Stroke

HUMAN STUDIES

Intravenous transplantation of mesenchymal stem cells preconditioned with early phase stroke serum: current evidence and study protocol for a randomized trial.
Kim SJ, Moon GJ, Chang WH, Kim YH, Bang OY; STARTING-2 (STem cell Application Researches and Trials In NeuroloGy-2) collaborators.
Trials. 2013 Oct 1;14:317. doi: 10.1186/1745-6215-14-317.

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A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke.
Lee JS, Hong JM, Moon GJ, Lee PH, Ahn YH, Bang OY; STARTING collaborators.
Stem Cells. 2010 Jun;28(6):1099-106. doi: 10.1002/stem.430.
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Autologous intravenous bone marrow mononuclear cell therapy for patients with subacuteischaemic stroke: a pilot study.
Prasad K, Mohanty S, Bhatia R, Srivastava MV, Garg A, Srivastava A, Goyal V, Tripathi M, Kumar A, Bal C, Vij A, Mishra NK.
Indian J Med Res. 2012 Aug;136(2):221-8.
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Circulating mesenchymal stem cells microparticles in patients with cerebrovascular disease.
Kim SJ, Moon GJ, Cho YH, Kang HY, Hyung NK, Kim D, Lee JH, Nam JY, Bang OY.
PLoS One. 2012;7(5):e37036. doi: 10.1371/journal.pone.0037036. Epub 2012 May 15.
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Mobilisation of hematopoietic CD34+ precursor cells in patients with acute stroke is safe--results of an open-labeled non randomized phase I/II trial.
Boy S, Sauerbruch S, Kraemer M, Schormann T, Schlachetzki F, Schuierer G, Luerding R, Hennemann B, Orso E, Dabringhaus A, Winkler J, Bogdahn U; RAIS (Regeneration in Acute Ischemic Stroke) Study Group.
PLoS One. 2011;6(8):e23099. doi: 10.1371/journal.pone.0023099. Epub 2011 Aug 26.
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Intravenous administration of auto serum-expanded autologous mesenchymal stem cells in stroke.
Honmou O, Houkin K, Matsunaga T, Niitsu Y, Ishiai S, Onodera R, Waxman SG, Kocsis JD.
Brain. 2011 Jun;134(Pt 6):1790-807. doi: 10.1093/brain/awr063. Epub 2011 Apr 14.
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PRECLINICAL STUDIES

Recovery of neurological function of ischemic stroke by application of conditioned medium of bone marrow mesenchymal stem cells derived from normal and cerebral ischemia rats.
Tsai MJ, Tsai SK, Hu BR, Liou DY, Huang SL, Huang MC, Huang WC, Cheng H, Huang SS.
J Biomed Sci. 2014 Jan 22;21:5. doi: 10.1186/1423-0127-21-5.
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Efficacy and dose-dependent safety of intra-arterial delivery of mesenchymalstem cells in a rodent stroke model.
Yavagal DR, Lin B, Raval AP, Garza PS, Dong C, Zhao W, Rangel EB, McNiece I, Rundek T, Sacco RL, Perez-Pinzon M, Hare JM.
PLoS One. 2014 May 7;9(5):e93735. doi: 10.1371/journal.pone.0093735. eCollection 2014.
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Intra-arterial transplantation of human umbilical cord blood mononuclear cells is more efficacious and safer compared with umbilical cord mesenchymal stromal cells in a rodent stroke model.
Karlupia N, Manley NC, Prasad K, Schäfer R, Steinberg GK.
Stem Cell Res Ther. 2014 Apr 1;5(2):45. [Epub ahead of print]
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Mesenchymal stem cells expressing brain-derived neurotrophic factor enhance endogenous neurogenesis in an ischemic stroke model.
Jeong CH, Kim SM, Lim JY, Ryu CH, Jun JA, Jeun SS.
Biomed Res Int. 2014;2014:129145. doi: 10.1155/2014/129145. Epub 2014 Feb 5.
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Effect of human umbilical cord blood mesenchymal stem cell transplantation on neuronal metabolites in ischemic rabbits.
Guan YM, Zhu Y, Liu XC, Huang HL, Wang ZW, Liu B, Zhu YZ, Wang QS.
BMC Neurosci. 2014 Mar 17;15:41. doi: 10.1186/1471-2202-15-41.
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Combination BMSC and Niaspan treatment of stroke enhances white matter remodeling and synaptic protein expression in diabetic rats.
Ye X, Yan T, Chopp M, Zacharek A, Ning R, Venkat P, Roberts C, Chen J.
Int J Mol Sci. 2013 Nov 11;14(11):22221-32. doi: 10.3390/ijms141122221.
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Low-level laser stimulation on adipose-tissue-derived stem cell treatments for focal cerebral ischemia in rats.
Shen CC, Yang YC, Chiao MT, Chan SC, Liu BS.
Evid Based Complement Alternat Med. 2013;2013:594906. doi: 10.1155/2013/594906. Epub 2013 Dec 2.
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Stem cell-like dog placenta cells afford neuroprotection against ischemic stroke model via heat shock protein upregulation.
Yu S, Tajiri N, Franzese N, Franzblau M, Bae E, Platt S, Kaneko Y, Borlongan CV.
PLoS One. 2013 Sep 25;8(9):e76329. doi: 10.1371/journal.pone.0076329. eCollection 2013.
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Intravenous administration of human umbilical cord blood-derived AC133+ endothelial progenitor cells in rat stroke model reduces infarct volume: magnetic resonance imaging and histological findings.
Iskander A, Knight RA, Zhang ZG, Ewing JR, Shankar A, Varma NR, Bagher-Ebadian H, Ali MM, Arbab AS, Janic B.
Stem Cells Transl Med. 2013 Sep;2(9):703-14. doi: 10.5966/sctm.2013-0066. Epub 2013 Aug 9.
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Effects of bone marrow-derived mesenchymal stem cells on the axonal outgrowth through activation of PI3K/AKT signaling in primary cortical neurons followed oxygen-glucose deprivation injury.
Liu Y, Zhang Y, Lin L, Lin F, Li T, Du H, Chen R, Zheng W, Liu N.
PLoS One. 2013 Nov 12;8(11):e78514. doi: 10.1371/journal.pone.0078514. eCollection 2013.
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Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats.
Xin H, Li Y, Cui Y, Yang JJ, Zhang ZG, Chopp M.
J Cereb Blood Flow Metab. 2013 Nov;33(11):1711-5. doi: 10.1038/jcbfm.2013.152. Epub 2013 Aug 21.
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Engraftment of human mesenchymal stem cells in a rat photothrombotic cerebral infarction model : comparison of intra-arterial and intravenous infusion using MRI and histological analysis.
Byun JS, Kwak BK, Kim JK, Jung J, Ha BC, Park S.
J Korean Neurosurg Soc. 2013 Dec;54(6):467-76. doi: 10.3340/jkns.2013.54.6.467. Epub 2013 Dec 31.
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Factors secreted by endothelial progenitor cells enhance neurorepair responses after cerebral ischemia in mice.
Rosell A, Morancho A, Navarro-Sobrino M, Martínez-Saez E, Hernández-Guillamon M, Lope-Piedrafita S, Barceló V, Borrás F, Penalba A, García-Bonilla L, Montaner J.
PLoS One. 2013 Sep 4;8(9):e73244. doi: 10.1371/journal.pone.0073244. eCollection 2013.
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Survival and differentiation of transplanted neural stem cells derived from human induced pluripotent stem cells in a rat stroke model.
Jensen MB, Yan H, Krishnaney-Davison R, Al Sawaf A, Zhang SC.
J Stroke Cerebrovasc Dis. 2013 May;22(4):304-8. doi: 10.1016/j.jstrokecerebrovasdis.2011.09.008. Epub 2011 Nov 10.
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Transfusion of CXCR4-primed endothelial progenitor cells reduces cerebral ischemic damage and promotes repair in db/db diabetic mice.
Chen J, Chen J, Chen S, Zhang C, Zhang L, Xiao X, Das A, Zhao Y, Yuan B, Morris M, Zhao B, Chen Y.
PLoS One. 2012;7(11):e50105. doi: 10.1371/journal.pone.0050105. Epub 2012 Nov 21.
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Intravenous grafts of amniotic fluid-derived stem cells induce endogenous cell proliferation and attenuate behavioral deficits in ischemic stroke rats.
Tajiri N, Acosta S, Glover LE, Bickford PC, Jacotte Simancas A, Yasuhara T, Date I, Solomita MA, Antonucci I, Stuppia L, Kaneko Y, Borlongan CV.
PLoS One. 2012;7(8):e43779. doi: 10.1371/journal.pone.0043779. Epub 2012 Aug 17.
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Minocycline-preconditioned neural stem cells enhance neuroprotection after ischemic stroke in rats.
Sakata H, Niizuma K, Yoshioka H, Kim GS, Jung JE, Katsu M, Narasimhan P, Maier CM, Nishiyama Y, Chan PH.
J Neurosci. 2012 Mar 7;32(10):3462-73. doi: 10.1523/JNEUROSCI.5686-11.2012.
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Magnetic resonance imaging and fluorescence labeling of clinical-grade mesenchymal stem cells without impacting their phenotype: study in a rat model of stroke.
Detante O, Valable S, de Fraipont F, Grillon E, Barbier EL, Moisan A, Arnaud J, Moriscot C, Segebarth C, Hommel M, Remy C, Richard MJ.
Stem Cells Transl Med. 2012 Apr;1(4):333-41. doi: 10.5966/sctm.2011-0043. Epub 2012 Apr 2.
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Therapeutic effects of human umbilical cord blood-derived mesenchymal stem cells after intrathecal administration by lumbar puncture in a rat model of cerebral ischemia.
Lim JY, Jeong CH, Jun JA, Kim SM, Ryu CH, Hou Y, Oh W, Chang JW, Jeun SS.
Stem Cell Res Ther. 2011 Sep 22;2(5):38. doi: 10.1186/scrt79.
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REVIEW ARTICLES

Stem cell-based therapies for ischemic stroke.
Hao L, Zou Z, Tian H, Zhang Y, Zhou H, Liu L.
Biomed Res Int. 2014;2014:468748. doi: 10.1155/2014/468748. Epub 2014 Feb 26.
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Hyaluronan, neural stem cells and tissue reconstruction after acute ischemic stroke.
Moshayedi P, Carmichael ST.
Biomatter. 2013 Jan-Mar;3(1). pii: e23863. doi: 10.4161/biom.23863. Epub 2013 Jan 1.
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The rise of cell therapy trials for stroke: review of published and registered studies.
Rosado-de-Castro PH, Pimentel-Coelho PM, da Fonseca LM, de Freitas GR, Mendez-Otero R.
Stem Cells Dev. 2013 Aug 1;22(15):2095-111. doi: 10.1089/scd.2013.0089. Epub 2013 Apr 25. Review.
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Endothelial progenitor cells: therapeutic perspective for ischemic stroke.
Zhao YH, Yuan B, Chen J, Feng DH, Zhao B, Qin C, Chen YF.
CNS Neurosci Ther. 2013 Feb;19(2):67-75. doi: 10.1111/cns.12040. Epub 2012 Dec 11. Review
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The potential benefit of stem cell therapy after stroke: an update.
Banerjee S, Williamson DA, Habib N, Chataway J.
Vasc Health Risk Manag. 2012;8:569-80. doi: 10.2147/VHRM.S25745. Epub 2012 Oct 10. Review.
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Cell therapy for stroke: emphasis on optimizing safety and efficacy profile of endothelial progenitor cells.
Kaneko Y, Tajiri N, Shinozuka K, Glover LE, Weinbren NL, Cortes L, Borlongan CV.
Curr Pharm Des. 2012;18(25):3731-4. Review.
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The potential of stem cell therapy for stroke: is PISCES the sign?
Smith HK, Gavins FN.
FASEB J. 2012 Jun;26(6):2239-52. doi: 10.1096/fj.11-195719. Epub 2012 Mar 16. Review
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Stem cell therapy for cerebral ischemia: from basic science to clinical applications.
Abe K, Yamashita T, Takizawa S, Kuroda S, Kinouchi H, Kawahara N.
J Cereb Blood Flow Metab. 2012 Jul;32(7):1317-31. doi: 10.1038/jcbfm.2011.187. Epub 2012 Jan 18. Review.
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Intra-arterial delivery of cell therapies for stroke.
Misra V, Lal A, El Khoury R, Chen PR, Savitz SI.
Stem Cells Dev. 2012 May 1;21(7):1007-15. doi: 10.1089/scd.2011.0612. Epub 2012 Feb 15. Review.
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Toward personalized cell therapies: autologous menstrual blood cells for stroke.
Rodrigues MC, Glover LE, Weinbren N, Rizzi JA, Ishikawa H, Shinozuka K, Tajiri N, Kaneko Y, Sanberg PR, Allickson JG, Kuzmin-Nichols N, Garbuzova-Davis S, Voltarelli JC, Cruz E, Borlongan CV.
J Biomed Biotechnol. 2011;2011:194720. doi: 10.1155/2011/194720. Epub 2011 Nov 20. Review.
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Last modified: Sep 10, 2014
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