MULTIPLE SCLEROSIS AND OTHER AUTOIMMUNE ENCEPHALOPATHIES

HUMAN STUDIES

Transplantation of umbilical cord and bone marrow-derived mesenchymal stem cells in a patient with relapsing-remitting multiple sclerosis.
Hou ZL, Liu Y, Mao XH, Wei CY, Meng MY, Liu YH, Zhuyun Yang Z, Zhu H, Short M, Bernard C, Xiao ZC.
Cell Adh Migr. 2013 Sep-Oct;7(5):404-7. doi: 10.4161/cam.26941. Epub 2013 Oct 30.
FREE ARTICLE

Guidelines of the Brazilian society of bone Marrow transplantation on hematopoietic stem cell transplantation as a treatment for the autoimmune diseases systemic sclerosis and multiple sclerosis.
Rodrigues MC, Hamerschlak N, de Moraes DA, Simões BP, Rodrigues M, Ribeiro AA, Voltarelli JC.
Rev Bras HematolHemoter. 2013;35(2):134-43. doi: 10.5581/1516-8484.20130035. No abstract available.
FREE ARTICLE

Effective combination of human bone marrow mesenchymal stem cells and minocycline in experimental autoimmune encephalomyelitis mice.
Hou Y, Ryu CH, Park KY, Kim SM, Jeong CH, Jeun SS.
Stem Cell Res Ther. 2013 Jul 5;4(4):77. doi: 10.1186/scrt228.
FREE ARTICLE

Characterization of autologous mesenchymal stem cell-derived neural progenitors as a feasible source of stem cells for central nervous system applications in multiple sclerosis.
Harris VK, Faroqui R, Vyshkina T, Sadiq SA.
Stem Cells Transl Med. 2012 Jul;1(7):536-47. doi: 10.5966/sctm.2012-0015. Epub 2012 Jun 28.
FREE ARTICLE

Autologous hematopoietic cell transplantation following high-dose immunosuppressive therapy for advanced multiple sclerosis: long-term results.
Bowen JD, Kraft GH, Wundes A, Guan Q, Maravilla KR, Gooley TA, McSweeney PA, Pavletic SZ, Openshaw H, Storb R, Wener M, McLaughlin BA, Henstorf GR, Nash RA.
Bone Marrow Transplant. 2012 Jul;47(7):946-51. doi: 10.1038/bmt.2011.208. Epub 2011 Nov 7.
FREE ARTICLE

The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessments.
Connick P, Kolappan M, Patani R, Scott MA, Crawley C, He XL, Richardson K, Barber K, Webber DJ, Wheeler-Kingshott CA, Tozer DJ, Samson RS, Thomas DL, Du MQ, Luan SL, Michell AW, Altmann DR, Thompson AJ, Miller DH, Compston A, Chandran S.
Trials. 2011 Mar 2;12:62. doi: 10.1186/1745-6215-12-62.
FREE ARTICLE

Clinical outcome of autologous peripheral blood stem cell transplantation in opticospinal and conventional forms of secondary progressive multiple sclerosis in a Chinese population.
Xu J, Ji BX, Su L, Dong HQ, Sun WL, Wan SG, Liu YO, Zhang P, Liu CY.
Ann Hematol. 2011 Mar;90(3):343-8. doi: 10.1007/s00277-010-1071-5. Epub 2010 Sep 25.
FREE ARTICLE

Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis.
Karussis D, Karageorgiou C, Vaknin-Dembinsky A, Gowda-Kurkalli B, Gomori JM, Kassis I, Bulte JW, Petrou P, Ben-Hur T, Abramsky O, Slavin S.
Arch Neurol. 2010 Oct;67(10):1187-94. doi: 10.1001/archneurol.2010.248.
FREE ARTICLE

Autologous haematopoietic stem cell transplantation fails to stop demyelination and neurodegeneration in multiple sclerosis.
Metz I, Lucchinetti CF, Openshaw H, Garcia-Merino A, Lassmann H, Freedman MS, Atkins HL, Azzarelli B, Kolar OJ, Brück W.
Brain. 2007 May;130(Pt 5):1254-62. Epub 2007 Feb 9.
FREE ARTICLE

Autologous HSCT for severe progressive multiple sclerosis in a multicenter trial: impact on disease activity and quality of life.
Saccardi R, Mancardi GL, Solari A, Bosi A, Bruzzi P, Di Bartolomeo P, Donelli A, Filippi M, Guerrasio A, Gualandi F, La Nasa G, Murialdo A, Pagliai F, Papineschi F, Scappini B, Marmont AM.
Blood. 2005 Mar 15;105(6):2601-7. Epub 2004 Nov 16.
FREE ARTICLE

Hematopoietic stem cell transplantation for progressive multiple sclerosis: failure of a total body irradiation-based conditioning regimen to prevent disease progression in patients with high disability scores.
Burt RK, Cohen BA, Russell E, Spero K, Joshi A, Oyama Y, Karpus WJ, Luo K, Jovanovic B, Traynor A, Karlin K, Stefoski D, Burns WH.
Blood. 2003 Oct 1;102(7):2373-8. Epub 2003 Jul 3.
FREE ARTICLE

High-dose immunosuppressive therapy and autologous peripheral blood stem cell transplantation for severe multiple sclerosis.
Nash RA, Bowen JD, McSweeney PA, Pavletic SZ, Maravilla KR, Park MS, Storek J, Sullivan KM, Al-Omaishi J, Corboy JR, DiPersio J, Georges GE, Gooley TA, Holmberg LA, LeMaistre CF, Ryan K, Openshaw H, Sunderhaus J, Storb R, Zunt J, Kraft GH.
Blood. 2003 Oct 1;102(7):2364-72. Epub 2003 May 22.
FREE ARTICLE

High-dose immunosuppressive therapy with PBPC support in the treatment of poor risk multiple sclerosis.
Kozák T, Havrdová E, Pit'ha J, Gregora E, Pytlík R, Maaloufová J, Marecková H, Kobylka P, Vodvárková S.
Bone Marrow Transplant. 2000 Mar;25(5):525-31.
FREE ARTICLE

T cell-depleted autologous hematopoietic stem cell transplantation for multiple sclerosis: report on the first three patients.
Burt RK, Traynor AE, Cohen B, Karlin KH, Davis FA, Stefoski D, Terry C, Lobeck L, Russell EJ, Goolsby C, Rosen S, Gordon LI, Keever-Taylor C, Brush M, Fishman M, Burns WH.
Bone Marrow Transplant. 1998 Mar;21(6):537-41.
FREE ARTICLE

Treatment of autoimmune disease by intense immunosuppressive conditioning and autologous hematopoieticstem cell transplantation.
Burt RK, Traynor AE, Pope R, Schroeder J, Cohen B, Karlin KH, Lobeck L, Goolsby C, Rowlings P, Davis FA, Stefoski D, Terry C, Keever-Taylor C, Rosen S, Vesole D, Fishman M, Brush M, Mujias S, Villa M, Burns WH.
Blood. 1998 Nov 15;92(10):3505-14.
FREE ARTICLE

 

PRECLINICAL STUDIES

Transplantation of Fas-deficient or wild-type neuralstem/progenitor cells (NPCs) is equally efficient in treating experimental autoimmune encephalomyelitis (EAE).
Hackett C, Knight J, Mao-Draayer Y.
Am J Transl Res. 2014 Jan 15;6(2):119-28. eCollection 2014.
FREE ARTICLE

Suppression of experimental autoimmune encephalomyelitis by interleukin-10 transduced neural stem/progenitor cells.
Klose J, Schmidt NO, Melms A, Dohi M, Miyazaki J, Bischof F, Greve B.
J Neuroinflammation. 2013 Sep 22;10:117. doi: 10.1186/1742-2094-10-117.
FREE ARTICLE

Mesenchymal stem cell conditioning promotes rat oligodendroglialcell maturation.
Jadasz JJ, Kremer D, Göttle P, Tzekova N, Domke J, Rivera FJ, Adjaye J, Hartung HP, Aigner L, Küry P.
PLoS One. 2013 Aug 12;8(8):e71814. doi: 10.1371/journal.pone.0071814. eCollection 2013.
FREE ARTICLE

Effects of murine and human bone marrow-derived mesenchymal stem cells on cuprizone induced demyelination.
Nessler J, Bénardais K, Gudi V, Hoffmann A, Salinas Tejedor L, Janßen S, Prajeeth CK, Baumgärtner W, Kavelaars A, Heijnen CJ, van Velthoven C, Hansmann F, Skripuletz T, Stangel M.
PLoS One. 2013 Jul 26;8(7):e69795. doi: 10.1371/journal.pone.0069795. Print 2013.
FREE ARTICLE

Intranasal Delivery of Neural Stem Cells: A CNS-specific, Non-invasive Cell-based Therapy for Experimental Autoimmune Encephalomyelitis.
Wu S, Li K, Yan Y, Gran B, Han Y, Zhou F, Guan YT, Rostami A, Zhang GX.
J ClinCellImmunol. 2013 Jun 1;4(3). doi: 10.4172/2155-9899.1000142.
FREE ARTICLE

Human iPSC-derived oligodendrocyte progenitor cells can myelinate and rescue a mouse model of congenital hypomyelination.
Wang S, Bates J, Li X, Schanz S, Chandler-Militello D, Levine C, Maherali N, Studer L, Hochedlinger K, Windrem M, Goldman SA.
CellStem Cell. 2013 Feb 7;12(2):252-64. doi: 10.1016/j.stem.2012.12.002.
FREE ARTICLE

Gene therapy of multiple sclerosis using interferon β-secreting human bone marrow mesenchymal stem cells.
Ryu CH, Park KY, Hou Y, Jeong CH, Kim SM, Jeun SS.
Biomed Res Int. 2013;2013:696738. doi: 10.1155/2013/696738. Epub 2013 Apr 22.
FREE ARTICLE

Myelin repair and functional recovery mediated by neural cell transplantation in a mouse model of multiple sclerosis.
Bai L, Hecker J, Kerstetter A, Miller RH.
Neurosci Bull. 2013 Apr;29(2):239-50. doi: 10.1007/s12264-013-1312-4. Epub 2013 Mar 8.
FREE ARTICLE

The Immunomodulatory and Neuroprotective Effects of Mesenchymal Stem Cells (MSCs) in Experimental Autoimmune Encephalomyelitis (EAE): A Model of Multiple Sclerosis (MS).
Al Jumah MA, Abumaree MH.
Int J Mol Sci. 2012;13(7):9298-331. doi: 10.3390/ijms13079298. Epub 2012 Jul 24.
FREE ARTICLE

Accelerated and enhanced effect of CCR5-transduced bone marrow neural stem cells on autoimmune encephalomyelitis.
Yang J, Yan Y, Ma CG, Kang T, Zhang N, Gran B, Xu H, Li K, Ciric B, Zangaladze A, Curtis M, Rostami A, Zhang GX.
ActaNeuropathol. 2012 Oct;124(4):491-503. doi: 10.1007/s00401-012-0989-1. Epub 2012 Apr 22.
FREE ARTICLE

Deletion of beta-2-microglobulin ameliorates spinal cord lesion load and promotes recovery of brainstem NAA levels in a murine model of multiple sclerosis.
Denic A, Pirko I, Wootla B, Bieber A, Macura S, Rodriguez M.
Brain Pathol. 2012 Sep;22(5):698-708. doi: 10.1111/j.1750-3639.2012.00576.x. Epub 2012 Mar 8.
FREE ARTICLE

Oligodendrocyte precursor cell transplantation into organotypic cerebellar shiverer slices: a model to study myelination and myelin maintenance.
Bin JM, Leong SY, Bull SJ, Antel JP, Kennedy TE.
PLoS One. 2012;7(7):e41237. doi: 10.1371/journal.pone.0041237. Epub 2012 Jul 20.
FREE ARTICLE

Early intervention with gene-modified mesenchymal stem cells overexpressing interleukin-4 enhances anti-inflammatory responses and functional recovery in experimental autoimmune demyelination.
Payne NL, Dantanarayana A, Sun G, Moussa L, Caine S, McDonald C, Herszfeld D, Bernard CC, Siatskas C.
Cell Adh Migr. 2012 May-Jun;6(3):179-89. doi: 10.4161/cam.20341. Epub 2012 May 1.
FREE ARTICLE

Amniotic epithelial cells from the human placenta potently suppress a mouse model of multiple sclerosis.
Liu YH, Vaghjiani V, Tee JY, To K, Cui P, Oh DY, Manuelpillai U, Toh BH, Chan J.
PLoS One. 2012;7(4):e35758. doi: 10.1371/journal.pone.0035758. Epub 2012 Apr 26.
FREE ARTICLE

Adipose-derived mesenchymal stem cells ameliorate chronic experimental autoimmune encephalomyelitis.
Constantin G, Marconi S, Rossi B, Angiari S, Calderan L, Anghileri E, Gini B, Bach SD, Martinello M, Bifari F, Galiè M, Turano E, Budui S, Sbarbati A, Krampera M, Bonetti B.
Stem Cells. 2009 Oct;27(10):2624-35. doi: 10.1002/stem.194.
FREE ARTICLE

Allogeneic mesenchymal stem cells for treatment of experimental autoimmune encephalomyelitis.
Rafei M, Birman E, Forner K, Galipeau J.
Mol Ther. 2009 Oct;17(10):1799-803. doi: 10.1038/mt.2009.157. Epub 2009 Jul 14.
FREE ARTICLE

Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis.
Bai L, Lennon DP, Eaton V, Maier K, Caplan AI, Miller SD, Miller RH.
Glia. 2009 Aug 15;57(11):1192-203. doi: 10.1002/glia.20841.
FREE ARTICLE

 

REVIEW ARTICLES

Mechanisms of oligodendrocyte regeneration from ventricular-subventricular zone-derived progenitor cellsin white matter diseases.
Maki T, Liang AC, Miyamoto N, Lo EH, Arai K.
Front CellNeurosci. 2013 Dec 26;7:275. doi: 10.3389/fncel.2013.00275. Review.
FREE ARTICLE

Cell therapy for multiple sclerosis.
Ben-Hur T.
Neurotherapeutics. 2011 Oct;8(4):625-42. doi: 10.1007/s13311-011-0073-x. Review.
FREE ARTICLE

Feasibility of cell therapy in multiple sclerosis: a systematic review of 83 studies.
Ardeshiry Lajimi A, Hagh MF, Saki N, Mortaz E, Soleimani M, Rahim F.
Int J Hematol Oncol Stem Cell Res. 2013;7(1):15-33. Review.
FREE ARTICLE

Hematopoietic stem cell therapy for multiple sclerosis: top 10 lessons learned.
Atkins HL, Freedman MS.
Neurotherapeutics. 2013 Jan;10(1):68-76. doi: 10.1007/s13311-012-0162-5. Review.
FREE ARTICLE

Adult mesenchymal stem cell therapy for myelin repair in multiple sclerosis.
Rivera FJ, Aigner L.
Biol Res. 2012;45(3):257-68. doi: 10.4067/S0716-97602012000300007. Review.
FREE ARTICLE

The potential of mesenchymal stromal cells as a novel cellular therapy for multiple sclerosis.
Auletta JJ, Bartholomew AM, Maziarz RT, Deans RJ, Miller RH, Lazarus HM, Cohen JA.
Immunotherapy. 2012 May;4(5):529-47. doi: 10.2217/imt.12.41. Review.
FREE ARTICLE

The therapeutic effect of mesenchymal stem cell transplantation in experimental autoimmune encephalomyelitis is mediated by peripheral and central mechanisms.
Morando S, Vigo T, Esposito M, Casazza S, Novi G, Principato MC, Furlan R, Uccelli A.
Stem Cell Res Ther. 2012 Jan 26;3(1):3. doi: 10.1186/scrt94. Review.
FREE ARTICLE

Immune mechanisms underlying the beneficial effects of autologous hematopoietic stem cell transplantation in multiple sclerosis.
Gosselin D, Rivest S.
Neurotherapeutics. 2011 Oct;8(4):643-9. doi: 10.1007/s13311-011-0062-0. Review.
FREE ARTICLE

Myelin regeneration in multiple sclerosis: targeting endogenous stem cells.
Huang JK, Fancy SP, Zhao C, Rowitch DH, Ffrench-Constant C, Franklin RJ.
Neurotherapeutics. 2011 Oct;8(4):650-8. doi: 10.1007/s13311-011-0065-x. Review.
FREE ARTICLE

Harnessing the therapeutic potential of mesenchymal stem cells in multiple sclerosis.
Darlington PJ, Boivin MN, Bar-Or A.
Expert Rev Neurother. 2011 Sep;11(9):1295-303. doi: 10.1586/ern.11.113. Review.
FREE ARTICLE

Autologous haematopoietic stem cell transplantation for the treatment of multiple sclerosis.
Loh YS, Hwang WY, Ratnagopal P.
Ann Acad Med Singapore. 2007 Jun;36(6):421-6. Review.
FREE ARTICLE

Stem cell therapy for demyelinating disorders.
Pazour J, Mokrý J.
Acta Medica (Hradec Kralove). 2006;49(2):79-85. Review.
FREE ARTICLE

High-dose immunoablative therapy with hematopoietic stem cell support in the treatment of severe autoimmune disease: current status and future direction.
Tyndall A, Koike T.
Intern Med. 2002 Aug;41(8):608-12. Review.
FREE ARTICLE

Last modified: Sep 10, 2014
ID=x22376