Mail Stop 3043
3901 Rainbow Boulevard
Kansas City, KS 66160-7401
Phone: (913) 588-7412
Fax: (913) 588-7430
gchaturvedi@kumc.edu
Hepatocellular carcinoma (HCC) is one of the most prevalent human cancers worldwide, with 625,000 estimated new cases per year and almost as many deaths. In the developed world, HCC nearly always develops in the setting of chronic hepatitis B or C virus infection. Since most patients have cirrhosis at the time of diagnosis, liver transplantation (LT) is generally the only potentially curative therapy. Unfortunately, patients succumb to the disease as a result of recurrence after LT. The most common pattern of recurrence after transplant is intrahepatic without metastases. This suggests that new tumor is seeded from a population of circulating tumor cells (CTC) that remained after the liver was removed. My reseach searches for CTCs by comparing circulating cell populations from HCC patients' blood samples and also at their site of origin by analyzing tissue specimens from resected liver after LT. Those with very large tumors, have extremely high risk of post-transplant recurrence. The long term goal of my research is to identify the circulating tumor cells responsible for hepatic tumor recurrence in order to 1) better stratify patients for risk of recurrence and 2) develop specific therapies directed against these cells to reduce the rate of tumor recurrence.
Additionally, I am also involved in deciphering the signaling mechanisms involved in HCV driven hepatocellular carcinoma especially in relation to Wnt/beta-catenin pathway.
Publications
1. GS Gupta, G Chaturvedi and A Joshi. Sex dependent immune responses by allogenic LDH isozymes. Mol. Cell. Biochem. 158: 115-119, 1996.
2. GS Gupta and G Chaturvedi. Regulation of immune functions by sperm-specific LDH and its differences with somatic isozymes in primary and secondary lymphocyte cultures. Am. J. Reprod. Immunol. 44(3): 160-169, 2000.
3. G. Chaturvedi, R Tewari, Mrigank, N Agnihotri, RA Vishwakarma and NK Ganguly. Structural evaluation of a peptide from a 20kDa adhesin which Inhibits Helicobacter pylori adherence to HEp-2 cells in vitro. Mol Cell Biochem 2001 Dec; 228(1-2):83-89
4. Farooq A, Chaturvedi G, Mujtaba S, Plotnikova O, Zeng L, Dhalluin C, Ashton R and Zhou MM. Solution Structure of Erk2 binding domain of MAPK Phosphatase MKP-3: Structural insights into MKP-3 activation by Erk2. Molecular Cell 2001 Feb; 7(2): 387-399.
5. Chaturvedi G., Farooq A., Zeng L., and Zhou M.-M 1H,13C and 15N resonance assignments of the catalytic domain of human MAPK phaphatase, PAC-1. J. Biomol. NMR. 2002,25:79-80
6. Farooq A., Plotnikova O., Chaturvedi G., Yan S., Zeng L., Zhang Q., and Zhou M.-M Solution Structure of the catalytic domain of MAPK phosphatase PAC-1: Insights in to substrate –induced enzymatic activation. Structure (Camb) 2002, 11: 155-164
7. M.Sharma, N.K. Ganguly, G Chaturvedi, SKS Thingnam, S.Majumdar and R.K.Suri. Cardioprotection mediated by HSP70 during ischemia/ reperfusion is linked to increased expression of CD69 and intracellular calcium. Molecular and Cellular Biochemistry 2003, 247: 31-36
8. M.Sharma, N.K. Ganguly, G Chaturvedi, SKS Thingnam, S.Majumdar and R.K.Suri. Release of Pro-Inflamatory Mediators during myocardial ischemia/ reperfusion, in coronary artery bypass graft surgery. Molecular and Cellular Biochemistry, 2003,247: 23-30
9. G Chaturvedi, K Arai, D Limback, K. F. Roby and P. F. Terranova. Regulation of cyp17 Expression in Theca-enriched Mouse Ovarian Cells by Src Tyrosine Kinase. Endocrine. 2004 Nov; 25(2):147-54.
10. G Chaturvedi, Arai K., K.F. Roby and P.F. Terranova. Mechanism of Cyp17 Expression and Androgen biosynthesis in mouse; involvement of ERK pathway. Mol. Cell. Biochem 2008, 318(1-2):191-200.
11. G Chaturvedi, P. Simone, R Ain, M.J. Soares and MW Wolfe. Noggin helps maintain pluripotency in human embryonic stem cells cultured on Matrigel. Cell. Proliferation, 2009 Aug;42(4):425-33.
12. Shaik SS, Soltau TD, Chaturvedi G, Totapally B, Hagood JS, Andrews WW, Killingsworth C, Patel RP, Fallon MB, Maheshwari A. Intra-circulatory Chemokine Gradients facilitate the Normal Arteriovenous Migration of Neutrophils. J Biol. Chem. 2009 Feb 27;284(9):5945-55
13. Madhulika Sharma, Jennifer G Brantley, Dianne Vassmer, Gaurav Chaturvedi, Jennifer Baas and Gregory Vanden Heuvel. The homeodomain protein Cux1 interacts with Grg4 to repress p27kip1 expression during kidney development Gene. 2009 Jun 15; 439(1-2):87-94.
14. Sun J, Chaturvedi G, Weinman SA. Viral Hepatitis C. In: Molecular Pathology of Liver Diseases. Edited by Monga SPS: Springer US; 2011. pp. 569-588.
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The University of Kansas Medical Center