Research Interests

The LH surge plays a key role in initiating events in the periovulatory follicle. These events include oocyte maturation, ovulation, and luteinization. Numerous studies have shown that the LH surge initiates the transcriptional up or down regulation of genes in the periovulatory granulosa cells. However, the post-transcriptional regulation of genes in the ovary has been largely unexplored.

Post-transcriptional gene regulation encompasses all aspects of mRNA processing, including splicing, transport, degradation, and initiation of translation. Polysomal RNA is messenger RNA associated with multiple ribosomes. Examination of polysomal RNA by microarray before and after the LH surge provides an approach for identifying and studying post-transcriptionally regulated genes. Therefore, our objectives are to:

• First, analyze the extent of post-transcriptional gene regulation following the LH surge in granulosa cells isolated from periovulatory follicles.
• Second, identify novel post-transcriptionally regulated genes.

Academic Training

B.A. - Oxbridge Molecular Biology, 2003, William Jewell College, Liberty, Missouri

Awards and Scholarships

• 2005-2009 KU Self Fellow
• Platform Presentation at Society for the Study of Reproduction: "Ovarian Post-Transcriptional Gene Regulation Following the LH Surge"
• USDA NRI Travel Fellow
• KUMC Travel Grant

Other Interests

I enjoy spending time with my husband (Matt) and my dog Tater (a white boxer).