Osteonecrosis (Avascular Necrosis)

HUMAN STUDIES

Use of concentrated bone marrow aspirate and platelet rich plasma during minimally invasive decompression of the femoral head in the treatment of osteonecrosis.
Martin JR, Houdek MT, Sierra RJ.
Croat Med J. 2013 Jun;54(3):219-24.
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Clinical results of auto-iliac cancellous bone grafts combined with implantation of autologous bone marrow cells for osteonecrosis of the femoral head: a minimum 5-year follow-up.
Kang JS, Moon KH, Kim BS, Kwon DG, Shin SH, Shin BK, Ryu DJ.
Yonsei Med J. 2013 Mar 1;54(2):510-5. doi: 10.3349/ymj.2013.54.2.510.
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Stem cell implantation for osteonecrosis of the femoral head.
Lim YW, Kim YS, Lee JW, Kwon SY.
ExpMol Med. 2013 Nov 15;45:e61. doi: 10.1038/emm.2013.128.
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The efficacy of targeted intraarterial delivery of concentrated autologous bone marrow containing mononuclear cells in the treatment of osteonecrosis of the femoral head: a five year follow-up study.
Mao Q, Jin H, Liao F, Xiao L, Chen D, Tong P.
Bone. 2013 Dec;57(2):509-16. doi: 10.1016/j.bone.2013.08.022. Epub 2013 Aug 29.
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Regeneration of human bones in hip osteonecrosis and human cartilage in knee osteoarthritis with autologous adipose-tissue-derived stem cells: a case series.
Pak J.
J Med Case Rep. 2011 Jul 7;5:296. doi: 10.1186/1752-1947-5-296.
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PRECLINICAL STUDIES

The effects of autologous bone marrow mesenchymal stem cell arterial perfusion on vascular repair and angiogenesis in osteonecrosis of the femoral head in dogs.
Jin H, Xia B, Yu N, He B, Shen Y, Xiao L, Tong P.
IntOrthop. 2012 Dec;36(12):2589-96. doi: 10.1007/s00264-012-1674-7. Epub 2012 Oct 13.
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HGF-transgenic MSCs can improve the effects of tissue self-repair in a rabbit model of traumatic osteonecrosis of the femoral head.
Wen Q, Jin D, Zhou CY, Zhou MQ, Luo W, Ma L.
PLoS One. 2012;7(5):e37503. doi: 10.1371/journal.pone.0037503. Epub 2012 May 21.
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Cell-based immunotherapy with mesenchymal stem cells cures bisphosphonate-related osteonecrosis of the jaw-like disease in mice.
Kikuiri T, Kim I, Yamaza T, Akiyama K, Zhang Q, Li Y, Chen C, Chen W, Wang S, Le AD, Shi S.
J Bone Miner Res. 2010 Jul;25(7):1668-79. doi: 10.1002/jbmr.37.
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Successful transplant of mesenchymal stem cells in induced osteonecrosis of the ovine femoral head: preliminary results.
Feitosa ML, Fadel L, Beltrão-Braga PC, Wenceslau CV, Kerkis I, Kerkis A, Birgel Júnior EH, Martins JF, Martins Ddos S, Miglino MA, Ambrósio CE.
Acta Cir Bras. 2010 Oct;25(5):416-22.
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Use of genetically engineered bone-marrow stem cells to treat femoral defects: an experimental study.
Cui Q, Xiao Z, Li X, Saleh KJ, Balian G.
J Bone Joint Surg Am. 2006 Nov;88 Suppl 3:167-72.
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REVIEW ARTICLES

Stem cell therapy for the treatment of early stage avascular necrosis of the femoral head: a systematic review.
Lau RL, Perruccio AV, Evans HM, Mahomed SR, Mahomed NN, Gandhi R.
BMC MusculoskeletDisord. 2014 May 16;15(1):156. doi: 10.1186/1471-2474-15-156.
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Stem cell treatment for avascular necrosis of the femoral head: current perspectives.
Houdek MT, Wyles CC, Martin JR, Sierra RJ.
Stem Cells Cloning. 2014 Apr 9;7:65-70. eCollection 2014. Review.
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Osteonecrosis repair with bone marrow cell therapies: State of the clinical art.
Hernigou P, Flouzat-Lachaniette CH, Delambre J, Poignard A, Allain J, Chevallier N, Rouard H.
Bone. 2014 Jul 10. pii: S8756-3282(14)00257-9. doi: 10.1016/j.bone.2014.04.034. [Epub ahead of print] Review.
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Stem cell- and growth factor-based regenerative therapies for avascular necrosis of the femoral head.
Rackwitz L, Eden L, Reppenhagen S, Reichert JC, Jakob F, Walles H, Pullig O, Tuan RS, Rudert M, Nöth U.
Stem Cell Res Ther. 2012 Feb 22;3(1):7. doi: 10.1186/scrt98. Review.
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Cellular-based therapy for osteonecrosis.
Gangji V, Hauzeur JP.
Orthop Clin North Am. 2009 Apr;40(2):213-21. doi: 10.1016/j.ocl.2008.10.009. Review
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The use of percutaneous autologous bone marrow transplantation in nonunion and avascular necrosis of bone.
Hernigou P, Poignard A, Manicom O, Mathieu G, Rouard H.
J Bone Joint Surg Br. 2005 Jul;87(7):896-902. Review. No abstract available.
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