Research Interests
Special Interests: Pediatric clinical pharmacology, pediatric pharmacogenetics, developmental pharmacogenomics
The Clinical Pharmacology staff evaluates adverse drug reactions, drug interactions and drug-induced diseases, and recommends pharmacotherapy for Children's Mercy patients. Our staff provides specialized services including pharmacokinetics, pharmacogenetic predisposition for drug efficacy and adverse effects. In addition, our Medical Toxicology specialist consults with local providers involved in unusual medical toxicology cases and provides inpatient consultations for children exposed to poisons.
Selected Publications
Leeder JS, Gaedigk R, Marcucci KA, Gaedigk A, Vyhlidal CA, Schindel BP, Pearce RE. Variability of CYP3A7 expression in human fetal liver. J Pharmacol Exp Ther 2005; 314:626-635.
Pearce RE, Uetrecht JP, Leeder JS. Pathways of carbamazepine bioactivation in vitro II. The role of human cytochrome P450 enzymes in the formation of 2-hydroxyiminostilbene. Drug Metab Disp 2005; 33: 1819-1826.
Vyhlidal CA, Gaedigk R, Leeder JS. Nuclear receptor expression in fetal and pediatric liver: Correlation with CYP3A expression. Drug Metab Disp 2006;34:131-137.
Gaedigk A, Baker DW, Totah RA, Gaedigk R, Pearce RE, Vyhlidal CA, Zeldin DC, Leeder JS. Variability of CYP2J2 expression in human fetal tissue. J Pharmacol Exp Ther 2006; 319:523-532.
Gaedigk A, Ndjountché L, Divakaran K, Bradford LD, Zineh I, Oberlander TF, Brousseau DC, McCarver GD, Johnson JA, Alander SW, Riggs KW, Leeder JS. Cytochrome P452D6 (CYP2D6) gene locus heterogeneity: Characterization of gene duplication events. Clin Pharmacol Ther 2007; 81:242-251.
Blake MJ, Gaedigk A, Pearce RE, Bomgaars LR, Christensen ML, Stowe C, James LP, Wilson JT, Kearns GL, Leeder JS. Ontogeny of dextromethorphan O- and N-demethylation in the first year of life. Clin Pharmacol Ther 2007; 81: 510-516.
Gaedigk A, Simon SD, Pearce RE, Bradford LD, Kennedy MJ, Leeder JS. The CYP2D6 activity score: Translating genotype information into a quantitative measure of phenotype. Clin Pharmacol Ther 2008; 83:234-242.
Adjei AA, Gaedigk A, Simon SD, Weinshilboum RM, Leeder JS. Interindividual variability in acetaminophen sulfation by human fetal liver: Implications for pharmacogenetic investigations of drug-induced birth defects. Birth Defects Res A Clin Mol Teratol 2008;82:155-165.
Leeder JS, Pearce RE, Gaedigk A, Modak A, Rosen DI. Evaluation of a [13C] dextromethorphan breath test to assess CYP2D6 phenotype. J. Clin. Pharmacol 2008; 48:1041-1051 DOI: 10.1177/0091270008319709.
Pearce RE, Lu W, Wang YQ, Uetrecht JP, Correia MA, Leeder JS. Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine. Drug Metab Disp 2008; 36:1637-1649.
Contact Information
J. Steven Leeder, Pharm. D., Ph.D.
Professor of Pediatrics and Pharmacology
Children’s Mercy Hospital
Division of Pediatric Pharmacology and Medical Technology
2401 Gillham Road
Kansas City, MO. 64108
Phone: (816) 234-3059
Fax: (816) 855-1958
Updated 8/24/09
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The University of Kansas Medical Center