My interest in biology developed thanks to my mom who is a medical doctor. The complexity of human body is far beyond any human-made machine, which always amazes me. While I was studying in Tsinghua University, I had opportunities to work in a neuroscience lab to study memory formation and a biochemistry lab to study signal transduction in stem cells. From these experiences, I was attracted by how the experimental tools could be used in different areas to solve interesting problems and add new knowledge to our understanding of life. Then I realized a graduate study was necessary for me to grow up as a biomedical scientist.
Research Interests
My focus of graduate study is on estrogens, which exert diverse and important biological functions in animals and humans, and it is believed that many of their actions are mediated by their direct interactions with the intracellular estrogen receptors. A major part of my current research is related to using computational modeling tools to study the structure-activity relationships of various endogenous estrogens for the activation of the human estrogen receptor alpha and beta subtypes. Also, I am evaluating the estrogenic and antiestrogenic activities of several newly-synthesized estrogen analogs in human breast cancer cells and also in intact animals. A third part of my interest is to study the cardiovascular effect of various estrogens and to discover the underlying mechanisms.
Publication:
Xiang-Rong Jiang*, Pan Wang*, Xinmiao Fu* and Bao Ting Zhu [2008] Chemical synthesis and biochemical characterization of a biotinylated derivative of 17β-estradiol with a long side chain covalently attached to its C-7α position. Steroids (Accepted). *These authors contributed almost equally to this study.
Hyoung-Woo Bai, Pan Wang and Bao Ting Zhu [2008] Identification of a novel triplet-point-mutation polymorphism for the human Catechol-O-Methyltransferase gene. (Submitted).
Xinmiao Fu, Pan Wang and Bao Ting Zhu [2008] Protein disulfide isomerase functions as an estrogen buffer in breast cancer cells and desensitizes the estrogen-induced response. (Submitted)
Fellowship Awarded:
Contact Information
Pan Wang
4038 KLSIC
Department of Pharmacology, Toxicology, and Therapeutics
The University of Kansas Medical Center
MS1018
3901 Rainbow Boulevard
Kansas City, KS 66160
Phone: (913) 588-9178
Fax: (913) 588-7501
E-Mail: pwang@kumc.edu
Updated 8/24/09
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The University of Kansas Medical Center