PARKINSON'S DISEASE

HUMAN STUDIES

Increased precursor cellproliferation after deep brain stimulation for Parkinson's disease: a human study.
Vedam-Mai V, Gardner B, Okun MS, Siebzehnrubl FA, Kam M, Aponso P, Steindler DA, Yachnis AT, Neal D, Oliver BU, Rath SJ, Faull RL, Reynolds BA, Curtis MA.
PLoS One. 2014 Mar 3;9(3):e88770. doi: 10.1371/journal.pone.0088770. eCollection 2014.
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PRECLINICAL STUDIES

Endogenous neural precursors influence grafted neural stem cellsand contribute to neuroprotection in the parkinsonian rat.
Madhavan L, Daley BF, Sortwell CE, Collier TJ.
Eur J Neurosci. 2012 Mar;35(6):883-95. doi: 10.1111/j.1460-9568.2012.08019.x. Epub 2012 Mar 14.
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Sox-2 Positive Neural Progenitors in the Primate Striatum Undergo Dynamic Changes after Dopamine Denervation.
Ordoñez C, Moreno-Murciano P, Hernandez M, Di Caudo C, Carril-Mundiñano I, Vazquez N, Garcia-Verdugo JM, Sanchez-Pernaute R, Luquin MR.
PLoS One. 2013 Jun 18;8(6):e66377. Print 2013.
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Hypoxia promotes dopaminergic differentiation of mesenchymal stem cells and shows benefits for transplantation in a rat model of Parkinson's disease.
Wang Y, Yang J, Li H, Wang X, Zhu L, Fan M, Wang X.
PLoS One. 2013;8(1):e54296. doi: 10.1371/journal.pone.0054296. Epub 2013 Jan 16.
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Bone marrow-derived microglia-based neurturin delivery protects against dopaminergic neurodegeneration in a mouse model of Parkinson's disease.
Biju KC, Santacruz RA, Chen C, Zhou Q, Yao J, Rohrabaugh SL, Clark RA, Roberts JL, Phillips KA, Imam SZ, Li S.
Neurosci Lett. 2013 Feb 22;535:24-9. doi: 10.1016/j.neulet.2012.12.034. Epub 2013 Jan 4.
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Stem cell grafting improves both motor and cognitive impairments in a genetic model of Parkinson's disease, the aphakia (ak) mouse.
Moon J, Lee HS, Kang JM, Park J, Leung A, Hong S, Chung S, Kim KS.
Cell Transplant. 2013;22(7):1263-79. doi: 10.3727/096368912X657242. Epub 2012 Oct 2.
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Neurogenic potential of progenitor cells isolated from postmortem human Parkinsonian brains.
Wang S, Okun MS, Suslov O, Zheng T, McFarland NR, Vedam-Mai V, Foote KD, Roper SN, Yachnis AT, Siebzehnrubl FA, Steindler DA.
Brain Res. 2012 Jun 29;1464:61-72. doi: 10.1016/j.brainres.2012.04.039. Epub 2012 Apr 27.
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Noninvasive near-infrared live imaging of human adult mesenchymal stem cells transplanted in a rodent model of Parkinson's disease.
Bossolasco P, Cova L, Levandis G, Diana V, Cerri S, Lambertenghi Deliliers G, Polli E, Silani V, Blandini F, Armentero MT.
Int J Nanomedicine. 2012;7:435-47. doi: 10.2147/IJN.S27537. Epub 2012 Jan 31.
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Transplantation of neuronal-primed human bone marrow mesenchymal stem cells in hemiparkinsonian rodents.
Khoo ML, Tao H, Meedeniya AC, Mackay-Sim A, Ma DD.
PLoS One. 2011;6(5):e19025. doi: 10.1371/journal.pone.0019025. Epub 2011 May 23.
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Protein-based human iPS cells efficiently generate functional dopamine neurons and can treat a rat model of Parkinson disease.
Rhee YH, Ko JY, Chang MY, Yi SH, Kim D, Kim CH, Shim JW, Jo AY, Kim BW, Lee H, Lee SH, Suh W, Park CH, Koh HC, Lee YS, Lanza R, Kim KS, Lee SH.
J Clin Invest. 2011 Jun;121(6):2326-35. doi: 10.1172/JCI45794. Epub 2011 May 16.
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Functional integration of grafted neural stem cell-derived dopaminergic neurons monitored by optogenetics in an in vitro Parkinson model.
Tønnesen J, Parish CL, Sørensen AT, Andersson A, Lundberg C, Deisseroth K, Arenas E, Lindvall O, Kokaia M.
PLoS One. 2011 Mar 4;6(3):e17560. doi: 10.1371/journal.pone.0017560.
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Endometrial stem cell transplantation restores dopamine production in a Parkinson's disease model.
Wolff EF, Gao XB, Yao KV, Andrews ZB, Du H, Elsworth JD, Taylor HS.
J Cell Mol Med. 2011 Apr;15(4):747-55. doi: 10.1111/j.1582-4934.2010.01068.x.
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Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats.
Hargus G, Cooper O, Deleidi M, Levy A, Lee K, Marlow E, Yow A, Soldner F, Hockemeyer D, Hallett PJ, Osborn T, Jaenisch R, Isacson O.
Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15921-6. doi: 10.1073/pnas.1010209107. Epub 2010 Aug 23.
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In vitro and in vivo enhanced generation of human A9 dopamine neurons from neural stem cells by Bcl-XL.
Courtois ET, Castillo CG, Seiz EG, Ramos M, Bueno C, Liste I, Martínez-Serrano A.
J Biol Chem. 2010 Mar 26;285(13):9881-97. doi: 10.1074/jbc.M109.054312. Epub 2010 Jan 27.
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Dopaminergic neurons derived from human induced pluripotent stem cells survive and integrate into 6-OHDA-lesioned rats.
Cai J, Yang M, Poremsky E, Kidd S, Schneider JS, Iacovitti L.
Stem Cells Dev. 2010 Jul;19(7):1017-23. doi: 10.1089/scd.2009.0319.
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Human neural stem cells migrate along the nigrostriatal pathway in a primate model of Parkinson's disease.
Bjugstad KB, Teng YD, Redmond DE Jr, Elsworth JD, Roth RH, Cornelius SK, Snyder EY, Sladek JR Jr.
Exp Neurol. 2008 Jun;211(2):362-9. doi: 10.1016/j.expneurol.2008.01.025. Epub 2008 Feb 14.
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Induction of A9 dopaminergic neurons from neural stem cells improves motor function in an animal model of Parkinson's disease.
O'Keeffe FE, Scott SA, Tyers P, O'Keeffe GW, Dalley JW, Zufferey R, Caldwell MA.
Brain. 2008 Mar;131(Pt 3):630-41. doi: 10.1093/brain/awm340. Epub 2008 Jan 17.
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Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice.
Parish CL, Castelo-Branco G, Rawal N, Tonnesen J, Sorensen AT, Salto C, Kokaia M, Lindvall O, Arenas E.
J Clin Invest. 2008 Jan;118(1):149-60.
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Transplantation of human neural stem cells exerts neuroprotection in a rat model of Parkinson's disease.
Yasuhara T, Matsukawa N, Hara K, Yu G, Xu L, Maki M, Kim SU, Borlongan CV.
J Neurosci. 2006 Nov 29;26(48):12497-511.
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Mesencephalic human neural progenitor cells transplanted into the neonatal hemiparkinsonian rat striatum differentiate into neurons and improve motor behaviour.
Hovakimyan M, Haas SJ, Schmitt O, Gerber B, Wree A, Andressen C.
J Anat. 2006 Dec;209(6):721-32.
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Survival and differentiation of transplanted neural stem cells in mice brain with MPTP-induced Parkinson disease.
Li XK, Guo AC, Zuo PP.
Acta Pharmacol Sin. 2003 Dec;24(12):1192-8.
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REVIEW ARTICLES

Patient heal thyself: modeling and treating neurological disorders using patient-derived stem cells.
Ess KC.
ExpBiol Med (Maywood). 2013 Mar;238(3):308-14. doi: 10.1177/1535370213480713. Review.
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Perivascular mesenchymal stem cells in the adult human brain: a future target for neuroregeneration?
Ozen I, Boix J, Paul G.
ClinTransl Med. 2012 Nov 23;1(1):30. doi: 10.1186/2001-1326-1-30.
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Induced pluripotent stem cell technology and direct conversion: new possibilities to study and treat Parkinson's disease.
Roessler R, Boddeke E, Copray S.
Stem Cell Rev. 2013 Aug;9(4):505-13. doi: 10.1007/s12015-012-9369-4. Review.
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Neural stem/progenitor cells as a promising candidate for regenerative therapy of the central nervous system.
Bonnamain V, Neveu I, Naveilhan P.
Front Cell Neurosci. 2012 Apr 11;6:17. doi: 10.3389/fncel.2012.00017. eCollection 2012.
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Redefining Parkinson's disease research using induced pluripotent stem cells.
Pu J, Jiang H, Zhang B, Feng J.
Curr Neurol Neurosci Rep. 2012 Aug;12(4):392-8. doi: 10.1007/s11910-012-0288-1. Review
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Progress on stem cell research towards the treatment of Parkinson's disease.
Gibson SA, Gao GD, McDonagh K, Shen S.
Stem Cell Res Ther. 2012 Apr 3;3(2):11. doi: 10.1186/scrt102. Review.
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Clinical application of stem cell therapy in Parkinson's disease.
Politis M, Lindvall O.
BMC Med. 2012 Jan 4;10:1. doi: 10.1186/1741-7015-10-1. Review.
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Prospects and challenges for the use of stem cell technologies to develop novel therapies for Parkinson disease.
Chinta SJ, Andersen JK.
Cell Cycle. 2011 Dec 15;10(24):4179-80. doi: 10.4161/cc.10.24.18835. Epub 2011 Dec 15. No abstract available.
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Dopamine cell transplantation in Parkinson's disease: challenge and perspective.
Ma Y, Peng S, Dhawan V, Eidelberg D.
Br Med Bull. 2011;100:173-89. doi: 10.1093/bmb/ldr040. Epub 2011 Aug 28. Review.
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Stem cells in human neurodegenerative disorders--time for clinical translation?
Lindvall O, Kokaia Z.
J Clin Invest. 2010 Jan;120(1):29-40. doi: 10.1172/JCI40543. Review.
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Bone marrow-derived mesenchymal stem cell therapy as a candidate disease-modifying strategy in Parkinson's disease and multiple system atrophy.
Lee PH, Park HJ.
J Clin Neurol. 2009 Mar;5(1):1-10. doi: 10.3988/jcn.2009.5.1.1. Epub 2009 Mar 31.
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Future of cell and gene therapies for Parkinson's disease.
Isacson O, Kordower JH.
Ann Neurol. 2008 Dec;64 Suppl 2:S122-38. doi: 10.1002/ana.21473.
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Benefits, risks and ethical considerations in translation of stem cell research to clinical applications in Parkinson's disease.
Master Z, McLeod M, Mendez I.
J Med Ethics. 2007 Mar;33(3):169-73. Review.
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Last modified: Sep 11, 2014
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