Albert Einstein College of Medicine, 19872016 Smith East (Bldg. 37)
3901 Rainbow Boulevard – Mail Stop 3043
Kansas City, KS 66160
Phone: (913) 588-7420
Fax: (913) 588-7430
slevine@kumc.edu
We perform translational research that is directed at identifying pathogenic mechanisms and novel interventions for multiple sclerosis, which is a neurological disease that can cause sensory, motor and/or cognitive declines. Our studies incorporate a team approach that includes clinical samples, flow cytometry, immunology, and animal models. Additional studies address intervention strategies for globoid cell leukodystrophy and identifying mechanisms of toxin-induced vessel injury.
Biswas S and LeVine SM (2002) Substrate reduction
therapy enhances the benefits of bone marrow transplantation
in young mice with globoid cell leukodystrophy. Pediatric
Res. 51:40-47.
Biswas S, Biesiada H, Williams TD and LeVine SM (2002) Delayed
clinical and pathological signs in twitcher (globoid cell leukodystrophy) mice
on a C57BL/6 x CAST/Ei background. Neurobiol. Dis. 10:344-357.
Emerson MR, Orentas DM, Lynch SG and LeVine SM (2002) Activation
of histamine H2 receptors ameliorates experimental allergic encephalomyelitis. NeuroReport 13:1407-1410.
LeVine SM, Maiti S, Emerson MR and Pedchenko TV (2002) Apoferritin
attenuates experimental allergic encephalomyelitis in SJL mice. Dev. Neurosci. 24:177-183.
Chakrabarty A, Emerson MR and LeVine SM (2003) Heme oxygenase-1
in SJL mice with experimental allergic encephalomyelitis. Multiple Sclerosis 9:372-381.
Biswas S, Biesiada H, Williams TD and LeVine SM (2003) Substrate
reduction intervention by L-cycloserine in twitcher mice (globoid cell leukodystrophy)
on a B6;CAST/Ei background. Neuroscience Lett., 347:33-36.
Esch SW, Williams TD, Biswas S, Chakrabarty A and LeVine SM (2003)
Sphingolipid profile in the CNS of the Twitcher (globoid cell leukodystrophy)
mouse: A lipidomics approach. Cell. Mol. Biol. 49:779-787.
Duzhak T, Emerson MR, Chakrabarty A, Alterman MA and LeVine SM (2003)
Analysis of protein induction in the CNS of SJL mice with experimental allergic
encephalomyelitis by proteomic screening and immunohistochemistry. Cell.
Mol. Biol. 49:723-732.
LeVine SM and Chakrabarty A (2004) The role of iron in the pathogenesis
of experimental allergic encephalomyelitis and multiple sclerosis. Annals
NYAS 1012:252-266.
Chakrabarty A, Danley MM and LeVine SM (2004) Immunohistochemical
localization of phosphorylated-protein kinase R and phosphorylated-eukaryotic
initiation factor-2a in the CNS of SJL mice with experimental allergic encephalomyelitis. J.
Neurosci. Res. 76:822-833.
Emerson ME and LeVine SM (2004) Experimental allergic encephalomyelitis
is exacerbated in mice deficient for 12/15-lipoxygenase or 5-lipoxygenase. Brain
Res. 1021:140-145.
Chakrabarty A, Fleming KK, Marquis JG and LeVine SM (2005) Quantifying
immunohistochemical staining of phospho-eIF2a, heme oxygenase-2 and NADPH cytochrome
P450 reductase in oligodendrocytes during experimental autoimmune encephalomyelitis. J.
Neurosci. Meth. 144:227-234.
Culley NC, Pinson DM, Chakrabarty A, Mayo MS and LeVine SM (2005) Pathophysiological manifestations in mice exposed to anthrax lethal toxin. Infect. Immun. 73:7006-7010.
Fleming KK, Bovaird JA, Mosier MC, Emerson MR, LeVine SM and Marquis JG (2005) Statistical analysis of data from studies on experimental autoimmune encephalomyelitis. J. Neuroimmunol. 170:71-84.
Mitchell KM, Dotson AL, Cool KM, Chakrabarty A, Benedict SH and LeVine SM (2007) Deferiprone, an orally deliverable iron chelator, ameliorates experimental autoimmune encephalomyelitis. Multiple Sclerosis 13:1118-1126.
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The University of Kansas Medical Center