AMYOTROPHIC LATERAL SCLEROSIS (ALS) AND OTHER MOVEMENT DISORDERS

HUMAN STUDIES

Neurotrophic bone marrow cellular nests prevent spinal motoneuron degeneration in amyotrophic lateral sclerosis patients: a pilot safety study.
Blanquer M, Moraleda JM, Iniesta F, Gómez-Espuch J, Meca-Lallana J, Villaverde R, Pérez-Espejo MÁ, Ruíz-López FJ, García Santos JM, Bleda P, Izura V, Sáez M, De Mingo P, Vivancos L, Carles R, Jiménez J, Hernández J, Guardiola J, Del Rio ST, Antúnez C, De la Rosa P, Majado MJ, Sánchez-Salinas A, López J, Martínez-Lage JF, Martínez S.
Stem Cells. 2012 Jun;30(6):1277-85. doi: 10.1002/stem.1080.
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Lumbar intraspinal injection of neural stem cells in patients with amyotrophic lateral sclerosis: results of a phase I trial in 12 patients.
Glass JD, Boulis NM, Johe K, Rutkove SB, Federici T, Polak M, Kelly C, Feldman EL.
Stem Cells. 2012 Jun;30(6):1144-51. doi: 10.1002/stem.1079.
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Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis.
Karussis D, Karageorgiou C, Vaknin-Dembinsky A, Gowda-Kurkalli B, Gomori JM, Kassis I, Bulte JW, Petrou P, Ben-Hur T, Abramsky O, Slavin S.
Arch Neurol. 2010 Oct;67(10):1187-94. doi: 10.1001/archneurol.2010.248.
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PRECLINICAL STUDIES

Human Motor Neurons Generated from Neural Stem Cells Delay Clinical Onset and Prolong Life in ALS Mouse Model.
Lee HJ, Kim KS, Ahn J, Bae HM, Lim I, Kim SU.
PLoS One. 2014 May 20;9(5):e97518. doi: 10.1371/journal.pone.0097518. eCollection 2014.
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Minimally invasive transplantation of iPSC-derived ALDHhiSSCloVLA4+ neural stem cellseffectively improves the phenotype of an amyotrophic lateral sclerosis model.
Nizzardo M, Simone C, Rizzo F, Ruggieri M, Salani S, Riboldi G, Faravelli I, Zanetta C, Bresolin N, Comi GP, Corti S.
Hum Mol Genet. 2014 Jan 15;23(2):342-54. doi: 10.1093/hmg/ddt425. Epub 2013 Sep 4.
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Motoneuron differentiation of induced pluripotent stem cells from SOD1G93A mice.
Yao XL, Ye CH, Liu Q, Wan JB, Zhen J, Xiang AP, Li WQ, Wang Y, Su H, Lu XL.
PLoS One. 2013 May 28;8(5):e64720. doi: 10.1371/journal.pone.0064720. Print 2013. Erratum in: PLoS One. 2013;8(7). doi:10.1371/annotation/2033887d-1abc-48d1-b87f-dc30f75cfa2d.
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Therapeutic potential of mesenchymal stromal cells and MSC conditioned medium in Amyotrophic Lateral Sclerosis (ALS)--in vitro evidence from primary motor neuron cultures, NSC-34 cells, astrocytes and microglia.
Sun H, Bénardais K, Stanslowsky N, Thau-Habermann N, Hensel N, Huang D, Claus P, Dengler R, Stangel M, Petri S.
PLoS One. 2013 Sep 12;8(9):e72926. doi: 10.1371/journal.pone.0072926. eCollection 2013.
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Intermittent hypoxia and stem cell implants preserve breathing capacity in a rodent model of amyotrophic lateral sclerosis.
Nichols NL, Gowing G, Satriotomo I, Nashold LJ, Dale EA, Suzuki M, Avalos P, Mulcrone PL, McHugh J, Svendsen CN, Mitchell GS.
Am J Respir Crit Care Med. 2013 Mar 1;187(5):535-42. doi: 10.1164/rccm.201206-1072OC. Epub 2012 Dec 6.
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Human neural stem cell replacement therapy for amyotrophic lateral sclerosis by spinal transplantation.
Hefferan MP, Galik J, Kakinohana O, Sekerkova G, Santucci C, Marsala S, Navarro R, Hruska-Plochan M, Johe K, Feldman E, Cleveland DW, Marsala M.
PLoS One. 2012;7(8):e42614. doi: 10.1371/journal.pone.0042614. Epub 2012 Aug 20.
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Intracerebroventricular injection of encapsulated human mesenchymal cells producing glucagon-like peptide 1 prolongs survival in a mouse model of ALS.
Knippenberg S, Thau N, Dengler R, Brinker T, Petri S.
PLoS One. 2012;7(6):e36857. doi: 10.1371/journal.pone.0036857. Epub 2012 Jun 20.
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Human skeletal muscle stem cell antiinflammatory activity ameliorates clinical outcome in amyotrophic lateral sclerosis models.
Canzi L, Castellaneta V, Navone S, Nava S, Dossena M, Zucca I, Mennini T, Bigini P, Parati EA.
Mol Med. 2012 May 9;18:401-11. doi: 10.2119/molmed.2011.00123.
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Human glial-restricted progenitor transplantation into cervical spinal cord of the SOD1 mouse model of ALS.
Lepore AC, O'Donnell J, Kim AS, Williams T, Tuteja A, Rao MS, Kelley LL, Campanelli JT, Maragakis NJ.
PLoS One. 2011;6(10):e25968. doi: 10.1371/journal.pone.0025968. Epub 2011 Oct 5.
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Cellular therapy and induced neuronal replacement for Huntington's disease.
Benraiss A, Goldman SA.
Neurotherapeutics. 2011 Oct;8(4):577-90. doi: 10.1007/s13311-011-0075-8. Review.
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Direct muscle delivery of GDNF with human mesenchymal stem cells improves motor neuron survival and function in a rat model of familial ALS.
Suzuki M, McHugh J, Tork C, Shelley B, Hayes A, Bellantuono I, Aebischer P, Svendsen CN.
Mol Ther. 2008 Dec;16(12):2002-10. doi: 10.1038/mt.2008.197. Epub 2008 Sep 16.
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Combined immunosuppressive agents or CD4 antibodies prolong survival of human neural stem cell grafts and improve disease outcomes in amyotrophic lateral sclerosis transgenic mice.
Yan J, Xu L, Welsh AM, Chen D, Hazel T, Johe K, Koliatsos VE.
Stem Cells. 2006 Aug;24(8):1976-85. Epub 2006 Apr 27.
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Motor neuron degeneration promotes neural progenitor cell proliferation, migration, and neurogenesis in the spinal cords of amyotrophic lateral sclerosis mice.
Chi L, Ke Y, Luo C, Li B, Gozal D, Kalyanaraman B, Liu R.
Stem Cells. 2006 Jan;24(1):34-43. Epub 2005 Aug 11.
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Patient-Specific Induced Pluripotent Stem Cells for SOD1-Associated Amyotrophic Lateral Sclerosis Pathogenesis Studies.
Chestkov IV, Vasilieva EA, Illarioshkin SN, Lagarkova MA, Kiselev SL.
ActaNaturae. 2014 Jan;6(1):54-60.
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REVIEW ARTICLES

Therapy development for spinal muscular atrophy in SMN independent targets.
Tsai LK.
Neural Plast. 2012;2012:456478. doi: 10.1155/2012/456478. Epub 2012 May 31. Review.
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Amyotrophic lateral sclerosis: applications of stem cells - an update.
Cova L, Silani V.
Stem Cells Cloning. 2010 Oct 27;3:145-56. doi: 10.2147/SCCAA.S8662. Review.
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Last modified: Sep 11, 2014
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