Research Interests
The overall research interest of the laboratory is to understand the role of ATP binding cassette (ABC) transporters in Biology and Medicine. These proteins, found in all species, use the energy of ATP hydrolysis to translocate specific substrates across cell membranes. Most of these transporters play important roles in normal biology and in the therapeutic response to medications.
Our current studies focus on 1) Identifying the physiological function, regulation and clinical significance of ABC transporters and 2) Understanding the significance of protein-protein interactions to the intracellular trafficking and functional activity of these multi domain transport machineries. We explore these questions through molecular and cellular biology, protein biochemistry and genetics. We complement our cell culture studies with whole animal studies to put our finding at the cellular level in the context of the whole animal. We expect that these studies will not only provide insight into the cellular role of these transporters but also help us translate this knowledge into new diagnostic and treatment strategies to optimize therapy.
Selected publications:
Krishnamurthy P., Schwab M., Takenaka K., Nachagari D., Morgan J., Leslie M., Du W., Boyd K., Cheok M., Nakauchi H., Marzolini C., Kim R. B., Poonkuzhali B., Schuetz E., Evans W. E., Relling M. V., and Schuetz J. D. Transporter mediated protection against Thiopurine-induced hematologic toxicity. In Review for Nature Medicine
Li C., Krishnamurthy P., Penmatsa H., Mars K. L., Wang X., Zaccolo M., Jalink K., Li M., Nelson D. J., Schuetz J. D and Naren A. P. Spatiotemporal coupling of cAMP Transporter to CFTR Chloride Channel Function in the Gut Ephithelia. Cell (In Press)
Krishnamurthy P and Schuetz J. D. (2007) The role of Transporters in cellular heme and porphyrin homeostasis. Pharmacology and Therapeutics 114: 345-358
Krishnamurthy P., Du G., Fukuda, Y., Daxi S., Sampath, J., Mercer K. E., Wang J., Sosa-pineda B., Murti G., and Schuetz J. D. (2006) Identification of a mammalian mitochondrial porphyrin transporter. Nature. 443: 586-589
Krishnamurthy P and Schuetz J. D. (2006) Role of ABCG2/BCRP in Biology and Medicine. Annu. Rev. Pharmacol. 46: 381-410
Krishnamurthy P and Schuetz J. D. (2005) The ABC transporter Abcg2/Bcrp: Role in hypoxia mediated survival. Biometals. 18: 349-358
Krishnamurthy P, Ross D. D., Nakanishi T., Zhou S., Mercer K. E., Sarkadi B., Sorrentino B. P., and Schuetz J. D. (2004) The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme. J Biol Chem. 279: 24218-24225.
Contact Information
Partha Krishnamurthy, Ph.D.,
Assistant Professor
Department of Pharmacology, Toxicology, and Therapeutics
The University of Kansas Medical Center
MS 1018, 3901 Rainbow Blvd
Kansas City, KS 66160
Phone: (913) 945-6631
Fax: (913) 588-7501
pkrishnamurthy@kumc.edu
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The University of Kansas Medical Center