Representative Publications: Todd Holyoak, Ph.D.

 

Holyoak, T., and Nowak, T. (2001) Structural investigation of the binding of nucleotide to phosphoenolpyruvate carboxykinase by NMR. Biochemistry 40, 11037-47.

Holyoak, T., Wilson, M. A., Fenn, T. D., Kettner, C. A., Petsko, G.A., Fuller, R. S., and Ringe, D. (2003) 2.4 angstrom resolution crystal structure of the prototypical hormone-processing protease Kex2 in complex with an Ala-Lys-Arg boronic acid inhibitor. Biochemistry 42, 6709-18.

Holyoak, T. Fenn, T.D., Wilson, M.A., Moulin, A.G., Ringe, D. and Petsko, G.A. (2003) Malonate: A versatile cryo-protectant and stabilizing solution for salt grown macromolecular crystals. Acta. Cryst. D59, 2356-58.

Holyoak, T
., Kettner, C. A., Petsko, G. A., Fuller, R. S., and Ringe, D. (2004) Structural basis for differences in selectivity in Kex2 and furin protein convertases. Biochemistry 43, 2412-21.

Holyoak, T. and Nowak, T. (2004) pH dependence of the reaction catalyzed by avian phosphoenolpyruvate carboxykinase. Biochemistry, 43, 7054-65.

Fenn, T.D., Holyoak, T., Stamper, G.F. and Ringe, D. (2005)Effect of a Y265F mutant on the transamination based cycloserine inactivation of alanine racemase. Biochemistry, in press.


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