DEMENTIA AND OTHER NEURODEGENERATIVE DISORDERS

HUMAN STUDIES

Stem cell transplantation for adult-onset krabbe disease: report of a case.
Sharp ME, Laule C, Nantel S, Mädler B, Aul RB, Yip S, Sirrs S.
JIMD Rep. 2013;10:57-9. doi: 10.1007/8904_2012_203. Epub 2012 Dec 29.
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Outcomes after allogeneic hematopoietic cell transplantation for childhood cerebral adrenoleukodystrophy: the largest single-institution cohort report.
Miller WP, Rothman SM, Nascene D, Kivisto T, DeFor TE, Ziegler RS, Eisengart J, Leiser K, Raymond G, Lund TC, Tolar J, Orchard PJ.
Blood. 2011 Aug 18;118(7):1971-8. doi: 10.1182/blood-2011-01-329235. Epub 2011 May 17.
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PRECLINICAL STUDIES

Human umbilical cord mesenchymal stem cell-derived neuron-like cells rescue memory deficits and reduce amyloid-beta deposition in an AβPP/PS1 transgenic mouse model.
Yang H, Xie Z, Wei L, Yang H, Yang S, Zhu Z, Wang P, Zhao C, Bi J.
Stem Cell Res Ther. 2013 Jul 4;4(4):76. [Epub ahead of print]
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Genetic correction of tauopathy phenotypes in neurons derived from human induced pluripotent stem cells.
Fong H, Wang C, Knoferle J, Walker D, Balestra ME, Tong LM, Leung L, Ring KL, Seeley WW, Karydas A, Kshirsagar MA, Boxer AL, Kosik KS, Miller BL, Huang Y.
Stem Cell Reports. 2013 Aug 29;1(3):226-34. doi: 10.1016/j.stemcr.2013.08.001. eCollection 2013.
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Establishment of induced pluripotent stem cells from centenarians for neurodegenerative disease research.
Yagi T, Kosakai A, Ito D, Okada Y, Akamatsu W, Nihei Y, Nabetani A, Ishikawa F, Arai Y, Hirose N, Okano H, Suzuki N.
PLoS One. 2012;7(7):e41572. doi: 10.1371/journal.pone.0041572. Epub 2012 Jul 25.
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Characterization and molecular profiling of PSEN1 familial Alzheimer's disease iPSC-derived neural progenitors.
Sproul AA, Jacob S, Pre D, Kim SH, Nestor MW, Navarro-Sobrino M, Santa-Maria I, Zimmer M, Aubry S, Steele JW, Kahler DJ, Dranovsky A, Arancio O, Crary JF, Gandy S, Noggle SA.
PLoS One. 2014 Jan 8;9(1):e84547. doi: 10.1371/journal.pone.0084547. eCollection 2014.
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Multiple low-dose infusions of human umbilical cord blood cells improve cognitive impairments and reduce amyloid-β-associated neuropathology in Alzheimer mice.
Darlington D, Deng J, Giunta B, Hou H, Sanberg CD, Kuzmin-Nichols N, Zhou HD, Mori T, Ehrhart J, Sanberg PR, Tan J.
Stem Cells Dev. 2013 Feb 1;22(3):412-21. doi: 10.1089/scd.2012.0345. Epub 2012 Sep 5.
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Placenta-derived mesenchymal stem cells improve memory dysfunction in an Aβ1-42-infused mouse model of Alzheimer's disease.
Yun HM, Kim HS, Park KR, Shin JM, Kang AR, il Lee K, Song S, Kim YB, Han SB, Chung HM, Hong JT.
Cell Death Dis. 2013 Dec 12;4:e958. doi: 10.1038/cddis.2013.490.
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The preventive and therapeutic effects of intravenous human adipose-derived stem cells in Alzheimer's disease mice.
Kim S, Chang KA, Kim Ja, Park HG, Ra JC, Kim HS, Suh YH.
PLoS One. 2012;7(9):e45757. doi: 10.1371/journal.pone.0045757. Epub 2012 Sep 26.
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Implantation of undifferentiated and pre-differentiated human neural stem cells in the R6/2 transgenic mouse model of Huntington's disease.
El-Akabawy G, Rattray I, Johansson SM, Gale R, Bates G, Modo M.
BMC Neurosci. 2012 Aug 9;13:97. doi: 10.1186/1471-2202-13-97.
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Examination of mesenchymal stem cell-mediated RNAi transfer to Huntington's disease affected neuronal cells for reduction of huntingtin.
Olson SD, Kambal A, Pollock K, Mitchell GM, Stewart H, Kalomoiris S, Cary W, Nacey C, Pepper K, Nolta JA.
Mol Cell Neurosci. 2012 Mar;49(3):271-81. doi: 10.1016/j.mcn.2011.12.001. Epub 2011 Dec 8.
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Soluble intracellular adhesion molecule-1 secreted by human umbilical cord blood-derived mesenchymal stem cell reduces amyloid-β plaques.
Kim JY, Kim DH, Kim JH, Lee D, Jeon HB, Kwon SJ, Kim SM, Yoo YJ, Lee EH, Choi SJ, Seo SW, Lee JI, Na DL, Yang YS, Oh W, Chang JW.
Cell Death Differ. 2012 Apr;19(4):680-91. doi: 10.1038/cdd.2011.140. Epub 2011 Oct 21.
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Human mesenchymal stem cells prolong survival and ameliorate motor deficit through trophic support in Huntington's disease mouse models.
Lin YT, Chern Y, Shen CK, Wen HL, Chang YC, Li H, Cheng TH, Hsieh-Li HM.
PLoS One. 2011;6(8):e22924. doi: 10.1371/journal.pone.0022924. Epub 2011 Aug 5.
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Human multipotent stromal cells (MSCs) increase neurogenesis and decrease atrophy of the striatum in a transgenic mouse model for Huntington's disease.
Snyder BR, Chiu AM, Prockop DJ, Chan AW.
PLoS One. 2010 Feb 22;5(2):e9347. doi: 10.1371/journal.pone.0009347.
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Intracerebral transplantation of bone marrow-derived mesenchymal stem cells reduces amyloid-beta deposition and rescues memory deficits in Alzheimer's disease mice by modulation of immune responses.
Lee JK, Jin HK, Endo S, Schuchman EH, Carter JE, Bae JS.
Stem Cells. 2010 Feb;28(2):329-43. doi: 10.1002/stem.277.
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Neural stem cells transplantation in cortex in a mouse model of Alzheimer's disease.
Wang Q, Matsumoto Y, Shindo T, Miyake K, Shindo A, Kawanishi M, Kawai N, Tamiya T, Nagao S.
J Med Invest. 2006 Feb;53(1-2):61-9.
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REVIEW ARTICLES

Use of genetically modified mesenchymal stem cells to treat neurodegenerative diseases.
Wyse RD, Dunbar GL, Rossignol J.
Int J Mol Sci. 2014 Jan 23;15(2):1719-45. doi: 10.3390/ijms15021719.
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Stem cell technology for neurodegenerative diseases.
Lunn JS, Sakowski SA, Hur J, Feldman EL.
Ann Neurol. 2011 Sep;70(3):353-61. doi: 10.1002/ana.22487. Review.
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Patient heal thyself: modeling and treating neurological disorders using patient-derived stem cells.
Ess KC.
ExpBiol Med (Maywood). 2013 Mar;238(3):308-14. doi: 10.1177/1535370213480713. Review.
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Concise review: Can stem cells be used to treat or model Alzheimer's disease?
Chen WW, Blurton-Jones M.
Stem Cells. 2012 Dec;30(12):2612-8. doi: 10.1002/stem.1240. Review.
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Genetically engineered mesenchymal stem cells as a proposed therapeutic for Huntington's disease.
Olson SD, Pollock K, Kambal A, Cary W, Mitchell GM, Tempkin J, Stewart H, McGee J, Bauer G, Kim HS, Tempkin T, Wheelock V, Annett G, Dunbar G, Nolta JA.
Mol Neurobiol. 2012 Feb;45(1):87-98. doi: 10.1007/s12035-011-8219-8. Epub 2011 Dec 9. Review
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Perivascular mesenchymal stem cells in the adult human brain: a future target for neuroregeneration?
Ozen I, Boix J, Paul G.
ClinTransl Med. 2012 Nov 23;1(1):30. doi: 10.1186/2001-1326-1-30.
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iPSCs to the rescue in Alzheimer's research.
Choi SH, Tanzi RE.
CellStem Cell. 2012 Mar 2;10(3):235-6. doi: 10.1016/j.stem.2012.02.011.
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Modeling familial Alzheimer's disease with induced pluripotent stem cells.
Yagi T, Ito D, Okada Y, Akamatsu W, Nihei Y, Yoshizaki T, Yamanaka S, Okano H, Suzuki N.
Hum Mol Genet. 2011 Dec 1;20(23):4530-9. doi: 10.1093/hmg/ddr394. Epub 2011 Sep 7.
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Human pluripotent stem cell therapy for Huntington's disease: technical, immunological, and safety challenges human pluripotent stem cell therapy for Huntington's disease: technical, immunological, and safety challenges.
Nicoleau C, Viegas P, Peschanski M, Perrier AL.
Neurotherapeutics. 2011 Oct;8(4):562-76. doi: 10.1007/s13311-011-0079-4.
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Stem cells for the treatment of neurodegenerative diseases.
Dantuma E, Merchant S, Sugaya K.
Stem Cell Res Ther. 2010 Dec 10;1(5):37. doi: 10.1186/scrt37. Review.
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Stem Cells Transplantation and Huntington's Disease.
Im W, Lee ST, Chu K, Kim M, Roh JK.
Int J Stem Cells. 2009 May;2(2):102-8. Review.
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Last modified: Sep 11, 2014
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