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Molecular & Integrative Physiology
Department of Molecular & Integrative Physiology  :  Faculty Research Board : Sang-Pil Lee, Ph.D.

Sang-Pil Lee, Ph.D.

Sang-Pil Lee’s research involves the characterization and understanding of biological processes in the brain in vivo at the cellular and molecular level using novel non-invasive magnetic resonance (MR) techniques. For example, in vivo measurements of iron contents, Aß plaques and axonal transport using contrast agents in transgenic animal models of Alzheimer’s disease. My research goal is early diagnosis and identification of changes in functional and physiological aspects of neurodegenerative diseases during the disease progression.

Text Box: Figure 1. Visualization of Aß plaques in a transgenic mouse model of Alzheimer’s disease (PS/APP) using ultra-high resolution magnetic resonance imaging (MRI). Co-registered MRI (left) and histology (right) of Aß plaques, a hallmark of AD.

Text Box: Figure 2. Collocalization of iron staining and Aß plaques. Consecutive sections of a PS/APP mouse brain stained with Aß antibody (A) and DAB enhanced Perl’s staining for iron (B). The presence of iron, a strong MRI relaxation agent, in the plaques is suggested to be the major source of the MRI contrast for the plaques seen in Figure 1 (left).