I completed my undergraduate education at Carleton College, majoring in biology. During this time, I participated in the Summer Program for Undergraduate Research at the Medical College of Wisconsin. After receiving a J.D. from the University of Minnesota School of Law, I returned to biomedical research by enrolling in the graduate program at KUMC. After completing the first year interdisciplinary program, I joined the Department of Pharmacology as a PhD student in Dr. Hagenbuch’s lab.
Research Interests
Adverse drug-drug interactions pose a significant health threat to many Americans, particularly the elderly. Recent research has shown that these interactions may be caused by transport proteins, which transport molecules through cell membranes. Organic anion transporting polypeptides (OATPs) are transporters that mediate the cellular uptake of a broad range of drugs, including the cholesterol-lowering statins. Drug-drug interactions at OATPs can alter drug disposition throughout the body, decreasing the effectiveness of the drug and/or increasing the severity of side effects. Identifying potential drug-drug interactions is essential to prevent these adverse effects. My research is focused on developing a working knowledge of the structure of OATPs, and the mechanism by which they recognize and transport a wide range of substrates. A detailed understanding of this mechanism is crucial for accurate prediction and prevention of OATP-mediated drug-drug interactions.
Contact Information
Megan Roth
Department of Pharmacology, Toxicology, and Therapeutics
The University of Kansas Medical Center
MS1018
3901 Rainbow Boulevard
Kansas City, KS 66160
Phone: (913) 588-9189
Fax: (913)588-7501
E-Mail: mroth@kumc.edu
Updated 11/13/08
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The University of Kansas Medical Center