel, D.B., Smirnova, I.V. and Andrews, G.K., Functional heterogeneity in the zinc fingers of the metalloregulatory transcription factor, MTF-1. J. Biol. Chem., 275: 37194 -37201, 2000.

Hernandez, J., Carrasco, J., Lee, D.K., Andrews, G.K., Bluthmann, H., and Hidalgo, J.,  IL-6 and TNF receptor 1 knockout mice reveal roles for IL-6 and TNF-alpha in liver metallothionein regulation during stress and inflammation.  Cytokine, 12: 791-796, 2000.

Andrews,G.K. and Geiser, J., Expression of the metallothionein-I and -II genes provides a reproductive advantage during maternal dietary zinc deficiency.  J. Nutr., 129: 1643-1648, 1999.

Lee, D.K., Carrasco, J., Hidalgo, J., and Andrews, G.K., Identification of a Signal Transducer and Activator of Transcription binding site in the mouse metallothionein-I promoter involved in interleukin-6 induced gene expression.  Biochem. J., 337: 59-65, 1999.

Chu, W.A., Moehlenkamp, J.D., Bittel, D., Andrews, G.K., and Johnson, J.A., Cadmium-mediated activation of the metal response element in human neuroblastoma cells lacking functional metal response element-binding transcription factor-1, J. Biol. Chem., 274: 5279-5284, 1999.

Murphy, B.J., Andrews, G.K., Bittel, D, Disher, D.J., McCue, J., Green, C.J., Yanovsky, M., Giaccia, A., Sutherland, R.M., Laderoute, R., and Webster, K., Activation of metallothionein gene expression by hypoxia involves metal response elements and MTF-1. Cancer Res., 59: 1315-1322, 1999.

Bittel, D., Dalton, T., Samson, S.L.-A, Gedamu, L., and Andrews, G.K., The DNA-binding activity of MRE-binding transcription factor-1 is activated in vivo and in vitro by Zn, but not by other transition metals. J. Biol Chem., 273: I7127-7133, 1998.