Post Graduate Institute of Medical Education & Research, 2002.
Pathogenesis of HIV-associated end stage diseases.
Research
My research involves understanding the interplay of macrophages, cytokines and chemokines in lung infections associated with HIV-infection. The complications associated with AIDS in the ART era are evolving away from those of an infectious nature and towards noninfectious consequences of prolonged survival. HIV-related pulmonary hypertension (HIV-PAH) is a particularly severe example and the majority of HPAH occurs in individuals with a history of intravenous drug use (IVDU). One of my primary research efforts is aimed at understanding mechanistically how HIV-1 and drugs of abuse contribute alone and in concert to the pathogenesis of PAH, which can later help in developing novel and effective therapeutic intervention strategies. Understanding pathways involved in viral-drugs of abuse interactions that cause dysfunction of pulmonary vasculature will add insight into the vascular biology of all arteriopathies such as PAH in general, coronary artery diseases and systemic hypertension. Other focus of the lab is to develop DNA vaccine encapsulated nanoparticles, targeted specifically to antigen presenting cells, as an effective oral vaccination strategy against HIV-1 infection.
Selected Peer Reviewed Publications:
Navneet K. Dhillon, Fuwang Peng, Richard R. Ransohoff, Shilpa Buch. 2007. PDGF Synergistically Enhances IFN-g Induced Expression of CXCL10 in Blood-Derived Macrophages: Implications for HIV-Dementia. J. Immunology Sep 1; 179(5):2722-30.
Navneet K. Dhillon, Rachel Williams, Fuwang Peng, Yi-jou Tsai, Sukhbir Dhillon, Brandon Nicolay, Milind Gadgil and Shilpa J. Buch. 2007. Cocaine-mediated Enhancement of Virus Replication in Macrophages: Implications for HIV-Dementia. J Neurovirology. Dec; 13(6):483-95.
Ajay Singh, Navneet K. Dhillon, S Sharma, G Khuller. 2008. Identification and purification of CREB like protein in Candida albicans. Mol Cell Biochem. Jan; 308(1-2):237-45. Epub 2007 Nov 16.
Navneet K. Dhillon, Rachel Williams, Shannon Callen, Chris Zien, Opendra Narayan, Shilpa J. Buch. 2008. Roles of MCP-1 in Development of HIV-Dementia, Frontiers in Biosciences. May 1; 13:3913-8.
Navneet K. Dhillon*, Xuhui Zhu*, Fuwang Peng, Honghong Yao, Rachel Williams, Shannon Callen, Amy O’Brien Ladner, and Shilpa Buch. (*co first authors).2008. Molecular Mechanism(s) Involved in the Synergistic Induction of CXCL10 by HIV-1 Tat and Interferon-g in Macrophages. J Neurovirolgy. May; 14(3):196-204.
Fuwang Peng, Navneet K. Dhillon，Honghong Yao, Xuhui Zhu, Shilpa Buch*. 2008. Mechanisms of platelet-derived growth factor-mediated neuroprotection--implications in HIV dementia. European J Neuroscience2008 Oct; 28(7):1255-64.
Sonja Bartolome, Navneet K. Dhillon, Shilpa Buch, Alfred J. Casillan, John G.Wood and Amy R. O'Brien-Ladner. 2009. Deferoxamine Mimics the Pattern of Hypoxia-related Injury at the Microvasculature. SHOCK 31(5):481-485.
Rachel Williams, Navneet K. Dhillon, Sonia T. Hegde, Honghong Yao, Fuwang Peng, Shannon Callen, Yahia Chebloune, Randall L. Davis, Shilpa Buch.2009. Pro-inflammatory cytokines and HIV-1 synergistically enhance CXCL10 expression in human astrocytes. GLIA. 57(7):734-743.
Navneet K. Dhillon*, William J. Murphy*, Michael B. Filla, Ana J. Crespo, Heath A. Latham and Amy O’Brien-Ladner (*co first authors). Down modulation of IFN-g Signaling in Alveolar Macrophages Isolated from Smokers. Toxicology & Applied Pharmacology. May 15; 237(1):22-8. Epub 2009 Mar 6.
A. Baoum, Navneet K. Dhillon, S. Buch, and C. Berkland. Cationic surface modification of PLG nanoparticles offers sustained gene delivery to pulmonary epithelial cells.2009. J. of Pharmaceutical Sciences. 2009 Nov 12[Epub ahead of print].
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