Adult Stem Cells in Wound Care

HUMAN STUDIES

Progenitor cell therapy for sacral pressure sore: a pilot study with a novel human chronic wound model.
Wettstein R, Savic M, Pierer G, Scheufler O, Haug M, Halter J, Gratwohl A, Baumberger M, Schaefer DJ, Kalbermatten DF.
Stem Cell Res Ther. 2014 Jan 29;5(1):18. [Epub ahead of print]
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Role of endothelial progenitor cells and inflammatory cytokines in healing of diabetic foot ulcers.
Tecilazich F, Dinh T, Pradhan-Nabzdyk L, Leal E, Tellechea A, Kafanas A, Gnardellis C, Magargee ML, Dejam A, Toxavidis V, Tigges JC, Carvalho E, Lyons TE, Veves A.
PLoS One. 2013 Dec 16;8(12):e83314. doi: 10.1371/journal.pone.0083314. eCollection 2013.
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Effect of combination therapy with alginate dressing and mouse epidermal growth factor on epidermal stem cells in patients with refractory wounds.
Bi Q, Zhang Q, Ma J, Xu M, Zhang SJ, Qiu BS, Xia B, Gu HF, Hong JF, Zhao C, Zhu DJ.
Chin Med J (Engl). 2012 Jan;125(2):257-61.
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PRECLINICAL STUDIES

Scalded skin of rat treated by using fibrin glue combined with allogeneic bone marrow mesenchymal stem cells.
Yang Y, Zhang W, Li Y, Fang G, Zhang K.
Ann Dermatol. 2014 Jun;26(3):289-95. doi: 10.5021/ad.2014.26.3.289. Epub 2014 Jun 12.
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Electrospun Tropoelastin for Delivery of Therapeutic Adipose-Derived Stem Cells to Full-Thickness Dermal Wounds.
Machula H, Ensley B, Kellar R.
Adv Wound Care (New Rochelle). 2014 May 1;3(5):367-375.
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New therapy of skin repair combining adipose-derived mesenchymal stem cells with sodium carboxymethylcellulose scaffold in a pre-clinical rat model.
Rodrigues C, de Assis AM, Moura DJ, Halmenschlager G, Saffi J, Xavier LL, Fernandes Mda C, Wink MR.
PLoS One. 2014 May 2;9(5):e96241. doi: 10.1371/journal.pone.0096241. eCollection 2014.
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Conditioned medium from hypoxic bone marrow-derived mesenchymal stem cells enhances wound healing in mice.
Chen L, Xu Y, Zhao J, Zhang Z, Yang R, Xie J, Liu X, Qi S.
PLoS One. 2014 Apr 29;9(4):e96161. doi: 10.1371/journal.pone.0096161. eCollection 2014.
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Human Wharton's Jelly Mesenchymal Stem Cells plasticity augments scar-free skin wound healing with hair growth.
Sabapathy V, Sundaram B, V M S, Mankuzhy P, Kumar S.
PLoS One. 2014 Apr 15;9(4):e93726. doi: 10.1371/journal.pone.0093726. eCollection 2014.
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Comparison of Markers and Functional Attributes of Human Adipose-Derived Stem Cells and Dedifferentiated Adipocyte Cells from Subcutaneous Fat of an Obese Diabetic Donor.
Watson JE, Patel NA, Carter G, Moor A, Patel R, Ghansah T, Mathur A, Murr MM, Bickford P, Gould LJ, Cooper DR.
Adv Wound Care (New Rochelle). 2014 Mar 1;3(3):219-228.
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Surgical sutures filled with adipose-derived stem cells promote wound healing.
Reckhenrich AK, Kirsch BM, Wahl EA, Schenck TL, Rezaeian F, Harder Y, Foehr P, Machens HG, Egaña JT.
PLoS One. 2014 Mar 13;9(3):e91169. doi: 10.1371/journal.pone.0091169. eCollection 2014.
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Human umbilical cord mesenchymal stem cells transplantation promotes cutaneous wound healing of severe burned rats.
Liu L, Yu Y, Hou Y, Chai J, Duan H, Chu W, Zhang H, Hu Q, Du J.
PLoS One. 2014 Feb 20;9(2):e88348. doi: 10.1371/journal.pone.0088348. eCollection 2014.
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Human Wharton's jelly-mesenchymal stem cells promote skin wound healing through paracrine signaling.
Arno AI, Amini-Nik S, Blit PH, Al-Shehab M, Belo C, Herer E, Tien CH, Jeschke MG.
Stem Cell Res Ther. 2014 Feb 24;5(1):28. [Epub ahead of print]
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Epidermal stem cells cultured on collagen-modified chitin membrane induce in situ tissue regeneration of full-thickness skin defects in mice.
Shen Y, Dai L, Li X, Liang R, Guan G, Zhang Z, Cao W, Liu Z, Mei S, Liang W, Qin S, Xu J, Chen H.
PLoS One. 2014 Feb 7;9(2):e87557. doi: 10.1371/journal.pone.0087557. eCollection 2014.
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Mesenchymal stem cells modified with angiopoietin-1 gene promote wound healing.
Li Y, Zheng L, Xu X, Song L, Li Y, Li W, Zhang S, Zhang F, Jin H.
Stem Cell Res Ther. 2013 Sep 16;4(5):113. doi: 10.1186/scrt324.
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Hypoxic conditioned medium from human amniotic fluid-derived mesenchymal stem cells accelerates skin wound healing through TGF-β/SMAD2 and PI3K/Akt pathways.
Jun EK, Zhang Q, Yoon BS, Moon JH, Lee G, Park G, Kang PJ, Lee JH, Kim A, You S.
Int J Mol Sci. 2014 Jan 6;15(1):605-28. doi: 10.3390/ijms15010605.
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Nanofiber-expanded human umbilical cord blood-derived CD34+ cell therapy accelerates murine cutaneous wound closure by attenuating pro-inflammatory factors and secreting IL-10.
Kanji S, Das M, Aggarwal R, Lu J, Joseph M, Basu S, Pompili VJ, Das H.
Stem Cell Res. 2014 Jan;12(1):275-88. doi: 10.1016/j.scr.2013.11.005. Epub 2013 Nov 15.
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New approach of bone marrow-derived mesenchymal stem cells and human amniotic epithelial cells applications in accelerating wound healing of irradiated albino rats.
Mehanni SS, Ibrahim NF, Hassan AR, Rashed LA.
Int J Stem Cells. 2013 May;6(1):45-54.
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Effect of bone marrow derived mesenchymal stem cells on healing of induced full-thickness skin wounds in albino rat.
Basiouny HS, Salama NM, Maadawi ZM, Farag EA.
Int J Stem Cells. 2013 May;6(1):12-25.
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Vasculoprotective effects of combined endothelial progenitor cells and mesenchymal stem cells in diabetic wound care: their potential role in decreasing wound-oxidative stress.
Sukpat S, Isarasena N, Wongphoom J, Patumraj S.
Biomed Res Int. 2013;2013:459196. doi: 10.1155/2013/459196. Epub 2013 Jun 17.
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Effects of human bone marrow mesenchymal stem cells on burn injury healing in a mouse model.
Xue L, Xu YB, Xie JL, Tang JM, Shu B, Chen L, Qi SH, Liu XS.
Int J Clin Exp Pathol. 2013 Jun 15;6(7):1327-36. Print 2013.
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Integration and regression of implanted engineered human vascular networks during deep wound healing.
Hanjaya-Putra D, Shen YI, Wilson A, Fox-Talbot K, Khetan S, Burdick JA, Steenbergen C, Gerecht S.
Stem Cells Transl Med. 2013 Apr;2(4):297-306. doi: 10.5966/sctm.2012-0111. Epub 2013 Mar 13.
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Human mesenchymal stem cell grafts enhance normal and impaired wound healing by recruiting existing endogenous tissue stem/progenitor cells.
Shin L, Peterson DA.
Stem Cells Transl Med. 2013 Jan;2(1):33-42. doi: 10.5966/sctm.2012-0041. Epub 2012 Dec 21.
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Effective delivery of stem cells using an extracellular matrix patch results in increased cell survival and proliferation and reduced scarring in skin wound healing.
Lam MT, Nauta A, Meyer NP, Wu JC, Longaker MT.
Tissue Eng Part A. 2013 Mar;19(5-6):738-47. doi: 10.1089/ten.TEA.2012.0480. Epub 2012 Nov 16.
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A novel autologous cell-based therapy to promote diabetic wound healing.
Castilla DM, Liu ZJ, Tian R, Li Y, Livingstone AS, Velazquez OC.
Ann Surg. 2012 Oct;256(4):560-72. doi: 10.1097/SLA.0b013e31826a9064.
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Effects of Human Adipose-derived Stem Cells on Cutaneous Wound Healing in Nude Mice.
Lee SH, Lee JH, Cho KH.
Ann Dermatol. 2011 May;23(2):150-5. doi: 10.5021/ad.2011.23.2.150. Epub 2011 May 27.
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Integration of blood outgrowth endothelial cells in dermal fibroblast sheets promotes full thickness wound healing.
Hendrickx B, Verdonck K, Van den Berge S, Dickens S, Eriksson E, Vranckx JJ, Luttun A.
Stem Cells. 2010 Jul;28(7):1165-77. doi: 10.1002/stem.445.
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Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis.
Wu Y, Chen L, Scott PG, Tredget EE.
Stem Cells. 2007 Oct;25(10):2648-59. Epub 2007 Jul 5.
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Mesenchymal stem cells are recruited into wounded skin and contribute to wound repair by transdifferentiation into multiple skin cell type.
Sasaki M, Abe R, Fujita Y, Ando S, Inokuma D, Shimizu H.
J Immunol. 2008 Feb 15;180(4):2581-7.
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Acceleration of sensory neural regeneration and wound healing with human mesenchymal stem cells in immunodeficient rats.
Imaizumi T, Akita S, Akino K, Hirano A.
Stem Cells. 2007 Nov;25(11):2956-63. Epub 2007 Aug 16.
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Transplantation of endothelial progenitor cells accelerates dermal wound healing with increased recruitment of monocytes/macrophages and neovascularization.
Suh W, Kim KL, Kim JM, Shin IS, Lee YS, Lee JY, Jang HS, Lee JS, Byun J, Choi JH, Jeon ES, Kim DK.
Stem Cells. 2005 Nov-Dec;23(10):1571-8. Epub 2005 Aug 4.
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Bone marrow-derived cells contribute to epithelial engraftment during wound healing.
Borue X, Lee S, Grove J, Herzog EL, Harris R, Diflo T, Glusac E, Hyman K, Theise ND, Krause DS.
Am J Pathol. 2004 Nov;165(5):1767-72.
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Leprdb diabetic mouse bone marrow cells inhibit skin wound vascularization but promote wound healing.
Stepanovic V, Awad O, Jiao C, Dunnwald M, Schatteman GC.
Circ Res. 2003 Jun 13;92(11):1247-53. Epub 2003 May 1.
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REVIEW ARTICLES

Clinical application of adipose stem cells in plastic surgery.
Kim YJ, Jeong JH.
J Korean Med Sci. 2014 Apr;29(4):462-7. doi: 10.3346/jkms.2014.29.4.462. Epub 2014 Apr 1
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Paracrine effects of stem cells in wound healing and cancer progression (Review).
Dittmer J, Leyh B.
Int J Oncol. 2014 Jun;44(6):1789-98. doi: 10.3892/ijo.2014.2385. Epub 2014 Apr 11.
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Epidermal Differentiation in Barrier Maintenance and Wound Healing.
Wikramanayake TC, Stojadinovic O, Tomic-Canic M.
Adv Wound Care (New Rochelle). 2014 Mar 1;3(3):272-280. Review.
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Cell therapy for wound healing.
You HJ, Han SK.
J Korean Med Sci. 2014 Mar;29(3):311-9. doi: 10.3346/jkms.2014.29.3.311. Epub 2014 Feb 27.
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Stem Cells and Healing: Impact on Inflammation.
Ennis WJ, Sui A, Bartholomew A.
Adv Wound Care (New Rochelle). 2013 Sep;2(7):369-378. Review.
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Epidermal Stem Cells in Homeostasis and Wound Repair of the Skin.
Senoo M.
Adv Wound Care (New Rochelle). 2013 Jul;2(6):273-282. Review.
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Stem cells in plastic surgery: a review of current clinical and translational applications.
Salibian AA, Widgerow AD, Abrouk M, Evans GR.
Arch Plast Surg. 2013 Nov;40(6):666-75. doi: 10.5999/aps.2013.40.6.666. Epub 2013 Nov 8. Review.
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The use of adipose-derived stem cells as sheets for wound healing.
McLaughlin MM, Marra KG.
Organogenesis. 2013 Apr-Jun;9(2):79-81. doi: 10.4161/org.24946. Epub 2013 Apr 1.
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Epithelial mechanobiology, skin wound healing, and the stem cell niche.
Evans ND, Oreffo RO, Healy E, Thurner PJ, Man YH.
J Mech Behav Biomed Mater. 2013 Dec;28:397-409. doi: 10.1016/j.jmbbm.2013.04.023. Epub 2013 May 14. Review.
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Mesenchymal stem cell therapy in skin: why and what for?
Khosrotehrani K.
Exp Dermatol. 2013 May;22(5):307-10. doi: 10.1111/exd.12141.
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Stem cell therapy for lower extremity diabetic ulcers: where do we stand?
Yang M, Sheng L, Zhang TR, Li Q.
Biomed Res Int. 2013;2013:462179. doi: 10.1155/2013/462179. Epub 2013 Mar 18. Review.
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Concise review: role of mesenchymal stem cells in wound repair.
Maxson S, Lopez EA, Yoo D, Danilkovitch-Miagkova A, Leroux MA.
Stem Cells Transl Med. 2012 Feb;1(2):142-9. doi: 10.5966/sctm.2011-0018. Review.
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Concise review: clinical translation of wound healing therapies based on mesenchymal stem cells.
Jackson WM, Nesti LJ, Tuan RS.
Stem Cells Transl Med. 2012 Jan;1(1):44-50. doi: 10.5966/sctm.2011-0024. Epub 2011 Dec 7. Review.
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Epithelial stem cells and implications for wound repair.
Plikus MV, Gay DL, Treffeisen E, Wang A, Supapannachart RJ, Cotsarelis G.
Semin Cell Dev Biol. 2012 Dec;23(9):946-53. doi: 10.1016/j.semcdb.2012.10.001. Epub 2012 Oct 17. Review.
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Tissue engineering for the management of chronic wounds: current concepts and future perspectives.
Wong VW, Gurtner GC.
Exp Dermatol. 2012 Oct;21(10):729-34. doi: 10.1111/j.1600-0625.2012.01542.x. Epub 2012 Jun 29. Review.
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Mesenchymal stem cell therapy for attenuation of scar formation during wound healing.
Jackson WM, Nesti LJ, Tuan RS.
Stem Cell Res Ther. 2012 May 31;3(3):20. doi: 10.1186/scrt111. Review
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Hypoxic Culturing Enhances the Wound-Healing Potential of Adipose-Derived Stem Cells.
Kim WS, Sung JH.
Adv Wound Care (New Rochelle). 2012 Aug;1(4):172-176. Review.
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Potential benefits of allogeneic bone marrow mesenchymal stem cells for wound healing.
Badiavas AR, Badiavas EV.
Expert Opin Biol Ther. 2011 Nov;11(11):1447-54. doi: 10.1517/14712598.2011.606212. Epub 2011 Aug 20. Review.
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Hair Regeneration
Therapeutic strategy for hair regeneration: hair cycle activation, niche environment modulation, wound-induced follicle neogenesis, and stem cell engineering.
Chueh SC, Lin SJ, Chen CC, Lei M, Wang LM, Widelitz R, Hughes MW, Jiang TX, Chuong CM.
Expert Opin Biol Ther. 2013 Mar;13(3):377-91. doi: 10.1517/14712598.2013.739601. Epub 2013 Jan 5. Review.
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Last modified: Aug 08, 2014
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